Abstract:
:Allergic rhinitis represents a global health burden. The disease can seriously affect quality of life and is associated with multiple co-morbidities. Histamine and leukotrienes are important pro-inflammatory mediators in nasal allergic inflammation. Their actions on target cells are mediated through specific receptors and, consequently, molecules that block the binding of histamine and leukotrienes to their receptors have been important areas of pharmacological research. The published literature of the pathophysiology of histamine and leukotrienes, and the effects of histamine H(1)-receptor antagonists (H(1) antihistamines) and leukotriene antagonists in monotherapy or in combination therapy in the treatment of allergic rhinitis was reviewed. The presented results are based on the best available evidence. The efficacy of H(1) antihistamines and leukotriene antagonists (montelukast in particular) in allergic rhinitis has been established in numerous randomised placebo-controlled trials. Results from meta-analyses indicate that H(1) antihistamines and leukotriene antagonists are equally effective in improving symptoms of allergic rhinitis and quality of life, but that both drugs are less effective than intranasal corticosteroids. Data on the combination of H(1) antihistamines and leukotriene antagonists in allergic rhinitis are limited. The available evidence shows that a combined mediator inhibition has additional benefits over the use of each agent alone, but is still inferior to intranasal corticosteroids. More well designed studies are needed to fully understand the benefits of a concomitant use of these agents.
journal_name
Drugsjournal_title
Drugsauthors
Van Hoecke H,Vandenbulcke L,Van Cauwenberge Pdoi
10.2165/00003495-200767180-00006subject
Has Abstractpub_date
2007-01-01 00:00:00pages
2717-26issue
18eissn
0012-6667issn
1179-1950pii
67186journal_volume
67pub_type
杂志文章,评审相关文献
DRUGS文献大全abstract::Rheumatoid arthritis is a disease of unknown aetiology characterised by persistent joint swelling, functional disability and increased mortality. No curative therapy exists at present but some therapeutic agents, commonly referred to as disease-modifying drugs, offer the potential for suppression of the inflammatory a...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199856030-00003
更新日期:1998-09-01 00:00:00
abstract::With its approval more than 15 years ago, subcutaneous etanercept (Enbrel(®)) was the first biological disease-modifying antirheumatic drug (bDMARD) and the first tumour necrosis factor inhibitor to be approved for use in rheumatic diseases. Etanercept remains an important cost-effective treatment option in adult pati...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-014-0258-9
更新日期:2014-08-01 00:00:00
abstract::Entecavir (Baraclude) is a novel nucleoside analogue of 2'-deoxyguanosine whose intracellular triphosphate form inhibits replication of the hepatitis B virus (HBV). In large, randomised, double-blind, phase III clinical trials in patients with chronic HBV infection, oral entecavir 0.5 or 1.0mg once daily for up to 96 ...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200666120-00009
更新日期:2006-01-01 00:00:00
abstract::Treatment of idiopathic membranous nephropathy is based on a 'symptomatic' therapy that includes ACE inhibitors or angiotensin II receptor antagonists, and on an 'aetiological' therapy aimed at modulating underlying immunological mechanisms. The role of the latter is still debated given the usually indolent course of ...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200969100-00002
更新日期:2009-07-09 00:00:00
abstract:INTRODUCTION:Several pharmacological treatments aiming at a better symptomatic control of osteoarthritis (OA) are used in daily practice but their efficacy is often disputed. The purpose of this network meta-analysis (NMA) is to assess the efficacy on pain and function of the drugs that are most widely prescribed again...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-020-01423-8
更新日期:2020-12-01 00:00:00
abstract::The optimal pharmacological therapy of community-acquired pneumonia (CAP) is one of the most ardently debated issues in medicine. Presently, most guidelines recommend either a fluoroquinolone alone or dual therapy with a third-generation cephalosporin plus a macrolide in patients hospitalised with CAP, but few provide...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200565140-00004
更新日期:2005-01-01 00:00:00
abstract::Anagrelide (Agrylin, Xagrid) is an oral imidazoquinazoline agent which is indicated in Europe for the reduction of elevated platelet counts in at-risk patients with essential thrombocythaemia who are intolerant of or refractory to their current therapy, and in the US for the reduction of elevated platelet counts and t...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200666010-00006
更新日期:2006-01-01 00:00:00
abstract::ZD1839 ('Iressa') is an orally active, selective epidermal growth factor receptor-tyrosine kinase inhibitor which blocks signal transduction pathways implicated in the proliferation and survival of cancer cells and other host-dependent processes promoting cancer growth. In preclinical studies, ZD1839 produced reversib...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200060001-00004
更新日期:2000-01-01 00:00:00
abstract::Pentamidine is an aromatic diamidine derivative which has become one of the standard therapies for Pneumocystis carinii pneumonia (PCP), particularly in patients with acquired immunodeficiency syndrome (AIDS). However, with parenteral administration of the drug there is a high risk of toxicity. Inhaled pentamidine pro...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199039050-00008
更新日期:1990-05-01 00:00:00
abstract::Aripiprazole (Abilify®) is an atypical antipsychotic indicated for the treatment of mania associated with bipolar I disorder. It is unique in its class, as it is a partial agonist of dopamine D(2) and D(3), and serotonin 5-HT(1A) receptors and a modest antagonist of 5-HT(2A) receptors. This article reviews the pharmac...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/11208320-000000000-00000
更新日期:2012-01-01 00:00:00
abstract::Nabumetone is a nonsteroidal anti-inflammatory drug (NSAID) of the 2,6-disubstituted naphthylalkanone class. It is a prodrug metabolised to an active metabolite, 6-methoxy-2-naphthylacetic acid (6-MNA), which preferentially inhibits cyclo-oxygenase-2 (COX-2) and has both anti-inflammatory and analgesic properties. The...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:
更新日期:2000-01-01 00:00:00
abstract::The binding of drugs to proteins is an important pharmacokinetic parameter. Many methods are available for the study of drug protein binding phenomena and there are also many ways to interpret the binding data. Although much emphasis has been placed on the binding of drugs in the plasma, binding also takes place in th...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-198325050-00003
更新日期:1983-05-01 00:00:00
abstract::Cibenzoline is a class I antiarrhythmic drug with limited class III and IV activity which can be administered orally or intravenously. An elimination half-life of about 8 to 12 hours permits twice daily administration, although age and renal function must be considered when determining dosage. Cibenzoline has some act...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199243050-00008
更新日期:1992-05-01 00:00:00
abstract::HIV-associated wasting, characterised by progressive loss of lean body mass and bodyweight, remains a significant problem in the era of highly active antiretroviral therapy (HAART). Loss of body cell mass, a component of lean body mass, is associated with decreased survival. Somatropin (recombinant human growth hormon...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200666030-00014
更新日期:2006-01-01 00:00:00
abstract::Aminoglycosides are potent water-soluble antibiotics, with peak concentration-dependent bactericidal activity against many pathogenic aerobic Gram-negative bacilli and Staphylococcus aureus. For systemic therapy, they must be given parenterally (intravenously or intramuscularly). In the body they remain largely extrac...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199447060-00004
更新日期:1994-06-01 00:00:00
abstract::It is well documented that long term treatment with nonsteroidal anti-inflammatory drugs (NSAIDs) increases the risk of peptic ulcer and that gastroduodenal mucosal erosions can be demonstrated in volunteers within 1 week of treatment initiation. However, long term studies in nonsurgical patients have not documented g...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199200445-00006
更新日期:1992-01-01 00:00:00
abstract::Evidence suggests that arterial hypertension, in addition to being a cardiovascular and renal risk factor, may also be associated with an impairment of male sexual function. Since other cardiovascular risk factors, especially diabetes mellitus, have also been shown to correlate with impaired sexual function it has bee...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200565060-00005
更新日期:2005-01-01 00:00:00
abstract::Accumulating evidence suggests the involvement of estrogen in depression. Estrogen can modulate neurotransmitter turnover, enhancing the levels of serotonin and noradrenaline (norepinephrine), and it is involved in the regulation of serotonin receptor number and function. Across the female reproductive life, fluctuati...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/11635960-000000000-00000
更新日期:2012-09-10 00:00:00
abstract::Amiodarone is a class III antiarrhythmic drug with sympatholytic properties, which prolongs the refractory period of all cardiac tissues, depresses sinus node automaticity and atrioventricular nodal conduction. It is active on all cardiac arrhythmias, its use being limited by the risk of side effects, mainly extracard...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199100412-00009
更新日期:1991-01-01 00:00:00
abstract::A number of new agents for the management of chronic obstructive pulmonary disease (COPD) are at different stages of development, including several inhaled long-acting antimuscarinics (LAMA). Long-acting bronchodilators are considered to be central to the management of COPD due to the evidence supporting their efficac...
journal_title:Drugs
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s40265-015-0532-5
更新日期:2016-03-01 00:00:00
abstract::Invasive candidiasis has emerged as an important cause of morbidity and mortality in intensive care unit patients. This short review focuses on many aspects of Candida infection in critically ill patients including epidemiology, impact on mortality, problems related to diagnosis, strategies to identify patients at ris...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/11315590-000000000-00000
更新日期:2009-01-01 00:00:00
abstract::Trifluridine/tipiracil (Lonsurf(®)) is a novel, orally active, antimetabolite agent comprised of trifluridine, a thymidine-based nucleoside analogue, and tipiracil, a potent thymidine phosphorylase inhibitor. Trifluridine is incorporated into DNA via phosphorylation, ultimately inhibiting cell proliferation. Tipiracil...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-016-0633-9
更新日期:2016-09-01 00:00:00
abstract::Trifluridine (trifluorothymidine) is an antiviral agent for topical use in the eye, and is structurally related to idoxuridine. In vitro studies have shown that it effectively inhibits the replication of herpes simplex virus type 1, which causes primary keratoconjunctivitis and recurrent epithelial keratitis in man. I...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-198223050-00001
更新日期:1982-05-01 00:00:00
abstract::Sulbactam 1g and ampicillin 2g were administered intravenously to 12 patients, and concentrations of the drugs were determined in the serum and myometrium for up to 120 minutes after infusion. The ratio of sulbactam to ampicillin was about 1:2 in the serum and myometrium. Both drugs penetrated well into the myometrium...
journal_title:Drugs
pub_type: 杂志文章
doi:10.2165/00003495-198600312-00007
更新日期:1986-01-01 00:00:00
abstract::An enteral suspension (ES)/intestinal gel formulation of levodopa/carbidopa (hereafter referred to as levodopa/carbidopa ES) [Duodopa® (EU); Duopa™ (USA)] has been developed to overcome the fluctuating plasma levodopa concentrations associated with oral levodopa/carbidopa formulations. In various countries, including ...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-019-01201-1
更新日期:2019-10-01 00:00:00
abstract::Although vascular smooth muscle cells (SMCs) play a key role in the development of atherosclerotic lesions, they are not a homogeneous cell type. Myosin has been used as a marker of SMC differentiation in order to identify distinct SMC populations in the adult rabbit aorta. The medial layer of the normal adult aorta c...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199400481-00003
更新日期:1994-01-01 00:00:00
abstract::Glaucoma, a group of progressive optic neuropathies with similar patterns of tissue loss, is primarily treated with medical therapy, followed by laser therapy and, later, incisional surgery. Aside from the introduction of prostaglandin analogs, topical carbonic anhydrase inhibitors, and topical alpha-agonists in the 1...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-019-01130-z
更新日期:2019-07-01 00:00:00
abstract::Migalastat (Galafold™)-a small molecule drug developed by Amicus Therapeutics that restores the activity of specific mutant forms of α-galactosidase-has been approved for the treatment of Fabry disease in the EU in patients with amenable mutations. Fabry disease is a rare disorder that results in a deficiency or absen...
journal_title:Drugs
pub_type: 杂志文章
doi:10.1007/s40265-016-0607-y
更新日期:2016-07-01 00:00:00
abstract::Grapefruit juice and grapefruit product consumption have potential health benefits; however, their intake is also associated with interactions with certain drugs, including calcium channel blockers, immunosuppressants and antihistamines. The primary mechanism through which interactions are mediated is mechanism-based ...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/11585250-000000000-00000
更新日期:2010-12-24 00:00:00
abstract::Safety data have been gathered in US clinical trials of nabumetone on 1912 patients from August 1981 to May 1988. Dosing in the double-blind trials was 100 mg at bedtime, but in open-label trials patients could increase the dosage of nabumetone to 1500 or 2000 mg if required. Adverse experiences reported in the double...
journal_title:Drugs
pub_type: 临床试验,杂志文章
doi:10.2165/00003495-199000405-00008
更新日期:1990-01-01 00:00:00