Hepcidin and iron metabolism disorders in patients with chronic kidney disease.

Abstract:

BACKGROUND/AIM:[corrected] Hepcidin may play a pathogenetic role in iron metobolism disorders. The aim of this study was to determine the correlation between hepcidin concentration and parameters of iron metabolism in patients with different stage of chronic kidney disease (CKD). METHODS:The study involved 104 patients with CKD: 64 on hemodialysis (HD) and 40 patients in pre-dialysis stadium (pre-HD) with adequate erythropoetin therapy and iron supplementation. The HD group was divided in four subgroups according to the level of serum ferritin (up to 100; 100-199; 200-499 and over 500 ng/mL). Parameters of anemia, iron status, in flamation and hepcidin level were evaluated. RESULTS:The HD patients had a significantly lower eritrocyte count, erythrocytes indexes, hemoglobin and transferrin saturation and significantly higher iron, ferritin, hepcidin and total iron binding capacity (TIBC). The HD subgroups up to 199 ng/mL of serum feritin had lower high-sensitivity C-reactive protein (hsCRP), iron and higher unbuffered iron binding capacity (UIBC), transferrin saturation and TIBC compared to the HD subgroups over 200 ng/mL. The lowest and the highest ferritin subgroups had the highest hepcidin level and it showed significant correlation with ferritin. CONCLUSION:Hepcidin may serve as a marker for better diagnosing and monitoring anemia and iron metabolism disorders in CKD.

journal_name

Vojnosanit Pregl

journal_title

Vojnosanitetski pregled

authors

Jelić M,Cvetković T,Djordjević V,Damnjanovć G,Vlahović P,Kocić G,Djindjić N,Jovović B,Antić A

doi

10.2298/vsp1304368j

subject

Has Abstract

pub_date

2013-04-01 00:00:00

pages

368-73

issue

4

eissn

0042-8450

issn

2406-0720

journal_volume

70

pub_type

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