Abstract:
:Grapefruit juice and grapefruit product consumption have potential health benefits; however, their intake is also associated with interactions with certain drugs, including calcium channel blockers, immunosuppressants and antihistamines. The primary mechanism through which interactions are mediated is mechanism-based intestinal cytochrome P450 3A4 inhibition by furanocoumarins resulting in increased bioavailability of administered medications that are substrates. Grapefruit products have also been associated with interactions with P-glycoprotein (P-gp) and uptake transporters (e.g. organic anion-transporting polypeptides [OATPs]). Polyphenolic compounds such as flavonoids have been proposed as the causative agents of the P-gp and OATP interactions. The mechanisms and magnitudes of the interactions can be influenced by the concentrations of furanocoumarins and flavonoids in the grapefruit product, the volume of juice consumed, and the inherent variability of specific enzymes and transporter components in humans. It is therefore challenging to predict the extent of grapefruit product-drug interactions and to compare available in vitro and in vivo data. The clinical significance of such interactions also depends on the disposition and toxicity profile of the drug being administered. The aim of this review is to outline the mechanisms of grapefruit-drug interactions and present a comprehensive summary of those agents affected and whether they are likely to be of clinical relevance.
journal_name
Drugsjournal_title
Drugsauthors
Seden K,Dickinson L,Khoo S,Back Ddoi
10.2165/11585250-000000000-00000subject
Has Abstractpub_date
2010-12-24 00:00:00pages
2373-407issue
18eissn
0012-6667issn
1179-1950pii
4journal_volume
70pub_type
杂志文章,评审相关文献
DRUGS文献大全abstract::Developments in drug delivery technology have expanded the formulations of 5-aminosalicylic acid (5-ASA) available to clinicians over the last 50 years. Delivery of adequate doses of 5-ASA to the colon can be achieved by pH-dependent, delayed-release or pro-drug formulations. Despite some variations in the pharmacokin...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200868080-00006
更新日期:2008-01-01 00:00:00
abstract::Alzheimer's disease (AD) is the most common age-related neurodegenerative disease and has become an urgent public health problem in most areas of the world. Substantial progress has been made in understanding the basic neurobiology of AD and, as a result, new drugs for its treatment have become available. Cholinestera...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200161010-00005
更新日期:2001-01-01 00:00:00
abstract::Sitagliptin (Januvia(®), Xelevia™, Glactiv(®), Tesavel(®)) is an orally administered, potent and highly selective inhibitor of dipeptidyl peptidase-4 (DPP-4) and was the first agent of its class to be approved for use in the management of adults with type 2 diabetes. Numerous randomized placebo- or active comparator-c...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-013-0169-1
更新日期:2014-02-01 00:00:00
abstract::Osteoporosis is a systemic bone disease characterized by low bone mass and bone mineral density, and deterioration of the underlying structure of bone tissue. These changes lead to an increase in bone fragility and an increased risk for fracture, which are the clinical consequences of osteoporosis. The classical triad...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/11587570-000000000-00000
更新日期:2011-01-01 00:00:00
abstract::We have analysed the published literature on eptacog alfa (recombinant factor VIIa; rFVIIa) for nonhaemophiliac conditions with the aim of determining its current place in therapy. Initial surgical and/or medical management is required for any patient with life-threatening bleeding. In those with continued life-threat...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200868120-00005
更新日期:2008-01-01 00:00:00
abstract::Alterations of skin and hair pigmentation are important features that have warranted treatment from ancient history on up to modern time. In some cultures, even today patients with vitiligo are regarded as social outcasts and are affected considerably both emotionally and physically. This article presents current opti...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200464010-00006
更新日期:2004-01-01 00:00:00
abstract::Meticillin-resistant Staphylococcus aureus (MRSA) is an important cause of infection, particularly in hospitalized patients and those with significant healthcare exposure. In recent years, epidemic community-associated MRSA (CA-MRSA) infections occurring in patients without healthcare risk factors have become more fre...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200969060-00004
更新日期:2009-01-01 00:00:00
abstract::The geminal bisphosphonates are a new class of drugs characterised by a P-C-P bond. Consequently, they are analogues of pyrophosphate, but are resistant to chemical and enzymatic hydrolysis. The bisphosphonates bind strongly to hydroxyapatite crystals and inhibit their formation and dissolution. This physicochemical e...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199142060-00003
更新日期:1991-12-01 00:00:00
abstract::Effective control of variceal rebleeding (secondary prophylaxis) or prevention of the initial bleeding (primary prophylaxis) are the main objectives of the treatment of portal hypertension. Endoscopic sclerotherapy is the treatment of choice for secondary prophylaxis, since it significantly decreases rebleeding and, t...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199200442-00007
更新日期:1992-01-01 00:00:00
abstract::Brexpiprazole (Rexulti®) is an atypical antipsychotic that has been developed by Otsuka Pharmaceutical Co. Ltd and H. Lundbeck A/S as an oral treatment for several psychiatric disorders. Brexpiprazole is a novel serotonin-dopamine activity modulator that acts as a partial agonist of serotonin 1A (5-HT1A) and dopamine ...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-015-0462-2
更新日期:2015-09-01 00:00:00
abstract::A new formulation of paclitaxel, 130-nanometre albumin-bound paclitaxel (nab-paclitaxel), solubilises hydrophobic paclitaxel and may increase paclitaxel delivery to tumour cells. Intravenous nab-paclitaxel 260 mg/m(2) had a higher maximum whole-blood concentration, shorter time to peak concentration, larger distributi...
journal_title:Drugs
pub_type: 杂志文章
doi:10.2165/00003495-200666070-00007
更新日期:2006-01-01 00:00:00
abstract::Etoposide is one of the most active agents for the therapy of lymphomas. Oral etoposide has proven to be active in and clearly beneficial for patients with previously treated lymphomas. The optimal dose and schedule of oral etoposide for use in combination chemotherapy are still uncertain, but low daily doses (50 to 1...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199958003-00006
更新日期:1999-01-01 00:00:00
abstract::Involuntary infertility is an increasing problem in this era of delayed childbearing. Fortunately, many advances have been made recently in the medical and surgical treatment of infertility. This article reviews the principal aetiologies of infertility and their treatments, and focuses on the current and future uses o...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-198632020-00004
更新日期:1986-08-01 00:00:00
abstract::Lefamulin is a novel oral and intravenous (IV) pleuromutilin developed as a twice-daily treatment for community-acquired bacterial pneumonia (CABP). It is a semi-synthetic pleuromutilin with a chemical structure that contains a tricyclic core of five-, six-, and eight-membered rings and a 2-(4-amino-2-hydroxycyclohexy...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-020-01443-4
更新日期:2020-11-28 00:00:00
abstract::Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV‑2), is now a global pandemic. This virus primarily affects the respiratory tract and causes lung injury characterized by acute respiratory distress syndrome. Although the pathophysiology of COVID-19 is not yet clea...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-020-01377-x
更新日期:2020-10-01 00:00:00
abstract::The disposition of many drugs in cystic fibrosis is abnormal. In general, changes in pharmacokinetics include: increased volume of distribution, decreased plasma concentration, and enhanced renal and sometimes non-renal elimination of drugs. Pathophysiology of the disease important for drug disposition includes: (a) h...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-198835050-00004
更新日期:1988-05-01 00:00:00
abstract::This article is a review of the principal drug-induced psychiatric symptoms that are likely to be encountered in daily clinical practice as a result of drug abuse, overdoses or side effects of drugs prescribed for treatment. Many categories of medication have the potential to produce psychiatric symptoms, but antitube...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-198122010-00004
更新日期:1981-07-01 00:00:00
abstract::Intravenous peramivir (Alpivab™; Rapivab®; Rapiacta®; PeramiFlu®), the most recent globally approved inhibitor of influenza neuraminidase, is indicated for the treatment of uncomplicated influenza in adults and children from the age of 2 years. This article, written from an EU perspective, reviews the clinical use of ...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-018-0981-8
更新日期:2018-09-01 00:00:00
abstract::Lung function can be reduced not only by a non-selective beta-blocker but also by a selective beta1-receptor blocker. If both types of drug are without intrinsic sympathomimetic activity, the effect of the non-selective drug is more pronounced than that of a beta1-receptor selective drug under basal conditions. The ef...
journal_title:Drugs
pub_type: 临床试验,杂志文章
doi:10.2165/00003495-197600111-00035
更新日期:1976-01-01 00:00:00
abstract::The European Commission and the European Parliament have acknowledged the specific need for a proper evaluation of new drugs in children. The evaluation of the antiepileptic drugs (AEDs) available on the market illustrates the deficit in therapeutic trials for childhood epilepsy syndromes. Currently, the development o...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200868010-00002
更新日期:2008-01-01 00:00:00
abstract::Amiodarone is a class III antiarrhythmic drug with sympatholytic properties, which prolongs the refractory period of all cardiac tissues, depresses sinus node automaticity and atrioventricular nodal conduction. It is active on all cardiac arrhythmias, its use being limited by the risk of side effects, mainly extracard...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199100412-00009
更新日期:1991-01-01 00:00:00
abstract::The clinical and bacteriological efficacy and adverse reactions of ofloxacin vs trimethoprim-sulphamethoxazole were investigated in a double-blind, randomised study in 250 female patients (125 in each group) with acute, uncomplicated lower urinary tract infections. The dosages of ofloxacin and trimethoprim-sulphametho...
journal_title:Drugs
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2165/00003495-198700341-00022
更新日期:1987-01-01 00:00:00
abstract::Subcutaneous dulaglutide (Trulicity®) is a once-weekly glucagon-like peptide-1 receptor agonist that is approved in numerous countries as an adjunct to diet and exercise for the treatment of adults with type 2 diabetes (T2D). In the clinical trial and real-world settings, once-weekly subcutaneous dulaglutide, as monot...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-020-01260-9
更新日期:2020-02-01 00:00:00
abstract::Acamprosate (calcium acetylhomotaurinate), a synthetic compound with a similar chemical structure to that of gamma-aminobutyric acid, is thought to act via several mechanisms affecting multiple neurotransmitter systems; inhibition of neuronal hyperexcitability by antagonism of excitatory amino acid activity and reduct...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199753060-00008
更新日期:1997-06-01 00:00:00
abstract::Lemborexant (DAYVIGO™) is an orally administered, dual orexin receptor (OXR) antagonist that exhibits reversible competitive antagonism at OXR1 and OXR2 (> affinity at OXR2) that was discovered and developed by Eisai Inc. for the treatment of adult patients with insomnia. In December 2019, lemborexant received its fir...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-020-01276-1
更新日期:2020-03-01 00:00:00
abstract::Nivolumab (Opdivo(®)) is a fully human monoclonal antibody against programmed death receptor-1, a negative regulatory checkpoint molecule with a role in immunosuppression. The drug is administered intravenously and is approved for the treatment of unresectable malignant melanoma in Japan. The potential for intravenous...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-014-0234-4
更新日期:2014-07-01 00:00:00
abstract::Damoctocog alfa pegol (Jivi®) is approved in the USA, EU, Japan and Canada for the treatment and prophylaxis of previously treated patients aged ≥ 12 years with haemophilia A. Formulated with a 60 kDa polyethylene glycol (PEG) moiety, damoctocog alfa pegol is an intravenously (IV) administered recombinant factor VIII ...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-019-01152-7
更新日期:2019-07-01 00:00:00
abstract::The original article can be found online. ...
journal_title:Drugs
pub_type: 已发布勘误
doi:10.1007/s40265-020-01407-8
更新日期:2020-09-01 00:00:00
abstract::Botulinum neurotoxin type A (BTX-A) weakens voluntary muscle strength and is an effective therapy for focal dystonia, including cervical dystonia (CD) and benign essential blepharospasm (BEB). It is also known to relieve hemifacial spasm and focal spasticity in children and adults. In addition, BTX-A has been shown to...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200767050-00003
更新日期:2007-01-01 00:00:00
abstract::MenB-FHbp (bivalent rLP2086; Trumenba®) is a recombinant protein-based vaccine targeting Neisseria meningitidis serogroup B (MenB), which has recently been licensed in the EU for active immunization to prevent invasive disease caused by MenB in individuals ≥ 10 years of age. The vaccine, which contains a variant from ...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-018-0869-7
更新日期:2018-02-01 00:00:00