Abstract：
:The Clinic for Rheumatology and Clinical Immunology of the Military Medical Academy, with the participation of the hosts and experts from eminent Yugoslav institutions, in April 1997 organized the symposium on two current and trendy subjects from clinical immunology: "Antiphospholipid syndrome" and "The use of polyvalent intravenous immunoglobulins in the clinical praxis". This paper summarizes the contemporary knowledge about the structure and biological activity of immunoglobulins, methods for their production, different pharmacokinetic and pharmacodynamic characteristics of two types (5S and 7S) IVIG preparations, etc. We pointed out three basic groups of indications for IVIG clinical use: 1) substitutional therapy in the primary and secondary immunodeficiencies; 2) adjuvant therapy for severe infections; 3) immunomodulation in autoimmune diseases. Particular emphasis was put on currently known mechanisms of immunosuppressive action of IVIG in autoimmune diseases. Except for presently accepted indications for their use (idiopathic thrombocytopenic purpura and Kawasaki syndrome) we mentioned about 40 different diseases in hematology, neurology, rheumatology and other branches of medicine, from neonatology to transplantology, in which IVIG had shown some efficacy. Possibilities of different therapeutic modalities and the choice of diverse pharmacokinetic and pharmacodynamic effects, benefit the very wide spectrum of diseases, while minimal incidence of adverse effects suggested them to be the therapy of the future in the clinical practice.
journal_name
Vojnosanit Pregljournal_title
Vojnosanitetski pregledauthors
Popović M,Petronijević M,Stefanović D,Dimitrijević Msubject
Has Abstractpub_date
1998-03-01 00:00:00pages
53-62issue
2 Suppleissn
0042-8450issn
2406-0720journal_volume
55pub_type
杂志文章,评审abstract：:The analysis of 44 intracranial aneurysms found at 7.687 autopsies is performed. The largest number of aneurysms was of congenital (secular) type, then, of arteriosclerotic type while inflammatory and traumatic aneurysms were very rare. The elastic and reticular fibres in the aneurysmal wall and the normal arteries of...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：
更新日期：1992-09-01 00:00:00
abstract：:Seventy four liver bioptic specimens of 66 patients with chronic hepatitis C were analyzed ultrastructurally and by light microscopy. According to histological activity of the disease, the patients were divided in groups with minimal activity (CPHa), mild activity (CPHb-CAHa), and moderate and severe activity (CAHb,c)...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：
更新日期：1999-07-01 00:00:00
abstract：BACKGROUND/AIM:Identification of patients with arterial hypertension and a possible onset of heart failure by determining the concentration of N-terminal pro-B-type natriuretic peptide (NT-proBNP) enables timely intensification of treatment and allows clinicians to prescribe and implement optimal and appropriate care. ...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：10.2298/vsp110322048p
更新日期：2013-08-01 00:00:00
abstract：:Aspirin (acetylsalicylic acid--ASA) inhibits pletlets thromboxane (TXA2) synthesis as well as endothelial prostacycline (PGI2) synthesis. Aiming to prevent PGI2 synthesis attempts have been made to reduce ASA doses. Here are presented results of ASA effects in daily dose of 100 mg given to 26 patients with mean age of...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：
更新日期：1991-05-01 00:00:00
abstract：BACKGROUND/AIM:Surgical treatment of patients with gastric adenocarcinoma means the total excision of a tumor and the pathways of its spreading with the risk of operational complications as low as possible. The aim of this study was to evaluate the type and frequency of early postoperative complications and mortality a...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：10.2298/vsp0603249k
更新日期：2006-03-01 00:00:00
abstract：:Since it has been recognized as a separate disease during the Korean war, hemorrhagic fever with renal syndrome (HFRS) has often been discovered among the members of different armies in various countries, military personnel being the highest risk group for the disease. In the period from March to May 1999 we treated 6...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：10.2298/vsp0305605c
更新日期：2003-09-01 00:00:00
abstract：BACKGROUND/AIM:Erythema infectiosum (EI) is a common childhood illness, caused by human parvovirus B19. It occurs sporadically or in epidemics and is characterized by mild constitutional symptoms and a blotchy or maculopapular lacy rash on the cheeks (slapped-cheek) spreading primarily to the extremities and trunk. The...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：10.2298/vsp110607026p
更新日期：2013-12-01 00:00:00
abstract：BACKGROUND/AIM:Despite vitamin D insufficiency being widely reported, in Serbia the epidemiological data lack information regarding vitamin D status in the sera of postmenopausal women. The aim of this study was to establish the prevalence of inadequate serum 25-hydroxyvitamin D [25(OH)D] concentrations in postmenopaus...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：
更新日期：2012-03-01 00:00:00
abstract：:Twenty eight patients (18 men and 10 women) with delayed pressure induced urticaria were analyzed. The average age was 35.5 years, and the illness lasted 1-20 years, 4.07 years on average. The spontaneous cessation of illness came in 8 patients after approximately 5.75 years. In 23 patients there was also a classical ...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：
更新日期：1995-05-01 00:00:00
abstract：BACKGROUND/AIM:Almost 200 cochlear implantations were done in the four centers (two in Belgrade, per one in Novi Sad and Nis) in Serbia from 2002 to 2009. Less than 10% of implantees were postlingually deaf adults. The vast majority, i.e. 90% were pre- and perilingually profoundly deaf children. The aim of this study w...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：10.2298/vsp1104349o
更新日期：2011-04-01 00:00:00
abstract：BACKGROUND/AIM:Myxoma is the most common benign primary cardiac neoplasm, and usually originates from the left atrial septum. Early diagnosis of cardiac myxomas depends on a high index of a clinical suspicion. Surgical management must be done as soon as possible after diagnosis. The aim of this retrospective study was ...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：10.2298/vsp1110851r
更新日期：2011-10-01 00:00:00
abstract：:Numerous clinical studies demonstrated that mycophenolate mofetil (MMF) was significantly more effective in prevention of acute rejection episodes than azathioprine. Since the data supporting the long-term benefits of MMF therapy are not available, and considering the high cost of this therapy, we examined the safety ...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：
更新日期：2001-05-01 00:00:00
abstract：BACKGROUND/AIM:Spinal cord injuries (SCI) could be associated with a significant functional impairment in the areas of mobility, self-care, bowel and bladder emptying and sexuality. The aim of this study was to compare demographic characteristics and functional outcomes of nontraumatic and traumatic spinal cord injury ...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：
更新日期：2012-12-01 00:00:00
abstract：:Atherosclerosis is the primary disease in the majority of patients with ischemic brain disease (IBD). Etiopathogenesis of atherosclerosis has not been more precisely defined, but risk factors significant for its generation and development, so as for IBD development, have been identified. They were designated as risk f...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：
更新日期：1998-05-01 00:00:00
abstract：:The cross-sectional study comprised 8095 officers of the Y.P.A. from the limited territory, and relationship between cardiovascular risk factors and prevalence of ischemic heart disease (IHD) has been analysed. The high and statistically significant positive relationship of serum cholesterol, blood pressure, relative ...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：
更新日期：1992-05-01 00:00:00
abstract：Background/Aim:Delirium is an acute or subacute, and most frequently reversible syndrome of higher cortical functions disturbances that is manifested as generalized disorder. If not prevented, it is associated with various adverse outcomes. The aim of this study was to determine the connection between the markers of in...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：10.2298/VSP141212012S
更新日期：2016-09-01 00:00:00
abstract：:In all 40 patients with pulmonary thromboembolism (PTE) radionuclide phlebography (RNP) detected deep venous thrombosis (DVT), most commonly in the left iliac veins, in 20 (50%). RNP and contrast phlebography (CP) were performed in 18 patients and RNP sensitivity was found in 100% in all localizations of DVT and the l...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：
更新日期：1991-03-01 00:00:00
abstract：INTRODUCTION:Carcinoma of the esophagus is in the eighth place by the frequency of malignant diseases and the sixth cause of death from cancer worldwide. It usually metastasizes to regional lymph nodes, liver, lungs, central nervous system, and bones, but metastases can appear to unusual locations such as facial skin a...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：
更新日期：2014-10-01 00:00:00
abstract：BACKGROUND/AIM:123I-FP-CIT brain single-photon emission computed tomography (SPECT), DaTSCAN imaging, offers a possibility to study structural and biochemical integrity of presinaptic dopaminergic neurotransmitter system. The aim of this study was to evaluate the usefulness of 123I-FP-CIT brain SPECT scintigraphy in pa...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：
更新日期：2012-02-01 00:00:00
abstract：BACKGROUND/AIM:There is a lack of data on the effects of prolactin on calcium metabolism and bone turnover in hyperprolactinemia of various origins. The aim of this study was to compare the influence of medicamentous and physiological hyperprolactinemia on bone turnover in female rats. METHODS:Experimental animals (18...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：
更新日期：2014-06-01 00:00:00
abstract：BACKGROUND:Arteriovenous malformations of the pancreas are very rare, most frequently congenital ones, but tending to increase frequency, predominantly due to the introduction and use of new diagnostic modalities. They usually present with gastrointestinal bleeding and abdominal pain. CASE REPORT:The autors presented ...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：10.2298/vsp0702155c
更新日期：2007-02-01 00:00:00
abstract：BACKGROUND/AIM:Decreasing of arterial flow below the critical level leads to capillary endothelium edema and to further worsening of tissue perfusion. Hypertonic solution infusion provides mild and short plasma osmolality increasing, while colloidal solutions intensify that effect. The aim of this study was to investig...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章,随机对照试验
doi：10.2298/vsp0710685s
更新日期：2007-10-01 00:00:00
abstract：INTRODUCTION:Metronidazole is the drug of choice in the treatment of periodontal pockets up to 5 mm in depth. It is topically applied--directly into the periodontal pockets. There are no registred trademark preparations for this purpose in the market of Serbia and Montenegro. The aim of our latest research was to test ...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章,随机对照试验
doi：10.2298/vsp0508565t
更新日期：2005-07-01 00:00:00
abstract：BACKGROUND/AIM:Hormone suppression therapy is used in men with advanced prostate cancer improving chances of longer survival. The aim of this study was to investigate the influence of androgen blockades on testosterone and luteinizing hormone (LH) values in patients with locally advanced and metastatic prostatic cancer...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：10.2298/vsp1104321v
更新日期：2011-04-01 00:00:00
abstract：BACKGROUND:To evaluate the long-term prognostic value of dobutamine stress-echocardiography (ECG) test for new coronary events (new episodes of angina pectoris, cardiac-related deaths, and reinfarctions) early after the first uncomplicated myocardial infarction. METHODS:Dobutamine stress-echocardiography tests were pe...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：10.2298/vsp0402155k
更新日期：2004-03-01 00:00:00
abstract：INTRODUCTION:Golden rule for the initiation of antiepileptic therapy in the majority of epileptic syndromes is "start low and go slow", a principle after the second unprovoked seizure. There are certain clinical situations however when fast titration of antiepileptic medication is needed. CASE REPORT:We present a case...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：10.2298/vsp0706425s
更新日期：2007-06-01 00:00:00
abstract：BACKGROUND/AIM:Ovarian cancer is the leading cause of death from gynecologic malignancies. Risk of malignancy index (RMI) is recommended in assessment of patients with adnexal masses. The aim of this study was to verify the effectiveness of the RMI in the discrimination between benign lesions and malignant adnexal mass...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：10.2298/vsp1107589t
更新日期：2011-07-01 00:00:00
abstract：BACKGROUND/AIM:There is a controversial opinion among implantologists on the method of dental implantation that provides more favourable response of soft and bone tissues. The aim of this study was to pathohistologicaly compare the influences of one- and two-phase implant surgical methods on the periimplant epithelial ...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：10.2298/vsp1003236m
更新日期：2010-03-01 00:00:00
abstract：BACKGROUND:[corrected] Descending necrotizing mediastinitis (DNM) is an acute, serious, septic disease which results from a complication of oropharyngeal infection. The disease requires a prompt diagnosis and radical surgical treatment to reduce high mortality (40%). The optimal form of mediastinal drainage remains con...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：10.2298/vsp0607677c
更新日期：2006-07-01 00:00:00
abstract：BACKGROUND/AIM:Cerebrovascular diseases are the third leading cause of mortality in the world, following malignant and cardiovascular diseases. Therefore, their timely and precise diagnostics is of great importance. The aim of this study was to compare duplex scan Color Doppler ultrasonography (CDU) with multislice com...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章,随机对照试验
doi：10.2298/vsp1105423v
更新日期：2011-05-01 00:00:00
