Abstract:
AIM:To evaluate the behavioral effects of lamotrigine as add-on therapy in treatment-resistant epilepsy. METHODS:An open, prospective, long-term study of lamotrigine as adjuvant therapy was performed in 56 patients with drug-resistant epilepsy (female/male ratio 35/21, age range 16-51 years). All the patients kept seizure diaries, and electroencephalograms were recorded at baseline and during 24 months of the treatment. Quality of life questionnaire, Hamilton depression scale (HMD), Beck depression scale (BDI), and Hamilton anxiety scale (HMA) were used before and during lamotrigine therapy. Comparative assessments were made in an age- and sex-matched control group treated with other antiepileptic drugs. RESULTS:Overall, seizure control was improved in 55.3% of the patients, remained unchanged in 39.3%, and deteriorated in 5.4%. Improvement in some quality of life measures occurred in 50% of the patients. The HMD subscales and BDI scale showed significant improvement in lamotrigine treated patients compared to the control group (ANOVA, p < 0.01). Negative behavioral effects occurred in 10.7% of the patients. CONCLUSION:Lamotrigine demonstrated significant antiepileptic long-term efficacy, and its positive effects on the mood and quality of life, which surpassed the negative behavioral effects, and contributed highly to the favorable treatment outcome.
journal_name
Vojnosanit Pregljournal_title
Vojnosanitetski pregledauthors
Martinović Z,Buder N,Milovanović M,Velićković Rdoi
10.2298/vsp0405485msubject
Has Abstractpub_date
2004-09-01 00:00:00pages
485-90issue
5eissn
0042-8450issn
2406-0720journal_volume
61pub_type
临床试验,杂志文章abstract::The analysis of 44 intracranial aneurysms found at 7.687 autopsies is performed. The largest number of aneurysms was of congenital (secular) type, then, of arteriosclerotic type while inflammatory and traumatic aneurysms were very rare. The elastic and reticular fibres in the aneurysmal wall and the normal arteries of...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:1992-09-01 00:00:00
abstract:INTRODUCTION/AIM:There are numerous factors that influence the formation of condylar processus: the growth and development of cranial base, growth and development of the jaws and alveolar extensions, teething, the way of intercuspidation, the overlap of incisors, functions of masticatory muscles, etc. Considering the f...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp0807513c
更新日期:2008-07-01 00:00:00
abstract:BACKGROUND/AIM:Nocturia often occures in patients with benign prostata hyperplasia (BPH). The aim of the study was to investigate the frequency of nocturia in patients with BPH. Nocturia and other factors associated with it were also investigated. METHODS:Forty patients with the confirmed diagnosis of BPH were studied...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp0810751l
更新日期:2008-10-01 00:00:00
abstract::Since the F response is the result of antidromic activation of limited number of alpha motor neurons, the motor neurons excitability level can be investigated and established by analyzing parameter values of F response. The excitability of alpha motor neurons is the result of balance between excitatory and inhibitory ...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:1996-05-01 00:00:00
abstract::Twenty eight patients (18 men and 10 women) with delayed pressure induced urticaria were analyzed. The average age was 35.5 years, and the illness lasted 1-20 years, 4.07 years on average. The spontaneous cessation of illness came in 8 patients after approximately 5.75 years. In 23 patients there was also a classical ...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:1995-05-01 00:00:00
abstract:INTRODUCTION:Helicobacter pylori (H. pylori) infection is known to be the must common cause of chronic gastritis having some endoscopic and pathologic characteristies as determinated by the Sydney System for Gastritis Classification. The aim of our case report was to point out the relationship between an endoscopic fin...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp0603313t
更新日期:2006-03-01 00:00:00
abstract::Fatigue of striated muscles is defined as the impossibility to generate the expected or required force during the repeated contraction. During the maximal voluntary teeth contraction in the position of central occlusion the initial fatigue in masticatory muscles during the isometric contraction occurs. If a person can...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp0201043m
更新日期:2002-01-01 00:00:00
abstract::This paper deals with the experimental results of the effect of 1% dopamine on intraocular pressure, pupillary diameter and hemodynamic parameters after its local application in the rabbit eye. Our results show that locally applied dopamine caused an initial increase of intraocular pressure (IOP) (1 h), followed by it...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:1999-09-01 00:00:00
abstract:BACKGROUND:Patients admitted to intensive-care units (ICU) are at a high risk of nosocomial infections (NI) due to susceptibility associated with severity of their condition, but also the invasive medical procedures they undergo. AIM:To determine the frequency of NI at the ICU of the General Hospital Uzice, and to ide...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp0504265m
更新日期:2005-04-01 00:00:00
abstract::The Clinic for Rheumatology and Clinical Immunology of the Military Medical Academy, with the participation of the hosts and experts from eminent Yugoslav institutions, in April 1997 organized the symposium on two current and trendy subjects from clinical immunology: "Antiphospholipid syndrome" and "The use of polyval...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章,评审
doi:
更新日期:1998-03-01 00:00:00
abstract:BACKGROUND:[corrected] Clinical features of inherited glucocerebrosidase deficiency were first described by Phillippe Charles Ernest Gaucher, French physician (1854-1918). Deficiency of glucocerebrosidase leads to the accumulation of the lipid glucocerebroside within the lysosomes of the monocyte macrophage system. Lip...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp0612039d
更新日期:2006-12-01 00:00:00
abstract::War injuries of colon and rectum are real challenge for war surgeons. The aim of the study was to point out the necessity of war surgical doctrine application, considering the risk factors in the choice of primary surgical procedure and surgeon's experience in managing this kind of injuries. Postoperative complication...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:1997-05-01 00:00:00
abstract:INTRODUCTION:Metastatic renal cell carcinoma (RCC) frequently spreads not only to neighboring lymph nodes, but also to distant organs, including the lungs, liver, bones and brain. CASE REPORT:We presented three cases of RCC with colon metastasis. In the first, 63-year-old patient, after left nephrectomy followed with ...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp120515014m
更新日期:2013-09-01 00:00:00
abstract::A 'new' group of pathogenic agents, enterohemorrhagic Escherichia coli (EHEC) (particularly the strains of O157 serogroup), emerged in the last 20 years, causing an increased number of sporadic and epidemic diarrhoeal diseases with hemorrhagic enterocolitis as a most common clinical manifestation of the infection. As ...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp0304493c
更新日期:2003-07-01 00:00:00
abstract:BACKGROUND:Arteriovenous malformations of the pancreas are very rare, most frequently congenital ones, but tending to increase frequency, predominantly due to the introduction and use of new diagnostic modalities. They usually present with gastrointestinal bleeding and abdominal pain. CASE REPORT:The autors presented ...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp0702155c
更新日期:2007-02-01 00:00:00
abstract:BACKGROUND/AIM:The number of elderly people in the world is growing, in Serbia as well. Serbia is already among the top ten countries with the oldest population, it is the fact. Aging influences the quality of life in different ways. The aim of this study was to assess the health-related quality of life of the elderly ...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp140831107u
更新日期:2015-11-01 00:00:00
abstract::Heart and brain vascular diseases present leading causes of death in civilized world. During development of brain ischemia cardiac complications are possible. The aim of this study was to determine the existence of cardiac complications' clinical predictors by assessing certain electrocardiographic changes in patients...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:1998-01-01 00:00:00
abstract::In retrospective, non-randomized study were analyzed 45 patients with local recurrences of rectal carcinoma treated by combined external beam radiotherapy (EBRT) and "High dose rate (HDR) remote afterloading" brachytherapy in the period from January 1st, 1988 to May 1st, 1988. Depending on the localization of the loca...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:1998-11-01 00:00:00
abstract:AIM:To establish the risk factors for complications and fatal outcome after the operative occlusion of cerebral aneurysms. METHODS:Retrospective study on 91 (lethality rate) and on 72 operated patients (complications). For survived and dead patients, as well as for patients with and without complications, following pa...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp0204355r
更新日期:2002-07-01 00:00:00
abstract:INTRODUCTION:Psychiatric symptoms are not rare manifestations of brain tumors. Brain tumors presented by symptoms of raised intracranial pressure, focal neurological signs, or convulsions are usually first seen by the neurologist or less frequently by the neurosurgeon in routine diagnostic procedures. On the other hand...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp1109809i
更新日期:2011-09-01 00:00:00
abstract:INTRODUCTION:Carcinoma of the esophagus is in the eighth place by the frequency of malignant diseases and the sixth cause of death from cancer worldwide. It usually metastasizes to regional lymph nodes, liver, lungs, central nervous system, and bones, but metastases can appear to unusual locations such as facial skin a...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:2014-10-01 00:00:00
abstract:INTRODUCTION:Prostatic gland basal cell proliferations exhibit morphological continuum ranging from basal cell hyperplasia to basal cell carcinoma. In the following report, we described clinical features, morphological spectrum, neuroendocrine differentiation and histogenesis of prostatic gland basal cell carcinoma in ...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp1106515g
更新日期:2011-06-01 00:00:00
abstract::The aim of this case-control study, conducted in Serbia during the period 1998-2000, was to investigate whether diet was associated with the development of gastric cancer. The case group consisted of 131 patients with histologically confirmed gastric cancer, and the control group of 131 patients with orthopedics disea...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp0306697s
更新日期:2003-11-01 00:00:00
abstract::The results of Cyclosporin A treatment of 15 patients with Behçet's disease were examined in the study--9 females (aged from 32 to 34 years, mean 33 years) and 12 males (aged from 25 to 55 years, approximately 34.33 years). Among them, the majority were with chorioretinitis (10/15 or 66.6%). Besides chorioretinitis tw...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:1997-07-01 00:00:00
abstract:BACKGROUND/AIM:The aim of this study was to evaluate the possible association between certain morphologic features of the craniofacial skeleton and the presence of symptoms of temporomandibular disorders in young subjects with natural dentitions. METHODS:The investigation was carried out on 80 lateral cephalometric ra...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp0609793d
更新日期:2006-09-01 00:00:00
abstract::The aim of this study was to determine the baseline state of oxidative stress indices in drug-naive patients with Parkinson's disease (PD). Cerebrospinal fluid (CSF) and peripheral blood samples of 31 subjects, in disease stages I-III, according to Hoehn & Yahr scale, were analyzed and compared with the control group....
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:1998-09-01 00:00:00
abstract:BACKGROUND/AIM:Community-associated methicillin-resistant Staphjlococcus aureus (CA-MRSA) strains appear to have rapidly disseminated among population in the community without established risk factors for MRSA worldwide. Panton-Valentine leukocidin (PVL) is a cytolytic toxin, encoded by the lukF-PV and lukF-PV genes. P...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND/AIM:Congenital absence of vagina is known from ancient times of Greek. According to the literature data, incidence is 1/4 000 to 1/20 000. Treatment of this anomaly includes non-operative and operative procedures. McIndoe procedure uses split skin graft by Thiersch. The aim of this study was to establish ana...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp0902107k
更新日期:2009-02-01 00:00:00
abstract:BACKGROUND:To evaluate the long-term prognostic value of dobutamine stress-echocardiography (ECG) test for new coronary events (new episodes of angina pectoris, cardiac-related deaths, and reinfarctions) early after the first uncomplicated myocardial infarction. METHODS:Dobutamine stress-echocardiography tests were pe...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp0402155k
更新日期:2004-03-01 00:00:00
abstract:BACKGROUND/AIM:Interaction between tumor cells and host's immunoregulatory cells in creation of microenvironment that supports tumor progression is the focus of numerous investigations in recent years. Myeloid-derived suppressor cells (MIDSCs) are heterogeneous population of immature dendritic cells, macrophages and gr...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp1504342s
更新日期:2015-04-01 00:00:00