[Effect of chlorambucil on B-lymphocytes in the peripheral blood of patients with chronic lymphocytic leukemia--study of cellular ultrastructure].

Abstract:

:B type Chronic Lymphocytic Leukemia (B-CLL) is a malignant disease characterized by the progressive accumulation of morphologically mature, but immunologically dysfunctional CD 5+ lymphocytes in the blood, bone marrow and lymphatic organs in the early phase of the cell cycle. B-CLL is an example of human malignancy caused by alternations in the pathways of programmed cell death--apoptosis. Recent investigations showed a probable role of apoptosis as a prognostic parameter in B-CLL patients. Since the introduction of chlorambucil in the therapy in 1952, besides all the achievements in modern oncology, chlorambucil remained the most common antineoplastic agent in the treatment of CLL. Numerous experimental studies, both in vitro and in vivo, showed the capability of antineoplastic agents to induce the process of apoptosis of neoplastically transformed cells. In this study the effect of chlorambucil on B lymphocytes was monitored in 16 samples of peripheral blood taken from B-CLL diagnosed patients. According to the investigations performed in this study by ultrastructure analysis of B-CLL cells, it was concluded that chlorambucil either induced apoptosis in B-CLL cells, or activated cell response to the stress.

journal_name

Vojnosanit Pregl

journal_title

Vojnosanitetski pregled

authors

Brajusković G,Marjanović S,Skaro-Milić A

doi

10.2298/vsp0302175b

subject

Has Abstract

pub_date

2003-03-01 00:00:00

pages

175-80

issue

2

eissn

0042-8450

issn

2406-0720

journal_volume

60

pub_type

杂志文章
  • [Significance of determination of certain clinical and laboratory parameters in the evaluation of severity and outcome in sepsis].

    abstract::Sepsis and its complications are severe clinical syndrome that is caused by systemic inflammatory response of the host to infection. Despite the use of common and numerous new therapeutic protocols, mortality from this severe disease is still very high. In the study are presented 155 patients (111 males, 44 females) o...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:

    authors: Mikić D,Bojić I,Rajić-Dimitrijević R,Trnjak Z,Djokić M,Begović V,Milanović M,Mirović V,Drmanić S,Curcić P

    更新日期:1999-11-01 00:00:00

  • [Effect of small doses of aspirin on thrombocyte aggregation].

    abstract::Aspirin (acetylsalicylic acid--ASA) inhibits pletlets thromboxane (TXA2) synthesis as well as endothelial prostacycline (PGI2) synthesis. Aiming to prevent PGI2 synthesis attempts have been made to reduce ASA doses. Here are presented results of ASA effects in daily dose of 100 mg given to 26 patients with mean age of...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:

    authors: Ciko Z,Mijić R,Tanasijević M

    更新日期:1991-05-01 00:00:00

  • The importance of timely ophthalmologic examination in preterm infants at risk of retinopathy occurrence.

    abstract:BACKGROUND/AIM:Retinopathy of prematurity (ROP) is a multifactorial disease in premature infants. The aim of this study was to determine the incidence of ROP in children treated at the Center of Neonatology, Pediatric Clinic, Clinical Center in Kragujevac, Serbia. METHODS:The study covered all children with birth weig...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:

    authors: Knezevic S,Stojanović N,Oros A,Knezević J

    更新日期:2012-09-01 00:00:00

  • [Cessation of epileptic seizures series using peroral valproate in an adult patient with partial epilepsy].

    abstract:INTRODUCTION:Golden rule for the initiation of antiepileptic therapy in the majority of epileptic syndromes is "start low and go slow", a principle after the second unprovoked seizure. There are certain clinical situations however when fast titration of antiepileptic medication is needed. CASE REPORT:We present a case...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:10.2298/vsp0706425s

    authors: Spasić M,Lukić S

    更新日期:2007-06-01 00:00:00

  • [Evaluation of the level of depression and dementia in patients with primary chronic active epilepsy using the Dementia Mood Assessment Scale].

    abstract::The study included 40 patients, aged 18-40 years with primary chronic active epilepsy, tested by clinical DMAS scale. We have found that the level of intelectual function damage (dementia) and mood (depression) rates depended on the long duration of epilepsy and the frequency of seizures, less on the frequency of spec...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:

    authors: Djokić G,Milović-Vujković M,Tomović M,Makević M

    更新日期:1998-07-01 00:00:00

  • Erosive pustular dermatosis of the scalp-is it really a rare condition?

    abstract:INTRODUCTION:Erosive pustular dermatosis of the scalp (EPDS) is a rare disorder of unknown etiology that usually occurs in the elderly and is characterised by multiple pustules, erosions and crusts that appear on the scalp leading to scarring alopecia. The histopathology and laboratory tests are not specific which is t...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:10.2298/vsp120216053l

    authors: Levakov O,Gajić B

    更新日期:2014-03-01 00:00:00

  • [Stability of B1 and G2 aflatoxins after routine water chlorination].

    abstract::Stability of aflatoxin B1 and G2 as water pollutants in the presence of active chlorine was examined. One liter of demineralized water was polluted with 0.5 mg of aflatoxin B1 and with 0.5 mg of aflatoxin G2. Routine chlorination with Pantacide tablets was applied afterwards. Initial aflatoxin concentrations and those...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:

    authors: Radosević P

    更新日期:1990-07-01 00:00:00

  • Relationship between outpatient antibiotic use and the prevalence of bacterial infections in Montenegro.

    abstract:Background/Aim:The overuse of antibiotics unnecessarily exposes patients to risk of side effects, encourages reconsultation for similar problems and enhances antimicrobial resistance. The use of antibiotics in the year 2011 in Montenegro was high (39.05 Defined Daily Dose – DDD/1,000 inhabitants/day), but it was not co...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:10.2298/VSP150626146S

    authors: Šahman-Zaimović M,Vukmirović S,Tomić N,Stilinović N,Horvat O,Tomić L

    更新日期:2017-01-01 00:00:00

  • [Vascular gastric anomalies as a cause of relapsing bleeding].

    abstract:BACKGROUND:Although relatively rare, gastric vascular anomalies can be recognized as a source of both chronic and acute blood loss, most often presenting as long term iron deficiency anemia, rarely as severe acute gastrointestinal bleeding. CASE REPORT:We present five patients with various gastric vascular anomalies, ...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:10.2298/vsp0809710g

    authors: Golubović G,Kiurski M,Spica V,Tomasević R,Pavlović A,Dukić N

    更新日期:2008-09-01 00:00:00

  • Intrathecal synthesis of complement components C3c and C4 in the central nervous system infections with signs of the acute serous meningitis syndrome.

    abstract::Two hundred and ten patients with meningismus and the infections of the central nervous system (CNS) with the clinical symptoms and signs of the acute serous meningitis syndrome, were divided in to groups according to etiology (enterovirus meningitis-ENTERO, serous meningitis various etiology-SM and tuberculous mening...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:10.2298/vsp0203265t

    authors: Tatomirović Z,Bokun R,Bokonjić D

    更新日期:2002-05-01 00:00:00

  • Use of mineral trioxide aggregate in the treatement of traumatized teeth in children--two case reports.

    abstract:INTRODUCTION:Dental injuries in immature permanent teeth often result in endodontic complications. Apexification technique using calcium hydroxide is associated with certain flaws, such as long treatment time, the possibility of tooth fracture and incomplete calcification. The use of an apical plug employing mineral tr...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:10.2298/vsp1308781c

    authors: Cetenović B,Marković D,Petrović B,Perić T,Jokanović V

    更新日期:2013-08-01 00:00:00

  • [Autologous spongious iliac bone graft in the treatment of ununited diaphyseal fractures of the long bones].

    abstract::In the treatment of ununited diaphyseal fractures the authors stick to three basic principles: rigid fragment stabilization, reduced fracture split and osteogenous stimulus addition. A multiple autologous spongious iliac bone graft was used as an ostogenous stimulus. This method was applied in 47 patients within the p...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:

    authors: Jovanović Z,Popović Z,Mircić M

    更新日期:1989-05-01 00:00:00

  • [Rational for the use of human immunoglobulins in clinical practice].

    abstract::The Clinic for Rheumatology and Clinical Immunology of the Military Medical Academy, with the participation of the hosts and experts from eminent Yugoslav institutions, in April 1997 organized the symposium on two current and trendy subjects from clinical immunology: "Antiphospholipid syndrome" and "The use of polyval...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章,评审

    doi:

    authors: Popović M,Petronijević M,Stefanović D,Dimitrijević M

    更新日期:1998-03-01 00:00:00

  • [Disturbances of protein C activity in abdominal sepsis: diagnostic and predictive importance].

    abstract:BACKGROUND:Despite improved diagnostic modalities, potent antibiotics, modern intensive care, and aggressive surgical treatment, more than one third of patients still die of severe secondary peritonitis. Clinical difficulties in the treatment of abdominal sepsis were related to inherent problems of limited clinical sig...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:10.2298/vsp0406599k

    authors: Karamarković A,Mirković D,Stanković N,Nikolić V,Jeremić V,Radenković D,Stefanović B

    更新日期:2004-11-01 00:00:00

  • Economic burden of cardiovascular diseases in Serbia.

    abstract:BACKGROUND/AIM:Cardiovascular disease imposes a burden to society in terms of mortality, morbidity and economic losses. The aim of this study was to estimate the economic burden of cardiovascular disease in Serbia in 2009 from the perspective of the society. METHODS:For the purpose of the study cardiovascular disease ...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:10.2298/vsp1402137l

    authors: Lakić D,Tasić L,Kos M

    更新日期:2014-02-01 00:00:00

  • [Effect of aging on visual evoked potentials].

    abstract::Experimental and clinical studies, aiming to establish the influence of aging on latence, amplitude and types of waves of visual evoked potentials (VEP) are numerous. It was concluded that P-100 latence prolonged with aging, particularly after the age of 55, while P-100 amplitude had been gradually decreased during th...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:

    authors: Aleksić P,Raicević R,Stamenković M,Djordjević D

    更新日期:2000-05-01 00:00:00

  • The A-test--reliability of functional recovery assessment during early rehabilitation of patients in an orthopedic ward.

    abstract:BACKGROUND/AIM:There are few tests for evaluation of functional abilities of patients surgically treated for hip fractures or osteoarthritis during early rehabilition period. The aim of this study was to investigate reliability (interobserver reproducibility and internal consistency) of the A-test, an original test for...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:10.2298/vsp130118042v

    authors: Vukomanović A,Djurović A,Popović Z,Ilić D

    更新日期:2014-07-01 00:00:00

  • Quantification of mast cells in different stages of periodontal disease.

    abstract:BACKGROUND/AIM:Mast cells are mononuclear cells originating from bone marrow. They produce various biologically active substances, which allow them to actively participate in immune and inflammatory processes associated with periodontal disease. The study focused on distribution and density of mast cells in healthy gin...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:10.2298/vsp141222030m

    authors: Marjanović D,Andjelković Z,Brkić Z,Videnović G,Šehalić M,Matvjenko V,Leštarević S,Djordjević N

    更新日期:2016-05-01 00:00:00

  • [Reliability of Cobas Amplicor PCR test in detection of Mycobacterium tuberculosis in respiratory and nonorespiratory specimens].

    abstract:BACKGROUND/AIM:Traditional methods for detection of mycobacteria, such as microscopic examination for the presence of acid-fast bacilli and isolation of the organism by culture, have either a low sensitivity and/or specificity, or take weeks before a definite result is available. Molecular methods, especially those bas...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:10.2298/vsp0912992l

    authors: Lepsanović Z,Savić D,Tomanović B

    更新日期:2009-12-01 00:00:00

  • [Antibiotic prophylaxis in elective colorectal surgery].

    abstract::The prospective clinical examination of 80 patients with the verified carcinoma of the colon and rectum was performed at the Clinic of General and Vascular Surgery of the M.M.A. in the period 1989-1990 with the aim to evaluate efficacy and justified use of antibiotic prophylaxis or prophylaxis and antibiotic therapy a...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:

    authors: Jevtić M,Petrović M,Stanković N

    更新日期:1993-05-01 00:00:00

  • [Risk factors for the development of hospital infections in the intensive care units].

    abstract:BACKGROUND:Patients admitted to intensive-care units (ICU) are at a high risk of nosocomial infections (NI) due to susceptibility associated with severity of their condition, but also the invasive medical procedures they undergo. AIM:To determine the frequency of NI at the ICU of the General Hospital Uzice, and to ide...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:10.2298/vsp0504265m

    authors: Mijovićc B,Janković S,Maksimović N,Marinković J

    更新日期:2005-04-01 00:00:00

  • [Predictive significance of residual ischemia detected by the dobutamine stress-echocardiography test soon after the first uncomplicated myocardial infarction].

    abstract:BACKGROUND:To evaluate the long-term prognostic value of dobutamine stress-echocardiography (ECG) test for new coronary events (new episodes of angina pectoris, cardiac-related deaths, and reinfarctions) early after the first uncomplicated myocardial infarction. METHODS:Dobutamine stress-echocardiography tests were pe...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:10.2298/vsp0402155k

    authors: Karanović N,Todorović L,Perisić Z,Pavlović M

    更新日期:2004-03-01 00:00:00

  • [Delayed-pressure urticaria--analysis of 28 patients].

    abstract::Twenty eight patients (18 men and 10 women) with delayed pressure induced urticaria were analyzed. The average age was 35.5 years, and the illness lasted 1-20 years, 4.07 years on average. The spontaneous cessation of illness came in 8 patients after approximately 5.75 years. In 23 patients there was also a classical ...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:

    authors: Mijailović B,Stefanović Z,Zecević R,Mladenović T,Ninković M

    更新日期:1995-05-01 00:00:00

  • [Ecstasy tablets intoxication with lethal autcome].

    abstract:BACKGROUND:Ecstasy, 3,4-methylenedioxymethamphetamine (MDMA), is a synthetic compound increasingly popular as a recreational drug. Tablets known as ecstasy contain MDMA, but may also contain caffeine, ephedrine, paramethoxyamphetamine, 3,4-methylenedioxyamphetamine (MDA), amphetamine, methamphetamine, and ketamine. Aft...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:10.2298/vsp0709635d

    authors: Dordević S,Tomasević G

    更新日期:2007-09-01 00:00:00

  • [Amiodarone--pro and con].

    abstract:OBJECTIVE:To compare and evaluate the data for and against the use of antiarrhythmic agent amiodarone in known cardiological indications. DATA SOURCES:A MEDLINE search was used to identify the articles dealing with amiodarone, published in the last 15 years. STUDY SELECTION:Articles and studies (uncontrolled retrospe...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:

    authors: Tadić V,Mijailović Z,Filipović S

    更新日期:1998-09-01 00:00:00

  • Multiple lateral sinus pericranii--A case report.

    abstract:INTRODUCTION:Sinus pericranii is a rare vascular anomaly. It is characterized by abnormal communication between the extracranial and intracranial venous system, usually involving the superior sagittal sinus and occasionally the transverse sinus. Off the midline lesions are extremely rare. Multiplicity, associated venou...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:10.2298/vsp140416065i

    authors: Ivetić D,Pavlićević G,Antić B,Kostić D

    更新日期:2015-09-01 00:00:00

  • [Masked depression].

    abstract::The study comprised 25 patients with masked depression and 30 patients with endogenous depression. According to the general characteristics both groups were homogenous and accordingly, comparable. Together with clinical evaluation of depressive syndrome, psychological management was applied. Rorschach test, Thematic A...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:

    authors: Preradović M,Griva D,Eror S

    更新日期:1991-01-01 00:00:00

  • [Complications and mortality in surgery of cerebral aneurysms].

    abstract:AIM:To establish the risk factors for complications and fatal outcome after the operative occlusion of cerebral aneurysms. METHODS:Retrospective study on 91 (lethality rate) and on 72 operated patients (complications). For survived and dead patients, as well as for patients with and without complications, following pa...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:10.2298/vsp0204355r

    authors: Roganović Z,Pavlićević G

    更新日期:2002-07-01 00:00:00

  • [Carbon dioxide inhibits the generation of active forms of oxygen in human and animal cells and the significance of the phenomenon in biology and medicine].

    abstract::Carbon dioxide (CO2) influence in generation of active oxygen forms (AOF) in human mononuclear cells (blood phagocytes and alveolar macrophages) and animal cells (tissue phagocytes, parenchymal and interstitial cells of liver, kidney, lung, brain and stomach) was investigated. The AOF generation was examined by the me...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:

    authors: Boljevic S,Kogan AH,Gracev SV,Jelisejeva SV,Daniljak IG

    更新日期:1996-07-01 00:00:00

  • [Surgical treatment of intra-articular fractures of the calcaneus with dislocations].

    abstract::Most calcaneal fractures occur in male industrial workers, having significant economic repercussions. Although current operative treatment has improved the outcome of the treatment in many patients, there is still no consensus on the classification, treatment, operative technique, or postoperative management. Computed...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:10.2298/vsp0304421p

    authors: Popović Z,Rajović J

    更新日期:2003-07-01 00:00:00