Differences in nonenzymatic glycation of histones.

abstract：:1. The insoluble collagen from Guerin epithelioma was isolated and its chemical composition was determined. The unusually high histidine content is accompanied in tumour collagen by a relatively small amount of lysine and arginine. 2. The isolated protein was strongly bound to glycoprotein, which could not be removed ...

journal_title：Acta biochimica Polonica

authors： Bańkowski E,Galasiński W,Gindzieẃski A,Rzeczycki W

更新日期：1975-01-01 00:00:00

abstract：:The present paper investigates the enhancement of the therapeutic effect of Paclitaxel (a potent anticancer drug) by increasing its cellular uptake in the cancerous cells with subsequent reduction in its cytotoxic effects. To fulfill these goals the Paclitaxel (PTX)-Biotinylated PAMAM dendrimer complexes were prepared...

journal_title：Acta biochimica Polonica

authors： Yao H,Ma J

更新日期：2018-01-01 00:00:00

abstract：:Pathogen-specific acquired immunity in bacteria is mediated by the CRISPR (clustered regularly interspaced short palindromic repeats)-Cas systems. Thermus thermophilus strain HB8 contains CRISPR systems of several major subtypes (type I, IIIA and IIIB), and has become a widely studied model for CRISPR biology. We have...

journal_title：Acta biochimica Polonica

authors： Szychowska M,Siwek W,Pawolski D,Kazrani AA,Pyrc K,Bochtler M

更新日期：2016-01-01 00:00:00

abstract：:The biodegradability and biocompatibility properties of ε-caprolactone homopolymers place it as a valuable raw material, particularly for controlled drug delivery and tissue engineering applications. However, the usefulness of such materials is limited by their low hydrophilicity and slow biodegradation rate. In order...

journal_title：Acta biochimica Polonica

authors： Todea A,Badea V,Nagy L,Kéki S,Boeriu CG,Péter F

更新日期：2014-01-01 00:00:00

abstract：:To develop a more potent antithrombin agent with thrombolytic and antiplatelet properties, a new staphylokinase (SAK) variant was constructed. The kringle 2 domain (K2) of tissue type-plasminogen activator (t-PA) containing a fibrin-specific binding site (i), the RGD sequence (Arg-Gly-Asp) for the prevention of platel...

journal_title：Acta biochimica Polonica

authors： Kowalski M,Brown G,Bieniasz M,Oszajca K,Chabielska E,Pietras T,Szemraj Z,Makandjou-Ola E,Bartkowiak J,Szemraj J

更新日期：2009-01-01 00:00:00

abstract：:Hereditary sensory and autonomic neuropathy type 2 is a rare disorder caused by recessive mutations in the WNK1/HSN2 gene located on chromosome 12p13.33. Phenotype of the patients is characterized by severe sensory loss affecting all sensory modalities. We report a novel homozygous Lys179fsX182 (HSN2); Lys965fsX968 (W...

journal_title：Acta biochimica Polonica

authors： Potulska-Chromik A,Kabzińska D,Lipowska M,Kostera-Pruszczyk A,Kochański A

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Tunneled catheters are becoming increasingly used as a permanent dialysis access. Easy way of insertion and good long-term patency make them competitive to fistulas in some groups of patients. METHODS:Late complications and survival of 180 tunneled catheters inserted from June 2010 to December 2013 in 171 u...

journal_title：Acta biochimica Polonica

authors： Weber E,Liberek T,Wołyniec W,Gruszecki M,Rutkowski B

更新日期：2016-01-01 00:00:00

abstract：:1. The amino acid composition of wheat germ EF2 differs to some extent from that of elongation factors from mammals and bacteria. 2. The purified wheat germ EF2, similarly as the factors from other sources, is active in the: EF1-dependent polymerization of phenylalanine; ribosome-dependent GTP hydrolysis; binding of g...

journal_title：Acta biochimica Polonica

authors： Twardowski T,Legocki A

更新日期：1977-01-01 00:00:00

abstract：:Gene promoters contain several classes of functional sequence elements (cis elements) recognized by protein agents, e.g. transcription factors and essential components of the transcription machinery. Here we describe a common DNA regulatory element (tandem TCTCGCGAGA motif) of human TATA-less promoters. A combination ...

journal_title：Acta biochimica Polonica

authors： Wyrwicz LS,Gaj P,Hoffmann M,Rychlewski L,Ostrowski J

更新日期：2007-01-01 00:00:00

abstract：:Angioarrestin is a recently described anti-angiogenic protein whose expression is down-regulated in solid tumours of various origins. It has a sequence identical to angiopoietin related protein-1. In this study we investigated anti-tumour properties of angioarrestin in B16 (F10) melanoma tumour model. We constructed a...

journal_title：Acta biochimica Polonica

authors： Smagur A,Szary J,Szala S

更新日期：2005-01-01 00:00:00

abstract：INTRODUCTION:The statin-induced effects on high density lipoprotein (HDL) are relatively small compared with those of low density lipoprotein (LDL) and, as a result, most clinical trials of statins are underpowered with respect to HDL parameters. This study experimentally investigated, the effects of statin on serum li...

journal_title：Acta biochimica Polonica

authors： Adekunle AS,Fatoki JO,Adelusi TI

更新日期：2013-01-01 00:00:00

abstract：:Murine leukemia L1210 cells contain active glucosamine 6-phosphate synthase inhibited by N3-4-methoxyfumaroyl-L-2,3-diaminopropanoic acid (FMDP). However, FMDP-peptides do not exhibit any cytotoxicity against these cells, HeLa S3 human cervical carcinoma cells, and LL2 murine Lewis lung carcinoma cells. It is suggeste...

journal_title：Acta biochimica Polonica

authors： Bontemps-Gracz M,Milewski S,Borowski E

更新日期：1991-01-01 00:00:00

abstract：:The bacterial Sm-like protein Hfq affects the regulation of translation by small noncoding RNAs (sRNAs). In this way, Hfq participates in the cell adaptation to environmental stress, regulation of cellular metabolism, and bacterial virulence. The majority of known sRNAs bind complementary sequences in the 5'-untransla...

journal_title：Acta biochimica Polonica

authors： Wroblewska Z,Olejniczak M

更新日期：2016-01-01 00:00:00

abstract：:The pathogenicity of RHDV (rabbit haemorrhagic disease virus) is mainly associated with its affinity to blood vessels, with causing disseminated intravascular coagulations (DIC), and with the stimulation of the host immune system. Moreover, there are implications suggesting that apoptosis may be a pivotal process in u...

journal_title：Acta biochimica Polonica

authors： Niedźwiedzka-Rystwej P,Hukowska-Szematowicz B,Tokarz-Deptuła B,Trzeciak-Ryczek A,Działo J,Deptuła W

更新日期：2013-01-01 00:00:00

abstract：:A trehalose synthase gene from Deinococcus radiodurans (DSMZ 20539) containing 1659 bp reading frame encoding 552 amino acids was amplified using PCR. The gene was finally ligated into pET30Ek/LIC vector and expressed after isopropyl β-d-thiogalactopyranoside induction in Escherichia coli (DE3) Rosetta pLysS. The reco...

journal_title：Acta biochimica Polonica

authors： Filipkowski P,Pietrow O,Panek A,Synowiecki J

更新日期：2012-01-01 00:00:00

abstract：:Two different molecular forms of bacteriolytic endo-N-acetylmuramidase (EC 3.2.1.17) were found in the Acanthamoeba castellanii culture. The enzymes were separated by column chromatography on DEAE-Sephadex or by polyacrylamide-gel electrophoresis. In young cultures only one molecular form of the enzyme was selectively...

journal_title：Acta biochimica Polonica

authors： Drozański W

更新日期：1978-01-01 00:00:00

abstract：:The importance of nosocomial infections caused by coagulase-negative staphylococci is constantly growing. The threat primarily affects immunocompromised patients, the elderly and neonates, particularly after invasive surgery. The problem is fundamentally exacerbated by expanding antibacterial drug resistance. A case r...

journal_title：Acta biochimica Polonica

authors： Savini V,Kosecka M,Siegwart E,Marrollo R,Polilli E,Palmieri D,Fazii P,Carretto E,Międzobrodzki J,Bukowski M

更新日期：2016-01-01 00:00:00

abstract：:1. The interaction of copper(II) with inosine, 2'-deoxyinosine, 1-methylinosine, 7-deazainosine, 6-methoxypurine riboside and IMP was examined. 2. Copper binds with the purine base of the nucleosides, and in IMP also with the phosphate group. Non interaction with ribose hydroxyl groups was observed. 3. In non-aqueous ...

journal_title：Acta biochimica Polonica

authors： Maskos K

更新日期：1978-01-01 00:00:00

abstract：:Nematodes were found to synthesize phosphorylcholine-containing molecules not present in higher organisms, i.e. phosphorylcholine-substituted glycosphingolipids and (glyco)proteins. Investigations on the biosynthesis of these structures provided first biochemical evidence for the presence of the Kennedy and Bremer-Gre...

journal_title：Acta biochimica Polonica

authors： Lochnit G,Geyer R

更新日期：2003-01-01 00:00:00

abstract：:The purpose of this study was to examine the effects of oxidative stress caused by hydroperoxide (H(2)O(2)) in the presence of iron ions (Fe(2+)) on mitochondria of the amoeba Acanthamoeba castellanii. We used isolated mitochondria of A. castellanii and exposed them to four levels of H(2)O(2) concentration: 0.5, 5, 15...

journal_title：Acta biochimica Polonica

authors： Trocha LK,Stobienia O

更新日期：2007-01-01 00:00:00

abstract：:Previous studies detected higher Golgi protein 73 levels in the serum of patients with chronic liver disease. The Beta-2 microglobulin levels were also observed to be higher in patients with chronic hepatitis B infection compared to the inactive carriers and the protein plays an important role in the response to viral...

journal_title：Acta biochimica Polonica

authors： Deveci O,Kaplan I,Tekin R,Celen MK,Bozkurt F,Aslan E,Cerrah S,Dayan S

更新日期：2020-03-19 00:00:00

abstract：:Trans-diamminedichloroplatinum(II) (trans-DDP) forms with DNA at 37 degrees C, more numerous interstrand cross-links than cis-DDP in the isolated DNA and DNA in the chromatin complex. An increase in the temperature to 42.5 degrees C had no effect on the interstrand cross-links of DND-Pt-DNA formed by the two isomers, ...

journal_title：Acta biochimica Polonica

authors： Kulamowicz I,Walter Z,Krupa R

更新日期：1990-01-01 00:00:00

abstract：:Lanthanides, also called rare-earth elements, are an interesting group of 15 chemically active, mainly trivalent, f-electronic, silvery-white metals. In fact, lanthanides are not as rare as the name implies, except for promethium, a radioactive artificial element not found in nature. The mean concentrations of lanthan...

journal_title：Acta biochimica Polonica

authors： Pałasz A,Czekaj P

更新日期：2000-01-01 00:00:00

abstract：:Fluorimetric method based on oxidation of the fluorogenic 6-methoxy-2-naphthaldehyde was applied to evaluate temporal and population variability of the specific activity of salivary aldehyde dehydrogenase (ALDH) and the degree of its inactivation in healthy human population. Analyzed was also its dependence on drinkin...

journal_title：Acta biochimica Polonica

authors： Giebułtowicz J,Dziadek M,Wroczyński P,Woźnicka K,Wojno B,Pietrzak M,Wierzchowski J

更新日期：2010-01-01 00:00:00

abstract：:Mushroom foraging is very popular in some regions of the world. Sometimes toxic and edible mushrooms are mistaken by mushroom collectors, leading to serious human poisoning. The group of mushrooms highly dangerous for human health includes Amanita phalloides. This mushroom produces a toxic octapeptide called α-amaniti...

journal_title：Acta biochimica Polonica

authors： Muszyńska K,Ostrowska D,Bartnicki F,Kowalska E,Bodaszewska-Lubaś M,Hermanowicz P,Faulstich H,Strzałka W

更新日期：2017-01-01 00:00:00

abstract：:Endogenous peptide antibiotics are known as evolutionarily old components of innate immunity. Due to interaction with cell membrane these peptides cause permeabilization of the membrane and lysis of invading microbes. However, some studies proved that antimicrobial peptides are universal multifunctional molecules and ...

journal_title：Acta biochimica Polonica

authors： Kamysz W,Okrój M,Łukasiak J

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:The coexistence of cystic fibrosis (CF) and celiac disease (CD) has been reported. To our knowledge there is no study directly comparing the incidence of CD in CF patients to that in the general population at the same time. There is no published data on genetic predisposition to CD in CF patients either. The...

journal_title：Acta biochimica Polonica

authors： Walkowiak J,Blask-Osipa A,Lisowska A,Oralewska B,Pogorzelski A,Cichy W,Sapiejka E,Kowalska M,Korzon M,Szaflarska-Popławska A

更新日期：2010-01-01 00:00:00

abstract：:The arginase structural gene (agaA) from Aspergillus nidulans has been cloned and characterised. Depending on the growth conditions of the mycelium, transcripts of this gene have different 5'ends. These differences could result either from the presence of multiple transcription initiation sites or from differential pr...

journal_title：Acta biochimica Polonica

authors： Borsuk P,Dzikowska A,Empel J,Grzelak A,Grześkowiak R,Weglenski P

更新日期：1999-01-01 00:00:00

abstract：:The activity of polyhydric alcohol dehydrogenases in Mycobacterium sp. 279 was studied under limitation of zinc in the growth medium. It was found that the activity of ribitol and sorbitol dehydrogenases were markedly lowered and that of D-arabinitol dehydrogenase remained unchanged in the Zn2+-deficient cells. Other ...

journal_title：Acta biochimica Polonica

authors： Szumiło T,Byra A

更新日期：1984-01-01 00:00:00

abstract：:This article reviews the evidence for the danger model in the context of immune response to tumors and the insufficiency of the immune system to eliminate tumor growth. Despite their potential immunogenicity tumors do not induce significant immune responses which could destroy malignant cells. According to the danger ...

journal_title：Acta biochimica Polonica

authors： Kowalczyk DW

更新日期：2002-01-01 00:00:00