Sexual dysfunction in male patients with hypertension: influence of antihypertensive drugs.

abstract：:In hospitals, oral quinolone therapy has lower daily associated costs (acquisition and administration) than most intravenous regimens. In addition, oral switch therapy shortens the duration of hospital stay for most patients. However, randomised trials are required to measure the economic impact of the switch to oral ...

journal_title：Drugs

authors： Davey P

更新日期：1999-01-01 00:00:00

abstract：:Glaucoma, a group of progressive optic neuropathies with similar patterns of tissue loss, is primarily treated with medical therapy, followed by laser therapy and, later, incisional surgery. Aside from the introduction of prostaglandin analogs, topical carbonic anhydrase inhibitors, and topical alpha-agonists in the 1...

journal_title：Drugs

authors： Schehlein EM,Robin AL

更新日期：2019-07-01 00:00:00

abstract：:Botulinum neurotoxin type A (BTX-A) weakens voluntary muscle strength and is an effective therapy for focal dystonia, including cervical dystonia (CD) and benign essential blepharospasm (BEB). It is also known to relieve hemifacial spasm and focal spasticity in children and adults. In addition, BTX-A has been shown to...

journal_title：Drugs

authors： Jost WH,Blümel J,Grafe S

更新日期：2007-01-01 00:00:00

abstract：:Many drugs alter the anticoagulant effect of oral coumarins. It is essential that physicians be aware of interactions leading to increased or decreased anticoagulation or to erratic control. Interacting drugs can be classified as influencing the pharmacodynamics (pharmacological actions) or the pharmacokinetics (absor...

journal_title：Drugs

authors： MacLeod SM,Sellers EM

更新日期：1976-01-01 00:00:00

abstract：:25 years have elapsed since the introduction of the first effective oral diuretic, chlorothiazide. Diuretics are now amongst the most widely prescribed drugs in clinical practice worldwide. Availability of these drugs has not only brought therapeutic benefit to countless numbers of patients but it has at the same time...

journal_title：Drugs

authors： Lant A

更新日期：1985-02-01 00:00:00

abstract：:Nizatidine is an H2-receptor antagonist which in animal studies was more active on a weight-for-weight basis than cimetidine in inhibiting basal and stimulated gastric acid secretion. Similarly, studies in humans have confirmed that nizatidine is a potent inhibitor of basal, nocturnal and stimulated gastric acid secre...

journal_title：Drugs

authors： Price AH,Brogden RN

更新日期：1988-11-01 00:00:00

abstract：:Pain is associated with emotional and physical suffering that severely impacts quality of life. Many guidelines for the treatment of moderate to severe cancer pain indicate the use of opioids. For a small proportion of the global population, opioids are readily accessible, but are consequently also subject to risk of ...

journal_title：Drugs

authors： Marchetti Calônego MA,Sikandar S,Ferris FD,Moreira de Barros GA

更新日期：2020-08-01 00:00:00

abstract：:The benefits of the treatment of hypertension currently consist of a substantially reduced incidence of premature stroke, left ventricular failure and malignant hypertension. The benefits for the individual are most clearcut in those who have already had severe or symptomatic hypertension. Older subjects who have a hi...

journal_title：Drugs

authors： Beilin LJ

更新日期：1988-01-01 00:00:00

abstract：UNLABELLED:Joint pain is the main complaint in patients affected by osteoarthritis (OA), and NSAIDs are commonly used to treat pain associated with OA. Over the past few years, cyclo-oxygenase (COX)-2-selective inhibitors have been proved to have certain advantages over non-selective NSAIDs and have been increasingly u...

journal_title：Drugs

authors： Bianchi M,Broggini M

更新日期：2003-01-01 00:00:00

abstract：:Although venous thromboembolism has occasionally been reported after hospital discharge in patients who have undergone total hip replacement (THR), this risk has not been fully quantified and the usefulness of a prophylactic treatment has not been evaluated. We conducted a single-centre prospective randomised double-b...

journal_title：Drugs

authors： Planes A,Vochelle N,Darmon JY,Fagola M,Bellaud M,Compan D,Saliba E,Weisslinger N,Huet Y

更新日期：1996-01-01 00:00:00

abstract：:Acyclovir (aciclovir) is a nucleoside antiviral drug with antiviral activity in vitro against members of the herpes group of DNA viruses. As an established treatment of herpes simplex infection, intravenous, oral and to a lesser extent topical formulations of acyclovir provide significant therapeutic benefit in genita...

journal_title：Drugs

authors： O'Brien JJ,Campoli-Richards DM

更新日期：1989-03-01 00:00:00

abstract：:Acute infectious diarrhoea is the major killer of children in the Third World. It is also the principal cause of malnutrition in children under 5 years of age. More than 4 million children die each year of diarrhoea and its complications. Acute diarrhoea kills by causing dehydration, which leads to hypovolaemia and me...

journal_title：Drugs

authors： Gold R

更新日期：1988-01-01 00:00:00

abstract：:Sodium-glucose co-transporter 2 (SGLT2) inhibitors are glucose-lowering drugs that reduce plasma glucose levels by inhibiting glucose and sodium reabsorption in the kidneys, thus resulting in glucosuria. Their effects consequently include reductions in HbA1c, blood glucose levels, and blood pressure, but also reductio...

journal_title：Drugs

authors： Pereira MJ,Eriksson JW

更新日期：2019-02-01 00:00:00

abstract：:The therapeutic efficacy of the new beta-lactam antibiotic, temocillin, was studied in 30 critically ill patients with peritonitis, abscesses, bronchopneumonia, and serious soft tissue infections. Patients were treated with temocillin Ig intravenously twice daily. The isolated pathogens comprised mainly Escherichia co...

journal_title：Drugs

authors： Pfeiffer M,Fock RR

更新日期：1985-01-01 00:00:00

abstract：:Alopecia areata (AA) is an autoimmune condition that affects up to 2% of the general population. Currently available treatment options for AA are of limited efficacy and can be associated with adverse effects. The advancement in understanding of the genetic and molecular mechanisms of AA has led to the development of ...

journal_title：Drugs

authors： Pourang A,Mesinkovska NA

更新日期：2020-05-01 00:00:00

abstract：:Stavudine is a nucleoside analogue which undergoes intracellular phosphorylation to its active metabolite, stavudine-5'-triphosphate. At clinically relevant concentrations, the active metabolite restricts HIV replication by inhibiting the inclusion of thymidine-5'-triphosphate into proviral DNA by HIV reverse transcri...

journal_title：Drugs

authors： Lea AP,Faulds D

更新日期：1996-05-01 00:00:00

abstract：:Eltrombopag (Revolade(®)) is an orally bioavailable, low molecular weight, synthetic nonpeptide thrombopoietin receptor agonist, which selectively binds to the transmembrane and juxtamembrane domains of the thrombopoietin receptor on the surface of platelets, megakaryocytes and megakaryocyte precursor cells, resulting...

journal_title：Drugs

authors： Garnock-Jones KP

更新日期：2011-07-09 00:00:00

abstract：:Trifluridine (trifluorothymidine) is an antiviral agent for topical use in the eye, and is structurally related to idoxuridine. In vitro studies have shown that it effectively inhibits the replication of herpes simplex virus type 1, which causes primary keratoconjunctivitis and recurrent epithelial keratitis in man. I...

journal_title：Drugs

authors： Carmine AA,Brogden RN,Heel RC,Speight TM,Avery GS

更新日期：1982-05-01 00:00:00

abstract：:Desloratadine is the orally active major metabolite of the nonsedating H1-antihistamine loratadine. The drug had no adverse cardiovascular effects in various animal models or when administered at 9 times the recommended adult dosage for 10 days in volunteers. Therapeutic dosages had no effects on wakefulness or psycho...

journal_title：Drugs

authors： McClellan K,Jarvis B

更新日期：2001-01-01 00:00:00

abstract：:Tuberous sclerosis complex (TSC) is a genetic disorder arising from mutations in the TSC1 or TSC2 genes. The resulting over-activation of the mammalian target of rapamycin (mTOR) signalling pathway leaves patients with TSC susceptible to the growth of non-malignant tumours in multiple organs. Previously, surgery was t...

journal_title：Drugs

authors： Curatolo P,Bjørnvold M,Dill PE,Ferreira JC,Feucht M,Hertzberg C,Jansen A,Jóźwiak S,Kingswood JC,Kotulska K,Macaya A,Moavero R,Nabbout R,Zonnenberg BA

更新日期：2016-04-01 00:00:00

abstract：:The simplest response to the question, what is the prevalence of hypertension in the United States today?, is given by a currently popular slogan: 23,000,000 Americans have hypertension. It is clear that the problem is large in scale, but this figure alone is an insufficient guide to many practical issues. The prevale...

journal_title：Drugs

authors： Labarthe DR

更新日期：1976-01-01 00:00:00

abstract：:Early identification of infants with sickle cell disease (SCD) by newborn screening, now universal in all 50 states in the US, has improved survival, mainly by preventing overwhelming sepsis with the early use of prophylactic penicillin. Routine transcranial Doppler screening with the institution of chronic transfusio...

journal_title：Drugs

authors： Meier ER,Miller JL

更新日期：2012-05-07 00:00:00

abstract：:Approximately 15% of patients with ulcerative colitis will experience a severe episode requiring hospitalization. Although intravenous corticosteroids are the current first-line therapy for these patients, about 30% of patients do not respond to corticosteroids and require either an alternative anti-inflammatory agent...

journal_title：Drugs

authors： Moss AC,Peppercorn MA

更新日期：2008-01-01 00:00:00

abstract：:The rapid spread of human immunodeficiency virus (HIV) infections and the grim outcome of these infections have focused interest on the possibilities for medical intervention. The end-stage of these infections, acquired immune deficiency syndrome (AIDS), was first recognised in 1981, and the causative agent isolated i...

journal_title：Drugs

authors： Sandström EG,Kaplan JC

更新日期：1987-09-01 00:00:00

abstract：:The Janus kinase/signal transduction and activator of transcription (JAK-STAT) signaling pathway is implicated in the pathogenesis of inflammatory and autoimmune diseases including rheumatoid arthritis, psoriasis, and inflammatory bowel disease. Many cytokines involved in the pathogenesis of autoimmune and inflammator...

journal_title：Drugs

authors： Banerjee S,Biehl A,Gadina M,Hasni S,Schwartz DM

更新日期：2017-04-01 00:00:00

abstract：:Emicizumab (Hemlibra®), a recombinant, humanized, bispecific monoclonal antibody, restores the function of missing activated factor VIII (FVIII) by bridging FIXa and FX to facilitate effective haemostasis in patients with haemophilia A. Subcutaneous emicizumab is approved in several countries, including in the USA and...

journal_title：Drugs

authors： Blair HA

更新日期：2019-10-01 00:00:00

abstract：:This review describes the tolerability profile of nimesulide as documented in a global assessment of the clinical data available to Helsinn for this drug. Data from 151 trials were considered and the relevant case report forms and study reports were used as source information. The analysis was conducted using between-...

journal_title：Drugs

authors： Fusetti G,Magni E,Armandola MC

更新日期：1993-01-01 00:00:00

abstract：:In general, hepatic encephalopathy (HE) is defined as a brain dysfunction caused by liver insufficiency and/or portal-systemic blood shunting. This article relates to the so-called type C HE: that is, HE in patients with liver cirrhosis. It manifests as a wide spectrum of neurological or psychiatric abnormalities, ran...

journal_title：Drugs

authors： Weissenborn K

更新日期：2019-02-01 00:00:00

abstract：:Lung tissue remodelling in chronic inflammatory lung diseases has long been regarded as a follow-up event to inflammation. Recent studies have indicated that, although airway and lung tissue remodelling is often independent of inflammation, it precedes or causes inflammation. None of the available therapies has a sign...

journal_title：Drugs

authors： Roth M

更新日期：2015-01-01 00:00:00

abstract：:Guillain-Barré syndrome (GBS) is clinically defined as an acute peripheral neuropathy causing limb weakness that progresses over a time period of days or, at the most, up to 4 weeks. GBS occurs throughout the world with a median annual incidence of 1.3 cases per population of 100 000, with men being more frequently af...

journal_title：Drugs

authors： Kuwabara S

更新日期：2004-01-01 00:00:00