Abstract:
:Prospective study was performed on the concentrations of inflammatory cytokines IL-1, TNF and IL-6 in serum and urine (ELISA tests) were determined in the scope of total clinical-laboratory and histologic treatment in 59 patients with primary IgA nephropathy. Control group consisted of 20 healthy subjects. IL-6 was not detected either in serum of patients with IgAN, or in control examinees. TNF alpha and IL-1 beta were detected in control patients' sera and in patients with IgAN, but detected concentrations were not significantly different. IL-1 beta in urine was detected in 82.8%, TNF alpha in 90.0%, and IL-6 in 40% of our patients with IgAN. The concentrations of IL-1 beta were significantly higher compared to IL-1 beta concentrations in urine of healthy subjects and significantly correlated with the severity of glomerular and tubulointerstitial changes, as well as with the degree of proteinuria. Direct and indirect toxicity of TNF alpha on renal structures was confirmed in significantly higher concentrations of that cytokine in urine of patients with mesangial sclerosis of different percentage compared to the patients with isolated mesangial hypercellularity. Also in the patients with index of chronic lesion over 7 significantly higher TNF alpha concentrations in urine were found compared to the patients with lesion index 0-3 and 4-7. Creatinine clearance was in negative correlation with TNF alpha concentrations in urine of our patients with IgAN. Concentrations of IL-6 in urine were in correlation neither with laboratory parameters of renal function, nor with the degree of histologic changes.
journal_name
Vojnosanit Pregljournal_title
Vojnosanitetski pregledauthors
Maksić D,Spasić P,Dimitrijević J,Colić M,Hrvacević R,Kovacević Z,Marić Msubject
Has Abstractpub_date
1998-03-01 00:00:00pages
141-9issue
2eissn
0042-8450issn
2406-0720journal_volume
55pub_type
杂志文章abstract:BACKGROUND/AIM:Anatomical parameters of the bony components of the hip joint are essential for better understanding of etiopathogenesis of diseases like primary osteoarthrosis of the hip joint. The aim of this reserch was to examine the normal acetabular morphometry in Serbian population and to determine whether there ...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:2011-11-01 00:00:00
abstract:BACKGROUND/AIM:The use of calcium channel blockers, especially nifedipine, causes gingival hyperplasia which leads to the destruction of the deeper periodontal tissues. During this process, inflammatory changes and the changes of colagen fibers occur. The aim of this study was to metrically compare the extent of prolif...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp0701019b
更新日期:2007-01-01 00:00:00
abstract::The forensic-medical expertise of 24 predominantly carbonized bodies, that were found at Kukin Do was reported. The victims were from Gospić and its surroundings, who disappeared between October 16-18, 1991. The expertise involved the identification of bodies, injury classification, determination of tools by which inj...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:1992-03-01 00:00:00
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pub_type: 杂志文章
doi:10.2298/vsp0802135i
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journal_title:Vojnosanitetski pregled
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doi:10.2298/vsp1112068p
更新日期:2011-12-01 00:00:00
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journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:1992-05-01 00:00:00
abstract:Background/Aim:Sametimes war veterans may resort to such strategies as preducing exaggerated symptoms and malingerating in order to obtain material compensation rights. The aim of this study was to assess the accuracy of the diagnosis of posttraumatic stress disorder (PTSD) on the basis of which war veterans were entit...
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pub_type: 杂志文章
doi:10.2298/VSP150124090S
更新日期:2016-10-01 00:00:00
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pub_type: 杂志文章
doi:10.2298/vsp1105387m
更新日期:2011-05-01 00:00:00
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journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp130118042v
更新日期:2014-07-01 00:00:00
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doi:
更新日期:1995-05-01 00:00:00
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更新日期:2010-11-01 00:00:00
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更新日期:2013-10-01 00:00:00
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更新日期:2003-03-01 00:00:00
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doi:
更新日期:2014-09-01 00:00:00
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journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp0811810t
更新日期:2008-11-01 00:00:00
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journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:1996-03-01 00:00:00
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journal_title:Vojnosanitetski pregled
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更新日期:2007-08-01 00:00:00
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pub_type: 杂志文章
doi:
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journal_title:Vojnosanitetski pregled
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doi:
更新日期:1989-05-01 00:00:00
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doi:10.2298/vsp0505365j
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更新日期:2013-04-01 00:00:00
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journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp0201043m
更新日期:2002-01-01 00:00:00
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doi:10.2298/vsp0905359r
更新日期:2009-05-01 00:00:00
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更新日期:2012-04-01 00:00:00
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更新日期:2014-12-01 00:00:00
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pub_type: 杂志文章
doi:
更新日期:1996-05-01 00:00:00
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pub_type: 杂志文章
doi:
更新日期:1998-11-01 00:00:00
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doi:10.2298/vsp0503213m
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