Abstract:
:Carbon dioxide (CO2) influence in generation of active oxygen forms (AOF) in human mononuclear cells (blood phagocytes and alveolar macrophages) and animal cells (tissue phagocytes, parenchymal and interstitial cells of liver, kidney, lung, brain and stomach) was investigated. The AOF generation was examined by the methods of chemiluminiscence (CL) using luminol, lucigenin and NBT (nitro blue tetrazolium) reaction. It was established that CO2 in concentrations similar to those in blood (5.1%, pCO2 37.5 mmHg) and at high concentrations (8.2%, pCO2 60 mmHg; 20%, pCO2 146 mmHg) showed pronounced inhibitory effect on the AOF generation in all the studied cells (usually reducing it 2 to 4 times). Those results were obtained not only after the direct contact of isolated cells with CO2, but also after the whole body exposure to CO2. Besides, it was established that venous blood gas mixture (CO2 - 45 mmHg, +O2 - 39 mmHg, + N2 - 646 mmHg) inhibited the AOF generation in cited cells more than the arterial blood gas mixture (CO2 - 40 mmHg, + O2 - 95 mmHg, + N2 - 595 mmHg). Carbon dioxide action mechanism was developed partially through the inhibition of the OAF generation in mitochondria and through deceleration of NADPH oxidative activity. Finally, it was established that CO2 led to the better coordination of oxidation and phosphorylation and increased the phosphorylation velocity in liver mitochondria. The results clearly confirmed the general property of CO2 to inhibit significantly the AOF generation in all the cell types. This favors the new explanation of the well-known evolutionary paradox: the Earth life and organisms preservation when the oxygen, that shows toxic effects on the cells through the AOF, occurs in the atmosphere. The results can also be used to explain in a new way the vasodilating effect of CO2 and the favorable hypercapnotherapy influence on the course of some bronchial asthma forms. The results are probably significant for the analysis of important bio-ecological problem, such as the increase of CO2 concentration in the atmosphere and its effect on the humans and animals.
journal_name
Vojnosanit Pregljournal_title
Vojnosanitetski pregledauthors
Boljevic S,Kogan AH,Gracev SV,Jelisejeva SV,Daniljak IGsubject
Has Abstractpub_date
1996-07-01 00:00:00pages
261-74issue
4eissn
0042-8450issn
2406-0720journal_volume
53pub_type
杂志文章abstract:BACKGROUND/AIM:Interaction between tumor cells and host's immunoregulatory cells in creation of microenvironment that supports tumor progression is the focus of numerous investigations in recent years. Myeloid-derived suppressor cells (MIDSCs) are heterogeneous population of immature dendritic cells, macrophages and gr...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp1504342s
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND:Although relatively rare, gastric vascular anomalies can be recognized as a source of both chronic and acute blood loss, most often presenting as long term iron deficiency anemia, rarely as severe acute gastrointestinal bleeding. CASE REPORT:We present five patients with various gastric vascular anomalies, ...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp0809710g
更新日期:2008-09-01 00:00:00
abstract:BACKGROUND/AIM:Hormone suppression therapy is used in men with advanced prostate cancer improving chances of longer survival. The aim of this study was to investigate the influence of androgen blockades on testosterone and luteinizing hormone (LH) values in patients with locally advanced and metastatic prostatic cancer...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp1104321v
更新日期:2011-04-01 00:00:00
abstract:BACKGROUND/AIM:Visceral fat is highly active metabolic and endocrine tissue which secretes many adipokines that act both on local and systemic level. It is believed that adipokines and "low-grade inflammatory state" represent a potential link between obesity, metabolic syndrome, insulin resistance and cardiovascular di...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp1303284v
更新日期:2013-03-01 00:00:00
abstract::A case of soldier with community acquired staphylococcal pneumonia and multiple pneumatoceles as the rare complication in adults is presented. Their recognition provides appropriate treatment. In the patient were developed bilateral pneumothorax, pleural empyema and sepsis. Surgical treatment was performed by thoracic...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:1999-09-01 00:00:00
abstract:BACKGROUND/AIM:Surgical treatment of patients with gastric adenocarcinoma means the total excision of a tumor and the pathways of its spreading with the risk of operational complications as low as possible. The aim of this study was to evaluate the type and frequency of early postoperative complications and mortality a...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp0603249k
更新日期:2006-03-01 00:00:00
abstract:BACKGROUND/AIM:Multiple sclerosis (MS) is a chronic inflammatory disease of central nervous system. The main physiopatological feature of MS is demyelination. Multiple sclerosis is one of three most common causes of severe disability in youngest people. In patients with MS, apart from complete psychophysical status and...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp0908645k
更新日期:2009-08-01 00:00:00
abstract:BACKGROUND/AIM:Reperfusion of previously ischemic tissue leads to injuries mediated by reactive oxygen species. The aim of the study was to investigate the effects of different anesthesia techniques on oxidative stress caused by tourniquet-induced ischemia-reperfusion (IR) injury during extremity operations at children...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章,随机对照试验
doi:10.2298/vsp1008659b
更新日期:2010-08-01 00:00:00
abstract:BACKGROUND/AIM:One of the most frequent indications for cesarean section is dystocia. It is impossible to predict, difficult to identify and coincident with the rapid expiry of the expected time, so it is important to point out some mistakes in expecting vaginal delivery. The aim of this study was to examine the freque...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:2012-07-01 00:00:00
abstract:BACKGROUND/AIM:Despite vitamin D insufficiency being widely reported, in Serbia the epidemiological data lack information regarding vitamin D status in the sera of postmenopausal women. The aim of this study was to establish the prevalence of inadequate serum 25-hydroxyvitamin D [25(OH)D] concentrations in postmenopaus...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:2012-03-01 00:00:00
abstract:BACKGROUND/AIM:Difficulties in the acceptance of dentures are multifactorial including psychosocial ones. It is questionable whether the patients' satisfaction depends only on the complete denture therapy characteristics. The aim of the study was to evaluated patients' expectation and satisfaction with complete denture...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp140229002z
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND:Cytokines are involved in almost every aspect of reproduction, and recent studies suggested a relationship between cytokines and male/female infertility. In the present study, the levels of interleukin-8 (IL-8) and interleukin-1 receptor antagonist (IL-1Ra) were determined in the cervical mucus of fertile an...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp0404359k
更新日期:2004-07-01 00:00:00
abstract:BACKGROUND:[corrected] Clinical features of inherited glucocerebrosidase deficiency were first described by Phillippe Charles Ernest Gaucher, French physician (1854-1918). Deficiency of glucocerebrosidase leads to the accumulation of the lipid glucocerebroside within the lysosomes of the monocyte macrophage system. Lip...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp0612039d
更新日期:2006-12-01 00:00:00
abstract::The retrospective analysis was performed of 26 patients (5 women and 21 men), mean age of 47.04 years, surgically treated for aortic dissecting aneurysm (ADA) at the Clinic of Cardiosurgery of the M.M.A. in the period 1988-1990. In the postoperative course acute renal insufficiency (ARI) has developed in 13 (50%) pati...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:1993-11-01 00:00:00
abstract::The results obtained by the use of the smear method were analyzed in ex tempore diagnostics of 240 neurosurgical biopsies, done in the period from 1991 to 1993. Thirty three different pathologic lesions were found that had their special morphology on smears, indicating the high specificity of this method. In 226 cases...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:1995-07-01 00:00:00
abstract:BACKGROUND/AIM:Among the proposed operative techniques for retinal detachment (RD) the most commonly applied are classical method with scleral buckling and pars plana vitrectomy (PPV). The aim of this paper was to determine which surgical intervention of these two leads to better morphological results in terms of the a...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:2014-10-01 00:00:00
abstract:BACKGROUND/AIM:Although total body irradiation (TBI) was considered to be the primary cause of thyroid dysfunction following hematopoietic stem cells transplantation (HSCT), a significant prevalence of subclinical hypothyroidism after HSCT with chemotherapy-only conditioning regimens has been observed in several studie...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp1412123m
更新日期:2014-12-01 00:00:00
abstract::Aspirin (acetylsalicylic acid--ASA) inhibits pletlets thromboxane (TXA2) synthesis as well as endothelial prostacycline (PGI2) synthesis. Aiming to prevent PGI2 synthesis attempts have been made to reduce ASA doses. Here are presented results of ASA effects in daily dose of 100 mg given to 26 patients with mean age of...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:1991-05-01 00:00:00
abstract:BACKGROUND:High-dose chemotherapy followed by hematopoietic stem cell support can be used as a first-line treatment in patients with germ-cell tumor (GCT) with poor prognosis. Long-term survival rate is attained in 50% of these patients. The aim of this paper was to present the experience at the Department of Hematolog...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp0503213m
更新日期:2005-03-01 00:00:00
abstract:BACKGROUND/AIM:Erythema infectiosum (EI) is a common childhood illness, caused by human parvovirus B19. It occurs sporadically or in epidemics and is characterized by mild constitutional symptoms and a blotchy or maculopapular lacy rash on the cheeks (slapped-cheek) spreading primarily to the extremities and trunk. The...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp110607026p
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND/AIM:Delivered dialysis dose has a cumulative effect and significant influence upon the adequacy of dialysis, quality of life and development of co-morbidity at patients on dialysis. Thus, a great attention is given to the optimization of dialysis treatment. On-line Clearance Monitoring (OCM) allows a precise...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp0608743v
更新日期:2006-08-01 00:00:00
abstract:UNLABELLED:BACKGRAUND/AIM: Conventional cytomorphology of thyroid cell aspirates is limited in preoperative differential diagnosis of follicular adenomas (FA) and hyperplastic adenomatoid nodular goiters from well differentiated thyroid follicular carcinoma (FTC) and follicular variant of thyroid papillary carcinoma (P...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp1108669k
更新日期:2011-08-01 00:00:00
abstract:BACKGROUND/AIM:There is a lack of data on the effects of prolactin on calcium metabolism and bone turnover in hyperprolactinemia of various origins. The aim of this study was to compare the influence of medicamentous and physiological hyperprolactinemia on bone turnover in female rats. METHODS:Experimental animals (18...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:2014-06-01 00:00:00
abstract::Since it has been recognized as a separate disease during the Korean war, hemorrhagic fever with renal syndrome (HFRS) has often been discovered among the members of different armies in various countries, military personnel being the highest risk group for the disease. In the period from March to May 1999 we treated 6...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp0305605c
更新日期:2003-09-01 00:00:00
abstract::Prospective study was performed on the concentrations of inflammatory cytokines IL-1, TNF and IL-6 in serum and urine (ELISA tests) were determined in the scope of total clinical-laboratory and histologic treatment in 59 patients with primary IgA nephropathy. Control group consisted of 20 healthy subjects. IL-6 was no...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:1998-03-01 00:00:00
abstract:BACKGROUND/AIM:World Health Organization (WHO) studies on the global level have shown that one of the major problems of the public health is hypertension. Blood pressure level greater than 140/90 mmHg is directly and predictively linked to other cardiovascular diseases. The aim of this research was to determine the pre...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章,多中心研究
doi:10.2298/vsp120423057m
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND/AIM:Basal cell carcinoma (BCC) is the most common form of skin cancer in the white population. Increasing incidence of BCC imposes the requirement to indentify the risk factors due to eventual preventive action. The aim of this study was to assess the role of some constitutional characteristics in developmen...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp0706375r
更新日期:2007-06-01 00:00:00
abstract:Background/Aim:Increasing epidemiological studies suggest the association between psoriasis and metabolic syndrome. The aim of this study was to assess the association of metabolic syndrome and its components with psoriasis in a sample of patients from Montenegro, and to predict the factors that determine the metabolic...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/VSP150114138R
更新日期:2016-11-01 00:00:00
abstract:OBJECTIVE:To evaluate how infection of extremity after war wound influenced the possibilities and immediate effects of a physical therapy. METHODS:The retrospective clinical investigation comparing two groups: group A (n = 86) with infection, group B (n = 87) without infection. Main indicators for possibilities of the...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:1997-11-01 00:00:00
abstract:INTRODUCTION:Golden rule for the initiation of antiepileptic therapy in the majority of epileptic syndromes is "start low and go slow", a principle after the second unprovoked seizure. There are certain clinical situations however when fast titration of antiepileptic medication is needed. CASE REPORT:We present a case...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp0706425s
更新日期:2007-06-01 00:00:00