Pheromone-dependent G1 cell cycle arrest requires Far1 phosphorylation, but may not involve inhibition of Cdc28-Cln2 kinase, in vivo.

abstract：:We have screened an adult rat cerebellar cDNA library in search of novel protein tyrosine-kinase (PTK) cDNAs. A cDNA for a putative PTK, trkB, was cloned, and its sequence indicates that it is likely to be derived from a gene for a ligand-regulated receptor closely related to the human trk oncogene. Northern (RNA) ana...

journal_title：Molecular and cellular biology

authors： Middlemas DS,Lindberg RA,Hunter T

更新日期：1991-01-01 00:00:00

abstract：:Expression of the Cyp 2d-9 (steroid 16 alpha-hydroxylase) gene in mouse liver is male specific in such Mus musculus domesticus strains as FVB/N, whereas the corresponding P450 genes in the wild mouse species Mus spretus are not sex specific in their expression. These parental differences in the gene expressions were i...

journal_title：Molecular and cellular biology

authors： Sueyoshi T,Kobayashi R,Nishio K,Aida K,Moore R,Wada T,Handa H,Negishi M

更新日期：1995-08-01 00:00:00

abstract：:The transcriptional coactivator Cbp plays an important role in a wide range of cellular processes, including proliferation, differentiation, and apoptosis. Although studies have shown its requirement for hematopoietic stem cell (HSC) development, its role in adult HSC maintenance, as well as the cellular and molecular...

journal_title：Molecular and cellular biology

authors： Chan WI,Hannah RL,Dawson MA,Pridans C,Foster D,Joshi A,Göttgens B,Van Deursen JM,Huntly BJ

更新日期：2011-12-01 00:00:00

abstract：:The immunosuppressant and anticancer drug rapamycin works by inducing inhibitory protein complexes with the kinase mTOR, an important regulator of growth and proliferation. The obligatory accessory partner of rapamycin is believed to be FK506-binding protein 12 (FKBP12). Here we show that rapamycin complexes of larger...

journal_title：Molecular and cellular biology

authors： März AM,Fabian AK,Kozany C,Bracher A,Hausch F

更新日期：2013-04-01 00:00:00

abstract：:Individuals with the inherited cancer predisposition syndrome neurofibromatosis 2 (NF2) develop several central nervous system (CNS) malignancies, including glial cell neoplasms (ependymomas). Recent studies have suggested that the NF2 protein, merlin (or schwannomin), may regulate receptor tyrosine kinase signaling, ...

journal_title：Molecular and cellular biology

authors： Houshmandi SS,Emnett RJ,Giovannini M,Gutmann DH

更新日期：2009-03-01 00:00:00

abstract：:The product of the Saccharomyces cerevisiae nuclear gene PET494 is required to promote the translation of the mitochondrial mRNA encoding cytochrome c oxidase subunit III (coxIII). The level of cytochrome c oxidase activity is affected by several different environmental conditions, which also influence coxIII expressi...

journal_title：Molecular and cellular biology

authors： Marykwas DL,Fox TD

更新日期：1989-02-01 00:00:00

abstract：:We generated a line of mice in which sterol regulatory element binding protein 1a (SREBP-1a) was specifically inactivated by insertional mutagenesis. Homozygous mutant mice were completely viable despite expressing SREBP-1a mRNA below 5% of normal, and there were minimal effects on expression of either SREBP-1c or -2....

journal_title：Molecular and cellular biology

authors： Im SS,Hammond LE,Yousef L,Nugas-Selby C,Shin DJ,Seo YK,Fong LG,Young SG,Osborne TF

更新日期：2009-09-01 00:00:00

abstract：:An extracellular acid phosphatase was detected in the growth media of Leishmania donovani promastigotes. The enzyme was released at all stages of the growth cycle and in amounts which accounted for 90% of the total amount of this enzyme in the culture. The exoenzyme exhibited a pH optimum of 4.5 to 5.0 and was active ...

journal_title：Molecular and cellular biology

authors： Gottlieb M,Dwyer DM

更新日期：1982-01-01 00:00:00

abstract：:The homeobox gene HOXA9 has recently been shown to be an important regulator of endothelial cell (EC) differentiation and activation in addition to its role in embryonic development and hematopoiesis. In this report, we have determined that the EC-leukocyte adhesion molecule E-selectin is a key target for HOXA9. The d...

journal_title：Molecular and cellular biology

authors： Bandyopadhyay S,Ashraf MZ,Daher P,Howe PH,DiCorleto PE

更新日期：2007-06-01 00:00:00

abstract：:DNA supercoiling in the chloroplast of the unicellular green alga Chlamydomonas reinhardtii was found to change with a diurnal rhythm in cells growing in alternating 12-h dark-12-h light periods. Highest and lowest DNA superhelicities occurred at the beginning and towards the end of the 12-h light periods, respectivel...

journal_title：Molecular and cellular biology

authors： Salvador ML,Klein U,Bogorad L

更新日期：1998-12-01 00:00:00

abstract：:The tyrosinase family comprises three members, tyrosinase (Tyr), tyrosinase-related protein 1 (Tyrp1), and dopachrome tautomerase (Dct). Null mutations and deletions at the Tyr and Tyrp1 loci are known and phenotypically affect coat color due to the absence of enzyme or intracellular mislocalization. At the Dct locus,...

journal_title：Molecular and cellular biology

authors： Guyonneau L,Murisier F,Rossier A,Moulin A,Beermann F

更新日期：2004-04-01 00:00:00

abstract：:Neighboring genes encoding the mouse sex-limited protein (Slp) and fourth component of complement (C4) show extensive homology. In contrast to C4, however, Slp is regulated by androgen. One region of the Slp gene capable of hormonal response following transfection was located about 2 kilobases upstream of the transcri...

journal_title：Molecular and cellular biology

authors： Loreni F,Stavenhagen J,Kalff M,Robins DM

更新日期：1988-06-01 00:00:00

abstract：:The Id subfamily of helix-loop-helix (HLH) proteins plays a fundamental role in the regulation of cellular proliferation and differentiation. The major mechanism by which Id proteins are thought to inhibit differentiation is through interaction with other HLH proteins and inhibition of their DNA-binding activity. Howe...

journal_title：Molecular and cellular biology

authors： Roberts EC,Deed RW,Inoue T,Norton JD,Sharrocks AD

更新日期：2001-01-01 00:00:00

abstract：:We have initiated a study of the promoter region of the alkaline extracellular protease gene (XPR2) from Yarrowia lipolytica to identify upstream sequences possibly involved in carbon, nitrogen, and peptone control of XPR2 expression. Deletion analysis showed that the TATA box and two major upstream activation sequenc...

journal_title：Molecular and cellular biology

authors： Blanchin-Roland S,Cordero Otero RR,Gaillardin C

更新日期：1994-01-01 00:00:00

abstract：:In self-fertile strains of the fission yeast Schizosaccharomyces pombe, nitrogen starvation initiates a program of sexual development in which cells express mating pheromones and receptors, arrest cell cycle progression in G1, and conjugate. This process is dependent on Rum1, an inhibitor of the Cdc2-Cdc13 and Cdc2-Ci...

journal_title：Molecular and cellular biology

authors： Wu L,Russell P

更新日期：1997-01-01 00:00:00

abstract：:The scid mouse mutation affects V(D)J rearrangement and double-strand break repair. scid V(D)J rearrangement is characterized by defective coding joint formation which prevents the development of mature B and T cells. Hairpin DNA has been implicated in the formation of V(D)J coding joints. We found scid cells to be pr...

journal_title：Molecular and cellular biology

authors： Staunton JE,Weaver DT

更新日期：1994-06-01 00:00:00

abstract：:Eukaryotic flagella are complex organelles composed of more than 200 polypeptides. Little is known about the regulatory mechanisms governing synthesis of the flagellar protein subunits and their assembly into this complex organelle. The unicellular green alga Chlamydomonas reinhardtii is the premier experimental model...

journal_title：Molecular and cellular biology

authors： Periz G,Keller LR

更新日期：1997-07-01 00:00:00

abstract：:Keratins K5 and K14 form the extensive intermediate filament network of mitotically active basal cells in all stratified epithelia. We have explored the regulatory mechanisms governing cell-type-specific and differentiation stage-specific expression of the human K5 gene in transiently transfected keratinocytes in vitr...

journal_title：Molecular and cellular biology

authors： Byrne C,Fuchs E

更新日期：1993-06-01 00:00:00

abstract：:The ErbB family includes four homologous transmembrane tyrosine kinases. Whereas ErbB-1 binds to the epidermal growth factor (EGF), both ErbB-3 and ErbB-4 bind to the Neu differentiation factors (NDFs, or neuregulins), and ErbB-2, the most oncogenic family member, is an orphan receptor whose function is still unknown....

journal_title：Molecular and cellular biology

authors： Tzahar E,Waterman H,Chen X,Levkowitz G,Karunagaran D,Lavi S,Ratzkin BJ,Yarden Y

更新日期：1996-10-01 00:00:00

abstract：:We have recently reported that the yeast chromatin-remodeling factor Swi1 can exist as a prion, [SWI(+)], demonstrating a link between prionogenesis and global transcriptional regulation. To shed light on how the Swi1 conformational switch influences Swi1 function and to define the sequence and structural requirements...

journal_title：Molecular and cellular biology

authors： Du Z,Crow ET,Kang HS,Li L

更新日期：2010-10-01 00:00:00

abstract：:Hox gene functions are intimately linked to correct developmental expression of the genes. The identification of cis-acting regulatory sequences and their associated trans-acting factors constitutes a key step in deciphering the mechanisms underlying the correct positioning of the functional domain of Hox genes along ...

journal_title：Molecular and cellular biology

authors： Tabariès S,Lapointe J,Besch T,Carter M,Woollard J,Tuggle CK,Jeannotte L

更新日期：2005-02-01 00:00:00

abstract：:Focal adhesion kinase (FAK) is a nonreceptor protein tyrosine kinase involved in integrin-mediated control of cell behavior. Following cell adhesion to components of the extracellular matrix, FAK becomes phosphorylated at multiple sites, including tyrosines 397, 576, and 577. Tyr-397 is an autophosphorylation site tha...

journal_title：Molecular and cellular biology

authors： Owen JD,Ruest PJ,Fry DW,Hanks SK

更新日期：1999-07-01 00:00:00

abstract：:Double-strand breaks (DSBs) stimulate chromosomal and extrachromosomal recombination and gene targeting. Transcription also stimulates spontaneous recombination by an unknown mechanism. We used Saccharomyces cerevisiae I-SceI to stimulate recombination between neo direct repeats in Chinese hamster ovary (CHO) cell chr...

journal_title：Molecular and cellular biology

authors： Taghian DG,Nickoloff JA

更新日期：1997-11-01 00:00:00

abstract：:In response to ionizing radiation (IR), the tumor suppressor p53 is stabilized and promotes either cell cycle arrest or apoptosis. Chk2 activated by IR contributes to this stabilization, possibly by direct phosphorylation. Like p53, Chk2 is mutated in patients with Li-Fraumeni syndrome. Since the ataxia telangiectasia...

journal_title：Molecular and cellular biology

authors： Hirao A,Cheung A,Duncan G,Girard PM,Elia AJ,Wakeham A,Okada H,Sarkissian T,Wong JA,Sakai T,De Stanchina E,Bristow RG,Suda T,Lowe SW,Jeggo PA,Elledge SJ,Mak TW

更新日期：2002-09-01 00:00:00

abstract：:The mouse cytochrome P1450 (CYP1A1) gene is responsible for the metabolism of numerous carcinogens and toxic chemicals. Induction by the environmental contaminant tetrachlorodibenzo-p-dioxin (TCDD) requires a functional aromatic hydrocarbon (Ah) receptor. We examined the 5'-flanking region of the CYP1A1 gene in mouse ...

journal_title：Molecular and cellular biology

authors： Neuhold LA,Shirayoshi Y,Ozato K,Jones JE,Nebert DW

更新日期：1989-06-01 00:00:00

abstract：:A fragment of the human gene for c-erb-B was used to map homologous sequences in mice. Analysis of somatic cell hybrids and recombinant inbred and congenic mouse strains indicated that this gene, designated Erbb, is closely linked to the gene for alpha-globin on mouse chromosome 11. Several genes controlling hematopoi...

journal_title：Molecular and cellular biology

authors： Silver J,Whitney JB 3rd,Kozak C,Hollis G,Kirsch I

更新日期：1985-07-01 00:00:00

abstract：:Transcription of Xenopus laevis mitochondrial DNA (xl-mtDNA) by the mitochondrial RNA polymerase requires a dissociable factor. This factor was purified to near homogeneity and identified as a 40-kDa protein. A second protein implicated in the transcription of mtDNA, the Xenopus homolog of the HMG box protein mtTFA, w...

journal_title：Molecular and cellular biology

authors： Antoshechkin I,Bogenhagen DF

更新日期：1995-12-01 00:00:00

abstract：:The connections between various nuclear processes and specific histone posttranslational modifications are dependent to a large extent on the acquisition of those modifications after histone synthesis. The reestablishment of histone posttranslational modifications after S phase is especially critical for H3K9 and H3K2...

journal_title：Molecular and cellular biology

authors： Zee BM,Britton LM,Wolle D,Haberman DM,Garcia BA

更新日期：2012-07-01 00:00:00

abstract：:Two mutator genes of mammalian cells were demonstrated. One was associated with the ribonucleoside diphosphate reductase, and the other was associated with an extreme adenosine sensitivity. ...

journal_title：Molecular and cellular biology

authors： Chan VL,Guttman S,Juranka P

更新日期：1981-06-01 00:00:00

abstract：:In an effort to identify widely active positive regulatory elements, we have examined the action of the cytomegalovirus enhancer-promoter in transgenic mice. These elements activated expression in 24 of 28 tissues tested. The greatest expression was observed in the heart, kidney, brain, and testis. Maximum expression ...

journal_title：Molecular and cellular biology

authors： Schmidt EV,Christoph G,Zeller R,Leder P

更新日期：1990-08-01 00:00:00