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The influence of L-norvalyl-N3-4-methoxyfumaroyl-L-2,3-diaminopropanoic acid, an antifungal agent, on mammalian cells in tissue culture.

Abstract：

:Murine leukemia L1210 cells contain active glucosamine 6-phosphate synthase inhibited by N3-4-methoxyfumaroyl-L-2,3-diaminopropanoic acid (FMDP). However, FMDP-peptides do not exhibit any cytotoxicity against these cells, HeLa S3 human cervical carcinoma cells, and LL2 murine Lewis lung carcinoma cells. It is suggested that the lack of cytotoxicity of FMDP-peptides, in spite of good drug uptake and the presence of target enzyme might be due to the poor rate of peptides cleavage by the intracellular peptidases.

journal_name

Acta Biochim Pol

journal_title

Acta biochimica Polonica

authors

Bontemps-Gracz M,Milewski S,Borowski E

subject

Has Abstract

pub_date

1991-01-01 00:00:00

pages

229-39

issue

2

eissn

0001-527X

issn

1734-154X

journal_volume

38

pub_type

杂志文章

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