Distinct roles for two purified factors in transcription of Xenopus mitochondrial DNA.

abstract：:Spatial control of cytokinesis is essential for proper cell division. The molecular mechanisms that anchor the dynamic assembly and constriction of the cytokinetic ring at the plasma membrane remain unclear. In the fission yeast Schizosaccharomyces pombe, the cytokinetic ring is assembled in the cell middle from corti...

journal_title：Molecular and cellular biology

authors： Guzman-Vendrell M,Baldissard S,Almonacid M,Mayeux A,Paoletti A,Moseley JB

更新日期：2013-01-01 00:00:00

abstract：:Self-renewal capacity and pluripotency, which are controlled by the Oct3/4-centered transcriptional regulatory network, are major characteristics of embryonic stem (ES) cells. Nuclear hormone receptor Dax1 is one of the crucial factors in the network. Here, we identified an orphan nuclear receptor, Esrrb (estrogen-rel...

journal_title：Molecular and cellular biology

authors： Uranishi K,Akagi T,Sun C,Koide H,Yokota T

更新日期：2013-05-01 00:00:00

abstract：:Nuclear receptor corepressors (N-CoR) and silencing mediator for retinoid and thyroid receptors (SMRT) have both been implicated in thyroid hormone receptor (TR)-mediated repression. Here we show that endogenous N-CoR, TBL1, and histone deacetylase 3 (HDAC3), but not HDAC1, -2, or -4, are recruited to a stably integra...

journal_title：Molecular and cellular biology

authors： Ishizuka T,Lazar MA

更新日期：2003-08-01 00:00:00

abstract：:In Saccharomyces cerevisiae, double-strand breaks (DSBs) activate DNA checkpoint pathways that trigger several responses including a strong G(2)/M arrest. We have previously provided evidence that the phosphatases Ptc2 and Ptc3 of the protein phosphatase 2C type are required for DNA checkpoint inactivation after a DSB...

journal_title：Molecular and cellular biology

authors： Guillemain G,Ma E,Mauger S,Miron S,Thai R,Guérois R,Ochsenbein F,Marsolier-Kergoat MC

更新日期：2007-05-01 00:00:00

abstract：:Transcriptional insulators are cis regulatory elements that organize chromatin into independently regulated domains. At the imprinted murine Igf2/H19 locus, the H19-ICR insulator prevents the activation of the Igf2 promoter on the maternal allele by enhancers that activate H19 on the same chromosome. Given the well-de...

journal_title：Molecular and cellular biology

authors： Singh V,Srivastava M

更新日期：2008-06-01 00:00:00

abstract：:We have previously shown that activation of extracellular signal-regulated kinase (Erk) by epidermal growth factor (EGF) treatment was significantly decreased in mouse fibroblast cells expressing a mutant Shp-2 molecule lacking 65 amino acids in the SH2-N domain, Shp-2(Delta46-110). To address the molecular mechanism ...

journal_title：Molecular and cellular biology

authors： Shi ZQ,Yu DH,Park M,Marshall M,Feng GS

更新日期：2000-03-01 00:00:00

abstract：:The murine int-1 proto-oncogene has been implicated in neural development and, when transcriptionally activated by mouse mammary tumor virus, contributes to the genesis of mammary tumors. To understand the function of the int-1 gene product in these processes, we have characterized the biochemical properties of int-1 ...

journal_title：Molecular and cellular biology

authors： Papkoff J,Schryver B

更新日期：1990-06-01 00:00:00

abstract：:The mammalian signal recognition particle (SRP) is a small cytoplasmic ribonucleoprotein required for the cotranslational targeting of secretory proteins to the endoplasmic reticulum membrane. The heterodimeric protein subunit SRP9/14 was previously shown to be essential for SRP to cause pausing in the elongation of s...

journal_title：Molecular and cellular biology

authors： Strub K,Moss J,Walter P

更新日期：1991-08-01 00:00:00

abstract：:Expression of vascular endothelial growth factor (VEGF) increases in cancer cells during hypoxia. Herein, we report that the MDM2 oncoprotein plays a role in hypoxia-mediated VEGF upregulation. In studying the characteristics of MDM2 and VEGF expression in neuroblastoma cells, we found that hypoxia induced significant...

journal_title：Molecular and cellular biology

authors： Zhou S,Gu L,He J,Zhang H,Zhou M

更新日期：2011-12-01 00:00:00

abstract：:Malignant gliomas are highly lethal neoplasms with limited treatment options. We previously found that the heparan sulfate proteoglycan glypican 1 (GPC1) is universally and highly expressed in human gliomas. In this study, we investigated the biological activity of GPC1 expression in both human glioma cells and normal...

journal_title：Molecular and cellular biology

authors： Qiao D,Meyer K,Friedl A

更新日期：2013-11-01 00:00:00

abstract：:To determine the types of alterations in gene structure induced by DNA-alkylating agents, we analyzed the restriction enzyme cleavage patterns of adenine phosphoribosyltransferase gene sequences in mutant strains of Chinese hamster ovary cells deficient in this enzyme. Base pair changes as detected by loss of restrict...

journal_title：Molecular and cellular biology

authors： Meuth M,Arrand JE

更新日期：1982-11-01 00:00:00

abstract：:Protein tyrosine kinases activate the STAT (signal transducer and activator of transcription) signaling pathway, which can play essential roles in cell differentiation, cell cycle control, and development. However, the potential role of the STAT signaling pathway in the induction of apoptosis remains unexplored. Here ...

journal_title：Molecular and cellular biology

authors： Chin YE,Kitagawa M,Kuida K,Flavell RA,Fu XY

更新日期：1997-09-01 00:00:00

abstract：:The cytokines tumor necrosis factor (TNF), beta interferon (IFN-beta), and IFN-gamma increase major histocompatibility complex class I molecule expression. A greater than additive (i.e., synergistic) induction of class I heavy-chain mRNA is observed in HeLa cells treated with TNF in combination with either type of IFN...

journal_title：Molecular and cellular biology

authors： Johnson DR,Pober JS

更新日期：1994-02-01 00:00:00

abstract：:The cys-3+ gene of Neurospora crassa encodes a bZIP (basic region-leucine zipper) regulatory protein that is essential for sulfur structural gene expression (e.g., ars-1+). Nuclear transcription assays confirmed that cys-3+ was under sulfur-regulated transcriptional control and that cys-3+ transcription was constituti...

journal_title：Molecular and cellular biology

authors： Paietta JV

更新日期：1992-04-01 00:00:00

abstract：:The class II transactivator (CIITA) is induced by gamma interferon (IFN-gamma) and activates major histocompatibility complex class II; however, this report shows it suppresses other genes. An N-terminal 36 amino acids of CIITA mediates suppression of the collagen alpha(2)(I) promoter via binding to CREB-binding prote...

journal_title：Molecular and cellular biology

authors： Zhu XS,Ting JP

更新日期：2001-10-01 00:00:00

abstract：:Ure2p of Saccharomyces cerevisiae normally functions in blocking utilization of a poor nitrogen source when a good nitrogen source is available. The non-Mendelian genetic element [URE3] is a prion (infectious protein) form of Ure2p, so that overexpression of Ure2p induces the de novo appearance of infectious [URE3]. E...

journal_title：Molecular and cellular biology

authors： Maddelein ML,Wickner RB

更新日期：1999-06-01 00:00:00

abstract：:We have characterized the role of YPR128cp, the orthologue of human PMP34, in fatty acid metabolism and peroxisomal proliferation in Saccharomyces cerevisiae. YPR128cp belongs to the mitochondrial carrier family (MCF) of solute transporters and is localized in the peroxisomal membrane. Disruption of the YPR128c gene r...

journal_title：Molecular and cellular biology

authors： van Roermund CW,Drissen R,van Den Berg M,Ijlst L,Hettema EH,Tabak HF,Waterham HR,Wanders RJ

更新日期：2001-07-01 00:00:00

abstract：:The mechanism(s) and site(s) of action of volatile inhaled anesthetics are unknown in spite of the clinical use of these agents for more than 150 years. In the present study, the model eukaryote Saccharomyces cerevisiae was used to investigate the action of anesthetic agents because of its powerful molecular genetics....

journal_title：Molecular and cellular biology

authors： Keil RL,Wolfe D,Reiner T,Peterson CJ,Riley JL

更新日期：1996-07-01 00:00:00

abstract：:F8dl is a simian virus 40 early-region deletion mutant that lacks the sequences between 0.169 and 0.423 map units. We show that cloned F8dl DNA immortalized early-passage Fisher rat embryo cells with an efficiency that was about 20% of that of cloned wild-type simian virus 40 DNA. In contrast, we detected no immortali...

journal_title：Molecular and cellular biology

authors： Sompayrac L,Danna KJ

更新日期：1985-05-01 00:00:00

abstract：:The CBP/p300 family of proteins comprises related acetyltransferases that coactivate signal-responsive transcription. Recent evidence suggests that p300/CBP may also interact directly with complexes that mediate different aspects of DNA metabolism such as replication and repair. In this report, we show that loss of dC...

journal_title：Molecular and cellular biology

authors： Smolik S,Jones K

更新日期：2007-01-01 00:00:00

abstract：:Budding yeast polo kinase Cdc5p localizes to the spindle pole body (SPB) and to the bud-neck and plays multiple roles during M-phase progression. To dissect localization-specific mitotic functions of Cdc5p, we tethered a localization-defective N-terminal kinase domain of Cdc5p (Cdc5pDeltaC) to the SPB or to the bud-ne...

journal_title：Molecular and cellular biology

authors： Park JE,Park CJ,Sakchaisri K,Karpova T,Asano S,McNally J,Sunwoo Y,Leem SH,Lee KS

更新日期：2004-11-01 00:00:00

abstract：:The recruitment of transcriptional coactivators, including histone modifying enzymes, is an important step in transcription regulation. A typical activator is thought to interact with several cofactors, presumably in a sequential manner. The common use of several cofactors raises the question of how activators achieve...

journal_title：Molecular and cellular biology

authors： Gamper AM,Roeder RG

更新日期：2008-04-01 00:00:00

abstract：:The J domain of simian virus 40 (SV40) large T antigen is required for efficient DNA replication and transformation. Despite previous reports demonstrating the promiscuity of J domains in heterologous systems, results presented here show the requirement for specific J-domain sequences in SV40 large-T-antigen-mediated ...

journal_title：Molecular and cellular biology

authors： Sullivan CS,Tremblay JD,Fewell SW,Lewis JA,Brodsky JL,Pipas JM

更新日期：2000-08-01 00:00:00

abstract：:We report a negative feedback loop between the signaling protein phospholipase D (PLD), phosphatidic acid (PA), and a specific set of microRNAs (miRNAs) during nutrient starvation of breast cancer cells. We show that PLD expression is increased in four breast cancer cell lines and that hypoxia, cell overcrowding, and ...

journal_title：Molecular and cellular biology

authors： Fite K,Elkhadragy L,Gomez-Cambronero J

更新日期：2016-01-19 00:00:00

abstract：:A variety of genes, including c-myc, are activated by chemical toxicants in vivo and in vitro. Although enforced c-myc expression induces apoptosis after withdrawing survival factors, it is not clear if activation of the endogenous c-myc gene is an apoptotic signal after toxicant exposure. The renal tubular epithelium...

journal_title：Molecular and cellular biology

authors： Zhan Y,Cleveland JL,Stevens JL

更新日期：1997-11-01 00:00:00

abstract：:Heterochromatin protein 1 (HP1) family members are versatile proteins involved in transcription, chromatin organization, and replication. Recent findings now have implicated HP1 proteins in the DNA damage response as well. Cell-biological approaches showed that reducing the levels of all three HP1 isoforms enhances DN...

journal_title：Molecular and cellular biology

authors： Dinant C,Luijsterburg MS

更新日期：2009-12-01 00:00:00

abstract：:The SF-21 insect cell line undergoes rapid and widespread apoptosis when treated with actinomycin D or when infected with a mutant of the baculovirus Autographa californica nuclear polyhedrosis virus lacking a p35 gene or a functionally active iap (inhibitor of apoptosis) gene. Here we provide evidence that the basis ...

journal_title：Molecular and cellular biology

authors： Clem RJ,Miller LK

更新日期：1994-08-01 00:00:00

abstract：:It is thought that degradation of nuclear proteins by the ubiquitylation system requires nuclear-cytoplasmic trafficking of E3 ubiquitin ligases. The von Hippel-Lindau (VHL) tumor suppressor protein is the substrate recognition component of a Cullin-2-containing E3 ubiquitin ligase that recruits hypoxia-inducible fact...

journal_title：Molecular and cellular biology

authors： Khacho M,Mekhail K,Pilon-Larose K,Payette J,Lee S

更新日期：2008-01-01 00:00:00

abstract：:To understand the mechanism of retinoid resistance, we studied the subcellular localization and function of retinoid receptors in human breast cancer cell lines. Retinoid X receptor alpha (RXR alpha) localized throughout the nucleoplasm in retinoid-sensitive normal human mammary epithelial cells and in retinoid-respon...

journal_title：Molecular and cellular biology

authors： Tanaka T,Dancheck BL,Trifiletti LC,Birnkrant RE,Taylor BJ,Garfield SH,Thorgeirsson U,De Luca LM

更新日期：2004-05-01 00:00:00

abstract：:Several eukaryotic transcription factors such as Sp1 or Oct1 contain glutamine-rich domains that mediate transcriptional activation. In human cells, promoter-proximally bound glutamine-rich activation domains activate transcription poorly in the absence of acidic type activators bound at distal enhancers, but synergis...

journal_title：Molecular and cellular biology

authors： Escher D,Bodmer-Glavas M,Barberis A,Schaffner W

更新日期：2000-04-01 00:00:00