Abstract:
BACKGROUND/AIM:There is a lack of data on the effects of prolactin on calcium metabolism and bone turnover in hyperprolactinemia of various origins. The aim of this study was to compare the influence of medicamentous and physiological hyperprolactinemia on bone turnover in female rats. METHODS:Experimental animals (18 weeks old, Wistar female rats) were divided as follows: the group P - 9 rats, 3 weeks pregnant; the group M3-10 rats that were intramuscularly administrated sulpirid (10 mg/kg) twice daily for 3 weeks, the group M6 - 10 rats that were intramuscularly administrated with sulpirid (10 mg/kg) twice daily for 6 weeks, and age matched nulliparous rats as the control group: 10 rats, 18-week-old (C1) and 7 rats, 24 weeks old (C2). Laboratory investigations included serum ionized calcium and phosphorus, urinary calcium and phosphorous excretion, osteocalcin and serum procollagen type 1 N-terminal propeptide (P1NP). RESULTS:Experimental animals in the group P compared to the control group, displayed lower mean serum ionized calcium (0.5 +/- 0.2 vs 1.12 +/- 0.04 mmol/L; p < 0.001); higher mean serum phosphorus (2.42 +/- 0.46 vs 2.05 +/- 0.2 mmol/L; p < 0.05); increased urinary calcium (3.90 +/- 0.46 vs 3.05 +/- 0.58; p < 0.01) and significantly increased P1NP (489.22 +/- 46.77 vs 361.9 +/- 53.01 pg/mL; p < 0.001). Experimental animals in the group M3 had significantly decreased P1NP, compared to the contol group. Prolongated medicamentous hyperprolactinemia (the group M6) induced increased serum ionized calcium (1.21 +/- 0.03 vs 1.15 +/- 0.02 mmol/L; p < 0.001); decreased serum phosphorus (1.70 +/- 0.13 vs 1.89 +/- 0.32 mmol/L; p < 0.001); decreased osteocalcin and P1NP. CONCLUSIONS:Physiological hyperprolactinemia does not have such harmful effect on bone metabolism as medicamentous hyperprolactinemia. Chronic medicamentous hyperprolactinemia produces lower serum levels of bone formation markers. Assessment of bone turnover markers in prolongated medicamentous hyperprolactinemia provides an opportunity for earlier diagnosis of bone metabolism disturbances and should be considered as mandatory.
journal_name
Vojnosanit Pregljournal_title
Vojnosanitetski pregledauthors
Radojković D,Pesić M,Ristić Tsubject
Has Abstractpub_date
2014-06-01 00:00:00pages
559-64issue
6eissn
0042-8450issn
2406-0720journal_volume
71pub_type
杂志文章abstract:INTRODUCTION:Peripartum cardiomyopathy is a life threatening condition of unknown cause that occurs in previously healthy women. It is characterized by symptoms of heart failure due to left ventricular dysfunction that occurs in the last month of pregnancy or the first five months after delivery. CASE REPORT:We presen...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:2012-06-01 00:00:00
abstract:BACKGROUND/AIM:The task of a forensic examiner during exhumation of skeletal remains is to calculate antemortem height of a person whose skeletal remains were found. Anthropological investigations which provided formulae for calculating ante-mortem body height date back from XIX or from the first half of XX centuries. ...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp1205394m
更新日期:2012-05-01 00:00:00
abstract::Sixty six conscripts were examined during the first 30 days of military service, in the period of adaptation to the military environment. Out of total number of the examined soldiers, 83.33% of them enlisted with previous problems from the civilian life. Two thirds of the examined soldiers experience difficulties endu...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:1996-01-01 00:00:00
abstract:INTRODUCTION/AIM:This research was done to establish recasting effects of nickel-chromium and cobalt-chromium alloys on the thickness of their metal-ceramic interface in making fixed partial dentures. Metal-ceramic interface determines their functional integrity and prevents damages on ceramics during mastication. Inve...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp0805365m
更新日期:2008-05-01 00:00:00
abstract:BACKGROUND/AIM:Almost 200 cochlear implantations were done in the four centers (two in Belgrade, per one in Novi Sad and Nis) in Serbia from 2002 to 2009. Less than 10% of implantees were postlingually deaf adults. The vast majority, i.e. 90% were pre- and perilingually profoundly deaf children. The aim of this study w...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp1104349o
更新日期:2011-04-01 00:00:00
abstract::The aim of this study was to investigate the influence of the corticosteroid therapy on the development and prognosis of proststreptococcal glomerulonephritis (PSGN) in the period of five years. The investigation included a group of 54 patients who were in the acute phase of poststreptococcal glomerulonephritis (PSGN)...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:2001-03-01 00:00:00
abstract::The controversy of data about the role of free radicals in the pathogenesis of bronchial asthma (BA) and lack of clear recommendations for the use of medicaments with antioxidant characteristics in the treatment of patients with BA has challenged us to undertake this study. The aim was to explain characteristics of ge...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:1993-01-01 00:00:00
abstract::Two hundred and ten patients with meningismus and the infections of the central nervous system (CNS) with the clinical symptoms and signs of the acute serous meningitis syndrome, were divided in to groups according to etiology (enterovirus meningitis-ENTERO, serous meningitis various etiology-SM and tuberculous mening...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp0203265t
更新日期:2002-05-01 00:00:00
abstract:BACKGROUND/AIM:Gunshot wounds caused by the automatic rifle M70AB2 (AK-47) 7.62 mm, after the primary surgical management, were closed with delayed primary suture during the next four to seven days. This period coincides with the fibroblastic phase of wound healing. Fibrin glue is used as a local hemostatic and as a ma...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp131106050d
更新日期:2015-09-01 00:00:00
abstract:BACKGROUND/AIM:Analysis of organophosphosphorus compounds and their metabolites in a biological material includes the use of numerous methods, covering both preparation of samples for analysis and their identification that is considered to be very complex. Low concentrations monitoring requires implementation of highly...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp1009717z
更新日期:2010-09-01 00:00:00
abstract::In retrospective, non-randomized study were analyzed 45 patients with local recurrences of rectal carcinoma treated by combined external beam radiotherapy (EBRT) and "High dose rate (HDR) remote afterloading" brachytherapy in the period from January 1st, 1988 to May 1st, 1988. Depending on the localization of the loca...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:1998-11-01 00:00:00
abstract:BACKGROUND/AIM:Erythema infectiosum (EI) is a common childhood illness, caused by human parvovirus B19. It occurs sporadically or in epidemics and is characterized by mild constitutional symptoms and a blotchy or maculopapular lacy rash on the cheeks (slapped-cheek) spreading primarily to the extremities and trunk. The...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp110607026p
更新日期:2013-12-01 00:00:00
abstract::Comparative clinical investigation was performed in 80 ASA I/II patients undergoing cataract surgery on one eye. Patients were randomly divided in to four groups, according to the method of anesthesia. Intraoperatively (T0-T6), decreasing of intraocular pressure (IOP) to the optimal values at the start of the operatio...
journal_title:Vojnosanitetski pregled
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:2000-03-01 00:00:00
abstract:UNLABELLED:BACKGROUND/AIM. In (counter)transference relationship therapist's interpersonal style, implying the perceived relation of therapist to a client (patient) in terms of control, autonomy, care and positive feedback, has been shown to be important. The aim of our study was to assess the relationship between ther...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp140911141h
更新日期:2016-02-01 00:00:00
abstract:INTRODUCTION:Secondary or metastatic tumors in the heart occur more frequently than primary ones, and, according to the published series, their frequency found in autopsic material ranges from 1.6% to 20.6%. Metastatic tumors in the heart are rarely clinically symptomatic, and, therefore, they are rarely diagnosed with...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp0512915r
更新日期:2005-12-01 00:00:00
abstract::Twenty eight patients (18 men and 10 women) with delayed pressure induced urticaria were analyzed. The average age was 35.5 years, and the illness lasted 1-20 years, 4.07 years on average. The spontaneous cessation of illness came in 8 patients after approximately 5.75 years. In 23 patients there was also a classical ...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:1995-05-01 00:00:00
abstract:BACKGROUND/AIM:Among the proposed operative techniques for retinal detachment (RD) the most commonly applied are classical method with scleral buckling and pars plana vitrectomy (PPV). The aim of this paper was to determine which surgical intervention of these two leads to better morphological results in terms of the a...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:2014-10-01 00:00:00
abstract:BACKGROUND/AIM:Oxidative stress is a state of disturbed balance between reactive oxygen species (ROS) and reactive nitrogen species (RNS) on the one hand, and antioxidative defense on the other. As a result of oxidative stress we have irreversible changes in cell function leading to pathological tissue changes, develop...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp0907551p
更新日期:2009-07-01 00:00:00
abstract::One of the fundamental rights of every human being is to enjoy "the highest attainable standard of health". Achieving better health requires no only adequate medical knowledge and technologies, laws and social measures in the field of health care, but also sufficient funding for fulfilling people's right to health. Ho...
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pub_type: 杂志文章
doi:10.2298/vsp120205002s
更新日期:2014-11-01 00:00:00
abstract:BACKGROUND/AIM:The differential diagnosis of fever of unknown origin (FUO) includes more than 200 different diseases and conditions. The aim of this study was to identify the most frequent causes of FUO among adult patients according to gender and age. METHODS:The study included 74 patients examined from June 2010 to ...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp140820128p
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND/AIM:Unknown cause of infertility exists in 10%-26% of couples with infertility problems. Treatment of these couples depends on the posibility of correcting the unidentified defect over time. Intrauterine insemination (IUI) and ovaluation stimulation are methods of choice in treatment of unexplained fertility...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp1204301j
更新日期:2012-04-01 00:00:00
abstract:BACKGROUND/AIM:Delivered dialysis dose has a cumulative effect and significant influence upon the adequacy of dialysis, quality of life and development of co-morbidity at patients on dialysis. Thus, a great attention is given to the optimization of dialysis treatment. On-line Clearance Monitoring (OCM) allows a precise...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp0608743v
更新日期:2006-08-01 00:00:00
abstract::Heart and brain vascular diseases present leading causes of death in civilized world. During development of brain ischemia cardiac complications are possible. The aim of this study was to determine the existence of cardiac complications' clinical predictors by assessing certain electrocardiographic changes in patients...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:1998-01-01 00:00:00
abstract::The cross-sectional study comprised 8095 officers of the Y.P.A. from the limited territory, and relationship between cardiovascular risk factors and prevalence of ischemic heart disease (IHD) has been analysed. The high and statistically significant positive relationship of serum cholesterol, blood pressure, relative ...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:1992-05-01 00:00:00
abstract:Background/Aim:Within the elderly population, residents in nursing homes, there is a greather risk of caries, periodontal disease and teeth loss. Assistance of caregivers in maintaininig good oral hygiene besides improving oral health can improve of residents general health and the qulity of their lives. The aim of thi...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/VSP141001065S
更新日期:2016-07-01 00:00:00
abstract:BACKGROUND/AIM:Dystonia is considered to be a prolonged involuntary contractions of the muscles leading to twisting, repetitive movements or irregular postures. Etiologically, it could be classified as primary and secondary dystonia. Dopa-responsive dystonia (DRD) belongs to a group of primary dystonia. The aim of this...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp0901029d
更新日期:2009-01-01 00:00:00
abstract::The study included 40 patients, aged 18-40 years with primary chronic active epilepsy, tested by clinical DMAS scale. We have found that the level of intelectual function damage (dementia) and mood (depression) rates depended on the long duration of epilepsy and the frequency of seizures, less on the frequency of spec...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:1998-07-01 00:00:00
abstract:BACKGROUND/AIM:Primary open-angle glaucoma is a multifactorial and progressive neuropathy, characterised by the acquired loss of ganglion cells of the retina and their axons. One of the risk factors for primary open-angle glaucoma is myopia over 5 diopters (D). The aim of our work was to investigate two groups of patie...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp111229024g
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND/AIM:Factors associated with mortality and morbidity following coronary artery bypass graft surgery have been well defined and the Parsonnet score is widely used in mortality prediction. The evaluation of quality of life has not been still implemented in everyday work and preoperative echocardiographic factor...
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pub_type: 杂志文章
doi:10.2298/vsp0909718z
更新日期:2009-09-01 00:00:00
abstract::Sepsis and its complications are severe clinical syndrome that is caused by systemic inflammatory response of the host to infection. Despite the use of common and numerous new therapeutic protocols, mortality from this severe disease is still very high. In the study are presented 155 patients (111 males, 44 females) o...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:1999-11-01 00:00:00