Rapamycin antifungal action is mediated via conserved complexes with FKBP12 and TOR kinase homologs in Cryptococcus neoformans.

abstract：:An in silico screen for myogenic long noncoding RNAs (lncRNAs) revealed nine lncRNAs that are upregulated more than 10-fold in myotubes versus levels in myoblasts. One of these lncRNAs, MyoD upstream noncoding (MUNC, also known as DRR(eRNA)), is encoded 5 kb upstream of the transcription start site of MyoD, a myogenic...

journal_title：Molecular and cellular biology

authors： Mueller AC,Cichewicz MA,Dey BK,Layer R,Reon BJ,Gagan JR,Dutta A

更新日期：2015-02-01 00:00:00

abstract：:The connections between various nuclear processes and specific histone posttranslational modifications are dependent to a large extent on the acquisition of those modifications after histone synthesis. The reestablishment of histone posttranslational modifications after S phase is especially critical for H3K9 and H3K2...

journal_title：Molecular and cellular biology

authors： Zee BM,Britton LM,Wolle D,Haberman DM,Garcia BA

更新日期：2012-07-01 00:00:00

abstract：:The retinoblastoma protein (Rb) regulates both the cell cycle and tissue-specific transcription, by modulating the activity of factors that associate with its A-B and C pockets. In skeletal muscle, Rb has been reported to regulate irreversible cell cycle exit and muscle-specific transcription. To identify factors inte...

journal_title：Molecular and cellular biology

authors： MacLellan WR,Xiao G,Abdellatif M,Schneider MD

更新日期：2000-12-01 00:00:00

abstract：:First characterized in Trypanosoma brucei, the spliced leader-associated (SLA) RNA gene locus has now been isolated from the kinetoplastids Leishmania tarentolae and Trypanosoma cruzi. In addition to the T. brucei SLA RNA, both L. tarentolae and T. cruzi SLA RNA repeat units also yield RNAs of 75 or 76 nucleotides (nt...

journal_title：Molecular and cellular biology

authors： Roberts TG,Sturm NR,Yee BK,Yu MC,Hartshorne T,Agabian N,Campbell DA

更新日期：1998-08-01 00:00:00

abstract：:Posttranslational modification of general transcription factors may be an important mechanism for global gene regulation. The general transcription factor IIA (TFIIA) binds to the TATA binding protein (TBP) and is essential for high-level transcription mediated by various activators. Modulation of the TFIIA-TBP intera...

journal_title：Molecular and cellular biology

authors： Solow SP,Lezina L,Lieberman PM

更新日期：1999-04-01 00:00:00

abstract：:A gene assigned to human chromosome 1q32-41 encodes a novel protein of 3,113 amino acids containing an internal tandem repeat of 177 amino acids. The protein, which we have named "mitosin," was identified by direct binding to purified retinoblastoma protein in vitro with a region distantly related to the retinoblastom...

journal_title：Molecular and cellular biology

authors： Zhu X,Mancini MA,Chang KH,Liu CY,Chen CF,Shan B,Jones D,Yang-Feng TL,Lee WH

更新日期：1995-09-01 00:00:00

abstract：:SRC family kinases play essential roles in a variety of cellular functions, including proliferation, survival, differentiation, and apoptosis. The activities of these kinases are regulated by intramolecular interactions and by heterologous binding partners that modulate the transition between active and inactive struc...

journal_title：Molecular and cellular biology

authors： Burnham MR,Bruce-Staskal PJ,Harte MT,Weidow CL,Ma A,Weed SA,Bouton AH

更新日期：2000-08-01 00:00:00

abstract：:In CBFbeta-SMMHC, core binding factor beta (CBFbeta) is fused to the alpha-helical rod domain of smooth muscle myosin heavy chain (SMMHC). We generated Ba/F3 hematopoietic cells expressing a CBFbeta-SMMHC variant lacking 28 amino acids homologous to the assembly competence domain (ACD) required for multimerization of ...

journal_title：Molecular and cellular biology

authors： Kummalue T,Lou J,Friedman AD

更新日期：2002-12-01 00:00:00

abstract：:Members of the Spalt gene family encode putative transcription factors characterized by seven to nine C2H2 zinc finger motifs. Four genes have been identified in mice--Spalt1 to Spalt4 (Sall1 to Sall4). Spalt homologues are widely expressed in neural and mesodermal tissues during early embryogenesis. Sall3 is normally...

journal_title：Molecular and cellular biology

authors： Parrish M,Ott T,Lance-Jones C,Schuetz G,Schwaeger-Nickolenko A,Monaghan AP

更新日期：2004-08-01 00:00:00

abstract：:The Sry-related high-mobility-group box transcription factor Sox9 recruits the redundant L-Sox5 and Sox6 proteins to effect chondrogenesis, but the mode of action of the trio remains unclear. We identify here a highly conserved 359-bp sequence 10 kb upstream of the Agc1 gene for aggrecan, a most essential cartilage pr...

journal_title：Molecular and cellular biology

authors： Han Y,Lefebvre V

更新日期：2008-08-01 00:00:00

abstract：:Our recent studies implicated key and distinct roles for the highly related RalA and RalB small GTPases (82% sequence identity) in pancreatic ductal adenocarcinoma (PDAC) tumorigenesis and invasive and metastatic growth, respectively. How RalB may promote PDAC invasion and metastasis has not been determined. In light ...

journal_title：Molecular and cellular biology

authors： Neel NF,Rossman KL,Martin TD,Hayes TK,Yeh JJ,Der CJ

更新日期：2012-04-01 00:00:00

abstract：:Changes in chromatin composition are often a prerequisite for gene induction. Nonallelic histone variants have recently emerged as key players in transcriptional control and chromatin modulation. While the changes in chromatin accessibility and histone posttranslational modification (PTM) distribution that accompany g...

journal_title：Molecular and cellular biology

authors： Sutcliffe EL,Parish IA,He YQ,Juelich T,Tierney ML,Rangasamy D,Milburn PJ,Parish CR,Tremethick DJ,Rao S

更新日期：2009-04-01 00:00:00

abstract：:We have been interested in how Rous sarcoma virus (RSV) influences transformed cell morphology and compared the molecular properties of chicken embryo cells (CEC) infected with mutants of RSV that induce the fusiform transformed cell morphology with those of CEC infected by wild-type RSV, which induces the more normal...

journal_title：Molecular and cellular biology

authors： Rohrschneider L,Reynolds S

更新日期：1985-11-01 00:00:00

abstract：:The Surf-3 gene of the unusually tight mouse Surfeit locus gene cluster has been identified as the highly conserved ribosomal protein gene L7a (rpL7a). The topography and juxtaposition of the Surfeit locus genes are conserved for the 600 million years of divergent evolution between mammals and birds. This suggests cis...

journal_title：Molecular and cellular biology

authors： Armes N,Fried M

更新日期：1995-05-01 00:00:00

abstract：:Interleukin 4 (IL-4), an immunoregulatory cytokine, is produced only by a subset of activated T cells and cells of the mast cell-basophil lineage. The production of IL-4 by mast cells likely represents a significant source of this protein in local immune-inflammatory responses in the skin, brain, gastrointestinal, and...

journal_title：Molecular and cellular biology

authors： Weiss DL,Hural J,Tara D,Timmerman LA,Henkel G,Brown MA

更新日期：1996-01-01 00:00:00

abstract：:A 215-base-pair (bp) region of the mouse MOPC 41 kappa light-chain immunoglobulin gene enhancer has been analyzed for specific binding of lymphoid and nonlymphoid nuclear factors. Mobility shift assays with a series of overlapping DNA fragments have mapped DNA-binding sites for three unique factors. The B-cell-specifi...

journal_title：Molecular and cellular biology

authors： Currie RA,Roeder RG

更新日期：1989-10-01 00:00:00

abstract：:TRPV5 and TRPV6 are the most Ca2+-selective members of the transient receptor potential (TRP) family of cation channels and play a pivotal role in the maintenance of Ca2+ balance in the body. However, little is known about the mechanisms controlling the plasma membrane abundance of these channels to regulate epithelia...

journal_title：Molecular and cellular biology

authors： van de Graaf SF,Chang Q,Mensenkamp AR,Hoenderop JG,Bindels RJ

更新日期：2006-01-01 00:00:00

abstract：:Most mammalian genes produce transcripts whose 3' ends are processed at multiple alternative positions by cleavage/polyadenylation (CPA). Poly(A) site cleavage frequently occurs cotranscriptionally and is facilitated by CPA factor binding to the RNA polymerase II (Pol II) C-terminal domain (CTD) phosphorylated on Ser2...

journal_title：Molecular and cellular biology

authors： Fusby B,Kim S,Erickson B,Kim H,Peterson ML,Bentley DL

更新日期：2015-11-02 00:00:00

abstract：:To interrogate genes essential for cell growth, proliferation and survival in human cells, we carried out a genome-wide clustered regularly interspaced short palindromic repeat (CRISPR)/Cas9 screen in a B-cell lymphoma line using a custom extended-knockout (EKO) library of 278,754 single-guide RNAs (sgRNAs) that targe...

journal_title：Molecular and cellular biology

authors： Bertomeu T,Coulombe-Huntington J,Chatr-Aryamontri A,Bourdages KG,Coyaud E,Raught B,Xia Y,Tyers M

更新日期：2017-12-13 00:00:00

abstract：:Activation of adult myoblasts called satellite cells during muscle degeneration is an important aspect of muscle regeneration. Satellite cells are believed to be the only myogenic stem cells in adult skeletal muscle and the source of regenerating muscle fibers. Upon activation, satellite cells proliferate, migrate to ...

journal_title：Molecular and cellular biology

authors： Taylor JM,Dupont-Versteegden EE,Davies JD,Hassell JA,Houlé JD,Gurley CM,Peterson CA

更新日期：1997-09-01 00:00:00

abstract：:Gamma interferon (IFN-γ) regulates immune defenses against viruses, intracellular pathogens, and tumors by modulating cell proliferation, migration, invasion, and vesicle trafficking processes. The large GTPase guanylate binding protein 1 (GBP-1) is among the cellular proteins that is the most abundantly induced by IF...

journal_title：Molecular and cellular biology

authors： Ostler N,Britzen-Laurent N,Liebl A,Naschberger E,Lochnit G,Ostler M,Forster F,Kunzelmann P,Ince S,Supper V,Praefcke GJ,Schubert DW,Stockinger H,Herrmann C,Stürzl M

更新日期：2014-01-01 00:00:00

abstract：:The proteins encoded by both viral and cellular forms of the c-myc oncogene have been previously demonstrated to have exceptionally short in vivo half-lives. In this paper we report a comparative study on the parameters affecting turnover of nuclear oncoproteins c-myc, c-myb, and the rapidly metabolized cytoplasmic en...

journal_title：Molecular and cellular biology

authors： Lüscher B,Eisenman RN

更新日期：1988-06-01 00:00:00

abstract：:A monoclonal antibody (MAb 30B6) was recently described by Rogalski and Singer (J. Cell Biol. 101:785-801, 1985) which identified an integral membrane glycoprotein of chicken cells that was associated with a wide variety of sites of actin microfilament attachments to membranes. In this report, we present a further cha...

journal_title：Molecular and cellular biology

authors： Maher PA,Singer SJ

更新日期：1988-02-01 00:00:00

abstract：:The carcinoembryonic antigen (CEA) family consists of a large group of evolutionarily and structurally divergent glycoproteins. The murine CEACAM9 and CEACAM11-related proteins as well as the pregnancy-specific glycoproteins (PSG) are secreted members of the CEA family which are differentially expressed in fetal troph...

journal_title：Molecular and cellular biology

authors： Finkenzeller D,Fischer B,Lutz S,Schrewe H,Shimizu T,Zimmermann W

更新日期：2003-01-01 00:00:00

abstract：:The class II transactivator (CIITA) is induced by gamma interferon (IFN-gamma) and activates major histocompatibility complex class II; however, this report shows it suppresses other genes. An N-terminal 36 amino acids of CIITA mediates suppression of the collagen alpha(2)(I) promoter via binding to CREB-binding prote...

journal_title：Molecular and cellular biology

authors： Zhu XS,Ting JP

更新日期：2001-10-01 00:00:00

abstract：:An increased level of unpolymerized tubulin caused by depolymerization of microtubules in sea urchin larvae resulted in a rapid loss of tubulin mRNA, which was prevented by nearly complete inhibition of protein synthesis. Results of an RNA run-on assay indicated that inhibition of protein synthesis does not alter tubu...

journal_title：Molecular and cellular biology

authors： Gong ZY,Brandhorst BP

更新日期：1988-08-01 00:00:00

abstract：:The minimal muscle-specific dystrophin promoter contains the consensus sequence CC(A/T)6GG, or the CArG element, which can be found in serum-inducible or muscle-specific promoters. The serum response factor (SRF), which mediates the transcriptional activation of the c-fos gene in response to serum stimulation, can bin...

journal_title：Molecular and cellular biology

authors： Galvagni F,Lestingi M,Cartocci E,Oliviero S

更新日期：1997-03-01 00:00:00

abstract：:mRNAs are monitored for errors in gene expression by RNA surveillance, in which mRNAs that cannot be fully translated are degraded by the nonsense-mediated mRNA decay pathway (NMD). RNA surveillance ensures that potentially deleterious truncated proteins are seldom made. NMD pathways that promote surveillance have bee...

journal_title：Molecular and cellular biology

authors： Lelivelt MJ,Culbertson MR

更新日期：1999-10-01 00:00:00

abstract：:The gastrointestinal glutathione peroxidase (GI-GPx, GPx2) is a selenoprotein that was suggested to act as barrier against hydroperoxide absorption but has also been implicated in the control of inflammation and malignant growth. In CaCo-2 cells, GI-GPx was induced by t-butyl hydroquinone (tBHQ) and sulforaphane (SFN)...

journal_title：Molecular and cellular biology

authors： Banning A,Deubel S,Kluth D,Zhou Z,Brigelius-Flohé R

更新日期：2005-06-01 00:00:00

abstract：:Little is known about the regions of RNA polymerase II (RNAPII) that are involved in the process of transcript elongation and interaction with elongation factors. One elongation factor, TFIIS, stimulates transcript elongation by binding to RNAPII and facilitating its passage through intrinsic pausing sites in vitro. I...

journal_title：Molecular and cellular biology

authors： Archambault J,Lacroute F,Ruet A,Friesen JD

更新日期：1992-09-01 00:00:00