Abstract:
BACKGROUND/AIM:The use of calcium channel blockers, especially nifedipine, causes gingival hyperplasia which leads to the destruction of the deeper periodontal tissues. During this process, inflammatory changes and the changes of colagen fibers occur. The aim of this study was to metrically compare the extent of proliferation of connective tissue in the deeper periodontal tissue in experimental animals regarding the dose and duration of nifedipine administration. METHODS:The study involved 50 Wistar rats to which water solution of nifedipine was given in certain time intervals and doses. Before starting the experiment, i.e. before nifedipine administration, and in the defined time intervals, measuring of the morphology of gingival size was performed including the buccolingual and mesiodistal wideness and vertical altitude of the central interdental papilla. The measurement was performed by the use of a special graduated probe. Histometric analyses of the tissue samples were done on the sagital cross-sections in the direction from the top to the bottom of papilla on five levels. For the statistical analysis of the data, the established values to the extent of the most present changes were used. The mesiodistal and buccolingual diameters for the levels L2 and L3 were quantitively determined and compared. These values were compared to the vertical diameter of gingival growth determined before the onset of patohistologic analyses of the tissue samples. RESULTS:At the begining of the experiment, the volume of the lower incisive central papilla in the rats was 12 mm(3). The central interdental papilla vertical altitude was 6.6 mm in rats which had received a lower dose of nifedipine, 8 mm in rats which had received a higher dose in the defined time intervals while the value for the control group was 3.8 mm. CONCLUSION:The obtained results showed that the administration of nifedipine led to the extensive gingival hyperplasia in the experimental animals. Gingival hyperplasia correlates with both the dose of nifedipine and the duration of its administration.
journal_name
Vojnosanit Pregljournal_title
Vojnosanitetski pregledauthors
Brkić Zdoi
10.2298/vsp0701019bsubject
Has Abstractpub_date
2007-01-01 00:00:00pages
19-23issue
1eissn
0042-8450issn
2406-0720journal_volume
64pub_type
杂志文章abstract::The results of quality testing of lozenges made by direct compression and by wet granulation procedure (Ph. Jug. IV) are presented. The aim was to determine hardness, friability and disintegration of the lozenges. Considering the fact that the produced tetracaine hydrochloride lozenges were not transported, but were m...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:2002-11-01 00:00:00
abstract::The study comprised 25 patients with masked depression and 30 patients with endogenous depression. According to the general characteristics both groups were homogenous and accordingly, comparable. Together with clinical evaluation of depressive syndrome, psychological management was applied. Rorschach test, Thematic A...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:1991-01-01 00:00:00
abstract::A case of soldier with community acquired staphylococcal pneumonia and multiple pneumatoceles as the rare complication in adults is presented. Their recognition provides appropriate treatment. In the patient were developed bilateral pneumothorax, pleural empyema and sepsis. Surgical treatment was performed by thoracic...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:1999-09-01 00:00:00
abstract:BACKGROUND/AIM:Interaction between tumor cells and host's immunoregulatory cells in creation of microenvironment that supports tumor progression is the focus of numerous investigations in recent years. Myeloid-derived suppressor cells (MIDSCs) are heterogeneous population of immature dendritic cells, macrophages and gr...
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pub_type: 杂志文章
doi:10.2298/vsp1504342s
更新日期:2015-04-01 00:00:00
abstract::Fahr's syndrome is a rare clinical entity consisting of certain metabolic, biochemical, neuroradiologic and neuropsychologic phenomena in which extrapyramidal phenomenology clinically dominates. In this report, primarily from educational reasons, we have presented a female patient, who was before admittance to our cli...
journal_title:Vojnosanitetski pregled
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doi:
更新日期:1998-03-01 00:00:00
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pub_type: 杂志文章
doi:
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abstract:INTRODUCTION/AIM:This research was done to establish recasting effects of nickel-chromium and cobalt-chromium alloys on the thickness of their metal-ceramic interface in making fixed partial dentures. Metal-ceramic interface determines their functional integrity and prevents damages on ceramics during mastication. Inve...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp0805365m
更新日期:2008-05-01 00:00:00
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journal_title:Vojnosanitetski pregled
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1999-03-01 00:00:00
abstract:BACKGROUND:Patients admitted to intensive-care units (ICU) are at a high risk of nosocomial infections (NI) due to susceptibility associated with severity of their condition, but also the invasive medical procedures they undergo. AIM:To determine the frequency of NI at the ICU of the General Hospital Uzice, and to ide...
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pub_type: 杂志文章
doi:10.2298/vsp0504265m
更新日期:2005-04-01 00:00:00
abstract::In the period 1986-1990 at the Clinic of Cardiac and Thoracic Surgery 86 patients with nonspecific pleural empyema were treated. There were 18 men and one woman, mean age of 35.6 years. Causes of empyema have been the following: pleuropneumonia (10 patients), chest trauma (2), iatrogenic pleural infection (2), spontan...
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pub_type: 杂志文章
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更新日期:1992-11-01 00:00:00
abstract::Spleen embolization is a method of percutaneous occlusion of instrasplenic vascular network, by which is achieved a partial embolization of arterial branches with the convenience of controlled circulation reduction. Reduction achieved in this way corrects clinical and laboratory symptoms of hypersplenism and improves ...
journal_title:Vojnosanitetski pregled
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doi:
更新日期:1998-11-01 00:00:00
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journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp0702155c
更新日期:2007-02-01 00:00:00
abstract::Prospective study was performed on the concentrations of inflammatory cytokines IL-1, TNF and IL-6 in serum and urine (ELISA tests) were determined in the scope of total clinical-laboratory and histologic treatment in 59 patients with primary IgA nephropathy. Control group consisted of 20 healthy subjects. IL-6 was no...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:1998-03-01 00:00:00
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journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:1998-09-01 00:00:00
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journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp1201009s
更新日期:2012-01-01 00:00:00
abstract::The test results of lithium carbonate tablets, made of various binding substances (maize starch, gelatin, sodium carboxymethylcellulose 7pp, kollidon 30) were presented. The content of lithium carbonate, tablets weight variation, hardness, friability, disintegration, as well as the lithium carbonate dissolution rate w...
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pub_type: 杂志文章
doi:
更新日期:2001-11-01 00:00:00
abstract::Fatigue of striated muscles is defined as the impossibility to generate the expected or required force during the repeated contraction. During the maximal voluntary teeth contraction in the position of central occlusion the initial fatigue in masticatory muscles during the isometric contraction occurs. If a person can...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp0201043m
更新日期:2002-01-01 00:00:00
abstract:Background/Aim:The mechanism of impaired bone healing in diabetes mellitus includes different tissue and cellular level activities due to micro- and macrovascular changes. As a chronic metabolic disease with vascular complications, diabetes affects a process of bone regeneration as well. The therapeutic approach in bon...
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更新日期:2016-12-01 00:00:00
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pub_type: 杂志文章
doi:10.2298/vsp0707459s
更新日期:2007-07-01 00:00:00
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pub_type: 杂志文章
doi:10.2298/vsp1204301j
更新日期:2012-04-01 00:00:00
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doi:10.2298/vsp0205499m
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journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp1001019g
更新日期:2010-01-01 00:00:00
abstract::Two hundred and ten patients with meningismus and the infections of the central nervous system (CNS) with the clinical symptoms and signs of the acute serous meningitis syndrome, were divided in to groups according to etiology (enterovirus meningitis-ENTERO, serous meningitis various etiology-SM and tuberculous mening...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp0203265t
更新日期:2002-05-01 00:00:00
abstract:INTRODUCTION:Golden rule for the initiation of antiepileptic therapy in the majority of epileptic syndromes is "start low and go slow", a principle after the second unprovoked seizure. There are certain clinical situations however when fast titration of antiepileptic medication is needed. CASE REPORT:We present a case...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp0706425s
更新日期:2007-06-01 00:00:00
abstract:OBJECTIVE:To compare and evaluate the data for and against the use of antiarrhythmic agent amiodarone in known cardiological indications. DATA SOURCES:A MEDLINE search was used to identify the articles dealing with amiodarone, published in the last 15 years. STUDY SELECTION:Articles and studies (uncontrolled retrospe...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:1998-09-01 00:00:00
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journal_title:Vojnosanitetski pregled
pub_type: 杂志文章,随机对照试验
doi:10.2298/vsp0804291v
更新日期:2008-04-01 00:00:00
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journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:1996-05-01 00:00:00
abstract::Stability of aflatoxin B1 and G2 as water pollutants in the presence of active chlorine was examined. One liter of demineralized water was polluted with 0.5 mg of aflatoxin B1 and with 0.5 mg of aflatoxin G2. Routine chlorination with Pantacide tablets was applied afterwards. Initial aflatoxin concentrations and those...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:1990-07-01 00:00:00
abstract::Sixty six conscripts were examined during the first 30 days of military service, in the period of adaptation to the military environment. Out of total number of the examined soldiers, 83.33% of them enlisted with previous problems from the civilian life. Two thirds of the examined soldiers experience difficulties endu...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:1996-01-01 00:00:00