Abstract:
BACKGROUND/AIM:The cell line C6 is a continuous cell line of rat glioma and, as a transplantable line, is frequently used for induction into in vivo model of primary brain tumor. It is believed that, pursuant to its histological traits and biological behavior, this experimental tumor corresponds to human anaplastic astrocytoma of grade II/III, which is characterized by proliferative and invasive potency, and marked cell differentiation. The aim of this study was to determine macroscopic analysis of rat brain with implanted tumor during tumorigenesis, histological features of tumor cells of induced brain tumor and markers of proliferation (proliferation cell nuclear antigen - PCNA, cytokeratin - CK 19) and differentiation (glial fibrillary acidic protein -GFAP) in rat brain with implanted tumor. METHODS:To determine histological structure of the brain with implanted C6 cells, we used brain sections stained for hematoxylin-eosin or kresyl violet, whereas other sections were immunohistochemically stained for GFAP, CK 19 and PCNA. RESULTS:A statistically significant difference in weights of the left and right brain hemispheres with implanted tumors during tumorigenesis in as soon as 7 days from the day of inducing tumors was revealed. The tumor was of cellular type, with distinct pleomorphism of cells and frequent hyperchromasia of the nucleus. Immunohistochemical staining for PCNA revealed a significant number of positive cells on the days 7, 14 and 21 day following the implantation of C6 cells. CK 19 positive cells were present in both brain hemispheres, and numerous GFAP positive astrocytes were found around the puncture lesion. CONCLUSIONS:Within the experimental conditions of the present research, C6 glioma did not demonstrate any relevant deviations concerning development, clinical symptomatology and macroscopic anatomy relative to those already described in the literature.
journal_name
Vojnosanit Pregljournal_title
Vojnosanitetski pregledauthors
Ristić S,Mirić M,Jović S,Ristić S,Karić Jsubject
Has Abstractpub_date
2014-09-01 00:00:00pages
828-32issue
9eissn
0042-8450issn
2406-0720journal_volume
71pub_type
杂志文章abstract:BACKGROUND/AIM:Study of the association between Epstein-Barr virus (EBV) and the tumors of the nasopharynx renders an opportunity to introduce causal treatment Already have been proven the anti-EBV (anti-Epstein-Barr nucleus antigene) antibodies in the blood serum of the patients infected with EBV, while over 91% of th...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp0707459s
更新日期:2007-07-01 00:00:00
abstract::Pseudomembranous colitis (PMC) is an infectious colon disease caused by Cl. difficile toxin. Each change of the intraluminal microbiological balance as well as damages of the hemato-enteral barrier may cause changes in the enteral flora and selective proliferation of anaerobic bacterial strains. PMC has been most freq...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
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journal_title:Vojnosanitetski pregled
pub_type: 杂志文章,随机对照试验
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更新日期:2011-05-01 00:00:00
abstract:BACKGROUND/AIM:Multiple sclerosis (MS) is a chronic inflammatory disease of central nervous system. The main physiopatological feature of MS is demyelination. Multiple sclerosis is one of three most common causes of severe disability in youngest people. In patients with MS, apart from complete psychophysical status and...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp0908645k
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abstract::Sixty six conscripts were examined during the first 30 days of military service, in the period of adaptation to the military environment. Out of total number of the examined soldiers, 83.33% of them enlisted with previous problems from the civilian life. Two thirds of the examined soldiers experience difficulties endu...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:1996-01-01 00:00:00
abstract:BACKGROUND/AIM:Congenital absence of vagina is known from ancient times of Greek. According to the literature data, incidence is 1/4 000 to 1/20 000. Treatment of this anomaly includes non-operative and operative procedures. McIndoe procedure uses split skin graft by Thiersch. The aim of this study was to establish ana...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp0902107k
更新日期:2009-02-01 00:00:00
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journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:1992-09-01 00:00:00
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journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
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journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
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更新日期:2011-09-01 00:00:00
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更新日期:2005-12-01 00:00:00
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journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp141222030m
更新日期:2016-05-01 00:00:00
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journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp0406599k
更新日期:2004-11-01 00:00:00
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journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp0612039d
更新日期:2006-12-01 00:00:00
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journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp111229024g
更新日期:2013-01-01 00:00:00
abstract::A 'new' group of pathogenic agents, enterohemorrhagic Escherichia coli (EHEC) (particularly the strains of O157 serogroup), emerged in the last 20 years, causing an increased number of sporadic and epidemic diarrhoeal diseases with hemorrhagic enterocolitis as a most common clinical manifestation of the infection. As ...
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pub_type: 杂志文章
doi:10.2298/vsp0304493c
更新日期:2003-07-01 00:00:00
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journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp1001019g
更新日期:2010-01-01 00:00:00
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journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp1106515g
更新日期:2011-06-01 00:00:00
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pub_type: 杂志文章
doi:10.2298/vsp0608743v
更新日期:2006-08-01 00:00:00
abstract::Fatigue of striated muscles is defined as the impossibility to generate the expected or required force during the repeated contraction. During the maximal voluntary teeth contraction in the position of central occlusion the initial fatigue in masticatory muscles during the isometric contraction occurs. If a person can...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp0201043m
更新日期:2002-01-01 00:00:00
abstract::The initial experience suggested that kidney transplantation could be hazardous for patients on peritoneal dialysis due to the high risk of peritonitis and a possible high incidence of acute rejection. In this paper we have presented our experience with kidney transplantation in these patients. During the last four ye...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:2001-09-01 00:00:00
abstract::Twenty eight patients (18 men and 10 women) with delayed pressure induced urticaria were analyzed. The average age was 35.5 years, and the illness lasted 1-20 years, 4.07 years on average. The spontaneous cessation of illness came in 8 patients after approximately 5.75 years. In 23 patients there was also a classical ...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:1995-05-01 00:00:00
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journal_title:Vojnosanitetski pregled
pub_type: 临床试验,杂志文章
doi:10.2298/vsp0405485m
更新日期:2004-09-01 00:00:00
abstract::With the aim to evaluate the clinical efficacy and tolerability of gabapentin as an adjuvant therapy in patients with refractory partial epilepsy we conducted an open-randomized study, with 12-weeks follow-up period. The study included 18 epilepsy patients with unsatisfactorily controlled seizures, in spite of the tre...
journal_title:Vojnosanitetski pregled
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1999-03-01 00:00:00
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journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp1401046k
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND/AIM:There is a controversial opinion among implantologists on the method of dental implantation that provides more favourable response of soft and bone tissues. The aim of this study was to pathohistologicaly compare the influences of one- and two-phase implant surgical methods on the periimplant epithelial ...
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pub_type: 杂志文章
doi:10.2298/vsp1003236m
更新日期:2010-03-01 00:00:00
abstract:INTRODUCTION:Neurofibromatosis type 1 (NF1), also known as von Recklinghausen disease, is one of the most common single-gene disorders (mutation on chromosome 17q) and usually associated with cutaneous, musculoskeletal and neurological disorders in humans. NF1 is generally complicated with one or more neurobehavioral d...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp141007146i
更新日期:2016-02-01 00:00:00
abstract::In all 40 patients with pulmonary thromboembolism (PTE) radionuclide phlebography (RNP) detected deep venous thrombosis (DVT), most commonly in the left iliac veins, in 20 (50%). RNP and contrast phlebography (CP) were performed in 18 patients and RNP sensitivity was found in 100% in all localizations of DVT and the l...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:1991-03-01 00:00:00
abstract:BACKGROUND:Atrial fibrillation is the most frequent cardiac dysrhythmia. The aim of this study was to show the role and the efficacy of a dual chamber pacemaker with the algorithm of atrial dynamic overdrive, in the suppression of paroxysmal atrial fibrillation. CASE REPORT:A woman with a classical bradycardia-tachyca...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp0504329r
更新日期:2005-04-01 00:00:00
abstract:BACKGROUND/AIM:Hormone suppression therapy is used in men with advanced prostate cancer improving chances of longer survival. The aim of this study was to investigate the influence of androgen blockades on testosterone and luteinizing hormone (LH) values in patients with locally advanced and metastatic prostatic cancer...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp1104321v
更新日期:2011-04-01 00:00:00
abstract:BACKGROUND:It has been established that many patients with chronic hepatitis C have elevated serum iron, feritin levels and iron deposites in the liver. Therefore, the liver damage due to hepatitis C virus may be aggravated with iron overload. In many studies higher levels of iron in the blood and the liver were connec...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp0502161n
更新日期:2005-02-01 00:00:00