Abstract:
:B type Chronic Lymphocytic Leukemia (B-CLL) is a malignant disease characterized by the progressive accumulation of morphologically mature, but immunologically dysfunctional CD 5+ lymphocytes in the blood, bone marrow and lymphatic organs in the early phase of the cell cycle. B-CLL is an example of human malignancy caused by alternations in the pathways of programmed cell death--apoptosis. Recent investigations showed a probable role of apoptosis as a prognostic parameter in B-CLL patients. Since the introduction of chlorambucil in the therapy in 1952, besides all the achievements in modern oncology, chlorambucil remained the most common antineoplastic agent in the treatment of CLL. Numerous experimental studies, both in vitro and in vivo, showed the capability of antineoplastic agents to induce the process of apoptosis of neoplastically transformed cells. In this study the effect of chlorambucil on B lymphocytes was monitored in 16 samples of peripheral blood taken from B-CLL diagnosed patients. According to the investigations performed in this study by ultrastructure analysis of B-CLL cells, it was concluded that chlorambucil either induced apoptosis in B-CLL cells, or activated cell response to the stress.
journal_name
Vojnosanit Pregljournal_title
Vojnosanitetski pregledauthors
Brajusković G,Marjanović S,Skaro-Milić Adoi
10.2298/vsp0302175bsubject
Has Abstractpub_date
2003-03-01 00:00:00pages
175-80issue
2eissn
0042-8450issn
2406-0720journal_volume
60pub_type
杂志文章abstract::Sepsis and its complications are severe clinical syndrome that is caused by systemic inflammatory response of the host to infection. Despite the use of common and numerous new therapeutic protocols, mortality from this severe disease is still very high. In the study are presented 155 patients (111 males, 44 females) o...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
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abstract::Aspirin (acetylsalicylic acid--ASA) inhibits pletlets thromboxane (TXA2) synthesis as well as endothelial prostacycline (PGI2) synthesis. Aiming to prevent PGI2 synthesis attempts have been made to reduce ASA doses. Here are presented results of ASA effects in daily dose of 100 mg given to 26 patients with mean age of...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:1991-05-01 00:00:00
abstract:BACKGROUND/AIM:Retinopathy of prematurity (ROP) is a multifactorial disease in premature infants. The aim of this study was to determine the incidence of ROP in children treated at the Center of Neonatology, Pediatric Clinic, Clinical Center in Kragujevac, Serbia. METHODS:The study covered all children with birth weig...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:2012-09-01 00:00:00
abstract:INTRODUCTION:Golden rule for the initiation of antiepileptic therapy in the majority of epileptic syndromes is "start low and go slow", a principle after the second unprovoked seizure. There are certain clinical situations however when fast titration of antiepileptic medication is needed. CASE REPORT:We present a case...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp0706425s
更新日期:2007-06-01 00:00:00
abstract::The study included 40 patients, aged 18-40 years with primary chronic active epilepsy, tested by clinical DMAS scale. We have found that the level of intelectual function damage (dementia) and mood (depression) rates depended on the long duration of epilepsy and the frequency of seizures, less on the frequency of spec...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:1998-07-01 00:00:00
abstract:INTRODUCTION:Erosive pustular dermatosis of the scalp (EPDS) is a rare disorder of unknown etiology that usually occurs in the elderly and is characterised by multiple pustules, erosions and crusts that appear on the scalp leading to scarring alopecia. The histopathology and laboratory tests are not specific which is t...
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doi:10.2298/vsp120216053l
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journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:1990-07-01 00:00:00
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pub_type: 杂志文章
doi:10.2298/VSP150626146S
更新日期:2017-01-01 00:00:00
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journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
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更新日期:2008-09-01 00:00:00
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pub_type: 杂志文章
doi:10.2298/vsp0203265t
更新日期:2002-05-01 00:00:00
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journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp1308781c
更新日期:2013-08-01 00:00:00
abstract::In the treatment of ununited diaphyseal fractures the authors stick to three basic principles: rigid fragment stabilization, reduced fracture split and osteogenous stimulus addition. A multiple autologous spongious iliac bone graft was used as an ostogenous stimulus. This method was applied in 47 patients within the p...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:1989-05-01 00:00:00
abstract::The Clinic for Rheumatology and Clinical Immunology of the Military Medical Academy, with the participation of the hosts and experts from eminent Yugoslav institutions, in April 1997 organized the symposium on two current and trendy subjects from clinical immunology: "Antiphospholipid syndrome" and "The use of polyval...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章,评审
doi:
更新日期:1998-03-01 00:00:00
abstract:BACKGROUND:Despite improved diagnostic modalities, potent antibiotics, modern intensive care, and aggressive surgical treatment, more than one third of patients still die of severe secondary peritonitis. Clinical difficulties in the treatment of abdominal sepsis were related to inherent problems of limited clinical sig...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp0406599k
更新日期:2004-11-01 00:00:00
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journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp1402137l
更新日期:2014-02-01 00:00:00
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journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:2000-05-01 00:00:00
abstract:BACKGROUND/AIM:There are few tests for evaluation of functional abilities of patients surgically treated for hip fractures or osteoarthritis during early rehabilition period. The aim of this study was to investigate reliability (interobserver reproducibility and internal consistency) of the A-test, an original test for...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp130118042v
更新日期:2014-07-01 00:00:00
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journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp141222030m
更新日期:2016-05-01 00:00:00
abstract:BACKGROUND/AIM:Traditional methods for detection of mycobacteria, such as microscopic examination for the presence of acid-fast bacilli and isolation of the organism by culture, have either a low sensitivity and/or specificity, or take weeks before a definite result is available. Molecular methods, especially those bas...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp0912992l
更新日期:2009-12-01 00:00:00
abstract::The prospective clinical examination of 80 patients with the verified carcinoma of the colon and rectum was performed at the Clinic of General and Vascular Surgery of the M.M.A. in the period 1989-1990 with the aim to evaluate efficacy and justified use of antibiotic prophylaxis or prophylaxis and antibiotic therapy a...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:1993-05-01 00:00:00
abstract:BACKGROUND:Patients admitted to intensive-care units (ICU) are at a high risk of nosocomial infections (NI) due to susceptibility associated with severity of their condition, but also the invasive medical procedures they undergo. AIM:To determine the frequency of NI at the ICU of the General Hospital Uzice, and to ide...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp0504265m
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journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp0402155k
更新日期:2004-03-01 00:00:00
abstract::Twenty eight patients (18 men and 10 women) with delayed pressure induced urticaria were analyzed. The average age was 35.5 years, and the illness lasted 1-20 years, 4.07 years on average. The spontaneous cessation of illness came in 8 patients after approximately 5.75 years. In 23 patients there was also a classical ...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:1995-05-01 00:00:00
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journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp0709635d
更新日期:2007-09-01 00:00:00
abstract:OBJECTIVE:To compare and evaluate the data for and against the use of antiarrhythmic agent amiodarone in known cardiological indications. DATA SOURCES:A MEDLINE search was used to identify the articles dealing with amiodarone, published in the last 15 years. STUDY SELECTION:Articles and studies (uncontrolled retrospe...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:1998-09-01 00:00:00
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pub_type: 杂志文章
doi:10.2298/vsp140416065i
更新日期:2015-09-01 00:00:00
abstract::The study comprised 25 patients with masked depression and 30 patients with endogenous depression. According to the general characteristics both groups were homogenous and accordingly, comparable. Together with clinical evaluation of depressive syndrome, psychological management was applied. Rorschach test, Thematic A...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:1991-01-01 00:00:00
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doi:10.2298/vsp0204355r
更新日期:2002-07-01 00:00:00
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journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:1996-07-01 00:00:00
abstract::Most calcaneal fractures occur in male industrial workers, having significant economic repercussions. Although current operative treatment has improved the outcome of the treatment in many patients, there is still no consensus on the classification, treatment, operative technique, or postoperative management. Computed...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp0304421p
更新日期:2003-07-01 00:00:00