Abstract:
:In 7 of 37 patients with cutaneous melanoma, mutations in the N-ras gene were found. The primary tumors of these seven patients were exclusively localized on body sites continuously exposed to sunlight. Moreover, the ras mutations were all at or near dipyrimidine sites known to be targets of UV damage. Two primary tumors were biclonal with respect to ras mutation. An active role for UV irradiation in induction of the mutations is suggested.
journal_name
Mol Cell Bioljournal_title
Molecular and cellular biologyauthors
van 't Veer LJ,Burgering BM,Versteeg R,Boot AJ,Ruiter DJ,Osanto S,Schrier PI,Bos JLdoi
10.1128/mcb.9.7.3114subject
Has Abstractpub_date
1989-07-01 00:00:00pages
3114-6issue
7eissn
0270-7306issn
1098-5549journal_volume
9pub_type
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