Abstract：
INTRODUCTION:Golden rule for the initiation of antiepileptic therapy in the majority of epileptic syndromes is "start low and go slow", a principle after the second unprovoked seizure. There are certain clinical situations however when fast titration of antiepileptic medication is needed. CASE REPORT:We present a case of the 48-year-old man referred for further management of uncontrolled partial seizures. At the age of 37 years, he had subarachnoid haemorrhage, due to aneurysm rupture of the left internal carotid artery, with consecutive vasospasm and right haemiparesis. Since that time he had received phenobarbital 100 mg nocte. On examination he had a right sided upper motor neuron weakness affecting the arm more than the leg, and mild dysarthria, EEG investigation showed frequent transitory spikewaves discharges above the left hemisphere with the fast contralateral propagation with generalised discharges and CT showed old infarction in distribution of left medial cerebral artery. Valproate therapy was initiated with the retard form in the loading dose of 2000 mg. Seizures stopped in 7th hours after the treatment initiation. Laboratory parameters (liver function tests, blood count, level of antiepileptic drugs) were monitored every day. No further seizures were recorded. The patient was discharged from the hospital after 15 days in excellent condition. CONCLUSION:In selected clinical conditions it is possible to apply the protocol for valproate loading and switch-off from the previous antiepileptic drugs to valproate monotherapy. Adverse effects are rare and mild but potentially serious, and close monitoring of clinical and laboratory parameters is necessary. Hence, a rapid switch to valproate monotherapy can be done safely only in an inpatient setting.
journal_name
Vojnosanit Pregljournal_title
Vojnosanitetski pregledauthors
Spasić M,Lukić Sdoi
10.2298/vsp0706425ssubject
Has Abstractpub_date
2007-06-01 00:00:00pages
425-7issue
6eissn
0042-8450issn
2406-0720journal_volume
64pub_type
杂志文章abstract：Introduction:Central retinal artery obstruction (CRAO) represents an abrupt diminution of blood flow through the CRA that is severe enough to cause ischemia of the inner retina with permanent unilateral visual loss. We presented the role of color Doppler imaging (CDI) of orbital vessels and of extracranial duplex sonog...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：10.2298/VSP140814087C
更新日期：2016-04-01 00:00:00
abstract：BACKGROUND/AIM:Basal cell carcinoma (BCC) is the most common form of skin cancer in the white population. Increasing incidence of BCC imposes the requirement to indentify the risk factors due to eventual preventive action. The aim of this study was to assess the role of some constitutional characteristics in developmen...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：10.2298/vsp0706375r
更新日期：2007-06-01 00:00:00
abstract：BACKGROUND/AIM:Peritoneal dialysis (PD) patients have an increased risk for cardiovascular diseases. The aim of the study was to evaluate the cardiovascular changes in patients undergoing chronic PD and the eventual existing differences depending on biocompatibility of dialysis solutions. METHODS:After 3 +/- 2 years o...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：10.2298/vsp0803221s
更新日期：2008-03-01 00:00:00
abstract：:The aim of this study was to investigate the influence of the corticosteroid therapy on the development and prognosis of proststreptococcal glomerulonephritis (PSGN) in the period of five years. The investigation included a group of 54 patients who were in the acute phase of poststreptococcal glomerulonephritis (PSGN)...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：
更新日期：2001-03-01 00:00:00
abstract：BACKGROUND/AIM:There are few tests for evaluation of functional abilities of patients surgically treated for hip fractures or osteoarthritis during early rehabilition period. The aim of this study was to investigate reliability (interobserver reproducibility and internal consistency) of the A-test, an original test for...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：10.2298/vsp130118042v
更新日期：2014-07-01 00:00:00
abstract：:The forensic-medical expertise of 24 predominantly carbonized bodies, that were found at Kukin Do was reported. The victims were from Gospić and its surroundings, who disappeared between October 16-18, 1991. The expertise involved the identification of bodies, injury classification, determination of tools by which inj...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：
更新日期：1992-03-01 00:00:00
abstract：BACKGROUND/AIM:Erythema infectiosum (EI) is a common childhood illness, caused by human parvovirus B19. It occurs sporadically or in epidemics and is characterized by mild constitutional symptoms and a blotchy or maculopapular lacy rash on the cheeks (slapped-cheek) spreading primarily to the extremities and trunk. The...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：10.2298/vsp110607026p
更新日期：2013-12-01 00:00:00
abstract：INTRODUCTION:Etiopathogenetically, there are two types of chollesteatomas: congenital, and acquired. Numerous theories in the literature try to explain the nature of the disease, however, the question about cholesteatomas remain still unanswered. The aim of the study was to present a case of external ear canal choleste...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：
更新日期：2012-04-01 00:00:00
abstract：Background/Aim:The overuse of antibiotics unnecessarily exposes patients to risk of side effects, encourages reconsultation for similar problems and enhances antimicrobial resistance. The use of antibiotics in the year 2011 in Montenegro was high (39.05 Defined Daily Dose – DDD/1,000 inhabitants/day), but it was not co...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：10.2298/VSP150626146S
更新日期：2017-01-01 00:00:00
abstract：BACKGROUND/AIM:Traditional methods for detection of mycobacteria, such as microscopic examination for the presence of acid-fast bacilli and isolation of the organism by culture, have either a low sensitivity and/or specificity, or take weeks before a definite result is available. Molecular methods, especially those bas...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：10.2298/vsp0912992l
更新日期：2009-12-01 00:00:00
abstract：BACKGROUND/AIM:Community-associated methicillin-resistant Staphjlococcus aureus (CA-MRSA) strains appear to have rapidly disseminated among population in the community without established risk factors for MRSA worldwide. Panton-Valentine leukocidin (PVL) is a cytolytic toxin, encoded by the lukF-PV and lukF-PV genes. P...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：
更新日期：2016-03-01 00:00:00
abstract：:The controversy of data about the role of free radicals in the pathogenesis of bronchial asthma (BA) and lack of clear recommendations for the use of medicaments with antioxidant characteristics in the treatment of patients with BA has challenged us to undertake this study. The aim was to explain characteristics of ge...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：
更新日期：1993-01-01 00:00:00
abstract：:The values of vital capacity (VC), forced expiratory volume in the first second (FEV1) and Tiffeneau index (100xFEV1/VC) were determined in 14,234 examinees in the period 1977-1987. Examinations were performed using the Godart expirometer. After the statistical analysis of the results being performed, the unique table...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：
更新日期：1990-05-01 00:00:00
abstract：BACKGROUND/AIM:Urinary tract infections are still the most frequent complications in patients with spinal cord injury (SCI). The aim of this study was to analyze the factors influencing development of urinary tract infections during rehabilitation in patients with SCI. METHODS:This retrospective case/control study inc...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：10.2298/vsp140725116s
更新日期：2015-12-01 00:00:00
abstract：:Carbon dioxide (CO2) influence in generation of active oxygen forms (AOF) in human mononuclear cells (blood phagocytes and alveolar macrophages) and animal cells (tissue phagocytes, parenchymal and interstitial cells of liver, kidney, lung, brain and stomach) was investigated. The AOF generation was examined by the me...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：
更新日期：1996-07-01 00:00:00
abstract：BACKGROUND/AIM:Primary open-angle glaucoma is a multifactorial and progressive neuropathy, characterised by the acquired loss of ganglion cells of the retina and their axons. One of the risk factors for primary open-angle glaucoma is myopia over 5 diopters (D). The aim of our work was to investigate two groups of patie...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：10.2298/vsp111229024g
更新日期：2013-01-01 00:00:00
abstract：INTRODUCTION:Helicobacter pylori (H. pylori) infection is known to be the must common cause of chronic gastritis having some endoscopic and pathologic characteristies as determinated by the Sydney System for Gastritis Classification. The aim of our case report was to point out the relationship between an endoscopic fin...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：10.2298/vsp0603313t
更新日期：2006-03-01 00:00:00
abstract：INTRODUCTION:Intermediate syndrome (IMS) was described a few decades ago, however, there is still a controversy regard ing its exact etiology, risk factors, diagnostic parameters and required therapy. Considering that acute poisonings are treated in different types of medical institutions this serious complication of o...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：10.2298/vsp120229037v
更新日期：2013-04-01 00:00:00
abstract：BACKGROUND/AIM:The number of elderly people in the world is growing, in Serbia as well. Serbia is already among the top ten countries with the oldest population, it is the fact. Aging influences the quality of life in different ways. The aim of this study was to assess the health-related quality of life of the elderly ...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：10.2298/vsp140831107u
更新日期：2015-11-01 00:00:00
abstract：INTRODUCTION:Behcet's disease is multisystemic vasculitis which affects vein and artery blood vessels. Intestinal perforation rarely occurs as clinic manifestation in as little as 1% of patients. The transverse colon is the most infrequent site of perforation. We presented a patient diagnosed with Behcet's disease who ...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：10.2298/vsp1111992t
更新日期：2011-11-01 00:00:00
abstract：:The test results of calcium carbonate tablets, made of different binding substances (microcrystal cellulose, gelatin, 7pp sodium carboxymethylcellulose and starch) were presented. The content of calcium-carbonate in tablets as well as varying, solidity, prodigality and aptness to decay was determined. The best propert...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：
更新日期：1996-03-01 00:00:00
abstract：BACKGROUND/AIM:Oxidative stress is a state of disturbed balance between reactive oxygen species (ROS) and reactive nitrogen species (RNS) on the one hand, and antioxidative defense on the other. As a result of oxidative stress we have irreversible changes in cell function leading to pathological tissue changes, develop...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：10.2298/vsp0907551p
更新日期：2009-07-01 00:00:00
abstract：BACKGROUND/AIM:Nocturia often occures in patients with benign prostata hyperplasia (BPH). The aim of the study was to investigate the frequency of nocturia in patients with BPH. Nocturia and other factors associated with it were also investigated. METHODS:Forty patients with the confirmed diagnosis of BPH were studied...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：10.2298/vsp0810751l
更新日期：2008-10-01 00:00:00
abstract：:Twenty eight patients (18 men and 10 women) with delayed pressure induced urticaria were analyzed. The average age was 35.5 years, and the illness lasted 1-20 years, 4.07 years on average. The spontaneous cessation of illness came in 8 patients after approximately 5.75 years. In 23 patients there was also a classical ...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：
更新日期：1995-05-01 00:00:00
abstract：INTRODUCTION:Myxomas arising from the right ventricle are extremely rare. CASE REPORT:We presented a 71-year-old patient with worsening symptoms of the exertional dyspnea and atypical chest pains lasting 6 months. A transthoracic and transesophageal echocardiogram revealed a large, 2.6 x 2.2 cm, ovoid, well-circumscri...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：10.2298/vsp1306609o
更新日期：2013-06-01 00:00:00
abstract：BACKGROUND/AIM:Although total body irradiation (TBI) was considered to be the primary cause of thyroid dysfunction following hematopoietic stem cells transplantation (HSCT), a significant prevalence of subclinical hypothyroidism after HSCT with chemotherapy-only conditioning regimens has been observed in several studie...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：10.2298/vsp1412123m
更新日期：2014-12-01 00:00:00
abstract：:Since the F response is the result of antidromic activation of limited number of alpha motor neurons, the motor neurons excitability level can be investigated and established by analyzing parameter values of F response. The excitability of alpha motor neurons is the result of balance between excitatory and inhibitory ...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：
更新日期：1996-05-01 00:00:00
abstract：BACKGROUND/AIM:Multiple sclerosis (MS) is a chronic inflammatory disease of central nervous system. The main physiopatological feature of MS is demyelination. Multiple sclerosis is one of three most common causes of severe disability in youngest people. In patients with MS, apart from complete psychophysical status and...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：10.2298/vsp0908645k
更新日期：2009-08-01 00:00:00
abstract：:In the period from January 1st, 1969, to December 31st, 1988, 585 osteosyntheses of the closed bone fractures of lower limbs were performed at the Orthopedic department at the Military Hospital in Nis. At the same period 25 postoperative osteomyelitis were registered, i.e., 4.27%. The average duration of osteosynthesi...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：
更新日期：1995-11-01 00:00:00
abstract：BACKGROUND/AIM:Lichen planus is a chronic, immunologic, mucocutaneous disease with a wide range of clinical manifestations. The aim of this retrospective study was to evaluate the most common forms of oral lichen planus (OLP) and its symptoms and to describe treatment responses in patients during 10-year period. METHO...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：
更新日期：2009-06-01 00:00:00
