Prescribing oral contraceptives.

abstract：:Locally advanced prostate cancer (LAPC) is a heterogeneous entity usually embracing T3-4 and/or pelvic lymph-node-positive disease in the absence of established metastases. Outcomes for LAPC with single therapies have traditionally been poor, leading to the investigation of adjuvant therapies. Prostate cancer is a hor...

journal_title：Drugs

authors： Martin JM,Supiot S,Berthold DR

更新日期：2011-05-28 00:00:00

abstract：:Stavudine is a nucleoside analogue which undergoes intracellular phosphorylation to its active metabolite, stavudine-5'-triphosphate. At clinically relevant concentrations, the active metabolite restricts HIV replication by inhibiting the inclusion of thymidine-5'-triphosphate into proviral DNA by HIV reverse transcri...

journal_title：Drugs

authors： Lea AP,Faulds D

更新日期：1996-05-01 00:00:00

abstract：:Although antiangiogenic treatments have produced milestone advances in the treatment of several diseases, and have significantly extended the median survival of cancer patients, these agents share some weaknesses, including a limited impact on the overall cure rate, a fleeting effect because of redundant pathways or e...

journal_title：Drugs

authors： Aprile G,Bonotto M,Ongaro E,Pozzo C,Giuliani F

更新日期：2013-12-01 00:00:00

abstract：:The phosphoinositide 3-kinase (PI3K)/Akt/mTOR pathway is implicated in the pathogenesis of lymphoma. Deeper understanding of the diversity and biological impact of this pathway has led to the development of specific inhibitors to this pathway. Preclinical data in cell lines, patient samples and disease models have bro...

journal_title：Drugs

authors： Seiler T,Hutter G,Dreyling M

更新日期：2016-04-01 00:00:00

abstract：:Invasive candidiasis has emerged as an important cause of morbidity and mortality in intensive care unit patients. This short review focuses on many aspects of Candida infection in critically ill patients including epidemiology, impact on mortality, problems related to diagnosis, strategies to identify patients at ris...

journal_title：Drugs

authors： Pennisi M,Antonelli M

更新日期：2009-01-01 00:00:00

abstract：:Pain is associated with emotional and physical suffering that severely impacts quality of life. Many guidelines for the treatment of moderate to severe cancer pain indicate the use of opioids. For a small proportion of the global population, opioids are readily accessible, but are consequently also subject to risk of ...

journal_title：Drugs

authors： Marchetti Calônego MA,Sikandar S,Ferris FD,Moreira de Barros GA

更新日期：2020-08-01 00:00:00

abstract：:The rationale for an arginine vasopressin (argipressin) infusion was put forward after it was discovered that patients in shock states might have an endogenous arginine vasopressin deficiency. Subsequently, several investigations impressively demonstrated that arginine vasopressin can successfully stabilise haemodynam...

journal_title：Drugs

authors： Dunser MW,Wenzel V,Mayr AJ,Hasibeder WR

更新日期：2003-01-01 00:00:00

abstract：:Azimilide is a potassium channel antagonist that, in contrast to existing class III antiarrhythmic agents, blocks both the rapidly (I(Kr)) and slowly (I(Ks)) activating components of the delayed rectifier potassium current. In animal and clinical studies, azimilide prolonged repolarisation by increasing the action pot...

journal_title：Drugs

authors： Clemett D,Markham A

更新日期：2000-02-01 00:00:00

abstract：:The antihypertensive effects of the regular immediate release formulation of verapamil (verapamil IR) and the newer sustained release formulation of verapamil (verapamil SR) were compared in Hispanic patients with untreated essential hypertension. Verapamil IR was given in 3 divided doses (80 or 160mg 3 times daily) a...

journal_title：Drugs

authors： Fuenmayor NT,Faggin BM,Cubeddu LX

更新日期：1992-01-01 00:00:00

abstract：:Aspirin (acetylsalicylic acid)-induced asthma (AIA) consists of the clinical triad of asthma, chronic rhinosinusitis with nasal polyps, and precipitation of asthma and rhinitis attacks in response to aspirin and other NSAIDs. The prevalence of the syndrome in the adult asthmatic populations is approximately 4-10%. Res...

journal_title：Drugs

authors： Hamad AM,Sutcliffe AM,Knox AJ

更新日期：2004-01-01 00:00:00

abstract：:The pathogenesis of postoperative ileus (PI) is multifactorial, and includes activation of inhibitory reflexes, inflammatory mediators and opioids (endogenous and exogenous). Accordingly, various strategies have been employed to prevent PI. As single-modality treatment, continuous postoperative epidural analgesia incl...

journal_title：Drugs

authors： Holte K,Kehlet H

更新日期：2002-01-01 00:00:00

abstract：:An increase in serum digoxin concentration occurs in 90% of patients given quinidine. On average, the serum digoxin doubles during treatment with therapeutic doses of quinidine. Almost every patient treated with quinidine will have a decrease in the renal clearance of digoxin and many will have a decrease in the volum...

journal_title：Drugs

authors： Bigger JT Jr,Leahey EB Jr

更新日期：1982-09-01 00:00:00

abstract：:The meningococcal groups C and Y and Haemophilus b (Hib) tetanus toxoid conjugate vaccine (HibMenCY-TT) contains Neisseria meningitidis serogroup C and Y capsular polysaccharide antigens, and Hib capsular polysaccharide [polyribosyl-ribitol-phosphate (PRP)]. The HibMenCY-TT vaccine is available in the USA for use as a...

journal_title：Drugs

authors： Perry CM

更新日期：2013-05-01 00:00:00

abstract：:Rabeprazole is an inhibitor of the gastric proton pump. It causes dose-dependent inhibition of acid secretion and has a more rapid onset of action than omeprazole. Duodenal ulcers healed faster after treatment with rabeprazole 20 or 40 mg/day than placebo or ranitidine 150 mg 4 times daily and at a generally similar r...

journal_title：Drugs

authors： Langtry HD,Markham A

更新日期：1999-10-01 00:00:00

abstract：:Allergic rhinitis represents a global health burden. The disease can seriously affect quality of life and is associated with multiple co-morbidities. Histamine and leukotrienes are important pro-inflammatory mediators in nasal allergic inflammation. Their actions on target cells are mediated through specific receptors...

journal_title：Drugs

authors： Van Hoecke H,Vandenbulcke L,Van Cauwenberge P

更新日期：2007-01-01 00:00:00

abstract：:Bisoprolol is a beta 1-adrenoceptor antagonist with no partial agonist (intrinsic sympathomimetic) activity or membrane stabilising (local anaesthetic) activity. The oral bioavailability of bisoprolol is high (90%) and the drug has a long elimination half-life which allows once-daily administration; in addition, it is...

journal_title：Drugs

authors： Lancaster SG,Sorkin EM

更新日期：1988-09-01 00:00:00

abstract：:Terfenadine is a selective histamine H1-receptor antagonist which, in pharmacodynamic studies, is devoid of central nervous system depressant activity. In clinical studies terfenadine is well tolerated and at a dose of 60mg administered twice daily the drug provides effective relief of symptoms in patients with allerg...

journal_title：Drugs

authors： McTavish D,Goa KL,Ferrill M

更新日期：1990-04-01 00:00:00

abstract：:Endothelial dysfunction and increased arterial stiffness occur early in the pathogenesis of diabetic vasculopathy. They are both powerful independent predictors of cardiovascular risk. Advances in non-invasive methodologies have led to widespread clinical investigation of these abnormalities in diabetes mellitus, gene...

journal_title：Drugs

authors： Woodman RJ,Chew GT,Watts GF

更新日期：2005-01-01 00:00:00

abstract：:Pain is the main reason prompting patients to consult their physicians. In acute conditions, pain has a very particular significance as a warning sign, enabling the physician to attempt a diagnosis. Nevertheless, its detrimental effect upon the individual (even in the case of acute pain) and its cost to society are no...

journal_title：Drugs

authors： Brasseur L

更新日期：1997-01-01 00:00:00

abstract：:Oxatomide is an orally active H1-histamine receptor antagonist which, as appears to occur with some other antihistamines, also inhibits mast cell degranulation. Oxatomide has demonstrated response rates similar to those with other more established members of its drug class in a few studies of chronic urticaria and all...

journal_title：Drugs

authors： Richards DM,Brogden RN,Heel RC,Speight TM,Avery GS

更新日期：1984-03-01 00:00:00

abstract：:After surgery, patients try to minimise discomfort by various manoeuvres including change of posture, immobilisation of injured areas and use of analgesic drugs. The characteristic finding with drug use, revealed by permitting patients to titrate themselves with analgesic from a machine, is that the interindividual do...

journal_title：Drugs

authors： Bullingham RE

更新日期：1985-04-01 00:00:00

abstract：:This review focuses on the biochemical and clinical aspects of methylation in neuropsychiatric disorders and the clinical potential of their treatment with ademetionine (S-adenosylmethionine; SAMe). SAMe is required in numerous transmethylation reactions involving nucleic acids, proteins, phospholipids, amines and oth...

journal_title：Drugs

authors： Bottiglieri T,Hyland K,Reynolds EH

更新日期：1994-08-01 00:00:00

abstract：:Part I of this article reviewed the targets against which anti-HIV drugs can be directed, problems in assessing active compounds (e.g. resistance development and use of surrogate end-points). and nucleoside analogues effective against HIV reverse transcriptase. Intensive research is currently being undertaken in labor...

journal_title：Drugs

authors： Sandström E,Oberg B

更新日期：1993-05-01 00:00:00

abstract：:In a noncomparative trial, 73 adults with acute sinusitis confirmed by x-ray received cefixime 400mg once daily for approximately 10 days. At the end of treatment, 60 patients (82%) were cured, 2 (2.7%) had improved and 7 (9.6%) had failed therapy; 4 patients were not evaluable. No relapses were observed at follow-up....

journal_title：Drugs

authors： Gehanno P,Boucot I,Berche P,Uhlrich J

更新日期：1991-01-01 00:00:00

abstract：:Systemic therapy for advanced non-small cell lung cancer (NSCLC) has evolved over the last two decades, with modest improvements in quality of life and overall survival. A plateau has been reached with traditional chemotherapy, and efforts are now being directed at developing molecularly targeted agents. To date, thre...

journal_title：Drugs

authors： Triano LR,Deshpande H,Gettinger SN

更新日期：2010-01-01 00:00:00

abstract：:Temocillin is a novel injectable beta-lactam antibiotic designed for parenteral use. It is active against the majority of Gram-negative bacteria and is stable to a wide range of beta-lactamases. Disposition and metabolic studies on temocillin in animals and man demonstrate that the drug is well distributed throughout ...

journal_title：Drugs

authors： Cockburn A,Mellows G,Jackson D,White DJ

更新日期：1985-01-01 00:00:00

abstract：:Aflibercept (Eylea(®)) is an anti-vascular endothelial growth factor agent indicated for intravitreal use in the treatment of diabetic macular oedema. In patients with diabetic macular oedema, significantly greater improvements from baseline to week 52 in visual acuity were seen with intravitreal aflibercept versus ma...

journal_title：Drugs

authors： Keating GM

更新日期：2015-07-01 00:00:00

abstract：:The proton pump inhibitors (PPIs) are the most successful class of drugs that have been introduced for the treatment of gastro-oesophageal reflux disease (GORD) because of their profound and consistent effect on gastric acid secretion. The PPIs have demonstrated an excellent adverse effect profile after approximately ...

journal_title：Drugs

authors： Dekel R,Morse C,Fass R

更新日期：2004-01-01 00:00:00

abstract：UNLABELLED:Gatifloxacin is an 8-methoxy fluoroquinolone antibacterial agent. The drug has a broader spectrum of antibacterial activity than the older fluoroquinolones (e.g. ciprofloxacin) and shows good activity against many Gram-positive and Gram-negative pathogens, atypical organisms and some anaerobes. Notably, gati...

journal_title：Drugs

authors： Perry CM,Ormrod D,Hurst M,Onrust SV

更新日期：2002-01-01 00:00:00

abstract：:Cefpodoxime, the active de-esterified molecule of the orally absorbable cephalosporin cefpodoxime proxetil, inhibits streptococci, Neisseria spp., and most Enterobacteriaceae, with MIC50 and/or MIC90 values of less than or equal to 2 mg/L; with regard to the latter family of bacteria, the MIC50 and/or MIC90 values of ...

journal_title：Drugs

authors： Wiedemann B,Luhmer E,Zühlsdorf MT

更新日期：1991-01-01 00:00:00