Abstract:
:TIN2 is a negative regulator of telomere elongation that interacts with telomeric DNA repeat binding factor 1 (TRF1) and affects telomere length by a telomerase-dependent mechanism. Here we show that inactivation of the mouse TRF1-interacting protein 2 (TIN2) gene results in early embryonic lethality. We further observed that the embryonic lethality of TIN2 mutant mice was not affected by inactivation of the telomerase reverse transcriptase gene, indicating that embryonic lethality is not the result of telomerase-dependent changes in telomere length or function. Our findings suggest that TIN2 has a role independent of telomere length regulation that is essential for embryonic development and cell viability.
journal_name
Mol Cell Bioljournal_title
Molecular and cellular biologyauthors
Chiang YJ,Kim SH,Tessarollo L,Campisi J,Hodes RJdoi
10.1128/MCB.24.15.6631-6634.2004subject
Has Abstractpub_date
2004-08-01 00:00:00pages
6631-4issue
15eissn
0270-7306issn
1098-5549pii
24/15/6631journal_volume
24pub_type
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