[Significance of iron reduction for the therapy of chronic hepatitis C].

Abstract:

BACKGROUND:It has been established that many patients with chronic hepatitis C have elevated serum iron, feritin levels and iron deposites in the liver. Therefore, the liver damage due to hepatitis C virus may be aggravated with iron overload. In many studies higher levels of iron in the blood and the liver were connected with the decreased response to interferon-alfa therapy for chronic viral hepatitis C. Recent introduction of pegylated interferons plus ribavirin has improved the therapeutic response, so it is now possible to cure more than 50% of the patients. CASE REPORT:Three patients with chronic hepatitis C and iron overload were presented. Iron reduction therapy using phlebotomy or eritrocytapheresis with plasmapheresis was done at different times in regard to specific antiviral therapy or as a sole therapy. CONCLUSION:It has been shown that iron reduction, sole or combined with antiviral therapy, led to the deacreased aminotransferase serum activity and might have slown down the evolution of chronic hepatitis C viral infection.

journal_name

Vojnosanit Pregl

journal_title

Vojnosanitetski pregled

authors

Nozić D,Balint B,Stanković N,Dimitrijević J,Nesković G 2nd

doi

10.2298/vsp0502161n

subject

Has Abstract

pub_date

2005-02-01 00:00:00

pages

161-4

issue

2

eissn

0042-8450

issn

2406-0720

journal_volume

62

pub_type

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