Abstract:
:Tofacitinib (Xeljanz®) is a potent, selective JAK inhibitor that preferentially inhibits Janus kinase (JAK) 1 and JAK3. In the EU, oral tofacitinib 5 mg twice daily is indicated for the treatment of moderate to severe active rheumatoid arthritis (RA) in adult patients who have responded inadequately to, or who are intolerant of, one or more DMARDs. Several clinical studies of ≤ 24 months' duration showed that tofacitinib monotherapy (as first- or second-line treatment) and combination therapy with a conventional synthetic DMARD (csDMARD; as second- or third-line treatment) was effective in reducing signs and symptoms of disease and improving health-related quality of life (HR-QOL), with benefits sustained during long-term therapy (≤ 96 months). Tofacitinib monotherapy inhibited progression of structural damage in methotrexate-naïve patients during ≤ 24 months' treatment, with beneficial effects also seen in patients receiving tofacitinib plus methotrexate as second-line therapy for 12 months. Tofacitinib was generally well tolerated during ≤ 114 months' treatment, with most adverse events of mild or moderate severity. The tolerability profile of tofacitinib was generally similar to that of biological DMARDs (bDMARDs), with infections and infestations the most common adverse events (AEs) in tofacitinib recipients. However, the incidence of herpes zoster (HZ) was higher with tofacitinib than in the general RA population, although infections were clinically manageable. When added to background methotrexate, tofacitinib was noninferior to adalimumab in terms of efficacy, and both combination therapies had generally similar tolerability profiles. Although additional comparative studies are needed to more definitively position tofacitinib relative to bDMARDs and other targeted synthetic DMARDs, current evidence indicates that oral tofacitinib is a useful option for the treatment of patients with RA.
journal_name
Drugsjournal_title
Drugsauthors
Dhillon Sdoi
10.1007/s40265-017-0835-9subject
Has Abstractpub_date
2017-12-01 00:00:00pages
1987-2001issue
18eissn
0012-6667issn
1179-1950pii
10.1007/s40265-017-0835-9journal_volume
77pub_type
杂志文章,评审相关文献
DRUGS文献大全abstract::74 cirrhotic patients with a history of variceal or gastric bleeding were randomly assigned to treatment with propranolol (40 to 360 mg/day) or placebo. The patients were all in good condition and doses of propranolol were titrated until a 25% reduction in heart rate was achieved. After 2 years, the cumulative percent...
journal_title:Drugs
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2165/00003495-198900372-00006
更新日期:1989-01-01 00:00:00
abstract::Flecainide is a Class I antiarrhythmic drug of the local anaesthetic type. It can be given either intravenously or orally and its pharmacokinetic properties allow relatively long (12 hours) dosing intervals with oral administration. In several open and a few controlled therapeutic trials, orally administered flecainid...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-198529010-00001
更新日期:1985-01-01 00:00:00
abstract::Cenobamate (XCOPRI®) is an oral, small molecule neurotherapeutic azole compound that is being developed by SK Life Science Inc. and Arvelle Therapeutics for the treatment of epilepsy. Based on results of two pivotal phase 2 trials, cenobamate was recently approved in the USA for use in the treatment of partial-onset s...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-019-01250-6
更新日期:2020-01-01 00:00:00
abstract::Nabumetone is a nonsteroidal anti-inflammatory drug (NSAID) of the 2,6-disubstituted naphthylalkanone class. It is a prodrug metabolised to an active metabolite, 6-methoxy-2-naphthylacetic acid (6-MNA), which preferentially inhibits cyclo-oxygenase-2 (COX-2) and has both anti-inflammatory and analgesic properties. The...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:
更新日期:2000-01-01 00:00:00
abstract::Pimavanserin (Nuplazid™) is a selective and potent serotonin 2A (5-HT2A) receptor inverse agonist and antagonist developed by ACADIA Pharmaceuticals that has been approved in the US as a treatment for patients with hallucinations and delusions associated with Parkinson's disease psychosis. Up to 60 % of patients with ...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-016-0597-9
更新日期:2016-07-01 00:00:00
abstract::Restless legs syndrome (RLS) is characterised by an urge to move the legs, uncomfortable sensations in the legs and worsening of these symptoms during rest with at least temporary relief brought on by activity. RLS occurs in 3-15% of the general population and in 10-30% of patients on maintenance dialysis. RLS may lea...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200666050-00003
更新日期:2006-01-01 00:00:00
abstract::Venous thromboembolism (VTE) is a major cause of morbidity, mortality, and healthcare expenditure. In the United States, approximately 0.1 % of the population experiences an initial VTE event each year. Anticoagulation therapy is the cornerstone of acute VTE treatment and for prevention of recurrent VTE events. Conven...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-014-0301-x
更新日期:2014-11-01 00:00:00
abstract::After surgery, patients try to minimise discomfort by various manoeuvres including change of posture, immobilisation of injured areas and use of analgesic drugs. The characteristic finding with drug use, revealed by permitting patients to titrate themselves with analgesic from a machine, is that the interindividual do...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-198529040-00004
更新日期:1985-04-01 00:00:00
abstract:UNLABELLED:Oral delayed-release mesalazine is an enteric-coated formulation which releases mesalazine in the terminal ileum and colon. Up to 74% of patients with mild to moderately active ulcerative colitis experience endoscopic or symptomatic improvement (including remission) or both when treated with oral delayed-rel...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199957030-00013
更新日期:1999-03-01 00:00:00
abstract:UNLABELLED:Dofetilide is a 'pure' class III antiarrhythmic agent which has demonstrated efficacy in the conversion of atrial fibrillation or flutter to sinus rhythm and the maintenance of sinus rhythm. By blocking the rapid component of the cardiac delayed rectifier potassium current (I(Kr)), dofetilide prolongs the ca...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199958060-00007
更新日期:1999-12-01 00:00:00
abstract:UNLABELLED:Almotriptan is a selective serotonin 5-HT(1B/1D) receptor agonist ('triptan'). Its efficacy and tolerability have been assessed in a number of randomised, controlled trials in over 4800 adults with moderate or severe attacks of migraine. Oral almotriptan has a rapid onset of action (significant headache reli...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200262020-00010
更新日期:2002-01-01 00:00:00
abstract::Lapatinib (Tyverb, Tykerb) is an orally active, small molecule, reversible, dual tyrosine kinase inhibitor of human epidermal growth factor receptor type 1 (HER1) and type 2 (HER2). In the EU, lapatinib in combination with capecitabine is indicated for the treatment of women with HER2-overexpressing, advanced or metas...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/11203240-000000000-00000
更新日期:2009-10-22 00:00:00
abstract::Pruritus is a common complication of end-stage renal disease (ESRD), affecting about one-third of dialysis patients. It is a chronic, unpleasant symptom with a strong negative impact on patients' quality of life, often inducing sleeplessness and mood disorders. Recent data show that it is also associated with increase...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200969030-00002
更新日期:2009-01-01 00:00:00
abstract::Gene rearrangements involving the neurotrophic receptor kinase genes NTRK1, NTRK2, and NTRK3 (referred to as TRK, encoding TRKA, TRKB, and TRKC, respectively) result in highly oncogenic fusions. TRK fusions are rare, with a prevalence of < 1% in solid tumors. Detection of TRK fusions can be based on fluorescence in-si...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-020-01459-w
更新日期:2021-01-05 00:00:00
abstract::Chronic spontaneous urticaria (CSU) is characterized by the presence of wheals, angioedema, or both for at least 6 weeks. It may persist for a long time-up to 50% of the patients have been reported to be symptomatic 5 years after the onset. Some patients can suffer more than one episode of CSU during their lifetime. C...
journal_title:Drugs
pub_type: 杂志文章
doi:10.1007/s40265-020-01387-9
更新日期:2020-11-01 00:00:00
abstract::During depression, chronobiological disorders occur, such as disturbances in body temperature and early urinary excretion of a noradrenaline metabolite. Sleep patterns are disturbed in 90% of depressed patients; early REM sleep and shortened slow-wave sleep (stages 3 and 4), resulting in an increase in REM sleep, have...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-198900381-00003
更新日期:1989-01-01 00:00:00
abstract::Etoposide is one of the most active agents for the therapy of lymphomas. Oral etoposide has proven to be active in and clearly beneficial for patients with previously treated lymphomas. The optimal dose and schedule of oral etoposide for use in combination chemotherapy are still uncertain, but low daily doses (50 to 1...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199958003-00006
更新日期:1999-01-01 00:00:00
abstract::The rationale for the use of nifedipine in patients with acute myocardial infarction (MI) is based on the various cardiovascular actions of the compound: reduction of myocardial oxygen consumption by attenuation of cardiac and vascular smooth muscle tension; augmentation of oxygen and substrate supply after increased ...
journal_title:Drugs
pub_type: 临床试验,杂志文章,随机对照试验,评审
doi:10.2165/00003495-199100422-00007
更新日期:1991-01-01 00:00:00
abstract::Stavudine is a nucleoside analogue which undergoes intracellular phosphorylation to its active metabolite, stavudine-5'-triphosphate. At clinically relevant concentrations, the active metabolite restricts HIV replication by inhibiting the inclusion of thymidine-5'-triphosphate into proviral DNA by HIV reverse transcri...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199651050-00009
更新日期:1996-05-01 00:00:00
abstract::Lanthanum carbonate is a novel, non-aluminium, non-calcium phosphate binding agent that forms a water-insoluble compound, lanthanum phosphate, in the gut. Lanthanum carbonate (elemental lanthanum 375-3000 mg/day) reduced serum phosphorus levels compared with placebo in two randomised, double-blind, multicentre 4-week ...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200464090-00008
更新日期:2004-01-01 00:00:00
abstract::This article is a review of the principal drug-induced psychiatric symptoms that are likely to be encountered in daily clinical practice as a result of drug abuse, overdoses or side effects of drugs prescribed for treatment. Many categories of medication have the potential to produce psychiatric symptoms, but antitube...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-198122010-00004
更新日期:1981-07-01 00:00:00
abstract::The article Latanoprostene Bunod Ophthalmic Solution 0.024%: A Review in Open-Angle Glaucoma and Ocular Hypertension, written by Sheridan Hoy, was originally published Online First without open access. ...
journal_title:Drugs
pub_type: 杂志文章,已发布勘误
doi:10.1007/s40265-018-0925-3
更新日期:2018-06-01 00:00:00
abstract::The incidence of squamous cell carcinoma of the head and neck (SCCHN) is on the rise in the US despite a drop in cigarette smoking rates. Much of this rise is due to the increasing incidence of SCCHN attributable to human papillomavirus (HPV). HPV-related SCCHN has a high cure rate, which contributes to the stable dea...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/11592540-000000000-00000
更新日期:2011-08-20 00:00:00
abstract::Evidence suggests that arterial hypertension, in addition to being a cardiovascular and renal risk factor, may also be associated with an impairment of male sexual function. Since other cardiovascular risk factors, especially diabetes mellitus, have also been shown to correlate with impaired sexual function it has bee...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200565060-00005
更新日期:2005-01-01 00:00:00
abstract::Avapritinib (AYVAKIT™) is a potent and selective tyrosine kinase inhibitor of platelet-derived growth factor receptor alpha (PDGFRA) and KIT activation loop mutants. It is being developed by Blueprint Medicines for the treatment of gastrointestinal stromal tumours (GIST), solid tumours and systemic mastocytosis. Avapr...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-020-01275-2
更新日期:2020-03-01 00:00:00
abstract::Health behaviors such as retention in HIV medical care and adherence to antiretroviral therapy (ART) pose major challenges to reducing new HIV infections, addressing health disparities, and improving health outcomes. Andersen's Behavioral Model of Health Service Use provides a conceptual framework for understanding ho...
journal_title:Drugs
pub_type: 杂志文章
doi:10.1007/s40265-015-0373-2
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND:The combination of an inhaled corticosteroid (ICS) and a long-acting bronchodilator is recommended in the treatment of patients with chronic obstructive pulmonary disease (COPD) who have frequent exacerbations. Budesonide/formoterol dry powder inhaler (DPI) has demonstrated efficacy and tolerability in patie...
journal_title:Drugs
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.2165/00003495-200868140-00004
更新日期:2008-01-01 00:00:00
abstract::Antihistamines are a diverse group of drugs which possess the ability to inhibit various histaminic actions. By and large, they bear a certain structural resemblance to histamine, and act principally to prevent histamine-receptor interaction through competition with histamine for histamine receptors. Consequently, the...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-197612040-00002
更新日期:1976-01-01 00:00:00
abstract::HIV-associated wasting, characterised by progressive loss of lean body mass and bodyweight, remains a significant problem in the era of highly active antiretroviral therapy (HAART). Loss of body cell mass, a component of lean body mass, is associated with decreased survival. Somatropin (recombinant human growth hormon...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200666030-00014
更新日期:2006-01-01 00:00:00
abstract::The studies reported here were designed to ascertain whether or not the new beta-lactam antibiotic, temocillin, would produce antibiotic-associated colitis in the hamster. The experiments were controlled with clindamycin and cefoxitin, which are known to induce antibiotic-associated colitis experimentally and clinical...
journal_title:Drugs
pub_type: 杂志文章
doi:10.2165/00003495-198500295-00012
更新日期:1985-01-01 00:00:00