[Changes in free radicals and possibility of their correction in patients with bronchial asthma].

Abstract:

:The controversy of data about the role of free radicals in the pathogenesis of bronchial asthma (BA) and lack of clear recommendations for the use of medicaments with antioxidant characteristics in the treatment of patients with BA has challenged us to undertake this study. The aim was to explain characteristics of generation of active forms of oxygen (AFO) by leukocytes, peroxide lipid oxidation (PLO) and antiperoxide plasma activities (APA) in patients with BA, evaluation of their pathogenetic importance and justified use of antioxidants in the complex therapy of BA. For this purpose, 92 patients with BA and 45 healthy volunteers were studied. Generation of AFO by blood leukocytes were examined by the method of luminol-dependent chemiluminiscence (CL). Basal and stimulated HL parameters have been measured. The intensity of PLO was determined according to the contents of malondialdehyde (MDA) in plasma. The APA was determined according to its resistance to the injection of free radicals oxidation of hydrogen peroxide. In patients with acute BA compared with healthy volunteers, both CL parameters were increased. In the same time the contents of plasma MDA and relationship of induced and spontaneous plasma CL were increased which suggested the decreased APA. In remission, both CL parameters of AFK generation by leukocytes and the contents of plasma MDA were decreased approximating the normal, but it was never reached. The direct proportional dependence of the degree of impairment and severity of the BA course and the intensity of free radical process were discovered as well as the reversed proportional dependence among the degree of impairment and severity of BA and plasma APA. However, the least parameters of AFK generation by leukocytes were obtained in patients with asthmatic state. In patients with steroid-dependent bronchial asthma the free radical process is more intensive, the plasma APA being lower than in patients with steroid-non-dependent bronchial asthma. Regarding the free radical process the most responsive was aspirin asthma, the mildest exercise-induced asthma. In patients with steroid-non-dependent BA and in patients with steroid-dependent BA who together with the traditional therapy received also antioxidants (aevit and glutamic acid), the decreased CL parameters of leukocyte AFK generation and the decreased contents of MDA were more manifested than in patients not taking antioxidants.

journal_name

Vojnosanit Pregl

journal_title

Vojnosanitetski pregled

authors

Boljevic S,Daniljak IG,Kogan AH

subject

Has Abstract

pub_date

1993-01-01 00:00:00

pages

3-18

issue

1

eissn

0042-8450

issn

2406-0720

journal_volume

50

pub_type

杂志文章
  • [Initial masseter muscle fatigue in maximal voluntary teeth clenching].

    abstract::Fatigue of striated muscles is defined as the impossibility to generate the expected or required force during the repeated contraction. During the maximal voluntary teeth contraction in the position of central occlusion the initial fatigue in masticatory muscles during the isometric contraction occurs. If a person can...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:10.2298/vsp0201043m

    authors: Miljković H,Zeljković M,Anojcić M

    更新日期:2002-01-01 00:00:00

  • [Evaluation of the level of depression and dementia in patients with primary chronic active epilepsy using the Dementia Mood Assessment Scale].

    abstract::The study included 40 patients, aged 18-40 years with primary chronic active epilepsy, tested by clinical DMAS scale. We have found that the level of intelectual function damage (dementia) and mood (depression) rates depended on the long duration of epilepsy and the frequency of seizures, less on the frequency of spec...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:

    authors: Djokić G,Milović-Vujković M,Tomović M,Makević M

    更新日期:1998-07-01 00:00:00

  • Histomorphometric evaluation of bone regeneration using autogenous bone and beta-tricalcium phosphate in diabetic rabbits.

    abstract:Background/Aim:The mechanism of impaired bone healing in diabetes mellitus includes different tissue and cellular level activities due to micro- and macrovascular changes. As a chronic metabolic disease with vascular complications, diabetes affects a process of bone regeneration as well. The therapeutic approach in bon...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:10.2298/VSP151125013Z

    authors: Živadinović M,Andrić M,Milošević V,Manojlović-Stojanoski M,Prokić B,Prokić B,Dimić A,Ćalasan D,Brković B

    更新日期:2016-12-01 00:00:00

  • [Outcome of kidney transplantation in patients on peritoneal dialysis].

    abstract::The initial experience suggested that kidney transplantation could be hazardous for patients on peritoneal dialysis due to the high risk of peritonitis and a possible high incidence of acute rejection. In this paper we have presented our experience with kidney transplantation in these patients. During the last four ye...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:

    authors: Hrvacevic R,Maksic Dj,Aleksic S,Paunic Z,Ignjatovic Lj,Vavic N,Draskovic-Pavlovic B,Maric M

    更新日期:2001-09-01 00:00:00

  • Differences in the bioenergetic potential of athletes participating in team sports.

    abstract:BACKGROUND/AIM:In modern training technology, assessment of aerobic bioenergetic potential in athletes is commonly performed by standard laboratory procedures to determine basic or specific functional abilities for specific sport activity or discipline. The aim of study was to assess the aerobic bioenergetic potential ...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:10.2298/vsp110208043m

    authors: Malacko J,Doder D,Djurdjević S,Savić B,Doder R

    更新日期:2013-07-01 00:00:00

  • Principles of surgical treatment of congenital, developmental and acquired female breast asymmetries.

    abstract:BACKGROUND/AIM:There is a natural asymmetry in normal female brests. When the difference in the shape, size or position of the breast and nipple-areola complex is visible, surgical correction is the only treatment option and presents one of the greatest challenges for a plastic surgeon. Based on the Nahai classificatio...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:10.2298/vsp1004313n

    authors: Novaković M,Lukac M,Kozarski J,Stepić N,Djordjević B,Vulović D,Rajović M,Milev B,Milićević S

    更新日期:2010-04-01 00:00:00

  • Markers of inflammation as risk predictors of lethal outcome in patients diagnosed with delirium.

    abstract:Background/Aim:Delirium is an acute or subacute, and most frequently reversible syndrome of higher cortical functions disturbances that is manifested as generalized disorder. If not prevented, it is associated with various adverse outcomes. The aim of this study was to determine the connection between the markers of in...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:10.2298/VSP141212012S

    authors: Stašević-Karličić I,Stašević S,Janković S,Đukić-Dejanović S,Milovanović S

    更新日期:2016-09-01 00:00:00

  • [Impact of dental implant insertion method on the periimplant epithelial seal--experimental study on dogs].

    abstract:BACKGROUND/AIM:There is a controversial opinion among implantologists on the method of dental implantation that provides more favourable response of soft and bone tissues. The aim of this study was to pathohistologicaly compare the influences of one- and two-phase implant surgical methods on the periimplant epithelial ...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:10.2298/vsp1003236m

    authors: Matić S,Stamatović N,Lazić Z,Petković-Curcin A,Bubalo M,Vojvodić D,Djurdjević D

    更新日期:2010-03-01 00:00:00

  • [Changes in F-response parameters in supraspinal lesions of the central nervous system].

    abstract::Since the F response is the result of antidromic activation of limited number of alpha motor neurons, the motor neurons excitability level can be investigated and established by analyzing parameter values of F response. The excitability of alpha motor neurons is the result of balance between excitatory and inhibitory ...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:

    authors: Jovicić A,Dordević D,Jovanović M,Petković S

    更新日期:1996-05-01 00:00:00

  • [Angiectatic pseudocyst of the pancreatic head].

    abstract:BACKGROUND:Arteriovenous malformations of the pancreas are very rare, most frequently congenital ones, but tending to increase frequency, predominantly due to the introduction and use of new diagnostic modalities. They usually present with gastrointestinal bleeding and abdominal pain. CASE REPORT:The autors presented ...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:10.2298/vsp0702155c

    authors: Colović R,Grubor N,Jovanović M,Micev M,Radak V,Sagić D

    更新日期:2007-02-01 00:00:00

  • [Colonic perforation as an unusual manifestation of Behcet's disease].

    abstract:INTRODUCTION:Behcet's disease is multisystemic vasculitis which affects vein and artery blood vessels. Intestinal perforation rarely occurs as clinic manifestation in as little as 1% of patients. The transverse colon is the most infrequent site of perforation. We presented a patient diagnosed with Behcet's disease who ...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:10.2298/vsp1111992t

    authors: Tomić-Lucić A,Jovanović S,Petronijević M,Veselinović M

    更新日期:2011-11-01 00:00:00

  • [Amiodarone--pro and con].

    abstract:OBJECTIVE:To compare and evaluate the data for and against the use of antiarrhythmic agent amiodarone in known cardiological indications. DATA SOURCES:A MEDLINE search was used to identify the articles dealing with amiodarone, published in the last 15 years. STUDY SELECTION:Articles and studies (uncontrolled retrospe...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:

    authors: Tadić V,Mijailović Z,Filipović S

    更新日期:1998-09-01 00:00:00

  • Differentiation of human dendritic cells from monocytes in vitro using granulocyte-macrophage colony stimulating factor and low concentration of interleukin-4.

    abstract::Several laboratories have developed culture systems that allow the generation of large numbers of human dendritic cells (DC) from monocytes using granulocyte-macrophage colony stimulating factor (GM-CSF), and interleukin-4 (IL-4). In this work we provided evidence that GM-CSF (100 ng/ml) in combination with a low conc...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:10.2298/vsp0305531c

    authors: Colić M,Jandrić D,Stojić-Vukanić Z,Antić-Stanković J,Popović P,Vasilijić S,Milosavljević P,Balint B

    更新日期:2003-09-01 00:00:00

  • Successful treatment with cladribine of Erdheim-Chester disease with orbital and central nervous system involvement developing after treatment of Langerhans cell histiocytosis.

    abstract:INTRODUCTION:Erdheim-Chester disease (ECD) is a rare, systemic form of non-Langerhans cell histiocytosis of the juvenile xanthogranuloma family with characteristic bilateral symmetrical long bone osteosclerosis, associated with xanthogranulomatous extra skeletal organ involvement. In ECD, central nervous system (CNS) a...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:10.2298/vsp140915037p

    authors: Perić P,Antić B,Knezević-Usaj S,Radić-Tasić O,Radovinović-Tasić S,Vasić-Vilić J,Sekulović L,Tarabar O,Tukić L,Jovandić S,Magić Z

    更新日期:2016-01-01 00:00:00

  • [Importance of personality traits and psychosocial factors for the development of coronary heart disease].

    abstract:BACKGROUND/AIM:Numerous studies have provided clear and convincing evidence that psychosocial factors contribute to the pathogenesis and expression of coronary heart disease (CHD). These factors have been related to the following psychosocial domains: personality factors and character traits, depression, anxiety, socia...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:10.2298/vsp0602153j

    authors: Jovanović D,Jakovljević B,Paunović K,Grubor D

    更新日期:2006-02-01 00:00:00

  • [Significance of inflammatory cytokines in the pathogenesis of IgA nephropathy].

    abstract::Prospective study was performed on the concentrations of inflammatory cytokines IL-1, TNF and IL-6 in serum and urine (ELISA tests) were determined in the scope of total clinical-laboratory and histologic treatment in 59 patients with primary IgA nephropathy. Control group consisted of 20 healthy subjects. IL-6 was no...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:

    authors: Maksić D,Spasić P,Dimitrijević J,Colić M,Hrvacević R,Kovacević Z,Marić M

    更新日期:1998-03-01 00:00:00

  • Demographic characteristics and functional outcomes in patients with traumatic and nontraumatic spinal cord injuries.

    abstract:BACKGROUND/AIM:Spinal cord injuries (SCI) could be associated with a significant functional impairment in the areas of mobility, self-care, bowel and bladder emptying and sexuality. The aim of this study was to compare demographic characteristics and functional outcomes of nontraumatic and traumatic spinal cord injury ...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:

    authors: Milićević S,Bukumirić Z,Nikolić AK,Babović R,Janković S

    更新日期:2012-12-01 00:00:00

  • [Immunohistochemical analysis of alpha-SMA and GFAP expression in liver stellate cells].

    abstract:BACKGROUND/AIM:Liver stellate cells play an important role in hepatic fibrosis, and its progression to cirrhosis. These cells show immunoreactivity with different monoclonal antibodies amongst which the commonest are alpha-smooth muscle actin (alpha-SMA) and glial fibrillary acid protein (GFAP). The aim of this study w...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:10.2298/vsp0606553t

    authors: Tomanović N,Boricić I,Brasanac D

    更新日期:2006-06-01 00:00:00

  • [Splenomegaly and thrombocytopenia in patients with liver cirrhosis].

    abstract:BACKGROUND/AIM:Splenomegaly is a frequent finding in patients with liver cirrhosis and portal hypertension and may cause hypersplenism. The occurrence of thrombocytopenia in those patients can be considered as an event with multiple etiologies. Two mechanisms may act alone or synergistically with splenic sequestration....

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:10.2298/vsp1002166d

    authors: Djordjević J,Svorcan P,Vrinić D,Dapcević B

    更新日期:2010-02-01 00:00:00

  • The A-test--reliability of functional recovery assessment during early rehabilitation of patients in an orthopedic ward.

    abstract:BACKGROUND/AIM:There are few tests for evaluation of functional abilities of patients surgically treated for hip fractures or osteoarthritis during early rehabilition period. The aim of this study was to investigate reliability (interobserver reproducibility and internal consistency) of the A-test, an original test for...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:10.2298/vsp130118042v

    authors: Vukomanović A,Djurović A,Popović Z,Ilić D

    更新日期:2014-07-01 00:00:00

  • Facial nerve injuries and its treatment.

    abstract::Twenty four patients with traumatic interruption of the conductivity of the facial nerve were treated in the period 1991-1996 at the Clinic for Maxillofacial Surgery. After topographic orientation about the site and level of the injury, the reconstruction of the nerve using nerve grafts was performed in all patients. ...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:

    authors: Mirković Z,Jović N,Stosić S,Cvetinović M

    更新日期:1997-07-01 00:00:00

  • [Ultrastructural changes in the hepatocytes in rats with dimethylaminoazobenzene poisoning].

    abstract::Chemical induction of hepatocyte transformation induced by dimethylaminoazobenzene (DAB) effect has been followed up in the initial phases of this process. Of great importance has been early recognition of primary cell population, i.e. early detection of chemical carcinogenic effects. ...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:

    authors: Skaro-Milić A,Bojanić N

    更新日期:1989-07-01 00:00:00

  • [Surgical treatment of intra-articular fractures of the calcaneus with dislocations].

    abstract::Most calcaneal fractures occur in male industrial workers, having significant economic repercussions. Although current operative treatment has improved the outcome of the treatment in many patients, there is still no consensus on the classification, treatment, operative technique, or postoperative management. Computed...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:10.2298/vsp0304421p

    authors: Popović Z,Rajović J

    更新日期:2003-07-01 00:00:00

  • Relationship of adipokine to insulin sensitivity and glycemic regulation in obese women--the effect of body weight reduction by caloric restriction.

    abstract:BACKGROUND/AIM:Visceral fat is highly active metabolic and endocrine tissue which secretes many adipokines that act both on local and systemic level. It is believed that adipokines and "low-grade inflammatory state" represent a potential link between obesity, metabolic syndrome, insulin resistance and cardiovascular di...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:10.2298/vsp1303284v

    authors: Golubović MV,Dimić D,Antić S,Radenković S,Djindjić B,Jovanović M

    更新日期:2013-03-01 00:00:00

  • [Effect of hypertonic-hyperoncotic solution infusion on tissue perfusion during surgical treatment of the abdominal aorta].

    abstract:BACKGROUND/AIM:Decreasing of arterial flow below the critical level leads to capillary endothelium edema and to further worsening of tissue perfusion. Hypertonic solution infusion provides mild and short plasma osmolality increasing, while colloidal solutions intensify that effect. The aim of this study was to investig...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章,随机对照试验

    doi:10.2298/vsp0710685s

    authors: Soskić L,Davidović L,Milicić B,Kocica M,Kovacević N,Simić T

    更新日期:2007-10-01 00:00:00

  • Unusual case of mixed form of femoroacetabular impingement combined with nonspecific synovitis of the hip joint in a young adult-- A case report.

    abstract:INTRODUCTION:Minimal bone changes in the acetabulum and/or proximal femur, through mechanism known as femoroacetabular impingement, during flexion, adduction and internal rotation lead to early contact between femoral head-neck junction and acetabular brim, in anterosuperior region. Each additional pathological substra...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:10.2298/vsp131207109m

    authors: Mladenović M,Micić I,Andjelković Z,Mladenović D,Stojiljković P

    更新日期:2015-12-01 00:00:00

  • [Vaccination against hepatitis B in the Sarajevo Military Hospital].

    abstract::The intermediate prevalence of HBV infection (28.6%) was found in the staff of the Sarajevo Military Hospital without any significant difference related to the profession of the examinees. The vaccination against hepatitis B was accepted by 23 (18.3%) of 126 candidates and it was performed with 3 doses of "ENGERIX-B" ...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:

    authors: Ler Z

    更新日期:1991-05-01 00:00:00

  • [Frequency of metastatic tumors in the heart].

    abstract:INTRODUCTION:Secondary or metastatic tumors in the heart occur more frequently than primary ones, and, according to the published series, their frequency found in autopsic material ranges from 1.6% to 20.6%. Metastatic tumors in the heart are rarely clinically symptomatic, and, therefore, they are rarely diagnosed with...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:10.2298/vsp0512915r

    authors: Rafajlovski S,Tatić V,Ilić S,Kanjuh V

    更新日期:2005-12-01 00:00:00

  • [Rapid simultaneous determination of organophosphorus pesticides in human serum and urine by liquid chromatography-mass spectrometry].

    abstract:BACKGROUND/AIM:Analysis of organophosphosphorus compounds and their metabolites in a biological material includes the use of numerous methods, covering both preparation of samples for analysis and their identification that is considered to be very complex. Low concentrations monitoring requires implementation of highly...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:10.2298/vsp1009717z

    authors: Zlatković M,Jovanović M,Djordjević D,Vucinić S

    更新日期:2010-09-01 00:00:00

  • [Oxidative status evaluation in elite karate athletes during training process].

    abstract:BACKGROUND/AIM:Oxidative stress is a state of disturbed balance between reactive oxygen species (ROS) and reactive nitrogen species (RNS) on the one hand, and antioxidative defense on the other. As a result of oxidative stress we have irreversible changes in cell function leading to pathological tissue changes, develop...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:10.2298/vsp0907551p

    authors: Pesić S,Jakovljević V,Cubrilo D,Zivković V,Jorga V,Mujović V,Stojimirović B

    更新日期:2009-07-01 00:00:00