Abstract:
BACKGROUND:Central nervous system hemangioblastomas (HBs) are uncommon, highly vascularized tumors that are predominantly found in the cerebellum. They occur sporadically or in association with von Hippel-Lindau (VHL) disease. HBs are of unknown histogenesis, and the origin of stromal cells is still a subject of debate. The aim of this study was to investigate the immunoprofile of neoplastic stromal component, and to determine whether the profile of the expression of immunomarkers used can contribute to the elucidation of the histogenesis of HBs. METHODS:A series of eight cerebellar HBs were histochemically examined for the detection of mast cells and immunohistochemically for the expression of factor VIII-related antigen (FVIII-RAg), CD34, vimentin, factor XIIIa (FXIIIa), S-100 protein, glial fibrillary acidic protein (GFAP), neuron-specific enolase (NSE), neurofilaments (NF), synaptophysin, chromogranin, and somatostatin. RESULTS:Mast cells were present in all hemangioblastomas, and were particularly abundant in one tumor. Immunohistochemically, intense reactivity for vimentin and NSE in the stromal cells was constantly seen. Immunoreactivity with S-100 protein and FXIIIa was variable, but generally many HBs stromal cells were negative for these markers. However, stromal cells were uniformly negative for FVIII-RAg in all HBs investigated. They were negative for CD34, GFAP, NF, synaptophysin, chromogranin, as well as somatostatin. GFAP-positivity of the occasional stromal type cells, located only peripherally, was interpreted as "pseudopositivity". CONCLUSION:The immunoprofile of neoplastic stromal component in this study suggested a possible origin from undifferentiated multipotential mesenchymal cells. High expression of NSE (glycolytic and hypoxia-inducible enzyme) in the HBs stromal cells might be related to the loss of the VHL protein function.
journal_name
Vojnosanit Pregljournal_title
Vojnosanitetski pregledauthors
Tasić D,Dimov D,Kostov M,Ilić S,Dojcinov D,Jovanović M,Stanojević G,Dimov Idoi
10.2298/vsp0403273tsubject
Has Abstractpub_date
2004-05-01 00:00:00pages
273-82issue
3eissn
0042-8450issn
2406-0720journal_volume
61pub_type
杂志文章abstract:Background/Aim:The mechanism of impaired bone healing in diabetes mellitus includes different tissue and cellular level activities due to micro- and macrovascular changes. As a chronic metabolic disease with vascular complications, diabetes affects a process of bone regeneration as well. The therapeutic approach in bon...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/VSP151125013Z
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND/AIM:Obesity is the most common disease of nutrition and is the consequence of reduced movement. Unfortunately, this problem is increasingly present in juvenile age, so that the pediatric outpatient offices are dominated by obese young people. The aim of this study was to evaluate and quantify the effects of ...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp1201009s
更新日期:2012-01-01 00:00:00
abstract:Background/Aim:The overuse of antibiotics unnecessarily exposes patients to risk of side effects, encourages reconsultation for similar problems and enhances antimicrobial resistance. The use of antibiotics in the year 2011 in Montenegro was high (39.05 Defined Daily Dose – DDD/1,000 inhabitants/day), but it was not co...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/VSP150626146S
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND/AIM:Visceral fat is highly active metabolic and endocrine tissue which secretes many adipokines that act both on local and systemic level. It is believed that adipokines and "low-grade inflammatory state" represent a potential link between obesity, metabolic syndrome, insulin resistance and cardiovascular di...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp1303284v
更新日期:2013-03-01 00:00:00
abstract:BACKGROUND/AIM:Modem ultrasound systems allow high-resolution transcranial sonography (TCS) of the brain structures. Enlargement of the echogenic signal (hyperechogenicity) of the substantia nigra (SN) has been reported as a highly characteristic finding in idiopathic Parkinson's disease (PD) and is thought to reflect ...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp0808601m
更新日期:2008-08-01 00:00:00
abstract::The prospective clinical examination of 80 patients with the verified carcinoma of the colon and rectum was performed at the Clinic of General and Vascular Surgery of the M.M.A. in the period 1989-1990 with the aim to evaluate efficacy and justified use of antibiotic prophylaxis or prophylaxis and antibiotic therapy a...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:1993-05-01 00:00:00
abstract::Sepsis and its complications are severe clinical syndrome that is caused by systemic inflammatory response of the host to infection. Despite the use of common and numerous new therapeutic protocols, mortality from this severe disease is still very high. In the study are presented 155 patients (111 males, 44 females) o...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:1999-11-01 00:00:00
abstract::Twenty eight patients (18 men and 10 women) with delayed pressure induced urticaria were analyzed. The average age was 35.5 years, and the illness lasted 1-20 years, 4.07 years on average. The spontaneous cessation of illness came in 8 patients after approximately 5.75 years. In 23 patients there was also a classical ...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:1995-05-01 00:00:00
abstract::With the aim to evaluate the clinical efficacy and tolerability of gabapentin as an adjuvant therapy in patients with refractory partial epilepsy we conducted an open-randomized study, with 12-weeks follow-up period. The study included 18 epilepsy patients with unsatisfactorily controlled seizures, in spite of the tre...
journal_title:Vojnosanitetski pregled
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1999-03-01 00:00:00
abstract:BACKGROUND/AIM:There is a natural asymmetry in normal female brests. When the difference in the shape, size or position of the breast and nipple-areola complex is visible, surgical correction is the only treatment option and presents one of the greatest challenges for a plastic surgeon. Based on the Nahai classificatio...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp1004313n
更新日期:2010-04-01 00:00:00
abstract:BACKGROUND:[corrected] Clinical features of inherited glucocerebrosidase deficiency were first described by Phillippe Charles Ernest Gaucher, French physician (1854-1918). Deficiency of glucocerebrosidase leads to the accumulation of the lipid glucocerebroside within the lysosomes of the monocyte macrophage system. Lip...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp0612039d
更新日期:2006-12-01 00:00:00
abstract::Cerebral ischemia could be observed as acute metabolic crisis, when oxygen and glucose supply is compromised and synthesis of energy is insufficient. Apart from the excitotoxicity, increased production of reactive oxygen species with consequent lipid peroxidation is also included in neuronal cell damage. Furthermore, ...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:2000-07-01 00:00:00
abstract:BACKGROUND/AIM:Retinopathy of prematurity (ROP) is a multifactorial disease in premature infants. The aim of this study was to determine the incidence of ROP in children treated at the Center of Neonatology, Pediatric Clinic, Clinical Center in Kragujevac, Serbia. METHODS:The study covered all children with birth weig...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:2012-09-01 00:00:00
abstract:BACKGROUND/AIM:Primary open-angle glaucoma is a multifactorial and progressive neuropathy, characterised by the acquired loss of ganglion cells of the retina and their axons. One of the risk factors for primary open-angle glaucoma is myopia over 5 diopters (D). The aim of our work was to investigate two groups of patie...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp111229024g
更新日期:2013-01-01 00:00:00
abstract::Incidence of the epicondylitis humeri lateralis in a sample of 48 patients was analyzed according to age groups. The highest incidence was found in the age group of 21-30 that corresponds to the etiologic factor of more intensive work with extended arm and clenched hand, practiced by tennis players, bricklayers, house...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:1994-03-01 00:00:00
abstract::The frequency of alcohol abuse in the soldiers of Herzegovinian corps of the Republic of Srpska Army during the 1992-1994 war, who took part in combat action was investigated by retrospective analysis of medical documentation. The same procedure was performed in the members of Yugoslav Army for the same period who did...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:1997-09-01 00:00:00
abstract:BACKGROUND/AIM:Hormone suppression therapy is used in men with advanced prostate cancer improving chances of longer survival. The aim of this study was to investigate the influence of androgen blockades on testosterone and luteinizing hormone (LH) values in patients with locally advanced and metastatic prostatic cancer...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp1104321v
更新日期:2011-04-01 00:00:00
abstract:BACKGROUND/AIM:Hip arthroplasty is a routine operation which relieves pain in patients with osteoarthritis. The role of physical therapy after hip arthroplasty was recognized, but the importance of preoperative physical therapy and education is still to be judged. The aim of this paper was to investigate the effect of ...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章,随机对照试验
doi:10.2298/vsp0804291v
更新日期:2008-04-01 00:00:00
abstract:INTRODUCTION:Epidemiological studies suggest that a high prevalence of alcohol addiction exists in female patients diagnosed with eating disorder in comparison to general population. For the purpose of explanation of the relationship of these disorders many conceptual models have been proposed. CASE REPORT:We presente...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp0703223v
更新日期:2007-03-01 00:00:00
abstract:BACKGROUND:Although the patients with diagnosed B-NHL are classified into the same disease stage on the basis of clinical, histopathological, and immunological parameters, they respond significantly different to the applied treatment. This points out the possibility that within the same group of lymphoma there are diff...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp0502087m
更新日期:2005-02-01 00:00:00
abstract:BACKGROUND:Atrial fibrillation is the most frequent cardiac dysrhythmia. The aim of this study was to show the role and the efficacy of a dual chamber pacemaker with the algorithm of atrial dynamic overdrive, in the suppression of paroxysmal atrial fibrillation. CASE REPORT:A woman with a classical bradycardia-tachyca...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp0504329r
更新日期:2005-04-01 00:00:00
abstract:BACKGROUND/AIM:Multiple sclerosis (MS) is a chronic inflammatory disease of central nervous system. The main physiopatological feature of MS is demyelination. Multiple sclerosis is one of three most common causes of severe disability in youngest people. In patients with MS, apart from complete psychophysical status and...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp0908645k
更新日期:2009-08-01 00:00:00
abstract:UNLABELLED:BACKGRAUND/AIM: Conventional cytomorphology of thyroid cell aspirates is limited in preoperative differential diagnosis of follicular adenomas (FA) and hyperplastic adenomatoid nodular goiters from well differentiated thyroid follicular carcinoma (FTC) and follicular variant of thyroid papillary carcinoma (P...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp1108669k
更新日期:2011-08-01 00:00:00
abstract::The forensic-medical expertise of 24 predominantly carbonized bodies, that were found at Kukin Do was reported. The victims were from Gospić and its surroundings, who disappeared between October 16-18, 1991. The expertise involved the identification of bodies, injury classification, determination of tools by which inj...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:1992-03-01 00:00:00
abstract:BACKGROUND:Patients admitted to intensive-care units (ICU) are at a high risk of nosocomial infections (NI) due to susceptibility associated with severity of their condition, but also the invasive medical procedures they undergo. AIM:To determine the frequency of NI at the ICU of the General Hospital Uzice, and to ide...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp0504265m
更新日期:2005-04-01 00:00:00
abstract:INTRODUCTION:Psychiatric symptoms are not rare manifestations of brain tumors. Brain tumors presented by symptoms of raised intracranial pressure, focal neurological signs, or convulsions are usually first seen by the neurologist or less frequently by the neurosurgeon in routine diagnostic procedures. On the other hand...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp1109809i
更新日期:2011-09-01 00:00:00
abstract:BACKGROUND/AIM:The aim of this study was to apply computer-assisted methodology in assessment of Ki-67 positivity in "adenoma-like" dysplasia associated lesions or masses (DALMs), and carcinoma in ulcerative colitis (UC), and to determine a new approach to grading of Ki-67 staining intensity. METHODS:Immunohistochemic...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp0711753z
更新日期:2007-11-01 00:00:00
abstract::The cross-sectional study comprised 8095 officers of the Y.P.A. from the limited territory, and relationship between cardiovascular risk factors and prevalence of ischemic heart disease (IHD) has been analysed. The high and statistically significant positive relationship of serum cholesterol, blood pressure, relative ...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:1992-05-01 00:00:00
abstract::During the last twenty-year period therapeutic plasma exchange (TPE) was used in the treatment of 68 patients with myasthenia gravis and 61 patients with multiple sclerosis. The therapeutic effects were evaluated on the basis of neurologic deficit changes, electrophysiological findings, necessary laboratory analyses a...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:2000-09-01 00:00:00
abstract:BACKGROUND/AIM:Retroperitoneal fibrosis (RPF) repre sents a chronic pathological process characterized by fibro sis which entraps and compresses the ureters and the grea blood vessels in the retroperitoneal space. A specific form of RPF is idiopathic RPF, an uncommon collagen vasculaj disease of unclear etiology. The s...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp140426076h
更新日期:2015-10-01 00:00:00