Abstract:
INTRODUCTION:Intermediate syndrome (IMS) was described a few decades ago, however, there is still a controversy regard ing its exact etiology, risk factors, diagnostic parameters and required therapy. Considering that acute poisonings are treated in different types of medical institutions this serious complication of organophosphate insecticide (OPI) poison ing is frequently overlooked. The aim of this paper was to present a case of IMS in organophosphate poisoning, which, we believe, provides additional data on the use of oxime or atropine. CASE REPORT:After a well-resolved cholinergic crisis, the patient developed clinical presentation of IMS within the first 72 h from deliberate malathion ingestion. The signs of IMS were weakness of proximal limb muscles and muscles innervated by motor cranial nerves, followed by the weakness of respiratory muscles and serious respiratory insufficiency. Malathion and its active metabolite were confirmed by ana lytical procedure (liquid chromatography-mass spectrometry). Pralidoxime methylsulphate, adiministered as a continuous in fusion until day 8 (total dose 38.4 g), and atropine until the day 10 (total dose 922 mg) did not prevent the development of IMS, hence the mechanical ventilation that was stopped after 27 h had to be continued until the day 10. CONCLUSION:Continuous pralidoxime methylsulphate infusion with atro pine did not prevent the development of IMS, most likely due to the delayed treatment and insufficient oxime dose but also because of chemical structure and lipophilicity of ingested OPI. A prolonged intensive care monitoring and respiratory care are the key management for the intermediate syndrome.
journal_name
Vojnosanit Pregljournal_title
Vojnosanitetski pregledauthors
Vucinić S,Antonijević B,Ilić NV,Ilić TVdoi
10.2298/vsp120229037vsubject
Has Abstractpub_date
2013-04-01 00:00:00pages
420-3issue
4eissn
0042-8450issn
2406-0720journal_volume
70pub_type
杂志文章abstract:BACKGROUND/AIM:Reperfusion of previously ischemic tissue leads to injuries mediated by reactive oxygen species. The aim of the study was to investigate the effects of different anesthesia techniques on oxidative stress caused by tourniquet-induced ischemia-reperfusion (IR) injury during extremity operations at children...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章,随机对照试验
doi:10.2298/vsp1008659b
更新日期:2010-08-01 00:00:00
abstract::Prospective study was performed on the concentrations of inflammatory cytokines IL-1, TNF and IL-6 in serum and urine (ELISA tests) were determined in the scope of total clinical-laboratory and histologic treatment in 59 patients with primary IgA nephropathy. Control group consisted of 20 healthy subjects. IL-6 was no...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:1998-03-01 00:00:00
abstract:INTRODUCTION:Neurofibromatosis type 1 (NF1), also known as von Recklinghausen disease, is one of the most common single-gene disorders (mutation on chromosome 17q) and usually associated with cutaneous, musculoskeletal and neurological disorders in humans. NF1 is generally complicated with one or more neurobehavioral d...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp141007146i
更新日期:2016-02-01 00:00:00
abstract::Occupational environment risk factors and health status of 172 soldiers and 89 officers were examined aiming to discover early signs of occupational diseases and disorders in artillery personnel. Among all physical and chemical risk factors noise caused by artillery and infantry firing (140 to over 170 dB) were the mo...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:1990-07-01 00:00:00
abstract::The study included 40 patients, aged 18-40 years with primary chronic active epilepsy, tested by clinical DMAS scale. We have found that the level of intelectual function damage (dementia) and mood (depression) rates depended on the long duration of epilepsy and the frequency of seizures, less on the frequency of spec...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:1998-07-01 00:00:00
abstract:BACKGROUND/AIM:Feasibility of radical prostatectomy (RP) in patients with locally invasive prostate cancer (PC) is assessed by the standard parameters such as the stage of the disease, serum prostate-specific antigen (PSA) and bioptic Gleason grade (GG). Intermediate values of PSA are important in predicting the local ...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp0708531c
更新日期:2007-08-01 00:00:00
abstract:INTRODUCTION:Erosive pustular dermatosis of the scalp (EPDS) is a rare disorder of unknown etiology that usually occurs in the elderly and is characterised by multiple pustules, erosions and crusts that appear on the scalp leading to scarring alopecia. The histopathology and laboratory tests are not specific which is t...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp120216053l
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND/AIM:Nocturia often occures in patients with benign prostata hyperplasia (BPH). The aim of the study was to investigate the frequency of nocturia in patients with BPH. Nocturia and other factors associated with it were also investigated. METHODS:Forty patients with the confirmed diagnosis of BPH were studied...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp0810751l
更新日期:2008-10-01 00:00:00
abstract:BACKGROUND/AIM:More than 90% of worldwide population is infected with human cytomegalovirus (CMV), one of the most common agents which complicate immunocompromised patients. Viral infections, in particular CMV ones are still a major cause of moratality and morbidity after stem cell transplantation (SCT). Monitoring is ...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp1005375k
更新日期:2010-05-01 00:00:00
abstract::Aspirin (acetylsalicylic acid--ASA) inhibits pletlets thromboxane (TXA2) synthesis as well as endothelial prostacycline (PGI2) synthesis. Aiming to prevent PGI2 synthesis attempts have been made to reduce ASA doses. Here are presented results of ASA effects in daily dose of 100 mg given to 26 patients with mean age of...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:1991-05-01 00:00:00
abstract::The results of Cyclosporin A treatment of 15 patients with Behçet's disease were examined in the study--9 females (aged from 32 to 34 years, mean 33 years) and 12 males (aged from 25 to 55 years, approximately 34.33 years). Among them, the majority were with chorioretinitis (10/15 or 66.6%). Besides chorioretinitis tw...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:1997-07-01 00:00:00
abstract:BACKGROUND:Ecstasy, 3,4-methylenedioxymethamphetamine (MDMA), is a synthetic compound increasingly popular as a recreational drug. Tablets known as ecstasy contain MDMA, but may also contain caffeine, ephedrine, paramethoxyamphetamine, 3,4-methylenedioxyamphetamine (MDA), amphetamine, methamphetamine, and ketamine. Aft...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp0709635d
更新日期:2007-09-01 00:00:00
abstract::The prospective clinical examination of 80 patients with the verified carcinoma of the colon and rectum was performed at the Clinic of General and Vascular Surgery of the M.M.A. in the period 1989-1990 with the aim to evaluate efficacy and justified use of antibiotic prophylaxis or prophylaxis and antibiotic therapy a...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:1993-05-01 00:00:00
abstract:BACKGROUND/AIM:Brachial artery flow-mediated dilation (FMD) is extensively used for non-invasive assessment of endothelial function. Traditionally, FMD is calculated as a percent change of arterial diameter from the baseline value at an arbitrary time point after cuff deflation (usually 60 seconds). Considerable indivi...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp0910813p
更新日期:2009-10-01 00:00:00
abstract::A 'new' group of pathogenic agents, enterohemorrhagic Escherichia coli (EHEC) (particularly the strains of O157 serogroup), emerged in the last 20 years, causing an increased number of sporadic and epidemic diarrhoeal diseases with hemorrhagic enterocolitis as a most common clinical manifestation of the infection. As ...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp0304493c
更新日期:2003-07-01 00:00:00
abstract:UNLABELLED:BACKROUND/AIM: Retraction agents for temporary vertical and lateral suppression of gingival tissue as well as bleeding control and fluid flow in the gingival sulcus are expected to have maximal efficiency without irreversible damage of local tissue and adverse systemic effects. The research started from the ...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp1401046k
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND/AIM:Interest in dental esthetics has increased rapidly during the last few decades among both patients and dentists, and the creation of a natural dental appearance has become an important task in all fields of dentistry, especially in prosthodontics and restorative dentistry. The aim of this research was to...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:2012-11-01 00:00:00
abstract::In order to detect biochemical parameters in the peripheral blood which would serve as an indicator of severity of blast injuries, the enzyme dynamics (creatine kinase, aspartat transaminase, alanin transaminase, lactic dehydrogenase, alkaline phosphatase, angiotensin convertase) has been followed up in the serum of s...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:1991-11-01 00:00:00
abstract:Background/Aim:Maternal morbidity is defined as any condition that is attributed to or aggravated by pregnancy and childbirth that has a negative impact on the woman's wellbeing. In recent years, a growing trend of cesarean section rates can be seen throughout the world. The aim of this study was to assess factors that...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/VSP150428055E
更新日期:2016-08-01 00:00:00
abstract:INTRODUCTION:Erdheim-Chester disease (ECD) is a rare, systemic form of non-Langerhans cell histiocytosis of the juvenile xanthogranuloma family with characteristic bilateral symmetrical long bone osteosclerosis, associated with xanthogranulomatous extra skeletal organ involvement. In ECD, central nervous system (CNS) a...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp140915037p
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND/AIM:In our Intensive Coronary Care Unit (CCU) a specific scoring system named the AMIS_NS was developed both for prediction of mortality in patients with acute myocardial infarction and for evaluation of the quality of work. One of the most important variables of the AMIS_NS system is the variable Jung which...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp110426006j
更新日期:2013-09-01 00:00:00
abstract:INTRODUCTION:Metronidazole is the drug of choice in the treatment of periodontal pockets up to 5 mm in depth. It is topically applied--directly into the periodontal pockets. There are no registred trademark preparations for this purpose in the market of Serbia and Montenegro. The aim of our latest research was to test ...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章,随机对照试验
doi:10.2298/vsp0508565t
更新日期:2005-07-01 00:00:00
abstract::Microscopic polyangiitis is a very rare disease characterized by the lesions of arteriolae, venulae and capillaries--mainly of the kidneys and lungs, but also of other systems and organs. The elevated titer of anti-myeloperoxidase ANCA is very important immunological indicator. The main changes in our patient were rel...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:2001-05-01 00:00:00
abstract:BACKGROUND/AIM:World Health Organization (WHO) studies on the global level have shown that one of the major problems of the public health is hypertension. Blood pressure level greater than 140/90 mmHg is directly and predictively linked to other cardiovascular diseases. The aim of this research was to determine the pre...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章,多中心研究
doi:10.2298/vsp120423057m
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND/AIM:The modification of implant surfaces could affect mechanical implant stability as well as dynamics and quality of peri-implant bone healing. The aim of this 3-month experimental study in dogs was to investigate implant stability, marginal bone levels and bone tissue response to zirconia dental implants w...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp121003034d
更新日期:2014-05-01 00:00:00
abstract::The initial experience suggested that kidney transplantation could be hazardous for patients on peritoneal dialysis due to the high risk of peritonitis and a possible high incidence of acute rejection. In this paper we have presented our experience with kidney transplantation in these patients. During the last four ye...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:2001-09-01 00:00:00
abstract::Epilepsy is chronic, multietiologic disease of the cerebrum, with different clinical features and with frequent occurrence of emotional and psychic disorders. In this report, we presented the case of female patient, 16 years old, examined in our Clinic twice. The diagnosis of epilepsy was established on the basis of t...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:1998-05-01 00:00:00
abstract::Cerebral ischemia could be observed as acute metabolic crisis, when oxygen and glucose supply is compromised and synthesis of energy is insufficient. Apart from the excitotoxicity, increased production of reactive oxygen species with consequent lipid peroxidation is also included in neuronal cell damage. Furthermore, ...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:2000-07-01 00:00:00
abstract:INTRODUCTION:Carcinoma of the esophagus is in the eighth place by the frequency of malignant diseases and the sixth cause of death from cancer worldwide. It usually metastasizes to regional lymph nodes, liver, lungs, central nervous system, and bones, but metastases can appear to unusual locations such as facial skin a...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:2014-10-01 00:00:00
abstract:BACKGROUND/AIM:Spinal muscular atrophy (SMA) is an autosomal recessive disease characterized by degeneration of alpha motor neurons in the spinal cord and the medulla oblongata, causing progressive muscle weakness and atrophy. The aim of this study was to determine association between the SMN2 gene copy number and dise...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp140328072z
更新日期:2015-10-01 00:00:00