Drosophila Ada2b is required for viability and normal histone H3 acetylation.

abstract：:GCN4 is a transcriptional activator of amino acid-biosynthetic genes in the yeast Saccharomyces cerevisiae. GCN2, a translational activator of GCN4 expression, contains a domain homologous to the catalytic subunit of eucaryotic protein kinases. Substitution of a highly conserved lysine residue in the kinase domain abo...

journal_title：Molecular and cellular biology

authors： Wek RC,Ramirez M,Jackson BM,Hinnebusch AG

更新日期：1990-06-01 00:00:00

abstract：:We have examined the interaction of transcription factors TFIIIC and TFIIID with a silkworm alanine tRNA gene. Previous functional analysis showed that the promoter for this gene is unusually large compared with the classical tRNA promoter elements (the A and B boxes) and includes sequences downstream from the transcr...

journal_title：Molecular and cellular biology

authors： Young LS,Rivier DH,Sprague KU

更新日期：1991-03-01 00:00:00

abstract：:Phosphorylation on tyrosine residues mediated by pp60src appears to be a primary biochemical event leading to the establishment of the transformed phenotype in Rous sarcoma virus (RSV)-infected cells. To identify the cellular proteins that undergo tyrosine phosphorylation during transformation, a 32P-labeled RSV-trans...

journal_title：Molecular and cellular biology

authors： Martinez R,Nakamura KD,Weber MJ

更新日期：1982-06-01 00:00:00

abstract：:The interleukin-2 receptor (IL-2R) beta chain (IL-2R beta) is an essential signaling component of high- and intermediate-affinity IL-2Rs. Our laboratory previously reported that a DNA fragment containing 857 bp of 5'-flanking sequence of the human IL-2R beta gene exhibited promoter activity. We have now further charac...

journal_title：Molecular and cellular biology

authors： Lin JX,Bhat NK,John S,Queale WS,Leonard WJ

更新日期：1993-10-01 00:00:00

abstract：:The SNAIL transcription factor contains C-terminal tandem zinc finger motifs and an N-terminal SNAG repression domain. The members of the SNAIL family have recently emerged as major contributors to the processes of development and metastasis via the regulation of epithelial-mesenchymal transition events during embryon...

journal_title：Molecular and cellular biology

authors： Hou Z,Peng H,Ayyanathan K,Yan KP,Langer EM,Longmore GD,Rauscher FJ 3rd

更新日期：2008-05-01 00:00:00

abstract：:Nuclear pore complexes (NPCs) play an essential role in RNA export. Nucleoporins required for mRNA export in Saccharomyces cerevisiae are found in the Nup84p and Nup82p subcomplexes of the NPC. The Nup82p subcomplex contains Nup82p, Rat7p/Nup159p, Nsp1p, Gle1p/Rss1p, and Rip1p/Nup42p and is found only on the cytoplasm...

journal_title：Molecular and cellular biology

authors： Rollenhagen C,Hodge CA,Cole CN

更新日期：2004-06-01 00:00:00

abstract：:A 249-nucleotide coding region instability determinant (CRD) destabilizes c-myc mRNA. Previous experiments identified a CRD-binding protein (CRD-BP) that appears to protect the CRD from endonuclease cleavage. However, it was unclear why a CRD-BP is required to protect a well-translated mRNA whose coding region is cove...

journal_title：Molecular and cellular biology

authors： Lemm I,Ross J

更新日期：2002-06-01 00:00:00

abstract：:The 3' AU-rich region of human beta-1 interferon (hu-IFN beta) mRNA was found to act as a translational inhibitory element. The translational regulation of this 3' AU-rich sequence and the effect of its association with the poly(A) tail were studied in cell-free rabbit reticulocyte lysate. A poly(A)-rich hu-IFN beta m...

journal_title：Molecular and cellular biology

authors： Grafi G,Sela I,Galili G

更新日期：1993-06-01 00:00:00

abstract：:Galanin is a neuropeptide implicated in the regulation of feeding, reproduction, cognition, nociception, and seizure susceptibility. There are three known galanin receptor (GALR) subtypes (GALR1, GALR2, and GALR3), which bind to galanin with different affinities and have their own unique distributions, signaling mecha...

journal_title：Molecular and cellular biology

authors： Gottsch ML,Zeng H,Hohmann JG,Weinshenker D,Clifton DK,Steiner RA

更新日期：2005-06-01 00:00:00

abstract：:The RGT1 gene of Saccharomyces cerevisiae plays a central role in the glucose-induced expression of hexose transporter (HXT) genes. Genetic evidence suggests that it encodes a repressor of the HXT genes whose function is inhibited by glucose. Here, we report the isolation of RGT1 and demonstrate that it encodes a bifu...

journal_title：Molecular and cellular biology

authors： Ozcan S,Leong T,Johnston M

更新日期：1996-11-01 00:00:00

abstract：:Xenopus laevis oogenesis is characterized by an active transcription which ceases abruptly upon maturation. To survey changes in the characteristics of the transcriptional machinery which might contribute to this transcriptional arrest, the phosphorylation status of the RNA polymerase II largest subunit (RPB1 subunit)...

journal_title：Molecular and cellular biology

authors： Bellier S,Dubois MF,Nishida E,Almouzni G,Bensaude O

更新日期：1997-03-01 00:00:00

abstract：:Mammalian ras genes substitute for the yeast RAS gene, and their products activate adenylate cyclase in yeast cells, although the direct target protein of mammalian ras p21s remains to be identified. ras p21s undergo posttranslational processing, including prenylation, proteolysis, methylation, and palmitoylation, at ...

journal_title：Molecular and cellular biology

authors： Horiuchi H,Kaibuchi K,Kawamura M,Matsuura Y,Suzuki N,Kuroda Y,Kataoka T,Takai Y

更新日期：1992-10-01 00:00:00

abstract：:Multipotential stem cell lines, derived specifically from long-term bone marrow cultures infected with a recombinant retrovirus carrying v-src, lack v-src. Stable consequences thus result from transient actions or indirect effects of v-src on other cells, with the latter possibility being favored by its mosaic express...

journal_title：Molecular and cellular biology

authors： Wyke JA,Stoker AW,Searle S,Spooncer E,Simmons P,Dexter TM

更新日期：1986-03-01 00:00:00

abstract：:O(6)-Methylguanine (m6G) is formed by the action of alkylating agents such as N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) on DNA. m6G is a highly mutagenic and carcinogenic lesion, and it presents a block to synthesis by DNA polymerases. Here, we provide genetic and biochemical evidence for the involvement of yeast an...

journal_title：Molecular and cellular biology

authors： Haracska L,Prakash S,Prakash L

更新日期：2000-11-01 00:00:00

abstract：:Vanin-1 is an epithelial ectoenzyme with pantetheinase activity and generating the amino-thiol cysteamine through the metabolism of pantothenic acid (vitamin B(5)). Here we show that Vanin-1(-/-) mice, which lack cysteamine in tissues, exhibit resistance to oxidative injury induced by whole-body gamma-irradiation or p...

journal_title：Molecular and cellular biology

authors： Berruyer C,Martin FM,Castellano R,Macone A,Malergue F,Garrido-Urbani S,Millet V,Imbert J,Duprè S,Pitari G,Naquet P,Galland F

更新日期：2004-08-01 00:00:00

abstract：:In yeast cells, mutations in the TATA-binding protein (TBP) that disrupt the interaction with the TATA element or with TFIIA can selectively impair the response to acidic activator proteins. We analyzed the transcriptional properties of TBP derivatives in which residues that directly interact with TFIIB were replaced ...

journal_title：Molecular and cellular biology

authors： Lee M,Struhl K

更新日期：1997-03-01 00:00:00

abstract：:Transcriptional factors of the NFAT family play an important role in regulating the expression of several cytokine genes during the immune response, such as the genes for interleukin 2 (IL-2) and IL-4, among others. Upon antigen stimulation, precursor CD4+ T helper (pTh) cells proliferate and differentiate into two po...

journal_title：Molecular and cellular biology

authors： Rincón M,Flavell RA

更新日期：1997-03-01 00:00:00

abstract：:Alkylpurine-DNA-N-glycosylase (APNG) null mice have been generated by homologous recombination in embryonic stem cells. The null status of the animals was confirmed at the mRNA level by reverse transcription-PCR and by the inability of cell extracts of tissues from the knockout (ko) animals to release 3-methyladenine ...

journal_title：Molecular and cellular biology

authors： Elder RH,Jansen JG,Weeks RJ,Willington MA,Deans B,Watson AJ,Mynett KJ,Bailey JA,Cooper DP,Rafferty JA,Heeran MC,Wijnhoven SW,van Zeeland AA,Margison GP

更新日期：1998-10-01 00:00:00

abstract：:RNA editing occurs in two higher-plant organelles, chloroplasts and mitochondria. Because chloroplasts and mitochondria exhibit some similarity in editing site selection, we investigated whether mitochondrial RNA sequences could be edited in chloroplasts. We produced transgenic tobacco plants that contained chimeric g...

journal_title：Molecular and cellular biology

authors： Sutton CA,Zoubenko OV,Hanson MR,Maliga P

更新日期：1995-03-01 00:00:00

abstract：:To understand the mechanisms by which the chromatin-remodeling SWI/SNF complex interacts with DNA and alters nucleosome organization, we have imaged the SWI/SNF complex with both naked DNA and nucleosomal arrays by using energy-filtered microscopy. By making ATP-independent contacts with DNA at multiple sites on its s...

journal_title：Molecular and cellular biology

authors： Bazett-Jones DP,Côté J,Landel CC,Peterson CL,Workman JL

更新日期：1999-02-01 00:00:00

abstract：:We investigated the interaction of phospholipase C-gamma (PLC-gamma) with wild-type and mutant forms of the platelet-derived growth factor (PDGF) beta-receptor both in vivo and in vitro. After PDGF treatment of CHO cell lines expressing wild-type or either of two mutant (delta Ki and Y825F) PDGF receptors, PLC-gamma b...

journal_title：Molecular and cellular biology

authors： Morrison DK,Kaplan DR,Rhee SG,Williams LT

更新日期：1990-05-01 00:00:00

abstract：:We investigated the role of RNA polymerase II (pol II) carboxy-terminal domain (CTD) phosphorylation in pre-mRNA processing coupled and uncoupled from transcription in Xenopus oocytes. Inhibition of CTD phosphorylation by the kinase inhibitors 5,6-dichloro-1beta-D-ribofuranosyl-benzimidazole and H8 blocked transcripti...

journal_title：Molecular and cellular biology

authors： Bird G,Zorio DA,Bentley DL

更新日期：2004-10-01 00:00:00

abstract：:The baker's yeast Saccharomyces cerevisiae possesses a single gene encoding heat shock transcription factor (HSF), which is required for the activation of genes that participate in stress protection as well as normal growth and viability. Yeast HSF (yHSF) contains two distinct transcriptional activation regions locate...

journal_title：Molecular and cellular biology

authors： Santoro N,Johansson N,Thiele DJ

更新日期：1998-11-01 00:00:00

abstract：:TEL-JAK2 fusion proteins, which are a result of t(9;12)(p24;p13) translocations associated with human leukemia, activate Stat5 in vitro and in vivo and cause a myelo- and lymphoproliferative disease in a murine bone marrow transplant model. We report that Socs-1, a member of the SOCS family of endogenous inhibitors of...

journal_title：Molecular and cellular biology

authors： Frantsve J,Schwaller J,Sternberg DW,Kutok J,Gilliland DG

更新日期：2001-05-01 00:00:00

abstract：:The myeloperoxidase (MPO) gene is transcribed specifically in immature myeloid cells and is regulated in part by a 414-bp proximal enhancer. Mutation of a core binding factor (CBF)-binding site at -288 decreased enhancer activity 30-fold in 32D cl3 myeloid cells cultured in granulocyte colony-stimulating factor (G-CSF...

journal_title：Molecular and cellular biology

authors： Britos-Bray M,Friedman AD

更新日期：1997-09-01 00:00:00

abstract：:The scid mouse mutation affects V(D)J rearrangement and double-strand break repair. scid V(D)J rearrangement is characterized by defective coding joint formation which prevents the development of mature B and T cells. Hairpin DNA has been implicated in the formation of V(D)J coding joints. We found scid cells to be pr...

journal_title：Molecular and cellular biology

authors： Staunton JE,Weaver DT

更新日期：1994-06-01 00:00:00

abstract：:In yeast, environmental stresses provoke sudden and dramatic increases in gene expression at stress-inducible loci. Stress gene transcription is accompanied by the transient eviction of histones from the promoter and the transcribed regions of these genes. We found that mutants defective in subunits of the INO80 compl...

journal_title：Molecular and cellular biology

authors： Klopf E,Paskova L,Solé C,Mas G,Petryshyn A,Posas F,Wintersberger U,Ammerer G,Schüller C

更新日期：2009-09-01 00:00:00

abstract：:Pref-1/Dlk1 is made as an epidermal growth factor (EGF) repeat-containing transmembrane protein but is cleaved by tumor necrosis factor alpha converting enzyme (TACE) to generate a biologically active soluble form. Soluble Pref-1 inhibits adipocyte differentiation through the activation of extracellular signal-regulat...

journal_title：Molecular and cellular biology

authors： Wang Y,Zhao L,Smas C,Sul HS

更新日期：2010-07-01 00:00:00

abstract：:Vesicle-associated-membrane protein 8 (VAMP8) is highly expressed in the kidney, but the exact physiological and molecular functions executed by this v-SNARE protein in nephrons remain elusive. Here, we show that the depletion of VAMP8 in mice resulted in hydronephrosis. Furthermore, the level of the vasopressin-respo...

journal_title：Molecular and cellular biology

authors： Wang CC,Ng CP,Shi H,Liew HC,Guo K,Zeng Q,Hong W

更新日期：2010-01-01 00:00:00

abstract：:The mammalian signal recognition particle (SRP) is a small cytoplasmic ribonucleoprotein required for the cotranslational targeting of secretory proteins to the endoplasmic reticulum membrane. The heterodimeric protein subunit SRP9/14 was previously shown to be essential for SRP to cause pausing in the elongation of s...

journal_title：Molecular and cellular biology

authors： Strub K,Moss J,Walter P

更新日期：1991-08-01 00:00:00