Identification of the first pyrimidine nucleobase transporter in Leishmania: similarities with the Trypanosoma brucei U1 transporter and antileishmanial activity of uracil analogues.

abstract：:Cysteine proteases of pathogenic protozoan parasites play pivotal roles in the life cycle of parasites, but strict regulation of their activities is also essential for maintenance of parasite physiology and interaction with hosts. In this study, we identified and characterized cryptostatin, a novel inhibitor of cystei...

journal_title：Parasitology

authors： Kang JM,Ju HL,Yu JR,Sohn WM,Na BK

更新日期：2012-07-01 00:00:00

abstract：:The molecular phylogeny and morphology of the oxyuroid nematode genus Aspiculuris from voles and house mice has been examined. Worms collected from Myodes glareolus in Poland, Eire and the UK are identified as Aspiculuris tianjinensis, previously known only from China, while worms from Mus musculus from a range of loc...

journal_title：Parasitology

authors： Behnke JM,Stewart A,Bajer A,Grzybek M,Harris PD,Lowe A,Ribas A,Smales L,Vandegrift KJ

更新日期：2015-10-01 00:00:00

abstract：:Levamisole (Lms) is an anthelminthic drug with immunomodulatory activity. Chagas disease (CD) is caused by Trypanosoma cruzi and there is very low access to the drugs available, benznidazole (Bz) and nifurtimox, both far from ideal. In a drug-repurposing strategy to test potential activity as antiparasitic and immunom...

journal_title：Parasitology

authors： Rocha Simões-Silva M,Brandão Peres R,Britto C,Machado Cascabulho C,de Melo Oliveira G,Nefertiti da Gama A,França da Silva C,Lima da Costa K,Finamore Araújo P,Diego de Souza Campos J,Meuser Batista M,Cristina Demarque K,da Cruz Mo

更新日期：2019-07-01 00:00:00

abstract：:There is increasing support for the presence of viruses and virus-like particles inside protozoan cells. This study describes viral-like RNA molecules that have been detected in two species of Eimeria that infect the chicken. The RNA molecule identified in E. maxima has been characterized: subcellular fractionation st...

journal_title：Parasitology

authors： Ellis J,Revets H

更新日期：1990-10-01 00:00:00

abstract：:Oocysts of fowl coccidia, suspended in a 12% aqueous solution of alginic acid, were dropped into 5% calcium chloride solution to form beads. Following ingestion by chicks, excystation of sporozoites was not affected. Oocyst viability was best when beads were air-dried to 33% of their original weight and stored in airt...

journal_title：Parasitology

authors： Norton CC,Joyner LP

更新日期：1986-06-01 00:00:00

abstract：:Monoclonal antibodies reacting with pellicular antigens of Toxoplasma gondii tachyzoites have been selected among hybridomas produced against this organism by immunofluorescence assay. These antigens have been further characterized by immunofluorescence on living zoites, Western immunoblotting and immunoprecipitation ...

journal_title：Parasitology

authors： Couvreur G,Sadak A,Fortier B,Dubremetz JF

更新日期：1988-08-01 00:00:00

abstract：:To compare the structures of natural and re-established populations of Ascaris in humans, universal (mass) chemotherapy was carried out at the beginning and the end of the study year using pyrantel pamoate. Worms expelled within 48 h of treatment were collected, their sex determined, and measurements made of length, w...

journal_title：Parasitology

authors： Peng W,Cui X,Zhou X

更新日期：2002-06-01 00:00:00

abstract：:SUMMARY The necessity to easily establish Histomonas meleagridis cultures has been underlined extensively by many researchers in order to gain more insights in the biology of H. meleagridis. In addition the occurrence of different protozoa in the caeca of birds impedes, however, the isolation and propagation of H. mel...

journal_title：Parasitology

authors： Pham AD,Mast J,DE Gussem JK,McDougald LR,Goddeeris BM

更新日期：2013-09-01 00:00:00

abstract：:Recombinant ribosomal DNA sequences were amplified by PCR and used as probes to perform a fingerprint analysis of total DNA from different Entamoeba histolytica isolates. RFLPs obtained with one of the probes, R-1, support previous proposals that pathogenic and non-pathogenic E. histolytica are closely related, yet ge...

journal_title：Parasitology

authors： Cruz-Reyes JA,Spice WM,Rehman T,Gisborne E,Ackers JP

更新日期：1992-04-01 00:00:00

abstract：:Changes during development in the elemental contents (Ca, P, K, Mg and S) of male and female Schistosoma mansoni from both mixed and single sex infections have been measured for the first time. In mixed infections, there is a significant difference between the calcium content of male and female worms; female worms hav...

journal_title：Parasitology

authors： Shaw MK,Erasmus DA

更新日期：1983-06-01 00:00:00

abstract：:The ultrastructure of the seminal vesicle, ejaculatory duct, cirrus sac and cirrus is described. The epithelium of the seminal vesicle consists of a single layer of squamous to cuboidal cells. The apical ends of the cells have thin polymorphic lamellae and long narrow pits, both of which enclose normal spermatozoa. Th...

journal_title：Parasitology

authors： Threadgold LT

更新日期：1975-12-01 00:00:00

abstract：:Human cysticercosis is a public health problem caused by Taenia solium metacestodes; thus, eradication of T. solium transmission by vaccination is an urgent requirement. The Cc48 mimotope from T. solium cysticerci was tested expressed in phage particles (mCc48) and chemically synthesized (sCc48) as a vaccine candidate...

journal_title：Parasitology

authors： Manhani MN,Tilelli CQ,Ribeiro VDS,Goulart LR,Costa-Cruz JM

更新日期：2020-10-01 00:00:00

abstract：:If the deleterious effects of non-specific parasites are greater on vulnerable host species than on reservoir host species then exclusion of the vulnerable host through apparent competition is more likely. Evidence suggests that such a mechanism occurs in interactions between the ring-necked pheasant (Phasianus colchi...

journal_title：Parasitology

authors： Tompkins DM,Greenman JV,Hudson PJ

更新日期：2001-02-01 00:00:00

abstract：:Oocysts of Cryptosporidium parvum showed relatively low levels of SOD activity. The SOD which had a pI of 4.8 and an approximate molecular weight of 35 kDa appeared to be iron dependent. Catalase, glutathione transferase, glutathione reductase and glutathione peroxidase activity could not be detected, nor could trypan...

journal_title：Parasitology

authors： Entrala E,Mascaro C,Barrett J

更新日期：1997-01-01 00:00:00

abstract：:The pentastomid parasite, Raillietiella frenata, is native to Asia where it infects the Asian House gecko, Hemidactylus frenatus. This gecko has been widely introduced and recently R. frenata was found in introduced populations of cane toads (Rhinella marina) in Australia, indicating a host-switch from introduced geck...

journal_title：Parasitology

authors： Kelehear C,Saltonstall K,Torchin ME

更新日期：2015-04-01 00:00:00

abstract：:The SICA[-] or non-agglutinable phenotype of Plasmodium knowlesi schizont-infected erythrocytes has been defined serologically but not biochemically. Similarly, non-cloned SICA[+] or agglutinable parasites have been shown serologically to express SICA or variant antigen(s) but the number and nature of such antigens ha...

journal_title：Parasitology

authors： Howard RJ,Barnwell JW

更新日期：1985-10-01 00:00:00

abstract：:Strongyloidiasis is frequently asymptomatic and diagnosis of latent infection is difficult due to limitations of current parasitological and serological methods. This study aimed to verify the use of conventional polymerase chain reaction (PCR) assay for molecular diagnosis of Strongyloides stercoralis infection. Fres...

journal_title：Parasitology

authors： Sitta RB,Malta FM,Pinho JR,Chieffi PP,Gryschek RC,Paula FM

更新日期：2014-04-01 00:00:00

abstract：:Hybridization events between Schistosoma species (Digenea, Platyhelminthes) are reported with increasing frequency, largely due to improved access to molecular tools. Nevertheless, little is known about the distribution and frequency of hybrid schistosomes in nature. Screening for hybrids on a large scale is complicat...

journal_title：Parasitology

authors： Boon NAM,Van Den Broeck F,Faye D,Volckaert FAM,Mboup S,Polman K,Huyse T

更新日期：2018-04-01 00:00:00

abstract：:The global seroprevalence of latent toxoplasmosis is estimated to be higher than 30%. The presence of slowly dividing parasites in tissue cysts located mainly in immunoprivileged organs was long considered asymptomatic. Recently, many studies have shown that latent Toxoplasma infections could have serious impacts on h...

journal_title：Parasitology

authors： Flegr J,Escudero DQ

更新日期：2016-12-01 00:00:00

abstract：:Steroids have been shown to be beneficial in patients and mice with eosinophilic meningitis caused by Angiostrongylus cantonensis infection; however, the mechanism for this beneficial effect is unknown. We speculated that the effect of steroids in eosinophilic meningitis caused by A. cantonensis infection may be media...

journal_title：Parasitology

authors： Tsai HC,Chen YH

更新日期：2020-10-02 00:00:00

abstract：:Virulence factors from the ROP2-family have been extensively studied in Toxoplasma gondii, but in the closely related Neospora caninum only NcROP2Fam-1 has been partially characterized to date. NcROP40 is a member of this family and was found to be more abundantly expressed in virulent isolates. Both NcROP2Fam-1 and N...

journal_title：Parasitology

authors： Pastor-Fernández I,Regidor-Cerrillo J,Jiménez-Ruiz E,Álvarez-García G,Marugán-Hernández V,Hemphill A,Ortega-Mora LM

更新日期：2016-01-01 00:00:00

abstract：:Most human cases of cryptosporidiosis are caused by Cryptosporidium parvum or Cryptosporidium hominis, but the use of molecular diagnostic methods has revealed that several other less common species or genotypes can also be involved. Here, we describe two unusual causes of cryptosporidiosis, one being the recently des...

journal_title：Parasitology

authors： Lebbad M,Beser J,Insulander M,Karlsson L,Mattsson JG,Svenungsson B,Axén C

更新日期：2013-12-01 00:00:00

abstract：:Macrogametogony and the formation of the oocyst wall has been examined in Eimeria acervulina. Macrogametes develop within a parasitophorous vacuole. Within the cytoplasm can be observed wall-forming bodies of Type I (WFBI) and Type II (WFBII), a nucleus, mitochondria, canaliculi and polysaccharide granules. WFBII are ...

journal_title：Parasitology

authors： Pittilo RM,Ball SJ

更新日期：1984-08-01 00:00:00

abstract：:As has been shown previously, immunologically intact mice with patent Schistosoma mansoni infections had a significantly lower mean platelet number than intact uninfected mice (P<0.0001). However, platelet numbers in T-cell deprived mice with patent infections were not significantly different from those in uninfected ...

journal_title：Parasitology

authors： Stanley RG,Ngaiza JR,Atieno E,Jell G,Francklow K,Jackson CL,Parry H,Doenhoff MJ

更新日期：2003-03-01 00:00:00

abstract：:Protoscoleces of Echinococcus granulosus absorb the L-amino acids proline, methionine, leucine, alanine, serine, phenylalanine, lysine and glutamic acid by a combination of mediated transport and diffusion. All eight amino acids were accumulated against a concentration gradient. Comparison of Kt and Vmax values sugges...

journal_title：Parasitology

authors： Jeffs SA,Arme C

更新日期：1987-08-01 00:00:00

abstract：:A cross-sectional sero-epidemiological study was performed in Magoda, Tanzania, an area where malaria is holoendemic. Blood samples were collected from children (1-4 years) and tested for IgG antibody reactivity against 2 recombinant protein fragments of Plasmodium falciparum Rhoptry-Associated Protein-1 (rRAP-1). The...

journal_title：Parasitology

authors： Alifrangis M,Lemnge MM,Moon R,Theisen M,Bygbjerg I,Ridley RG,Jakobsen PH

更新日期：1999-10-01 00:00:00

abstract：:Diseases caused by viruses are a constant and major problem for livestock production world wide. The diseases range from highly contagious acute forms with high mortality, to chronic disabling diseases with an insidious effect on production. Such diseases cannot be regarded as static in nature due to the highly mutabl...

journal_title：Parasitology

authors： Crowther JR

更新日期：1998-01-01 00:00:00

abstract：:In recent years, through a national programme for schistosomiasis control, this infection has been eliminated from Iran. The aim of this study was to report the process of significant decrease of urogenital schistosomiasis in southwestern Iran. During national programme surveillance for urogenital schistosomiasis cont...

journal_title：Parasitology

authors： Khademvatan S,Salmanzadeh S,Foroutan-Rad M,Ghomeshi M

更新日期：2016-09-01 00:00:00

abstract：:Laboratory experiments indicated that the active life-span of the cercariae of Cryptocotyle lingua was temperature-dependent. An increase in water temperature and population age both correlated with a tendency for the organisms to become decaudate. The larvae were strongly photoresponsive to lateral light but with tim...

journal_title：Parasitology

authors： Rea JG,Irwin SW

更新日期：1992-08-01 00:00:00

abstract：:Sexual size dimorphism (SSD) in mammals reveals the extent of sexual selection, which may in turn explain why males are often more infected by parasites than females and that parasites may contribute to the association between SSD and male-biased mortality. Here, we investigated the relationship between SSD in small m...

journal_title：Parasitology

authors： Morand S,De Bellocq JG,Stanko M,Miklisová D

更新日期：2004-10-01 00:00:00