Abstract:
:The biosynthesis of influenza virus hemagglutinin (HA) and its translocation across microsomal membranes were studied in a mammalian cell-free system. All forms of HA could be cotranslationally translocated with high efficiency. However, only truncated forms of HA were translocated after protein synthesis has been terminated. The efficiency of this posttranslational translocation was dependent on the extent of the truncation. Posttranslational translocation was ribosome dependent and occurred only in the presence of a functional N-terminal signal sequence. The molecular mechanism of protein targeting and translocation across the membrane of the endoplasmic reticulum is discussed.
journal_name
Mol Cell Bioljournal_title
Molecular and cellular biologyauthors
Chao CC,Bird P,Gething MJ,Sambrook Jdoi
10.1128/mcb.7.10.3842subject
Has Abstractpub_date
1987-10-01 00:00:00pages
3842-5issue
10eissn
0270-7306issn
1098-5549journal_volume
7pub_type
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journal_title:Molecular and cellular biology
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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