Abstract:
:The controversy of data about the role of free radicals in the pathogenesis of bronchial asthma (BA) and lack of clear recommendations for the use of medicaments with antioxidant characteristics in the treatment of patients with BA has challenged us to undertake this study. The aim was to explain characteristics of generation of active forms of oxygen (AFO) by leukocytes, peroxide lipid oxidation (PLO) and antiperoxide plasma activities (APA) in patients with BA, evaluation of their pathogenetic importance and justified use of antioxidants in the complex therapy of BA. For this purpose, 92 patients with BA and 45 healthy volunteers were studied. Generation of AFO by blood leukocytes were examined by the method of luminol-dependent chemiluminiscence (CL). Basal and stimulated HL parameters have been measured. The intensity of PLO was determined according to the contents of malondialdehyde (MDA) in plasma. The APA was determined according to its resistance to the injection of free radicals oxidation of hydrogen peroxide. In patients with acute BA compared with healthy volunteers, both CL parameters were increased. In the same time the contents of plasma MDA and relationship of induced and spontaneous plasma CL were increased which suggested the decreased APA. In remission, both CL parameters of AFK generation by leukocytes and the contents of plasma MDA were decreased approximating the normal, but it was never reached. The direct proportional dependence of the degree of impairment and severity of the BA course and the intensity of free radical process were discovered as well as the reversed proportional dependence among the degree of impairment and severity of BA and plasma APA. However, the least parameters of AFK generation by leukocytes were obtained in patients with asthmatic state. In patients with steroid-dependent bronchial asthma the free radical process is more intensive, the plasma APA being lower than in patients with steroid-non-dependent bronchial asthma. Regarding the free radical process the most responsive was aspirin asthma, the mildest exercise-induced asthma. In patients with steroid-non-dependent BA and in patients with steroid-dependent BA who together with the traditional therapy received also antioxidants (aevit and glutamic acid), the decreased CL parameters of leukocyte AFK generation and the decreased contents of MDA were more manifested than in patients not taking antioxidants.
journal_name
Vojnosanit Pregljournal_title
Vojnosanitetski pregledauthors
Boljevic S,Daniljak IG,Kogan AHsubject
Has Abstractpub_date
1993-01-01 00:00:00pages
3-18issue
1eissn
0042-8450issn
2406-0720journal_volume
50pub_type
杂志文章abstract::Fatigue of striated muscles is defined as the impossibility to generate the expected or required force during the repeated contraction. During the maximal voluntary teeth contraction in the position of central occlusion the initial fatigue in masticatory muscles during the isometric contraction occurs. If a person can...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp0201043m
更新日期:2002-01-01 00:00:00
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journal_title:Vojnosanitetski pregled
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pub_type: 杂志文章,随机对照试验
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更新日期:2007-10-01 00:00:00
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更新日期:2015-12-01 00:00:00
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更新日期:1991-05-01 00:00:00
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