Management of Thrombotic Complications in COVID-19: An Update.

abstract：:Grapefruit juice and grapefruit product consumption have potential health benefits; however, their intake is also associated with interactions with certain drugs, including calcium channel blockers, immunosuppressants and antihistamines. The primary mechanism through which interactions are mediated is mechanism-based ...

journal_title：Drugs

authors： Seden K,Dickinson L,Khoo S,Back D

更新日期：2010-12-24 00:00:00

abstract：:Pegylation of interferon-alpha-2a is associated with improved sustained virological response rates in patients with chronic hepatitis C. Subsequently, combination therapy with peginterferon-alpha-2a (40kD) [Pegasys] and ribavirin (Copegus trade mark, Rebetol) was investigated to establish if the efficacy of peginterfe...

journal_title：Drugs

authors： Keating GM,Curran MP

更新日期：2003-01-01 00:00:00

abstract：:Tofacitinib (Xeljanz®) is a potent, selective JAK inhibitor that preferentially inhibits Janus kinase (JAK) 1 and JAK3. In the EU, oral tofacitinib 5 mg twice daily is indicated for the treatment of moderate to severe active rheumatoid arthritis (RA) in adult patients who have responded inadequately to, or who are int...

journal_title：Drugs

authors： Dhillon S

更新日期：2017-12-01 00:00:00

abstract：:Sulbactam is a semisynthetic beta-lactamase inhibitor which when combined with certain beta-lactam antibacterials extends their activity against bacteria that are normally resistant to the antibiotic due to production of beta-lactamases. In combination with ampicillin it extends the antibacterial activity of ampicilli...

journal_title：Drugs

authors： Campoli-Richards DM,Brogden RN

更新日期：1987-06-01 00:00:00

abstract：:In a double-blind, crossover study we have investigated the effect of nedocromil sodium on neurokinin A (NKA)-induced bronchoconstriction in asthmatics. 12 patients with mild asthma inhaled either nedocromil sodium 4mg or placebo, on 2 separate days, as 2 puffs from a metered-dose aerosol 30 minutes before challenge w...

journal_title：Drugs

authors： Joos GF,Pauwels RA,Van der Straeten ME

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND:While a variety of intervention options have been described for pemphigus vulgaris, the optimal treatment strategy has not been established. OBJECTIVES:The objective of this systematic review is to assess the literature on the efficacy and safety of interventions for the treatment of pemphigus vulgaris. DA...

journal_title：Drugs

authors： Zhao CY,Murrell DF

更新日期：2015-02-01 00:00:00

abstract：:Patients with viral infections of the central nervous system (CNS) may present with a variety of neurological symptoms, most commonly dominated by either encephalitis or meningitis. The aetiological panorama varies in different parts of the world as well as over time. Thus, virological first-line diagnostics must be a...

journal_title：Drugs

authors： Studahl M,Lindquist L,Eriksson BM,Günther G,Bengner M,Franzen-Röhl E,Fohlman J,Bergström T,Aurelius E

更新日期：2013-02-01 00:00:00

abstract：:Utilising a modified fixed-dose, 4 x 3 factorial design, the antihypertensive effects of all combinations of 4 doses of pinacidil (0, 12.5, 25 and 37.5 mg bid) with 3 doses of hydrochlorothiazide (0, 12.5 and 25 mg bid) were studied in patients with supine diastolic blood pressure of 95 to 110mm Hg. The decreases in s...

journal_title：Drugs

authors： Goldberg MR,Offen WW

更新日期：1988-01-01 00:00:00

abstract：:Glaucoma, a group of progressive optic neuropathies with similar patterns of tissue loss, is primarily treated with medical therapy, followed by laser therapy and, later, incisional surgery. Aside from the introduction of prostaglandin analogs, topical carbonic anhydrase inhibitors, and topical alpha-agonists in the 1...

journal_title：Drugs

authors： Schehlein EM,Robin AL

更新日期：2019-07-01 00:00:00

abstract：:Pentamidine is an aromatic diamidine derivative which has become one of the standard therapies for Pneumocystis carinii pneumonia (PCP), particularly in patients with acquired immunodeficiency syndrome (AIDS). However, with parenteral administration of the drug there is a high risk of toxicity. Inhaled pentamidine pro...

journal_title：Drugs

authors： Monk JP,Benfield P

更新日期：1990-05-01 00:00:00

abstract：:In type 1 and 2 diabetes mellitus patients, hyperglycaemia is independently related to the development of microvascular and macrovascular complications. Glycaemic targets and the benefits of intensive versus conventional glucose control are under debate. The purpose of this review is to provide an overview of the rand...

journal_title：Drugs

authors： Mattila TK,de Boer A

更新日期：2010-12-03 00:00:00

abstract：:Methylnaltrexone is a selective mu-opioid receptor antagonist that has restricted ability to cross the blood-brain barrier, thus enabling reversal of opioid-induced peripheral effects, such as constipation, without affecting the central effects, such as pain relief. Treatment with subcutaneous methylnaltrexone 0.15-0....

journal_title：Drugs

authors： Garnock-Jones KP,McKeage K

更新日期：2010-05-07 00:00:00

abstract：UNLABELLED:5-Methoxypsoralen, a naturally occurring linear furocoumarin, has been successfully used in combination with ultraviolet (UV) A irradiation [psoralen plus UV (PUVA)] to manage psoriasis and vitiligo. In patients and volunteers, PUVA 5-methoxypsoralen causes a dose-related increase in cutaneous photosensitivi...

journal_title：Drugs

authors： McNeely W,Goa KL

更新日期：1998-10-01 00:00:00

abstract：:Empagliflozin/linagliptin (Glyxambi(®)) is a once-daily sodium glucose co-transporter type 2 (SGLT2) inhibitor and dipeptidyl peptidase (DPP)-4 inhibitor fixed-dose combination product that is approved in the USA as an adjunct to diet and exercise in adults with type 2 diabetes (T2D) when treatment with both empaglifl...

journal_title：Drugs

authors： Kim ES,Deeks ED

更新日期：2015-09-01 00:00:00

abstract：:Buflomedil hydrochloride is a vasoactive drug with a variety of pharmacodynamic properties. Importantly, it seems to improve nutritional blood flow in ischaemic tissue of patients with peripheral and/or cerebral vascular disease by a combination of pharmacological effects: inhibition of alpha-adrenoceptors, inhibition...

journal_title：Drugs

authors： Clissold SP,Lynch S,Sorkin EM

更新日期：1987-05-01 00:00:00

abstract：:In human lung tissue in vitro, nedocromil sodium inhibited the release of histamine and leukotrienes induced by anti-IgE, as well as the contraction of isolated bronchi which followed this challenge. In the hamster cheek pouch in vivo, nedocromil sodium inhibited the inflammatory response induced by challenge with eit...

journal_title：Drugs

authors： Dahlén SE,Björck T,Kumlin M,Sydbom A,Raud J,Palmertz U,Franzén L,Grönneberg R,Hedqvist P

更新日期：1989-01-01 00:00:00

abstract：UNLABELLED:Gatifloxacin is an 8-methoxy fluoroquinolone antibacterial agent. The drug has a broader spectrum of antibacterial activity than the older fluoroquinolones (e.g. ciprofloxacin) and shows good activity against many Gram-positive and Gram-negative pathogens, atypical organisms and some anaerobes. Notably, gati...

journal_title：Drugs

authors： Perry CM,Ormrod D,Hurst M,Onrust SV

更新日期：2002-01-01 00:00:00

abstract：:Significant progress has been made in the battle against transmission of HIV-1 from mother to infant. Antiretroviral regimens covering the later part of gestation, labour and the first few weeks of neonatal life have shown great efficacy in reducing such transmission. With the advent of combination antiretroviral ther...

journal_title：Drugs

authors： Kourtis AP

更新日期：2002-01-01 00:00:00

abstract：UNLABELLED:Darunavir is an oral nonpeptidic HIV-1 protease inhibitor (PI) that is used, together with a low boosting dose of ritonavir, as part of an antiretroviral therapy (ART) regimen in treatment-experienced and -naive patients with HIV-1 infection. Compared with early-generation PIs, boosted darunavir has a high g...

journal_title：Drugs

authors： McKeage K,Perry CM,Keam SJ

更新日期：2009-01-01 00:00:00

abstract：:Chenodeoxycholic acid (chenic acid; CDCA) is 1 of the 3 major biliary bile acids in man. When administered in pharmacological doses it causes a decrease in cholesterol saturation of bile, which in turn may lead to gradual dissolution of cholesterol gallstones. The stone dissolution rate during CDCA therapy has varied ...

journal_title：Drugs

authors： Iser JH,Sali A

更新日期：1981-02-01 00:00:00

abstract：:The cardiovascular and cardiorenal disease continuum comprises the transition from cardiovascular risk factors to endothelial dysfunction and atherosclerosis, to clinical complications such as myocardial infarction (MI) and stroke, to the development of persistent target-organ damage and, ultimately, to chronic conges...

journal_title：Drugs

authors： Werner C,Pöss J,Böhm M

更新日期：2010-07-09 00:00:00

abstract：:Hypertension affects 65 million people in the US, and is a major cause of morbidity and mortality, but less than one-third of patients with hypertension are treated to goal blood pressure. Multiple factors have been cited, and include suboptimal adherence to treatment and lifestyle modifications, limited access to hea...

journal_title：Drugs

authors： Mustone Alexander L

更新日期：2006-01-01 00:00:00

abstract：:HMG-CoA reductase inhibitors (statins) have been shown to reduce mortality and cardiovascular morbidity in patients with hyperlipidaemia and those with coronary artery disease. However, evidence for statin treatment in patients with chronic heart failure (CHF) remains a subject of debate. Patients with heart failure w...

journal_title：Drugs

authors： Laufs U,Custodis F,Böhm M

更新日期：2006-01-01 00:00:00

abstract：:The rapid spread of human immunodeficiency virus (HIV) infections and the grim outcome of these infections have focused interest on the possibilities for medical intervention. The end-stage of these infections, acquired immune deficiency syndrome (AIDS), was first recognised in 1981, and the causative agent isolated i...

journal_title：Drugs

authors： Sandström EG,Kaplan JC

更新日期：1987-09-01 00:00:00

abstract：:Pregabalin, the pharmacologically active S-enantiomer of 3-aminomethyl-5-methyl-hexanoic acid, has a similar pharmacological profile to that of its developmental predecessor gabapentin, but showed greater analgesic activity in rodent models of neuropathic pain. The exact mechanism of action of pregabalin is unclear, a...

journal_title：Drugs

authors： Frampton JE,Scott LJ

更新日期：2004-01-01 00:00:00

abstract：:Gastro-oesophageal reflux disease (GORD or GERD) is a very common disorder, and advancement in drug development over the years has markedly improved disease management. Proton pump inhibitors (PPIs) remain the mainstay of treatment for GERD due to their profound and consistent inhibitory effect on acid secretion. Howe...

journal_title：Drugs

authors： Hershcovici T,Fass R

更新日期：2011-12-24 00:00:00

abstract：:A new formulation of paclitaxel, 130-nanometre albumin-bound paclitaxel (nab-paclitaxel), solubilises hydrophobic paclitaxel and may increase paclitaxel delivery to tumour cells. Intravenous nab-paclitaxel 260 mg/m(2) had a higher maximum whole-blood concentration, shorter time to peak concentration, larger distributi...

journal_title：Drugs

authors： Robinson DM,Keating GM

更新日期：2006-01-01 00:00:00

abstract：:Schistosomiasis, a grave and debilitating disease of socioeconomic importance, is increasing in incidence despite concerted efforts to control and contain the disease in all the endemic areas. While a multipronged method of control using health education, sanitation and snail control has been used, chemotherapy and ch...

journal_title：Drugs

authors： Shekhar KC

更新日期：1991-09-01 00:00:00

abstract：:Increases in cancer diagnosis have tremendous negative impacts on patients and their families, and major societal and economic costs. The beneficial effect of chemotherapeutic agents on tumor suppression comes with major unwanted side effects such as weight and hair loss, nausea and vomiting, and neuropathic pain. Che...

journal_title：Drugs

authors： Blanton HL,Brelsfoard J,DeTurk N,Pruitt K,Narasimhan M,Morgan DJ,Guindon J

更新日期：2019-06-01 00:00:00

abstract：:Globally, tuberculosis (TB) and HIV interact in deadly synergy. The high burden of TB among HIV-infected individuals underlies the importance of TB diagnosis, treatment and prevention for clinicians involved in HIV care. Despite expanding access to antiretroviral therapy (ART) to treat HIV infection in resource-limite...

journal_title：Drugs

authors： Venkatesh KK,Swaminathan S,Andrews JR,Mayer KH

更新日期：2011-06-18 00:00:00