[Replacement of mycophenolate mofetil with azathioprine in patients with renal transplants].

Abstract:

:Numerous clinical studies demonstrated that mycophenolate mofetil (MMF) was significantly more effective in prevention of acute rejection episodes than azathioprine. Since the data supporting the long-term benefits of MMF therapy are not available, and considering the high cost of this therapy, we examined the safety of conversion from MMF to azathioprine in renal transplant patients. In 12 renal transplant patients (4 cadaveric and 8 living related donors) on triple immunosuppressive therapy (prednisone/MMF/cyclosporine) conversion from MMF to azathioprine was done after the first six to twelve post-transplant months. The majority of patients were in the low immunological risk of transplantation, and 7 (58.3%) received antithymocite globulin due to the delayed graft function. The mean follow-up period after the conversion to azathioprine was 6.4 months (range 3-12 months). Acute rejection episode was noticed only in one patient 8 months after the conversion following acute graft pyelonephritis. In all other patients graft function remained unchanged. We have concluded that the conversion from MMF to azathioprine in renal transplant patients on triple immunosuppressive therapy is safe and without detrimental effects on short-term allograft function. Long-term follow-up studies on larger number of patients are needed to confirm these observations.

journal_name

Vojnosanit Pregl

journal_title

Vojnosanitetski pregled

authors

Hrvacević R,Ignjatović Lj,Butorajac J,Vavić N,Drasković-Pavlović B,Dujić A,Marić M

subject

Has Abstract

pub_date

2001-05-01 00:00:00

pages

255-8

issue

3

eissn

0042-8450

issn

2406-0720

journal_volume

58

pub_type

杂志文章
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    authors: Stanković Z

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  • [Impact of dental implant insertion method on the periimplant epithelial seal--experimental study on dogs].

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    doi:

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    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:10.2298/vsp140131098b

    authors: Bosković T,Zivojinov M,Sabo JI,Budakov Z,Veljković R,Zivojinov S

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  • Prevalence of hypertension in adults in the Sumadija district, Serbia -a cross-sectional study.

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    pub_type: 杂志文章,多中心研究

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  • Incidence and treatment outcome of oral lichen planus in southeast Serbia in a 10-year period (1997-2007).

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    journal_title:Vojnosanitetski pregled

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    authors: Kesić L,Obradović R,Mihailović D,Radicević G,Stanković S,Todorović K

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  • [Colonic perforation as an unusual manifestation of Behcet's disease].

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  • [Correlation between disease progression and histopathologic criterions of the lip squamous cell carcinoma].

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    journal_title:Vojnosanitetski pregled

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  • [Anterior pituitary lobe atrophy as late complication of hemorrhagic fever with renal syndrome].

    abstract:INTRODUCTION:Hemorrhagic fever with renal syndrome (HFRS) is acute infective multisystemic disease followed by febrility, hemorrhages and acute renal insufficiency. Bleeding in the anterior pituitary lobe leading to tissue necrosis occurs in acute stage of severe clinical forms of HFRS, while atrophy of the anterior pi...

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    pub_type: 杂志文章

    doi:

    authors: Jovanović D,Kovacević Z,Rabrenović V,Skatarić V

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  • Color Doppler ultrasonography and multislice computer tomography angiography in carotid plaque detection and characterization.

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    pub_type: 杂志文章,随机对照试验

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  • [Predictive significance of residual ischemia detected by the dobutamine stress-echocardiography test soon after the first uncomplicated myocardial infarction].

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    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:10.2298/vsp0402155k

    authors: Karanović N,Todorović L,Perisić Z,Pavlović M

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  • Differentiation of human dendritic cells from monocytes in vitro using granulocyte-macrophage colony stimulating factor and low concentration of interleukin-4.

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    doi:10.2298/vsp0305531c

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  • [Importance of personality traits and psychosocial factors for the development of coronary heart disease].

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    journal_title:Vojnosanitetski pregled

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  • [Delayed-pressure urticaria--analysis of 28 patients].

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    authors: Mijailović B,Stefanović Z,Zecević R,Mladenović T,Ninković M

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  • Antiepileptic, behavioral, and antidepressant effects of adjuvant lamotrigine therapy in drug-resistant epilepsy.

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    pub_type: 临床试验,杂志文章

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  • [Therapeutic approach to progressive Takayasu's arteritis].

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  • Improvement of post-hypoxic action myoclonus with levetiracetam add-on therapy: A case report.

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    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:

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  • [Verification of vital capacity and 1 second forced expiratory volume values in 14,234 candidates for aviation school].

    abstract::The values of vital capacity (VC), forced expiratory volume in the first second (FEV1) and Tiffeneau index (100xFEV1/VC) were determined in 14,234 examinees in the period 1977-1987. Examinations were performed using the Godart expirometer. After the statistical analysis of the results being performed, the unique table...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:

    authors: Ranković N,Colak S

    更新日期:1990-05-01 00:00:00

  • The A-test--reliability of functional recovery assessment during early rehabilitation of patients in an orthopedic ward.

    abstract:BACKGROUND/AIM:There are few tests for evaluation of functional abilities of patients surgically treated for hip fractures or osteoarthritis during early rehabilition period. The aim of this study was to investigate reliability (interobserver reproducibility and internal consistency) of the A-test, an original test for...

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    pub_type: 杂志文章

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    pub_type: 杂志文章

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  • Preoperative echocardiographic parameters influencing quality of life five years after coronary artery bypass graft surgery.

    abstract:BACKGROUND/AIM:Factors associated with mortality and morbidity following coronary artery bypass graft surgery have been well defined and the Parsonnet score is widely used in mortality prediction. The evaluation of quality of life has not been still implemented in everyday work and preoperative echocardiographic factor...

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    pub_type: 杂志文章

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  • [Descending necrotizing mediastinitis].

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    pub_type: 杂志文章

    doi:10.2298/vsp0607677c

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  • [Roentgencraniometric evaluation of the craniofacial dimensions in subjects with symptoms of temporomandibular disorders].

    abstract:BACKGROUND/AIM:The aim of this study was to evaluate the possible association between certain morphologic features of the craniofacial skeleton and the presence of symptoms of temporomandibular disorders in young subjects with natural dentitions. METHODS:The investigation was carried out on 80 lateral cephalometric ra...

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    pub_type: 杂志文章

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    authors: Dodić S,Vukadinović M,Sinobad V

    更新日期:2006-09-01 00:00:00

  • Index of lipid peroxidation and glucose utilization in the cerebrospinal fluid in patients with cerebral infarction.

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    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:

    authors: Selaković V,Jovanović MD,Jovicić A,Mrsulja BJ,Malicević Z,Ninković M,Mihajlović R,Vasiljević I

    更新日期:2000-07-01 00:00:00