New and Emerging Therapies for Alopecia Areata.

abstract：:Systemic therapy for advanced non-small cell lung cancer (NSCLC) has evolved over the last two decades, with modest improvements in quality of life and overall survival. A plateau has been reached with traditional chemotherapy, and efforts are now being directed at developing molecularly targeted agents. To date, thre...

journal_title：Drugs

authors： Triano LR,Deshpande H,Gettinger SN

更新日期：2010-01-01 00:00:00

abstract：:Vemurafenib is the first molecularly targeted therapy to be licensed in the US and Europe for treatment of advanced melanoma. Its mechanism of action involves selective inhibition of the mutated BRAF V600E kinase that leads to reduced signalling through the aberrant mitogen-activated protein kinase (MAPK) pathway. Its...

journal_title：Drugs

authors： Sharma A,Shah SR,Illum H,Dowell J

更新日期：2012-12-03 00:00:00

abstract：:When used to treat patients with Parkinson's disease pergolide acts at dopamine receptors in the corpus striatum to improve locomotor activity, reducing the tremor, gait disturbances, bradykinesia or akinesia and rigidity experienced by such patients. Treatment with pergolide often allows substantial reductions in con...

journal_title：Drugs

authors： Langtry HD,Clissold SP

更新日期：1990-03-01 00:00:00

abstract：:Multiple sclerosis (MS) is thought to be a chronic inflammatory disorder of the CNS. The past decade has seen the introduction of the new immunomodulatory drugs, interferon (IFN)-beta and glatiramer acetate, that have considerably improved the therapeutic options for this often disabling disease. The efficacy of these...

journal_title：Drugs

authors： Flachenecker P,Rieckmann P

更新日期：2003-01-01 00:00:00

abstract：:Several large-scale clinical trials have assessed the efficacy of atorvastatin in the primary and secondary prevention of cardiovascular events in patients with diabetes mellitus and/or metabolic syndrome. In primary prevention, CARDS (Collaborative Atorvastatin Diabetes Study) showed that atorvastatin 10 mg/day (vs p...

journal_title：Drugs

authors： Arca M

更新日期：2007-01-01 00:00:00

abstract：:Treatment of idiopathic membranous nephropathy is based on a 'symptomatic' therapy that includes ACE inhibitors or angiotensin II receptor antagonists, and on an 'aetiological' therapy aimed at modulating underlying immunological mechanisms. The role of the latter is still debated given the usually indolent course of ...

journal_title：Drugs

authors： Quaglia M,Stratta P

更新日期：2009-07-09 00:00:00

abstract：:Through years of evolutionary selection pressures, organisms have developed potent toxins that coincidentally have marked antineoplastic activity. These natural products have been vital for the development of multiagent treatment regimens currently employed in cancer chemotherapy, and are used in the treatment of a va...

journal_title：Drugs

authors： Trendowski M

更新日期：2015-11-01 00:00:00

abstract：:Exenatide extended-release (exenatide ER) [Bydureon(®)] is a glucagon-like peptide-1 receptor agonist, approved for the treatment of type 2 diabetes mellitus. It is injected subcutaneously by patients once weekly, with no dose titration required. This article updates an earlier review of exenatide ER in the management...

journal_title：Drugs

authors： Syed YY,McCormack PL

更新日期：2015-07-01 00:00:00

abstract：:Acute renal failure (ARF) occurs frequently in hospitalised patients, and is associated with significant morbidity and mortality. The most common and generalised forms of acute renal failure are pre-renal conditions and intra-renal acute tubular necrosis (ATN). Pre-renal ARF in its pure state should be entirely revers...

journal_title：Drugs

authors： Dishart MK,Kellum JA

更新日期：2000-01-01 00:00:00

abstract：:Involuntary infertility is an increasing problem in this era of delayed childbearing. Fortunately, many advances have been made recently in the medical and surgical treatment of infertility. This article reviews the principal aetiologies of infertility and their treatments, and focuses on the current and future uses o...

journal_title：Drugs

authors： Quigley MM

更新日期：1986-08-01 00:00:00

abstract：:A number of new agents for the management of chronic obstructive pulmonary disease (COPD) are at different stages of development, including several inhaled long-acting antimuscarinics (LAMA). Long-acting bronchodilators are considered to be central to the management of COPD due to the evidence supporting their efficac...

journal_title：Drugs

authors： Pleasants RA,Wang T,Gao J,Tang H,Donohue JF

更新日期：2016-03-01 00:00:00

abstract：:Aspirin (acetylsalicylic acid)-induced asthma (AIA) consists of the clinical triad of asthma, chronic rhinosinusitis with nasal polyps, and precipitation of asthma and rhinitis attacks in response to aspirin and other NSAIDs. The prevalence of the syndrome in the adult asthmatic populations is approximately 4-10%. Res...

journal_title：Drugs

authors： Hamad AM,Sutcliffe AM,Knox AJ

更新日期：2004-01-01 00:00:00

abstract：:In a double-blind study, 128 patients with essential hypertension, refractory to beta-blocker monotherapy, were randomised to 1 of 4 treatment groups. Felodipine 2.5 mg twice daily, 5mg twice daily, 10mg twice daily or matched placebo twice daily were administered in addition to the beta-blocker for 4 weeks. Mean supi...

journal_title：Drugs

authors： Sluiter HE

更新日期：1987-01-01 00:00:00

abstract：:Aliskiren/hydrochlorothiazide is a single-pill combination of the first in the new class of non-peptide direct renin inhibitors (aliskiren) and a thiazide diuretic (hydrochlorothiazide [HCTZ]) that achieves blood pressure (BP) reductions greater than those seen with either component alone. In double-blind, 8-week clin...

journal_title：Drugs

authors： Baldwin CM,Plosker GL

更新日期：2009-01-01 00:00:00

abstract：:A somatropin preparation (Zorbtive) produced by recombinant DNA technology has been evaluated in patients with short bowel syndrome. Somatropin is thought to enhance intestinal adaptation in this condition through direct or indirect effects on the intestine. In a randomised, double-blind study in patients with short b...

journal_title：Drugs

authors： Keating GM,Wellington K

更新日期：2004-01-01 00:00:00

abstract：:Fenfluramine has been used for a number of years as a short-term adjunct to diet in the management of obesity. Controlled studies and clinical experience have shown that it possesses anorectic activity at least as good as that of other therapeutically useful drugs of its type, but like these drugs it has only a limite...

journal_title：Drugs

authors： Pinder RM,Brogden RN,Sawyer PR,Speight TM,Avery GS

更新日期：1975-01-01 00:00:00

abstract：:Purine nucleoside analogues are a new class of drugs with activity against nondividing lymphocytes; thus, they should play a major role in the treatment of low grade lymphoid malignancies. As these drugs are active against resting lymphocytes, harmful effects related to this action were expected and have been reported...

journal_title：Drugs

authors： Dighiero G

更新日期：1994-01-01 00:00:00

abstract：:Irinotecan (CPT-II) is a semisynthetic derivative of camptothecin. It and other camptothecin analogues/derivatives appear to exert their antitumour activity by binding to topoisomerase I. The active metabolite of irinotecan, 7-ethyl-10-hydroxycamptothecin (SN-38), has demonstrated potent growth inhibition of human col...

journal_title：Drugs

authors： Wiseman LR,Markham A

更新日期：1996-10-01 00:00:00

abstract：:Drug-resistant tuberculosis (DR-TB) is an emerging global health threat as treatment involves complex multiple drug regimens, which are longer and more toxic than standard therapy and yet have worse outcomes. In the presence of resistance to one or more first-line drugs, an alternative regimen should be designed. A ma...

journal_title：Drugs

authors： Albanna AS,Menzies D

更新日期：2011-05-07 00:00:00

abstract：:Despite the availability of effective pharmacological treatments to aid the control of blood pressure, the global rate of uncontrolled blood pressure remains high. As such, further measures are required to improve blood pressure control. Recently, several national and international guidelines for the management of hyp...

journal_title：Drugs

authors： Kjeldsen S,Feldman RD,Lisheng L,Mourad JJ,Chiang CE,Zhang W,Wu Z,Li W,Williams B

更新日期：2014-11-01 00:00:00

abstract：:Transdermal nicotine delivery systems are a cigarette smoking cessation aid designed to deliver nicotine into the systemic circulation via the skin. The partial replacement of plasma nicotine, which would have otherwise been obtained from cigarettes, reduces the severity of nicotine withdrawal symptoms, and so allows ...

journal_title：Drugs

authors： Palmer KJ,Buckley MM,Faulds D

更新日期：1992-09-01 00:00:00

abstract：:Peripheral arterial occlusive disease is a common condition with possible serious consequences. It is usually diagnosed at the intermittent claudication stage. There are 2 objectives of treatment: to prevent ischaemic attacks and to improve quality of life. Treatment efficacy is, however, usually evaluated only in ter...

journal_title：Drugs

authors： Marquis P

更新日期：1998-01-01 00:00:00

abstract：:Potassium channel openers or agonists represent a novel new class of compounds in the treatment of a range of cardiovascular disorders, particularly angina pectoris and hypertension. Nicorandil is the only clinically available potassium channel opener with antianginal effects, and with comparable efficacy and tolerabi...

journal_title：Drugs

authors： Gomma AH,Purcell HJ,Fox KM

更新日期：2001-01-01 00:00:00

abstract：:Various foods and fluids have been used in traditional treatments for diarrhoeal illnesses in infants and children for centuries. During the last 2 decades, however, with the advent of an improved scientific understanding of oral rehydration, effective treatment of dehydrating diarrhoea has been improved, expanded and...

journal_title：Drugs

authors： Sack DA

更新日期：1991-04-01 00:00:00

abstract：:Gastro-oesophageal reflux disease (GORD or GERD) is a very common disorder, and advancement in drug development over the years has markedly improved disease management. Proton pump inhibitors (PPIs) remain the mainstay of treatment for GERD due to their profound and consistent inhibitory effect on acid secretion. Howe...

journal_title：Drugs

authors： Hershcovici T,Fass R

更新日期：2011-12-24 00:00:00

abstract：:The benefits of the treatment of hypertension currently consist of a substantially reduced incidence of premature stroke, left ventricular failure and malignant hypertension. The benefits for the individual are most clearcut in those who have already had severe or symptomatic hypertension. Older subjects who have a hi...

journal_title：Drugs

authors： Beilin LJ

更新日期：1988-01-01 00:00:00

abstract：:Mild to moderate hypertension still remains poorly controlled. This relates to multiple factors including low antihypertensive efficacy of single drug therapies reluctance of primary care physicians to modify/titrate initially chosen therapy to obtain target blood pressure, and poor compliance with medication. Several...

journal_title：Drugs

authors： Ruzicka M,Leenen FH

更新日期：2001-01-01 00:00:00

abstract：:Management of renal cell carcinoma (RCC) has made considerable progress in recent years, and new emerging strategies are being developed. On the basis of the results of two randomised studies in the early 2000s, nephrectomy has now become the standard as cytoreductive surgery before embarking on systemic treatment wit...

journal_title：Drugs

authors： Escudier B

更新日期：2007-01-01 00:00:00

abstract：:The lipid-modifying profile of bezafibrate is characterised by marked decreases in elevated triglyceride levels, increases in high density lipoprotein (HDL) cholesterol levels and decreases in total and low density lipoprotein (LDL) cholesterol levels. Bezafibrate also reduces elevated levels of lipoprotein(a) [Lp(a)]...

journal_title：Drugs

authors： Goa KL,Barradell LB,Plosker GL

更新日期：1996-11-01 00:00:00

abstract：:In ten large, well-controlled, randomised trials (n = 203 to 1089), valdecoxib, a selective inhibitor of cyclo-oxygenase-2, was significantly more effective than placebo in the treatment of osteoarthritis, rheumatoid arthritis and pain associated with primary dysmenorrhoea, and for postsurgical analgesia. Valdecoxib 1...

journal_title：Drugs

authors： Ormrod D,Wellington K,Wagstaff AJ

更新日期：2002-01-01 00:00:00