Abstract:
:The scid mouse mutation affects V(D)J rearrangement and double-strand break repair. scid V(D)J rearrangement is characterized by defective coding joint formation which prevents the development of mature B and T cells. Hairpin DNA has been implicated in the formation of V(D)J coding joints. We found scid cells to be proficient in hairpin processing in the context of DNA integration. In addition, we found that the scid defect did not impair integration of linear DNA via nonhomologous recombination. Therefore, hairpin processing and integration of DNA into the genome are distinct from hypersensitivity to ionizing radiation and the defect in V(D)J recombination.
journal_name
Mol Cell Bioljournal_title
Molecular and cellular biologyauthors
Staunton JE,Weaver DTdoi
10.1128/mcb.14.6.3876subject
Has Abstractpub_date
1994-06-01 00:00:00pages
3876-83issue
6eissn
0270-7306issn
1098-5549journal_volume
14pub_type
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pub_type: 杂志文章
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pub_type: 杂志文章,收录出版
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pub_type: 杂志文章
doi:10.1128/MCB.02136-07
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journal_title:Molecular and cellular biology
pub_type: 杂志文章
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更新日期:1985-11-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1128/MCB.25.13.5543-5551.2005
更新日期:2005-07-01 00:00:00
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doi:10.1128/mcb.18.3.1156
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pub_type: 杂志文章
doi:10.1128/mcb.18.3.1444
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更新日期:2003-06-01 00:00:00
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pub_type: 杂志文章
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