UBF binding in vivo is not restricted to regulatory sequences within the vertebrate ribosomal DNA repeat.

abstract：:We previously established that the phage phiC31 integrase, a site-specific recombinase, mediates efficient integration in the human cell environment at attB and attP phage attachment sites on extrachromosomal vectors. We show here that phage attP sites inserted at various locations in human and mouse chromosomes serve...

journal_title：Molecular and cellular biology

authors： Thyagarajan B,Olivares EC,Hollis RP,Ginsburg DS,Calos MP

更新日期：2001-06-01 00:00:00

abstract：:The treatment of cells with histone deacetylase inhibitors (HDACi) was reported to reveal the acetylation of STAT1 at lysine 410 and lysine 413 (O. H. Krämer et al., Genes Dev. 20:473-485, 2006). STAT1 acetylation was proposed to regulate apoptosis by facilitating binding to NF-κB and to control immune responses by su...

journal_title：Molecular and cellular biology

authors： Antunes F,Marg A,Vinkemeier U

更新日期：2011-07-01 00:00:00

abstract：:Because of its central regulatory role, T-cell receptor (TCR) signal transduction is a common target of viruses. We report here the identification of a small signaling protein, ORF5, of the T-lymphotropic tumor virus herpesvirus saimiri (HVS). ORF5 is predicted to contain 89 to 91 amino acids with an amino-terminal my...

journal_title：Molecular and cellular biology

authors： Lee SH,Chung YH,Cho NH,Gwack Y,Feng P,Jung JU

更新日期：2004-06-01 00:00:00

abstract：:All-trans retinoic acid (RA) induces transforming growth factor beta (TGF-beta)-dependent autocrine growth of mouse embryonic fibroblasts (MEFs). We have used chromatin immunoprecipitation to map 354 RA receptor (RAR) binding loci in MEFs, most of which were similarly occupied by the RAR alpha and RAR gamma receptors....

journal_title：Molecular and cellular biology

authors： Delacroix L,Moutier E,Altobelli G,Legras S,Poch O,Choukrallah MA,Bertin I,Jost B,Davidson I

更新日期：2010-01-01 00:00:00

abstract：:hsa-miR-33a and hsa-miR-33b, intronic microRNAs (miRNAs) located within the sterol regulatory element-binding protein 2 and 1 genes (Srebp-2 and -1), respectively, have recently been shown to regulate lipid homeostasis in concert with their host genes. Although the functional role of miR-33a and -b has been highly inv...

journal_title：Molecular and cellular biology

authors： Goedeke L,Vales-Lara FM,Fenstermaker M,Cirera-Salinas D,Chamorro-Jorganes A,Ramírez CM,Mattison JA,de Cabo R,Suárez Y,Fernández-Hernando C

更新日期：2013-06-01 00:00:00

abstract：:Transthyretin (TTR) and alpha 1-antitrypsin (alpha 1-AT) are expressed at high levels in the liver and also in at least one other cell type. We report here a detailed analysis of the proximal regulatory region of the TTR gene, which has uncovered two new DNA-binding factors that are present mainly (or only) in hepatoc...

journal_title：Molecular and cellular biology

authors： Costa RH,Grayson DR,Darnell JE Jr

更新日期：1989-04-01 00:00:00

abstract：:The relationship between chromatin remodeling and histone acetylation at the yeast CUP1 gene was addressed. CUP1 encodes a metallothionein required for cell growth at high copper concentrations. Induction of CUP1 with copper resulted in targeted acetylation of both H3 and H4 at the CUP1 promoter. Nucleosomes containin...

journal_title：Molecular and cellular biology

authors： Shen CH,Leblanc BP,Neal C,Akhavan R,Clark DJ

更新日期：2002-09-01 00:00:00

abstract：:Hes1 is a mammalian basic helix-loop-helix transcriptional repressor that inhibits neuronal differentiation together with corepressors of the Groucho (Gro)/Transducin-like Enhancer of split (TLE) family. The interaction of Hes1 with Gro/TLE is mediated by a WRPW tetrapeptide present in all Hairy/Enhancer of split (Hes...

journal_title：Molecular and cellular biology

authors： Gratton MO,Torban E,Jasmin SB,Theriault FM,German MS,Stifani S

更新日期：2003-10-01 00:00:00

abstract：:The protein-tyrosine kinases (PTKs) are a burgeoning family of proteins, each of which bears a conserved domain of 250 to 300 amino acids capable of phosphorylating substrate proteins on tyrosine residues. We recently exploited the existence of two highly conserved sequence elements within the catalytic domain to gene...

journal_title：Molecular and cellular biology

authors： Wilks AF,Harpur AG,Kurban RR,Ralph SJ,Zürcher G,Ziemiecki A

更新日期：1991-04-01 00:00:00

abstract：:In 7 of 37 patients with cutaneous melanoma, mutations in the N-ras gene were found. The primary tumors of these seven patients were exclusively localized on body sites continuously exposed to sunlight. Moreover, the ras mutations were all at or near dipyrimidine sites known to be targets of UV damage. Two primary tum...

journal_title：Molecular and cellular biology

authors： van 't Veer LJ,Burgering BM,Versteeg R,Boot AJ,Ruiter DJ,Osanto S,Schrier PI,Bos JL

更新日期：1989-07-01 00:00:00

abstract：:Aromatic aminotransferase II, product of the ARO9 gene, catalyzes the first step of tryptophan, phenylalanine, and tyrosine catabolism in Saccharomyces cerevisiae. ARO9 expression is under the dual control of specific induction and nitrogen source regulation. We have here identified UASaro, a 36-bp upstream element ne...

journal_title：Molecular and cellular biology

authors： Iraqui I,Vissers S,André B,Urrestarazu A

更新日期：1999-05-01 00:00:00

abstract：:Non-long terminal repeat (LTR) retrotransposons are major components of the higher eukaryotic genome. Most of them have two open reading frames (ORFs): ORF2 encodes mainly the endonuclease and reverse transcriptase domains, but the functional features of ORF1 remain largely unknown. We used telomere-specific non-LTR r...

journal_title：Molecular and cellular biology

authors： Matsumoto T,Hamada M,Osanai M,Fujiwara H

更新日期：2006-07-01 00:00:00

abstract：:The tetradecanoyl phorbol acetate-induced sequence 7 gene (tis7) is regulated during cell fate processes and functions as a transcriptional coregulator. Here, we describe the generation and analysis of mice lacking the tis7 gene. Surprisingly, TIS7 knockout mice show no gross histological abnormalities and are fertile...

journal_title：Molecular and cellular biology

authors： Vadivelu SK,Kurzbauer R,Dieplinger B,Zweyer M,Schafer R,Wernig A,Vietor I,Huber LA

更新日期：2004-04-01 00:00:00

abstract：:Circadian clock genes are regulated through a transcriptional-translational feedback loop. Alterations of the chromatin structure by histone acetyltransferases and histone deacetylases (HDACs) are commonly implicated in the regulation of gene transcription. However, little is known about the transcriptional regulation...

journal_title：Molecular and cellular biology

authors： Naruse Y,Oh-hashi K,Iijima N,Naruse M,Yoshioka H,Tanaka M

更新日期：2004-07-01 00:00:00

abstract：:Human CRK protein is a homolog of the chicken v-crk oncogene product and consists mostly of src homology region 2 (SH2) and SH3, which are shared by many proteins, in particular those involved in signal transduction. SH2 has been shown to bind specifically to phosphotyrosine-containing peptides. We report here that bo...

journal_title：Molecular and cellular biology

authors： Tanaka S,Hattori S,Kurata T,Nagashima K,Fukui Y,Nakamura S,Matsuda M

更新日期：1993-07-01 00:00:00

abstract：:clk-1 encodes a demethoxyubiquinone (DMQ) hydroxylase that is necessary for ubiquinone biosynthesis. When Caenorhabditis elegans clk-1 mutants are grown on bacteria that synthesize ubiquinone (UQ), they are viable but have a pleiotropic phenotype that includes slowed development, behaviors, and aging. However, when gr...

journal_title：Molecular and cellular biology

authors： Branicky R,Nguyen PA,Hekimi S

更新日期：2006-05-01 00:00:00

abstract：:The SMRT corepressor complex participates in transcriptional repression by a diverse array of vertebrate transcription factors. The ability to recruit SMRT appears to play a crucial role in leukemogenesis by the PML-retinoic acid receptor alpha (RARalpha) oncoprotein, an aberrant nuclear hormone receptor implicated in...

journal_title：Molecular and cellular biology

authors： Hong SH,Yang Z,Privalsky ML

更新日期：2001-11-01 00:00:00

abstract：:The Drosophila Hrb98DE locus encodes proteins that are highly homologous to the mammalian A1 protein, a major component of heterogeneous nuclear ribonucleoprotein (RNP) particles. The Hrb98DE locus is transcribed throughout development, with the highest transcript levels found in ovaries, early embryos, and pupae. Eig...

journal_title：Molecular and cellular biology

authors： Haynes SR,Raychaudhuri G,Beyer AL

更新日期：1990-01-01 00:00:00

abstract：:Genetics and in vitro studies have shown that the direct interaction between Gal3p and Gal80p plays a central role in galactose-dependent Gal4p-mediated GAL gene expression in the yeast Saccharomyces cerevisiae. Precisely how Gal3p-Gal80p interaction effects induction is not clear. It has been assumed that Gal3p inter...

journal_title：Molecular and cellular biology

authors： Peng G,Hopper JE

更新日期：2000-07-01 00:00:00

abstract：:The transcriptional coactivator BOB.1/OBF.1 confers B-cell specificity on the transcription factors Oct1 and Oct2 at octamer site-containing promoters. A hallmark of the BOB.1/OBF.1 mutation in the mouse is the absence of germinal center development in secondary lymphoid organs, demonstrating the requirement for BOB.1...

journal_title：Molecular and cellular biology

authors： Hess J,Nielsen PJ,Fischer KD,Bujard H,Wirth T

更新日期：2001-03-01 00:00:00

abstract：:The mouse myosin light-chain 1A (MLC1A) gene, expressed in the atria of the adult heart, is one of the first muscle genes to be activated when skeletal as well as cardiac muscles form in the embryo. It is also transcribed in skeletal muscle cell lines at the onset of differentiation. Transient transfection assays of m...

journal_title：Molecular and cellular biology

authors： Catala F,Wanner R,Barton P,Cohen A,Wright W,Buckingham M

更新日期：1995-08-01 00:00:00

abstract：:The xCR1 protein is a maternal determinant and cofactor for nodal signaling in vertebrate embryos. The xCR1 protein accumulates specifically in the animal cells of Xenopus embryos, but maternal xCR1 mRNA is distributed equally throughout all embryonic cells. Here, we show that vegetal cell-specific translational repre...

journal_title：Molecular and cellular biology

authors： Zhang Y,Forinash KD,McGivern J,Fritz B,Dorey K,Sheets MD

更新日期：2009-07-01 00:00:00

abstract：:The c-Jun NH2-terminal protein kinase (JNK) is a member of the mitogen-activated protein kinase (MAPK) group and is an essential component of a signaling cascade that is activated by exposure of cells to environmental stress. JNK activation is regulated by phosphorylation on both Thr and Tyr residues by a dual-specifi...

journal_title：Molecular and cellular biology

authors： Tournier C,Whitmarsh AJ,Cavanagh J,Barrett T,Davis RJ

更新日期：1999-02-01 00:00:00

abstract：:To examine the role of clathrin-dependent insulin receptor internalization in insulin-stimulated signal transduction events, we expressed a dominant-interfering mutant of dynamin (K44A/dynamin) by using a recombinant adenovirus in the H4IIE hepatoma and 3T3L1 adipocyte cell lines. Expression of K44A/dynamin inhibited ...

journal_title：Molecular and cellular biology

authors： Ceresa BP,Kao AW,Santeler SR,Pessin JE

更新日期：1998-07-01 00:00:00

abstract：:p27(Kip1) is a member of the Cip-Kip family of cyclin-dependent kinase (Cdk) inhibitors that binds to cyclin-Cdk complexes and inhibits their catalytic activity in response to antiproliferative stimuli. p27(Kip1) is regulated by several posttranscriptional mechanisms, including subcellular localization. We have identi...

journal_title：Molecular and cellular biology

authors： Smitherman M,Lee K,Swanger J,Kapur R,Clurman BE

更新日期：2000-08-01 00:00:00

abstract：:Nicotine adenine dinucleotide (NAD(+)) performs key roles in electron transport reactions, as a substrate for poly(ADP-ribose) polymerase and NAD(+)-dependent protein deacetylases. In the latter two processes, NAD(+) is consumed and converted to ADP-ribose and nicotinamide. NAD(+) levels can be maintained by regenerat...

journal_title：Molecular and cellular biology

authors： Bedalov A,Hirao M,Posakony J,Nelson M,Simon JA

更新日期：2003-10-01 00:00:00

abstract：:Regulation of chromatin through histone acetylation is an important step in gene expression. The Gcn5 histone acetyltransferase is part of protein complexes, e.g., the SAGA complex, that interact with transcriptional activators, targeting the enzyme to specific promoters and assisting in recruitment of the basal RNA p...

journal_title：Molecular and cellular biology

authors： Qi D,Larsson J,Mannervik M

更新日期：2004-09-01 00:00:00

abstract：:Phosphoinositide-specific phospholipase C (PLC) is a key enzyme in phosphoinositide turnover and is involved in a variety of physiological functions. We analyzed PLCdelta1 knockout mice and found that PLCdelta1 is required for the maintenance of skin homeostasis. However, there were no remarkable abnormalities except ...

journal_title：Molecular and cellular biology

authors： Nakamura Y,Hamada Y,Fujiwara T,Enomoto H,Hiroe T,Tanaka S,Nose M,Nakahara M,Yoshida N,Takenawa T,Fukami K

更新日期：2005-12-01 00:00:00

abstract：:Initiation of T-lymphocyte-mediated immune responses involves two cellular processes: entry into the cell cycle (G(0)-->G(1)) for clonal proliferation and coordinated changes in surface and secreted molecules that mediate effector functions. However, a point during G(0)-->G(1) beyond which T cells are committed to ent...

journal_title：Molecular and cellular biology

authors： Lea NC,Orr SJ,Stoeber K,Williams GH,Lam EW,Ibrahim MA,Mufti GJ,Thomas NS

更新日期：2003-04-01 00:00:00

abstract：:Three classes of E3 ubiquitin ligases, members of the Cbl, Hakai, and SOCS-Cul5-RING ligase families, stimulate the ubiquitination of phosphotyrosine-containing proteins, including receptor and nonreceptor tyrosine kinases and their phosphorylated substrates. Because ubiquitination frequently routes proteins for degra...

journal_title：Molecular and cellular biology

authors： Cooper JA,Kaneko T,Li SS

更新日期：2015-06-01 00:00:00