Hes6 promotes cortical neurogenesis and inhibits Hes1 transcription repression activity by multiple mechanisms.

abstract：:Despite distinct dissimilarities, diverse cancers express several common protumorigenic traits. We present here evidence that the proapoptotic protein Par-4 utilizes one such common tumorigenic trait to become selectively activated and induce apoptosis in cancer cells. Elevated protein kinase A (PKA) activity noted in...

journal_title：Molecular and cellular biology

authors： Gurumurthy S,Goswami A,Vasudevan KM,Rangnekar VM

更新日期：2005-02-01 00:00:00

abstract：:Interferon (IFN) regulatory factor 1 (IRF-1) and IRF-2 were originally identified as transcription factors involved in the regulation of the IFN system. IRF-1 functions as a transcriptional activator, while IRF-2 represses IRF-1 function. More recently, evidence has been provided that IRF-1 and IRF-2 manifest antionco...

journal_title：Molecular and cellular biology

authors： Tanaka N,Kawakami T,Taniguchi T

更新日期：1993-08-01 00:00:00

abstract：:Two peroxins of the AAA family, PpPex1p and PpPex6p, are required for peroxisome biogenesis in the yeast Pichia pastoris. Cells from the corresponding deletion strains (Pp delta pex1 and Pp delta pex6) contain only small vesicular remnants of peroxisomes, the bulk of peroxisomal matrix proteins is mislocalized to the ...

journal_title：Molecular and cellular biology

authors： Faber KN,Heyman JA,Subramani S

更新日期：1998-02-01 00:00:00

abstract：:Intracisternal A-particle (IAP) expression in mouse cells has been correlated with hypomethylation of HhaI and HpaII sites in proviral long terminal repeats (LTRs). In a previous study, in vitro methylation of three HhaI sites in the U3 region of the LTR from the cloned genomic IAP element, MIA14, was shown to inhibit...

journal_title：Molecular and cellular biology

authors： Falzon M,Kuff EL

更新日期：1991-01-01 00:00:00

abstract：:The Drosophila melanogaster GAGA factor (encoded by the Trithorax-like [Trl] gene) is required for correct chromatin architecture at diverse chromosomal sites. The Trl gene encodes two alternatively spliced isoforms of the GAGA factor (GAGA-519 and GAGA-581) that are identical except for the length and sequence of the...

journal_title：Molecular and cellular biology

authors： Greenberg AJ,Schedl P

更新日期：2001-12-01 00:00:00

abstract：:RNA polymerase III (pol III) transcripts of the highly repeated mouse B2 gene family are increased in many oncogenically transformed murine cell lines. In cells transformed by simian virus 40, the small, cytoplasmic B2 RNAs are present at 20-fold-higher levels than in normal cells (M. R. D. Scott, K. Westphal, and P. ...

journal_title：Molecular and cellular biology

authors： Carey MF,Singh K,Botchan M,Cozzarelli NR

更新日期：1986-09-01 00:00:00

abstract：:The tumor suppressor p21 acts as a cell cycle inhibitor and has also been shown to regulate gene expression by functioning as a transcription corepressor. Here, we identified p21-regulated microRNAs (miRNAs) by sequencing small RNAs from isogenic p21(+/+) and p21(-/-) cells. Three abundant miRNA clusters, miR-200b-200...

journal_title：Molecular and cellular biology

authors： Li XL,Hara T,Choi Y,Subramanian M,Francis P,Bilke S,Walker RL,Pineda M,Zhu Y,Yang Y,Luo J,Wakefield LM,Brabletz T,Park BH,Sharma S,Chowdhury D,Meltzer PS,Lal A

更新日期：2014-02-01 00:00:00

abstract：:Deacetylation of histones is carried out by a corepressor complex in which Sin3A is an essential scaffold protein. Two proteins in this complex, the Sin3A-associated proteins SAP30L and SAP30, have previously been suggested to function as linker molecules between various corepressors. In this report, we demonstrate ne...

journal_title：Molecular and cellular biology

authors： Viiri KM,Jänis J,Siggers T,Heinonen TY,Valjakka J,Bulyk ML,Mäki M,Lohi O

更新日期：2009-01-01 00:00:00

abstract：:Cellular senescence is an irreversible growth arrest and is presumed to be a natural barrier to tumor development. Like telomere shortening, certain defects in chromosome integrity can trigger senescence; however, the roles of centromere proteins in regulating commitment to the senescent state remains to be establishe...

journal_title：Molecular and cellular biology

authors： Maehara K,Takahashi K,Saitoh S

更新日期：2010-05-01 00:00:00

abstract：:The molecular mechanisms underlying lymphatic vascular development and function are not well understood. Recent studies have suggested a role for endothelial cell (EC) mitogen-activated protein kinase kinase kinase kinase 4 (Map4k4) in developmental angiogenesis and atherosclerosis. Here, we show that constitutive los...

journal_title：Molecular and cellular biology

authors： Roth Flach RJ,Guo CA,Danai LV,Yawe JC,Gujja S,Edwards YJ,Czech MP

更新日期：2016-05-31 00:00:00

abstract：:In addition to the highly conserved AATAAA sequence, there is a requirement for specific sequences downstream of polyadenylic acid [poly(A)] cleavage sites to generate correct mRNA 3' termini. Previous experiments demonstrated that 35 nucleotides downstream of the E2A poly(A) site were sufficient but 20 nucleotides we...

journal_title：Molecular and cellular biology

authors： Hart RP,McDevitt MA,Ali H,Nevins JR

更新日期：1985-11-01 00:00:00

abstract：:Because of its central regulatory role, T-cell receptor (TCR) signal transduction is a common target of viruses. We report here the identification of a small signaling protein, ORF5, of the T-lymphotropic tumor virus herpesvirus saimiri (HVS). ORF5 is predicted to contain 89 to 91 amino acids with an amino-terminal my...

journal_title：Molecular and cellular biology

authors： Lee SH,Chung YH,Cho NH,Gwack Y,Feng P,Jung JU

更新日期：2004-06-01 00:00:00

abstract：:The precise expression of the N-myc proto-oncogene is essential for normal mammalian development, whereas altered N-myc gene regulation is known to be a determinant factor in tumor formation. Using transgenic mouse embryos, we show that N-myc sequences from kb -8.7 to kb +7.2 are sufficient to reproduce the N-myc embr...

journal_title：Molecular and cellular biology

authors： Potvin E,Beuret L,Cadrin-Girard JF,Carter M,Roy S,Tremblay M,Charron J

更新日期：2010-11-01 00:00:00

abstract：:Angiotensin II (AII), a potent vasoactive hormone, acts on numerous organs via G-protein-coupled receptors and elicits cell-specific responses. At the level of the heart, AII stimulation alters gene transcription and leads to cardiomyocyte hypertrophy. Numerous intracellular signaling pathways are activated in this pr...

journal_title：Molecular and cellular biology

authors： Wang J,Paradis P,Aries A,Komati H,Lefebvre C,Wang H,Nemer M

更新日期：2005-11-01 00:00:00

abstract：:TIN2 is a negative regulator of telomere elongation that interacts with telomeric DNA repeat binding factor 1 (TRF1) and affects telomere length by a telomerase-dependent mechanism. Here we show that inactivation of the mouse TRF1-interacting protein 2 (TIN2) gene results in early embryonic lethality. We further obser...

journal_title：Molecular and cellular biology

authors： Chiang YJ,Kim SH,Tessarollo L,Campisi J,Hodes RJ

更新日期：2004-08-01 00:00:00

abstract：:The Csk tyrosine kinase negatively regulates the Src family kinases Lck and Fyn in T cells. Engagement of the T-cell antigen receptor results in a removal of Csk from the lipid raft-associated transmembrane protein PAG/Cbp. Instead, Csk becomes associated with an approximately 72-kDa tyrosine-phosphorylated protein, w...

journal_title：Molecular and cellular biology

authors： Rahmouni S,Vang T,Alonso A,Williams S,van Stipdonk M,Soncini C,Moutschen M,Schoenberger SP,Mustelin T

更新日期：2005-03-01 00:00:00

abstract：:Cryptococcus neoformans is a fungal pathogen that causes meningitis in patients immunocompromised by AIDS, chemotherapy, organ transplantation, or high-dose steroids. Current antifungal drug therapies are limited and suffer from toxic side effects and drug resistance. Here, we defined the targets and mechanisms of ant...

journal_title：Molecular and cellular biology

authors： Cruz MC,Cavallo LM,Görlach JM,Cox G,Perfect JR,Cardenas ME,Heitman J

更新日期：1999-06-01 00:00:00

abstract：:Copper is an essential cofactor of two mitochondrial enzymes: cytochrome c oxidase (COX) and Cu-Zn superoxide dismutase (Sod1p). Copper incorporation into these enzymes is facilitated by metallochaperone proteins which probably use copper from a mitochondrial matrix-localized pool. Here we describe a novel conserved m...

journal_title：Molecular and cellular biology

authors： Horn D,Al-Ali H,Barrientos A

更新日期：2008-07-01 00:00:00

abstract：:Plk is a mammalian serine/threonine protein kinase whose activity peaks at the onset of M phase. It is closely related to other mammalian kinases, Snk, Fnk, and Prk, as well as to Xenopus laevis Plx1, Drosophila melanogaster polo, Schizosaccharomyces pombe Plo1, and Saccharomyces cerevisiae Cdc5. The M phase of the ce...

journal_title：Molecular and cellular biology

authors： Lee KS,Erikson RL

更新日期：1997-06-01 00:00:00

abstract：:Integrin-mediated interactions of cells with components of the extracellular matrix regulate cell survival, cell proliferation, cell differentiation, and cell migration. Some of these physiological responses are regulated via activation of transcription factors such as activator protein 1 (AP-1). Integrin-linked kinas...

journal_title：Molecular and cellular biology

authors： Troussard AA,Tan C,Yoganathan TN,Dedhar S

更新日期：1999-11-01 00:00:00

abstract：:We constructed a series of recombinant genomes which directed expression of the enzyme chloramphenicol acetyltransferase (CAT) in mammalian cells. The prototype recombinant in this series, pSV2-cat, consisted of the beta-lactamase gene and origin of replication from pBR322 coupled to a simian virus 40 (SV40) early tra...

journal_title：Molecular and cellular biology

authors： Gorman CM,Moffat LF,Howard BH

更新日期：1982-09-01 00:00:00

abstract：:Differentiation of skeletal muscle involves withdrawal of myoblasts from the cell cycle, fusion to form myotubes, and the coordinate expression of a variety of muscle-specific gene products. Fibroblast growth factor and type beta transforming growth factor specifically inhibit myogenesis; however, the transmembrane si...

journal_title：Molecular and cellular biology

authors： Olson EN,Spizz G,Tainsky MA

更新日期：1987-06-01 00:00:00

abstract：:The PKC1-associated mitogen-activated protein (MAP) kinase pathway of Saccharomyces cerevisiae regulates cell integrity by controlling the actin cytoskeleton and cell wall synthesis. Activation of PKC1 occurs via the GTPase RHO1 and the kinase pair PKH1 and PKH2. Here we report that YPK1 and YPK2, an essential pair of...

journal_title：Molecular and cellular biology

authors： Schmelzle T,Helliwell SB,Hall MN

更新日期：2002-03-01 00:00:00

abstract：:The regulation of a thyroid hormone-responsive gene in rats, designated spot 14, was explored. The expression of this gene in liver is rapidly (less than 10 min) and markedly (greater than 10-fold) altered by the administration of 3,5,3'-triiodo-L-thyronine (T3) to hypothyroid rats (P. Narayan, C. W. Liaw, and H. C. T...

journal_title：Molecular and cellular biology

authors： Narayan P,Towle HC

更新日期：1985-10-01 00:00:00

abstract：:Both chemotaxis and phagocytosis depend upon actin-driven cell protrusions and cell membrane remodeling. While chemoattractant receptors rely upon canonical G-protein signaling to activate downstream effectors, whether such signaling pathways affect phagocytosis is contentious. Here, we report that Gαi nucleotide exch...

journal_title：Molecular and cellular biology

authors： Huang NN,Becker S,Boularan C,Kamenyeva O,Vural A,Hwang IY,Shi CS,Kehrl JH

更新日期：2014-11-15 00:00:00

abstract：:The homeobox gene HOXA9 has recently been shown to be an important regulator of endothelial cell (EC) differentiation and activation in addition to its role in embryonic development and hematopoiesis. In this report, we have determined that the EC-leukocyte adhesion molecule E-selectin is a key target for HOXA9. The d...

journal_title：Molecular and cellular biology

authors： Bandyopadhyay S,Ashraf MZ,Daher P,Howe PH,DiCorleto PE

更新日期：2007-06-01 00:00:00

abstract：:The human tumor necrosis factor alpha (TNF-alpha) gene is rapidly activated in response to multiple signals of stress and inflammation. We have identified transcription factors present in the TNF-alpha enhancer complex in vivo following ionophore stimulation (ATF-2/Jun and NFAT) and virus infection (ATF-2/Jun, NFAT, a...

journal_title：Molecular and cellular biology

authors： Falvo JV,Uglialoro AM,Brinkman BM,Merika M,Parekh BS,Tsai EY,King HC,Morielli AD,Peralta EG,Maniatis T,Thanos D,Goldfeld AE

更新日期：2000-03-01 00:00:00

abstract：:Using competition mobility shift, methylation interference, and proteolytic clipping DNA binding assays, we demonstrate that the protein binding the major histocompatibility complex A beta CCAAT box is indistinguishable from the protein previously named NF-Y, which binds the major histocompatibility complex E alpha CC...

journal_title：Molecular and cellular biology

authors： Kern MJ,Woodward JG

更新日期：1991-01-01 00:00:00

abstract：:Approximately 30% of human tumors examined for mutations in polymerase beta (pol beta) appear to express pol beta variant proteins (D. Starcevic, S. Dalal, and J. B. Sweasy, Cell Cycle 3:998-1001, 2004). Many of these variants result from a single amino acid substitution. We have previously shown that the K289M and I2...

journal_title：Molecular and cellular biology

authors： Lang T,Dalal S,Chikova A,DiMaio D,Sweasy JB

更新日期：2007-08-01 00:00:00

abstract：:T cell antigen receptor (TCR) activation triggers profound changes in the actin cytoskeleton. In addition to controlling cellular shape and polarity, this process regulates vital T cell responses, such as T cell adhesion, motility, and proliferation. These depend on the recruitment of the signaling proteins Nck and Wi...

journal_title：Molecular and cellular biology

authors： Pauker MH,Reicher B,Fried S,Perl O,Barda-Saad M

更新日期：2011-07-01 00:00:00