Abstract：
BACKGROUND/AIM:Traditional methods for detection of mycobacteria, such as microscopic examination for the presence of acid-fast bacilli and isolation of the organism by culture, have either a low sensitivity and/or specificity, or take weeks before a definite result is available. Molecular methods, especially those based on nucleic acid amplification, are rapid diagnostic methods which combine high sensitivity and high specificity. The aim of this study was to determine the usefulness of the Cobas Amplicor Mycobacterium tuberculosis polymerase chain reaction (CA-PCR) assay in detecting the tuberculosis cause in respiratory and nonrespiratory specimens (compared to culture). METHODS:Specimens were decontaminated by the N-acetyl-L-cystein-NaOH method. A 500 microL aliquot of the processed specimen were used for inoculation of Löwenstein-Jensen (L-J) slants, a drop for acid-fast staining, and 100 microL for PCR. The Cobas Amplicor PCR was performed according to the manufacturer's instructions. RESULTS:A total of 110 respiratory and 355 nonrespiratory specimens were investigated. After resolving discrepancies by reviewing medical history, overall sensitivity, specificity, and positive and negative predictive values for CA-PCR assay compared to culture, were 83%, 100%, 100%, and 96.8%, respectively. In comparison, they were 50%, 99.7%, 87.5%, and 98%, respectively, for the nonrespiratory specimens. The inhibition rate was 2.8% for respiratory, and 7.6% for nonrespiratory specimens. CONCLUSION:CA-PCR is a reliable assay that enables specialists to start treatment promptly on a positive test result. Lower value for specificity in a group of nonrespiratory specimens is a consequence of an extremely small number of mycobacteria in some of them.
journal_name
Vojnosanit Pregljournal_title
Vojnosanitetski pregledauthors
Lepsanović Z,Savić D,Tomanović Bdoi
10.2298/vsp0912992lsubject
Has Abstractpub_date
2009-12-01 00:00:00pages
992-7issue
12eissn
0042-8450issn
2406-0720journal_volume
66pub_type
杂志文章abstract：Background/Aim:Increasing epidemiological studies suggest the association between psoriasis and metabolic syndrome. The aim of this study was to assess the association of metabolic syndrome and its components with psoriasis in a sample of patients from Montenegro, and to predict the factors that determine the metabolic...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：10.2298/VSP150114138R
更新日期：2016-11-01 00:00:00
abstract：UNLABELLED:BACKGRAUND/AIM: The Thyroid Specific Patient Reported Outcome Measure (ThyPRO) questionnaire is self-administered and intended to measure quality of life of thyroid patients. The aim of this study was to investigate the validity and reliability of the translated new, ThyPRO questionnaire in Serbian patients ...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：10.2298/vsp131112035b
更新日期：2015-07-01 00:00:00
abstract：BACKGROUND/AIM:Interaction between tumor cells and host's immunoregulatory cells in creation of microenvironment that supports tumor progression is the focus of numerous investigations in recent years. Myeloid-derived suppressor cells (MIDSCs) are heterogeneous population of immature dendritic cells, macrophages and gr...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：10.2298/vsp1504342s
更新日期：2015-04-01 00:00:00
abstract：BACKGROUND:Central nervous system hemangioblastomas (HBs) are uncommon, highly vascularized tumors that are predominantly found in the cerebellum. They occur sporadically or in association with von Hippel-Lindau (VHL) disease. HBs are of unknown histogenesis, and the origin of stromal cells is still a subject of debate...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：10.2298/vsp0403273t
更新日期：2004-05-01 00:00:00
abstract：:Experimental and clinical studies, aiming to establish the influence of aging on latence, amplitude and types of waves of visual evoked potentials (VEP) are numerous. It was concluded that P-100 latence prolonged with aging, particularly after the age of 55, while P-100 amplitude had been gradually decreased during th...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：
更新日期：2000-05-01 00:00:00
abstract：BACKGROUND/AIM:World Health Organization (WHO) studies on the global level have shown that one of the major problems of the public health is hypertension. Blood pressure level greater than 140/90 mmHg is directly and predictively linked to other cardiovascular diseases. The aim of this research was to determine the pre...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章,多中心研究
doi：10.2298/vsp120423057m
更新日期：2014-03-01 00:00:00
abstract：:B type Chronic Lymphocytic Leukemia (B-CLL) is a malignant disease characterized by the progressive accumulation of morphologically mature, but immunologically dysfunctional CD 5+ lymphocytes in the blood, bone marrow and lymphatic organs in the early phase of the cell cycle. B-CLL is an example of human malignancy ca...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：10.2298/vsp0302175b
更新日期：2003-03-01 00:00:00
abstract：INTRODUCTION:Liposarcomas are malignant tumors derived from fat tissues. Liposarcoma of the paratesticular tissue is rare. CASE REPORT:We presented a 51-year-old man with liposarcoma of paratesticular tissue and the spermatic cord, mimicking a testicular tumor. Ultrasound examination of this scrotal mass was hyperecho...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：10.2298/vsp1307695v
更新日期：2013-07-01 00:00:00
abstract：INTRODUCTION:Myxomas arising from the right ventricle are extremely rare. CASE REPORT:We presented a 71-year-old patient with worsening symptoms of the exertional dyspnea and atypical chest pains lasting 6 months. A transthoracic and transesophageal echocardiogram revealed a large, 2.6 x 2.2 cm, ovoid, well-circumscri...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：10.2298/vsp1306609o
更新日期：2013-06-01 00:00:00
abstract：INTRODUCTION:Secondary or metastatic tumors in the heart occur more frequently than primary ones, and, according to the published series, their frequency found in autopsic material ranges from 1.6% to 20.6%. Metastatic tumors in the heart are rarely clinically symptomatic, and, therefore, they are rarely diagnosed with...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：10.2298/vsp0512915r
更新日期：2005-12-01 00:00:00
abstract：INTRODUCTION:Trichobezoars are foreign bodies in gastrointestinal tract, composed of hair. They occur mainly in children and adolescents suffering from trichotillophagia. They commonly occur in the stomach, but as they enlarge over time, they can extend through the pylorus into distal parts of the small intestine resem...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：
更新日期：2012-08-01 00:00:00
abstract：:The effect of gamaphos (0.6 mmol kg-1 im, 20 min before irradiation) was investigated upon the course and outcome of the surgical management of combined radiation-gunshot injury in pigs. The hypothesis was tested that the infliction of perforating gunshot injury (LD0/30 days) in pigs in the latent phase of the acute r...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：
更新日期：1994-05-01 00:00:00
abstract：:Considering that migraine patients ask for the physician's help in outpatient clinics and hospitals due to the acute attacks dominated by headaches, the latest research in pathophysiology and pharmacotherapy of migraine, directed the aim of this research to investigate the efficiency of dihydroergotamine in the treatm...
journal_title：Vojnosanitetski pregled
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1995-01-01 00:00:00
abstract：BACKGROUND/AIM:Nocturia often occures in patients with benign prostata hyperplasia (BPH). The aim of the study was to investigate the frequency of nocturia in patients with BPH. Nocturia and other factors associated with it were also investigated. METHODS:Forty patients with the confirmed diagnosis of BPH were studied...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：10.2298/vsp0810751l
更新日期：2008-10-01 00:00:00
abstract：BACKGROUND/AIM:123I-FP-CIT brain single-photon emission computed tomography (SPECT), DaTSCAN imaging, offers a possibility to study structural and biochemical integrity of presinaptic dopaminergic neurotransmitter system. The aim of this study was to evaluate the usefulness of 123I-FP-CIT brain SPECT scintigraphy in pa...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：
更新日期：2012-02-01 00:00:00
abstract：Background/Aim:Within the elderly population, residents in nursing homes, there is a greather risk of caries, periodontal disease and teeth loss. Assistance of caregivers in maintaininig good oral hygiene besides improving oral health can improve of residents general health and the qulity of their lives. The aim of thi...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：10.2298/VSP141001065S
更新日期：2016-07-01 00:00:00
abstract：:Most calcaneal fractures occur in male industrial workers, having significant economic repercussions. Although current operative treatment has improved the outcome of the treatment in many patients, there is still no consensus on the classification, treatment, operative technique, or postoperative management. Computed...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：10.2298/vsp0304421p
更新日期：2003-07-01 00:00:00
abstract：BACKGROUND/AIM:Unknown cause of infertility exists in 10%-26% of couples with infertility problems. Treatment of these couples depends on the posibility of correcting the unidentified defect over time. Intrauterine insemination (IUI) and ovaluation stimulation are methods of choice in treatment of unexplained fertility...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：10.2298/vsp1204301j
更新日期：2012-04-01 00:00:00
abstract：BACKGROUND/AIM:Socio-economic changes that occured in the wake of dismemberment of former Yugoslavia resulted in the appearance of social pathology, one of which was the increase in the use of psychoactive substances. The overwhole epidemiological research in the use of psychoactive substances has not been conducted so...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：10.2298/vsp0806441p
更新日期：2008-06-01 00:00:00
abstract：BACKGROUND/AIM:Primary open-angle glaucoma is a multifactorial and progressive neuropathy, characterised by the acquired loss of ganglion cells of the retina and their axons. One of the risk factors for primary open-angle glaucoma is myopia over 5 diopters (D). The aim of our work was to investigate two groups of patie...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：10.2298/vsp111229024g
更新日期：2013-01-01 00:00:00
abstract：INTRODUCTION:Chronic post-anoxic myoclonus, also known as Lance-Adams syndrome, may develop following hypoxic brain injury, and is resistant to pharmacological therapy. CASE REPORT:The patient we presented developed post-anoxic action myoclonus with severe, completely incapacitating myoclonic jerks. Myoclonus did not ...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：
更新日期：2014-05-01 00:00:00
abstract：BACKGROUND/AIM:Enlargement of optical zone (OZ) diameter during laser in situ keratomileusis (LASIK) correction of myopia postoperatively improves the optical outcome, however, it also leads to the increased stroma tissue consumption--progressive corneal thinning. The aim of this investigation was to present the possib...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：10.2298/vsp140627029m
更新日期：2016-06-01 00:00:00
abstract：:A 'new' group of pathogenic agents, enterohemorrhagic Escherichia coli (EHEC) (particularly the strains of O157 serogroup), emerged in the last 20 years, causing an increased number of sporadic and epidemic diarrhoeal diseases with hemorrhagic enterocolitis as a most common clinical manifestation of the infection. As ...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：10.2298/vsp0304493c
更新日期：2003-07-01 00:00:00
abstract：BACKGROUND/AIM:Numerous studies have provided clear and convincing evidence that psychosocial factors contribute to the pathogenesis and expression of coronary heart disease (CHD). These factors have been related to the following psychosocial domains: personality factors and character traits, depression, anxiety, socia...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：10.2298/vsp0602153j
更新日期：2006-02-01 00:00:00
abstract：BACKGROUND:It has been established that many patients with chronic hepatitis C have elevated serum iron, feritin levels and iron deposites in the liver. Therefore, the liver damage due to hepatitis C virus may be aggravated with iron overload. In many studies higher levels of iron in the blood and the liver were connec...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：10.2298/vsp0502161n
更新日期：2005-02-01 00:00:00
abstract：BACKGROUND/AIM:Hormone suppression therapy is used in men with advanced prostate cancer improving chances of longer survival. The aim of this study was to investigate the influence of androgen blockades on testosterone and luteinizing hormone (LH) values in patients with locally advanced and metastatic prostatic cancer...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：10.2298/vsp1104321v
更新日期：2011-04-01 00:00:00
abstract：INTRODUCTION:Minimal bone changes in the acetabulum and/or proximal femur, through mechanism known as femoroacetabular impingement, during flexion, adduction and internal rotation lead to early contact between femoral head-neck junction and acetabular brim, in anterosuperior region. Each additional pathological substra...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：10.2298/vsp131207109m
更新日期：2015-12-01 00:00:00
abstract：BACKGROUND/AIM:The differential diagnosis of fever of unknown origin (FUO) includes more than 200 different diseases and conditions. The aim of this study was to identify the most frequent causes of FUO among adult patients according to gender and age. METHODS:The study included 74 patients examined from June 2010 to ...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：10.2298/vsp140820128p
更新日期：2016-01-01 00:00:00
abstract：:Numerous clinical studies demonstrated that mycophenolate mofetil (MMF) was significantly more effective in prevention of acute rejection episodes than azathioprine. Since the data supporting the long-term benefits of MMF therapy are not available, and considering the high cost of this therapy, we examined the safety ...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：
更新日期：2001-05-01 00:00:00
abstract：BACKGROUND/AIM:There are few tests for evaluation of functional abilities of patients surgically treated for hip fractures or osteoarthritis during early rehabilition period. The aim of this study was to investigate reliability (interobserver reproducibility and internal consistency) of the A-test, an original test for...
journal_title：Vojnosanitetski pregled
pub_type： 杂志文章
doi：10.2298/vsp130118042v
更新日期：2014-07-01 00:00:00
