[Histometric analysis of gingival hyperplasia in Wistar rats during nifedipine administration].

Abstract:

BACKGROUND/AIM:The use of calcium channel blockers, especially nifedipine, causes gingival hyperplasia which leads to the destruction of the deeper periodontal tissues. During this process, inflammatory changes and the changes of colagen fibers occur. The aim of this study was to metrically compare the extent of proliferation of connective tissue in the deeper periodontal tissue in experimental animals regarding the dose and duration of nifedipine administration. METHODS:The study involved 50 Wistar rats to which water solution of nifedipine was given in certain time intervals and doses. Before starting the experiment, i.e. before nifedipine administration, and in the defined time intervals, measuring of the morphology of gingival size was performed including the buccolingual and mesiodistal wideness and vertical altitude of the central interdental papilla. The measurement was performed by the use of a special graduated probe. Histometric analyses of the tissue samples were done on the sagital cross-sections in the direction from the top to the bottom of papilla on five levels. For the statistical analysis of the data, the established values to the extent of the most present changes were used. The mesiodistal and buccolingual diameters for the levels L2 and L3 were quantitively determined and compared. These values were compared to the vertical diameter of gingival growth determined before the onset of patohistologic analyses of the tissue samples. RESULTS:At the begining of the experiment, the volume of the lower incisive central papilla in the rats was 12 mm(3). The central interdental papilla vertical altitude was 6.6 mm in rats which had received a lower dose of nifedipine, 8 mm in rats which had received a higher dose in the defined time intervals while the value for the control group was 3.8 mm. CONCLUSION:The obtained results showed that the administration of nifedipine led to the extensive gingival hyperplasia in the experimental animals. Gingival hyperplasia correlates with both the dose of nifedipine and the duration of its administration.

journal_name

Vojnosanit Pregl

journal_title

Vojnosanitetski pregled

authors

Brkić Z

doi

10.2298/vsp0701019b

subject

Has Abstract

pub_date

2007-01-01 00:00:00

pages

19-23

issue

1

eissn

0042-8450

issn

2406-0720

journal_volume

64

pub_type

杂志文章
  • [Manufacture of tetracaine hydrochloride tablets using direct compression and moist granulation].

    abstract::The results of quality testing of lozenges made by direct compression and by wet granulation procedure (Ph. Jug. IV) are presented. The aim was to determine hardness, friability and disintegration of the lozenges. Considering the fact that the produced tetracaine hydrochloride lozenges were not transported, but were m...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:

    authors: Gazikalović E,Obrenović D,Nidzović Z,Colić O

    更新日期:2002-11-01 00:00:00

  • [Masked depression].

    abstract::The study comprised 25 patients with masked depression and 30 patients with endogenous depression. According to the general characteristics both groups were homogenous and accordingly, comparable. Together with clinical evaluation of depressive syndrome, psychological management was applied. Rorschach test, Thematic A...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:

    authors: Preradović M,Griva D,Eror S

    更新日期:1991-01-01 00:00:00

  • [Staphylococcal pneumonia associated with pneumatoceles, bilateral pyopneumothorax and sepsis].

    abstract::A case of soldier with community acquired staphylococcal pneumonia and multiple pneumatoceles as the rare complication in adults is presented. Their recognition provides appropriate treatment. In the patient were developed bilateral pneumothorax, pleural empyema and sepsis. Surgical treatment was performed by thoracic...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:

    authors: Stanić V,Stepić V,Sikimić S,Cvorović N,Cvijanović V

    更新日期:1999-09-01 00:00:00

  • Interferon alpha-induced reduction in the values of myeloid-derived suppressor cells in melanoma patients.

    abstract:BACKGROUND/AIM:Interaction between tumor cells and host's immunoregulatory cells in creation of microenvironment that supports tumor progression is the focus of numerous investigations in recent years. Myeloid-derived suppressor cells (MIDSCs) are heterogeneous population of immature dendritic cells, macrophages and gr...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:10.2298/vsp1504342s

    authors: Stanojević I,Gavević M,Jović M,Mijugković Z,Zevević R,Zolotarevski L,Jauković L,Rajović M,Novaković M,Binić I,Vojvodić D

    更新日期:2015-04-01 00:00:00

  • [The Fahr syndrome].

    abstract::Fahr's syndrome is a rare clinical entity consisting of certain metabolic, biochemical, neuroradiologic and neuropsychologic phenomena in which extrapyramidal phenomenology clinically dominates. In this report, primarily from educational reasons, we have presented a female patient, who was before admittance to our cli...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:

    authors: Raicević R,Jovicić A,Djordjević D,Dincić E,Marković Lj

    更新日期:1998-03-01 00:00:00

  • Histological characteristics and markers of proliferation and differentiation in rat brain with experimental glioma.

    abstract:BACKGROUND/AIM:The cell line C6 is a continuous cell line of rat glioma and, as a transplantable line, is frequently used for induction into in vivo model of primary brain tumor. It is believed that, pursuant to its histological traits and biological behavior, this experimental tumor corresponds to human anaplastic ast...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:

    authors: Ristić S,Mirić M,Jović S,Ristić S,Karić J

    更新日期:2014-09-01 00:00:00

  • [Effect of recasting on the thickness of metal-ceramic interface of nickel-chromium and cobalt-chromium alloys].

    abstract:INTRODUCTION/AIM:This research was done to establish recasting effects of nickel-chromium and cobalt-chromium alloys on the thickness of their metal-ceramic interface in making fixed partial dentures. Metal-ceramic interface determines their functional integrity and prevents damages on ceramics during mastication. Inve...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:10.2298/vsp0805365m

    authors:

    更新日期:2008-05-01 00:00:00

  • [Gabapentin as adjuvant therapy in the treatment of refractory partial epilepsy].

    abstract::With the aim to evaluate the clinical efficacy and tolerability of gabapentin as an adjuvant therapy in patients with refractory partial epilepsy we conducted an open-randomized study, with 12-weeks follow-up period. The study included 18 epilepsy patients with unsatisfactorily controlled seizures, in spite of the tre...

    journal_title:Vojnosanitetski pregled

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Tomović M,Ilić T,Mihajlović M,Jovicić A

    更新日期:1999-03-01 00:00:00

  • [Risk factors for the development of hospital infections in the intensive care units].

    abstract:BACKGROUND:Patients admitted to intensive-care units (ICU) are at a high risk of nosocomial infections (NI) due to susceptibility associated with severity of their condition, but also the invasive medical procedures they undergo. AIM:To determine the frequency of NI at the ICU of the General Hospital Uzice, and to ide...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:10.2298/vsp0504265m

    authors: Mijovićc B,Janković S,Maksimović N,Marinković J

    更新日期:2005-04-01 00:00:00

  • [Decortication of the lung in the treatment of nonspecific pleural empyema].

    abstract::In the period 1986-1990 at the Clinic of Cardiac and Thoracic Surgery 86 patients with nonspecific pleural empyema were treated. There were 18 men and one woman, mean age of 35.6 years. Causes of empyema have been the following: pleuropneumonia (10 patients), chest trauma (2), iatrogenic pleural infection (2), spontan...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:

    authors: Stanić V,Cvetanović D,Stepić V,Dautović M,Cvijanović V

    更新日期:1992-11-01 00:00:00

  • [Therapeutic embolization of the spleen].

    abstract::Spleen embolization is a method of percutaneous occlusion of instrasplenic vascular network, by which is achieved a partial embolization of arterial branches with the convenience of controlled circulation reduction. Reduction achieved in this way corrects clinical and laboratory symptoms of hypersplenism and improves ...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:

    authors: Pervulov S,Rusović S,Nikolić G,Draganić M,Jakovljević O

    更新日期:1998-11-01 00:00:00

  • [Angiectatic pseudocyst of the pancreatic head].

    abstract:BACKGROUND:Arteriovenous malformations of the pancreas are very rare, most frequently congenital ones, but tending to increase frequency, predominantly due to the introduction and use of new diagnostic modalities. They usually present with gastrointestinal bleeding and abdominal pain. CASE REPORT:The autors presented ...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:10.2298/vsp0702155c

    authors: Colović R,Grubor N,Jovanović M,Micev M,Radak V,Sagić D

    更新日期:2007-02-01 00:00:00

  • [Significance of inflammatory cytokines in the pathogenesis of IgA nephropathy].

    abstract::Prospective study was performed on the concentrations of inflammatory cytokines IL-1, TNF and IL-6 in serum and urine (ELISA tests) were determined in the scope of total clinical-laboratory and histologic treatment in 59 patients with primary IgA nephropathy. Control group consisted of 20 healthy subjects. IL-6 was no...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:

    authors: Maksić D,Spasić P,Dimitrijević J,Colić M,Hrvacević R,Kovacević Z,Marić M

    更新日期:1998-03-01 00:00:00

  • Oxidative stress and Parkinson's disease.

    abstract::The aim of this study was to determine the baseline state of oxidative stress indices in drug-naive patients with Parkinson's disease (PD). Cerebrospinal fluid (CSF) and peripheral blood samples of 31 subjects, in disease stages I-III, according to Hoehn & Yahr scale, were analyzed and compared with the control group....

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:

    authors: Ilić T,Jovanović M,Jovicić A,Tomović M

    更新日期:1998-09-01 00:00:00

  • [Reduction of juvenile obesity by programmed physical exercise and controlled diet].

    abstract:BACKGROUND/AIM:Obesity is the most common disease of nutrition and is the consequence of reduced movement. Unfortunately, this problem is increasingly present in juvenile age, so that the pediatric outpatient offices are dominated by obese young people. The aim of this study was to evaluate and quantify the effects of ...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:10.2298/vsp1201009s

    authors: Sente J,Jakonić D,Smajić M,Mihajlović I,Vasić G,Romanov R,Marić L

    更新日期:2012-01-01 00:00:00

  • [Formulation of lithium carbonate tablets with various binding substances].

    abstract::The test results of lithium carbonate tablets, made of various binding substances (maize starch, gelatin, sodium carboxymethylcellulose 7pp, kollidon 30) were presented. The content of lithium carbonate, tablets weight variation, hardness, friability, disintegration, as well as the lithium carbonate dissolution rate w...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:

    authors: Gazikolovic E,Obrenovic D,Nicovic Z

    更新日期:2001-11-01 00:00:00

  • [Initial masseter muscle fatigue in maximal voluntary teeth clenching].

    abstract::Fatigue of striated muscles is defined as the impossibility to generate the expected or required force during the repeated contraction. During the maximal voluntary teeth contraction in the position of central occlusion the initial fatigue in masticatory muscles during the isometric contraction occurs. If a person can...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:10.2298/vsp0201043m

    authors: Miljković H,Zeljković M,Anojcić M

    更新日期:2002-01-01 00:00:00

  • Histomorphometric evaluation of bone regeneration using autogenous bone and beta-tricalcium phosphate in diabetic rabbits.

    abstract:Background/Aim:The mechanism of impaired bone healing in diabetes mellitus includes different tissue and cellular level activities due to micro- and macrovascular changes. As a chronic metabolic disease with vascular complications, diabetes affects a process of bone regeneration as well. The therapeutic approach in bon...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:10.2298/VSP151125013Z

    authors: Živadinović M,Andrić M,Milošević V,Manojlović-Stojanoski M,Prokić B,Prokić B,Dimić A,Ćalasan D,Brković B

    更新日期:2016-12-01 00:00:00

  • [Significance of confirming Epstein-Barr virus nuclear antibody as tumor marker].

    abstract:BACKGROUND/AIM:Study of the association between Epstein-Barr virus (EBV) and the tumors of the nasopharynx renders an opportunity to introduce causal treatment Already have been proven the anti-EBV (anti-Epstein-Barr nucleus antigene) antibodies in the blood serum of the patients infected with EBV, while over 91% of th...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:10.2298/vsp0707459s

    authors: Stosić-Divjak S,Dukić V,Boricić I,Racić AJ,Divjak I,Krsmanović V

    更新日期:2007-07-01 00:00:00

  • Right ventricular myxoma - a case report.

    abstract:INTRODUCTION:Myxomas arising from the right ventricle are extremely rare. CASE REPORT:We presented a 71-year-old patient with worsening symptoms of the exertional dyspnea and atypical chest pains lasting 6 months. A transthoracic and transesophageal echocardiogram revealed a large, 2.6 x 2.2 cm, ovoid, well-circumscri...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:10.2298/vsp1306609o

    authors: Obrenović-Kirćanski B,Mikić A,Velinović M,Bozić V,Kovacević-Kostić N,Karan R,Parapid B,Djukić P,Savić D,Vranes M

    更新日期:2013-06-01 00:00:00

  • [Success rate of intrauterine insemination in patients with unknown infertility].

    abstract:BACKGROUND/AIM:Unknown cause of infertility exists in 10%-26% of couples with infertility problems. Treatment of these couples depends on the posibility of correcting the unidentified defect over time. Intrauterine insemination (IUI) and ovaluation stimulation are methods of choice in treatment of unexplained fertility...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:10.2298/vsp1204301j

    authors: Jasović V,Jasović-Siveska E

    更新日期:2012-04-01 00:00:00

  • [Antibiotic resistance in hospital strains of Enterococcus faecalis and Enterococcus faecium].

    abstract::The aim of this study was to determine the resistance of Enterococcus faecalis (E. faecalis) and Enterococcus faecium (E. faecium) to penicillin, ampicillin, vancomycin, teicoplanin, gentamicin (high level), streptomycin (high level), oxytetracycline, chloramphenicol, rifampin, erythromycin, ciprofloxacin, norfloxacin...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:10.2298/vsp0205499m

    authors: Mirović V

    更新日期:2002-09-01 00:00:00

  • [Correlation between disease progression and histopathologic criterions of the lip squamous cell carcinoma].

    abstract:BACKGROUND/AIM:The most common malignancy of the lip is squamous cell carcinoma (SCC). In our population, according to epidemiological data, almost a half of all (45%) SCC of oral mucous tissue spreads over the lower and upper lip. The aim of this study was to estimate prognostic importance of histopathologic character...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:10.2298/vsp1001019g

    authors: Golubović M,Asanin B,Jelovac D,Petrović M,Antunović M

    更新日期:2010-01-01 00:00:00

  • Intrathecal synthesis of complement components C3c and C4 in the central nervous system infections with signs of the acute serous meningitis syndrome.

    abstract::Two hundred and ten patients with meningismus and the infections of the central nervous system (CNS) with the clinical symptoms and signs of the acute serous meningitis syndrome, were divided in to groups according to etiology (enterovirus meningitis-ENTERO, serous meningitis various etiology-SM and tuberculous mening...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:10.2298/vsp0203265t

    authors: Tatomirović Z,Bokun R,Bokonjić D

    更新日期:2002-05-01 00:00:00

  • [Cessation of epileptic seizures series using peroral valproate in an adult patient with partial epilepsy].

    abstract:INTRODUCTION:Golden rule for the initiation of antiepileptic therapy in the majority of epileptic syndromes is "start low and go slow", a principle after the second unprovoked seizure. There are certain clinical situations however when fast titration of antiepileptic medication is needed. CASE REPORT:We present a case...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:10.2298/vsp0706425s

    authors: Spasić M,Lukić S

    更新日期:2007-06-01 00:00:00

  • [Amiodarone--pro and con].

    abstract:OBJECTIVE:To compare and evaluate the data for and against the use of antiarrhythmic agent amiodarone in known cardiological indications. DATA SOURCES:A MEDLINE search was used to identify the articles dealing with amiodarone, published in the last 15 years. STUDY SELECTION:Articles and studies (uncontrolled retrospe...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:

    authors: Tadić V,Mijailović Z,Filipović S

    更新日期:1998-09-01 00:00:00

  • The effects of short-term preoperative physical therapy and education on early functional recovery of patients younger than 70 undergoing total hip arthroplasty.

    abstract:BACKGROUND/AIM:Hip arthroplasty is a routine operation which relieves pain in patients with osteoarthritis. The role of physical therapy after hip arthroplasty was recognized, but the importance of preoperative physical therapy and education is still to be judged. The aim of this paper was to investigate the effect of ...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章,随机对照试验

    doi:10.2298/vsp0804291v

    authors: Vukomanović A,Popović Z,Durović A,Krstić L

    更新日期:2008-04-01 00:00:00

  • [Changes in F-response parameters in supraspinal lesions of the central nervous system].

    abstract::Since the F response is the result of antidromic activation of limited number of alpha motor neurons, the motor neurons excitability level can be investigated and established by analyzing parameter values of F response. The excitability of alpha motor neurons is the result of balance between excitatory and inhibitory ...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:

    authors: Jovicić A,Dordević D,Jovanović M,Petković S

    更新日期:1996-05-01 00:00:00

  • [Stability of B1 and G2 aflatoxins after routine water chlorination].

    abstract::Stability of aflatoxin B1 and G2 as water pollutants in the presence of active chlorine was examined. One liter of demineralized water was polluted with 0.5 mg of aflatoxin B1 and with 0.5 mg of aflatoxin G2. Routine chlorination with Pantacide tablets was applied afterwards. Initial aflatoxin concentrations and those...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:

    authors: Radosević P

    更新日期:1990-07-01 00:00:00

  • [Adaptation problems of soldiers to the military environment].

    abstract::Sixty six conscripts were examined during the first 30 days of military service, in the period of adaptation to the military environment. Out of total number of the examined soldiers, 83.33% of them enlisted with previous problems from the civilian life. Two thirds of the examined soldiers experience difficulties endu...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:

    authors: Dedić G,Krstić J

    更新日期:1996-01-01 00:00:00