NFATx, a novel member of the nuclear factor of activated T cells family that is expressed predominantly in the thymus.

abstract：:A 249-nucleotide coding region instability determinant (CRD) destabilizes c-myc mRNA. Previous experiments identified a CRD-binding protein (CRD-BP) that appears to protect the CRD from endonuclease cleavage. However, it was unclear why a CRD-BP is required to protect a well-translated mRNA whose coding region is cove...

journal_title：Molecular and cellular biology

authors： Lemm I,Ross J

更新日期：2002-06-01 00:00:00

abstract：:The adenovirus EIa gene products activate transcription from the viral EIII and EIIaE promoters. We studied the mechanism of this stimulation by constructing a series of chimeric promoter recombinants containing the upstream regions of the EIII and EIIaE promoters linked to the TATA box-start-site regions of the viral...

journal_title：Molecular and cellular biology

authors： Leff T,Chambon P

更新日期：1986-01-01 00:00:00

abstract：:SH2 (src homology region 2) domains are implicated in protein-protein interactions involved in signal transduction pathways. Isolated SH2 domains bind proteins that are tyrosine phosphorylated. A novel, phosphotyrosine-independent binding interaction between BCR, the Philadelphia chromosome breakpoint cluster region g...

journal_title：Molecular and cellular biology

authors： Muller AJ,Pendergast AM,Havlik MH,Puil L,Pawson T,Witte ON

更新日期：1992-11-01 00:00:00

abstract：:TSLC1/IGSF4, an immunoglobulin superfamily molecule, is predominantly expressed in the brain, lungs, and testes and plays important roles in epithelial cell adhesion, cancer invasion, and synapse formation. We generated Tslc1/Igsf4-deficient mice by disrupting exon 1 of the gene and found that Tslc1(-/-) mice were bor...

journal_title：Molecular and cellular biology

authors： Yamada D,Yoshida M,Williams YN,Fukami T,Kikuchi S,Masuda M,Maruyama T,Ohta T,Nakae D,Maekawa A,Kitamura T,Murakami Y

更新日期：2006-05-01 00:00:00

abstract：:An analysis of the sizes and sequence content of nuclear RNA transcripts of the heavy-chain locus in two B-cell lymphomas, 70Z/3 and 38C-13, and in selected hybridoma derivatives of 38C has led to the identification of two distinct precursors of the mRNAs encoding the membrane and secretory forms of mu chain. These pr...

journal_title：Molecular and cellular biology

authors： Nelson KJ,Haimovich J,Perry RP

更新日期：1983-07-01 00:00:00

abstract：:Changes in chromatin composition are often a prerequisite for gene induction. Nonallelic histone variants have recently emerged as key players in transcriptional control and chromatin modulation. While the changes in chromatin accessibility and histone posttranslational modification (PTM) distribution that accompany g...

journal_title：Molecular and cellular biology

authors： Sutcliffe EL,Parish IA,He YQ,Juelich T,Tierney ML,Rangasamy D,Milburn PJ,Parish CR,Tremethick DJ,Rao S

更新日期：2009-04-01 00:00:00

abstract：:Using PCR-coupled subtractive screening-representational difference analysis, we have cloned a novel gene from AML1-ETO knockin mice. This gene is highly expressed in the yolk sac and fetal liver of the knockin mice. Nucleotide sequence analysis indicates that its cDNA contains an 1,107-bp open reading frame encoding ...

journal_title：Molecular and cellular biology

authors： Liu LQ,Ilaria R Jr,Kingsley PD,Iwama A,van Etten RA,Palis J,Zhang DE

更新日期：1999-04-01 00:00:00

abstract：:Three subtypes of retinoic acid receptors (RAR), termed RAR alpha, RAR beta, and RAR gamma, have been described. They are composed of different structural domains, including distinct domains for DNA and ligand binding. RARs specifically bind all-trans-retinoic acid (RA), 9-cis-RA, and retinoid analogs. In this study, ...

journal_title：Molecular and cellular biology

authors： Lamour FP,Lardelli P,Apfel CM

更新日期：1996-10-01 00:00:00

abstract：:Saccharomyces mating-type switching occurs through a double-strand break-initiated gene conversion event at MAT, using one of two donors located distantly on the same chromosome, HMLalpha and HMRa. MATa cells preferentially choose HMLalpha, a decision that depends on the recombination enhancer (RE) that controls recom...

journal_title：Molecular and cellular biology

authors： Coïc E,Sun K,Wu C,Haber JE

更新日期：2006-07-01 00:00:00

abstract：:Protein ubiquitination plays a key role in the regulation of a variety of DNA repair mechanisms. Protein ubiquitination is controlled by the coordinate activity of ubiquitin ligases and deubiquitinating enzymes (DUBs). The deubiquitinating enzyme USP1 regulates DNA repair and the Fanconi anemia pathway through its ass...

journal_title：Molecular and cellular biology

authors： Murai J,Yang K,Dejsuphong D,Hirota K,Takeda S,D'Andrea AD

更新日期：2011-06-01 00:00:00

abstract：:A mouse adenine phosphoribosyltransferase (aprt) pseudogene that had previously been recovered from a BALB/c sperm DNA library possessed several unusual features. Its nucleotide sequence, like that of other processed pseudogenes, was colinear with its corresponding mRNA, but it was truncated at its 3' end and lacked a...

journal_title：Molecular and cellular biology

authors： Dush MK,Tischfield JA,Khan SA,Feliciano E,Sikela JM,Kozak CA,Stambrook PJ

更新日期：1986-12-01 00:00:00

abstract：:The Eph receptors are the largest known family of receptor tyrosine kinases and are notable for distinctive expression patterns in the nervous system and in early vertebrate development. However, all were identified as orphan receptors, and only recently have there been descriptions of a corresponding family of ligand...

journal_title：Molecular and cellular biology

authors： Bergemann AD,Cheng HJ,Brambilla R,Klein R,Flanagan JG

更新日期：1995-09-01 00:00:00

abstract：:Although TRAIL is considered a potential anticancer agent, it enhances tumor progression by activating NF-κB in apoptosis-resistant cells. Cellular FLICE-like inhibitory protein (cFLIP) overexpression and caspase-8 activation have been implicated in TRAIL-induced NF-κB activation; however, the underlying mechanisms ar...

journal_title：Molecular and cellular biology

authors： Zhang L,Blackwell K,Workman LM,Chen S,Pope MR,Janz S,Habelhah H

更新日期：2015-10-01 00:00:00

abstract：:Fragile X syndrome, the most common form of hereditary mental retardation, usually results from lack of expression of the FMR1 gene. The FMR1 protein is a cytoplasmic RNA-binding protein. The RNA-binding activity of FMR1 is an essential feature of FMR1, as fragile X syndrome can also result from the expression of muta...

journal_title：Molecular and cellular biology

authors： Siomi MC,Zhang Y,Siomi H,Dreyfuss G

更新日期：1996-07-01 00:00:00

abstract：:We show that the nuclear genes for the cytoplasmic and mitochondrial leucyl-tRNA synthetase (LeuRS) of Neurospora crassa are distinct in their encoded proteins, codon usage, mRNA levels, and regulation. The 4.2-kilobase-pair region representing the structural gene for cytoplasmic LeuRS and flanking regions has been se...

journal_title：Molecular and cellular biology

authors： Chow CM,Rajbhandary UL

更新日期：1989-11-01 00:00:00

abstract：:A potential p120 GTPase-activating protein (RasGAP) effector, G3BP (RasGAP Src homology 3 [SH3] binding protein), was previously identified based on its ability to bind the SH3 domain of RasGAP. Here we show that G3BP colocalizes and physically interacts with RasGAP at the plasma membrane of serum-stimulated but not q...

journal_title：Molecular and cellular biology

authors： Gallouzi IE,Parker F,Chebli K,Maurier F,Labourier E,Barlat I,Capony JP,Tocque B,Tazi J

更新日期：1998-07-01 00:00:00

abstract：:Entry into mitosis requires the activity of the Cdc2 kinase. Cdc2 associates with the B-type cyclins, and the Cdc2-cyclin B heterodimer is in turn regulated by phosphorylation. Phosphorylation of threonine 161 is required for the Cdc2-cyclin B complex to be catalytically active, whereas phosphorylation of threonine 14...

journal_title：Molecular and cellular biology

authors： Liu F,Stanton JJ,Wu Z,Piwnica-Worms H

更新日期：1997-02-01 00:00:00

abstract：:Hybridization to synthetic oligonucleotides representing conserved regions in the promoter and first intron of several vertebrate beta-actin genes was used to discriminate between what appears to be a single functional beta-actin gene and numerous pseudogenes in the mouse genome. Sequences derived from the 5' end of t...

journal_title：Molecular and cellular biology

authors： Elder PK,French CL,Subramaniam M,Schmidt LJ,Getz MJ

更新日期：1988-01-01 00:00:00

abstract：:Integration of protein kinases into transcription activation complexes influences the magnitude of gene expression. The nuclear factor of activated T cells (NFAT) group of proteins are critical transcription factors that direct gene expression in immune and nonimmune cells. A balance of phosphotransferase activity is ...

journal_title：Molecular and cellular biology

authors： Yang TT,Xiong Q,Graef IA,Crabtree GR,Chow CW

更新日期：2005-02-01 00:00:00

abstract：:We reported the identification of a new family of DNA-binding proteins from our characterization of the dead ringer (dri) gene of Drosophila melanogaster. We show that dri encodes a nuclear protein that contains a sequence-specific DNA-binding domain that bears no similarity to known DNA-binding domains. A number of p...

journal_title：Molecular and cellular biology

authors： Gregory SL,Kortschak RD,Kalionis B,Saint R

更新日期：1996-03-01 00:00:00

abstract：:Centrins in vertebrates have traditionally been associated with microtubule-nucleating centers such as the centrosome. Unexpectedly, we found centrin 2 to associate biochemically with nucleoporins, including the Xenopus laevis Nup107-160 complex, a critical subunit of the vertebrate nuclear pore in interphase and of t...

journal_title：Molecular and cellular biology

authors： Resendes KK,Rasala BA,Forbes DJ

更新日期：2008-03-01 00:00:00

abstract：:The c-myc proto-oncogene encodes a transcription factor that participates in the regulation of cellular proliferation, differentiation, and apoptosis. Ectopic overexpression of c-Myc has been shown to sensitize cells to apoptosis. We report here that cells lacking c-Myc activity due to disruption of the c-myc gene by ...

journal_title：Molecular and cellular biology

authors： Adachi S,Obaya AJ,Han Z,Ramos-Desimone N,Wyche JH,Sedivy JM

更新日期：2001-08-01 00:00:00

abstract：:The ESC-E(Z) complex of Drosophila melanogaster Polycomb group (PcG) repressors is a histone H3 methyltransferase (HMTase). This complex silences fly Hox genes, and related HMTases control germ line development in worms, flowering in plants, and X inactivation in mammals. The fly complex contains a catalytic SET domai...

journal_title：Molecular and cellular biology

authors： Ketel CS,Andersen EF,Vargas ML,Suh J,Strome S,Simon JA

更新日期：2005-08-01 00:00:00

abstract：:The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor that can be activated by structurally diverse chemicals. To examine the mechanisms responsible for the promiscuity in AhR ligand binding, we determined the effects of mutations within the AhR ligand-binding domain (LBD) on the activity of d...

journal_title：Molecular and cellular biology

authors： Soshilov AA,Denison MS

更新日期：2014-05-01 00:00:00

abstract：:The HMG box containing protein UBF binds to the promoter of vertebrate ribosomal repeats and is required for their transcription by RNA polymerase I in vitro. UBF can also bind in vitro to a variety of sequences found across the intergenic spacer in Xenopus and mammalian ribosomal DNA (rDNA) repeats. The high abundanc...

journal_title：Molecular and cellular biology

authors： O'Sullivan AC,Sullivan GJ,McStay B

更新日期：2002-01-01 00:00:00

abstract：:mRNA in the yeast Saccharomyces cerevisiae is primarily degraded through a pathway that is stimulated by removal of the mRNA cap structure. Here we report that a mutation in the SPB8 (YJL124c) gene, initially identified as a suppressor mutation of a poly(A)-binding protein (PAB1) gene deletion, stabilizes the mRNA cap...

journal_title：Molecular and cellular biology

authors： Boeck R,Lapeyre B,Brown CE,Sachs AB

更新日期：1998-09-01 00:00:00

abstract：:The activity of p21ras is required for the proliferative response to colony-stimulating factor 1 (CSF-1), and signals transduced by both the CSF-1 receptor (CSF-1R) and p21ras stimulate transcription from promoter elements containing overlapping binding sites for Fos/Jun- and Ets-related proteins. A sequence encoding ...

journal_title：Molecular and cellular biology

authors： Langer SJ,Bortner DM,Roussel MF,Sherr CJ,Ostrowski MC

更新日期：1992-12-01 00:00:00

abstract：:In yeast, the pheromone alpha-factor acts as an antiproliferative factor that induces G1 arrest and cellular differentiation. Previous data have indicated that Far1, a factor dedicated to pheromone-induced cell cycle arrest, is under positive and negative posttranslational regulation. Phosphorylation by the pheromone-...

journal_title：Molecular and cellular biology

authors： Gartner A,Jovanović A,Jeoung DI,Bourlat S,Cross FR,Ammerer G

更新日期：1998-07-01 00:00:00

abstract：:The tyrosinase family comprises three members, tyrosinase (Tyr), tyrosinase-related protein 1 (Tyrp1), and dopachrome tautomerase (Dct). Null mutations and deletions at the Tyr and Tyrp1 loci are known and phenotypically affect coat color due to the absence of enzyme or intracellular mislocalization. At the Dct locus,...

journal_title：Molecular and cellular biology

authors： Guyonneau L,Murisier F,Rossier A,Moulin A,Beermann F

更新日期：2004-04-01 00:00:00

abstract：:Smad proteins play a key role in the intracellular signaling of the transforming growth factor beta (TGF-beta) superfamily of extracellular polypeptides that initiate signaling from the cell surface through serine/threonine kinase receptors. A subclass of Smad proteins, including Smad6 and Smad7, has been shown to fun...

journal_title：Molecular and cellular biology

authors： Datta PK,Moses HL

更新日期：2000-05-01 00:00:00