当前位置： SCI文献检索 > Vojnosanitetski Pregled期刊下所有文献 > [Incidence of locally invasive prostate cancer in patients with intermediate values of prostate-specific antigen].

[Incidence of locally invasive prostate cancer in patients with intermediate values of prostate-specific antigen].

Abstract：

BACKGROUND/AIM:Feasibility of radical prostatectomy (RP) in patients with locally invasive prostate cancer (PC) is assessed by the standard parameters such as the stage of the disease, serum prostate-specific antigen (PSA) and bioptic Gleason grade (GG). Intermediate values of PSA are important in predicting the local confines of the tumor, but can also be detected in more than 30% of patients with locally advanced PC. The aim of this study was to find out the incidence of locally advanced PC in the patients with intermediate serum PSA in whom RP had been performed. METHODS:We used the biopsy cores and the tissue obtained after RP from 46 patients who had intermidiate PSA values which were defined as PSA from 2.6-10 ng/ml. In all the patients classical regional lymphadenectomy was performed. In all the patients, preoperative stage was determined according to the Partin tables (PT) from 2001. RESULTS:In 52, 17% of the patients biopsy GG was < or = 6, while it was 7 in 47.83% of the patients. Clinically localized disease (cT2b) was found in 86.96% of patients; other 13.04% of the patients had locally advanced PC. After RP, the incidence of localized PC was 47.83%, while the advanced disease was found in 52.17%. Metastasis in one or two regional lymph nodes (N1) was found in 10.87% of the patients with the advanced PC. According to PT, the expected incidence of positive lymph nodes should have been 8% for pT3 stage. Positive correlation between the assumed N1 stage according to PT and N1 stage in our radical prostatectomies was statistically significant (p = 0.012). CONCLUSION:In more than 50% of patients with intermediate values of PSA locally advanced disease can be expected after RP. The use of the Partin tables have an important predictive value in assessing the local confines of the cancer and metastasis in regional lymph nodes.

journal_name

Vojnosanit Pregl

journal_title

Vojnosanitetski pregled

authors

Cerović S,Jeremić N,Brajusković G,Milović N,Maletić-Vukotić V

doi

10.2298/vsp0708531c

subject

Has Abstract

pub_date

2007-08-01 00:00:00

pages

531-7

issue

eissn

0042-8450

issn

2406-0720

journal_volume

pub_type

杂志文章

在线工具

[Incidence of locally invasive prostate cancer in patients with intermediate values of prostate-specific antigen].