Botulinum neurotoxin type A free of complexing proteins (XEOMIN) in focal dystonia.

abstract：:Pain represents a major clinical, social and economic problem, with estimates of its prevalence ranging from 8% to more than 60%, depending on the population. The impact of pain on economies is enormous, with the cost of back pain alone equivalent to more than one-fifth of one country's total health expenditure and 1....

journal_title：Drugs

authors： Phillips CJ

更新日期：2003-01-01 00:00:00

abstract：:Lapatinib (Tyverb, Tykerb) is an orally active, small molecule, reversible, dual tyrosine kinase inhibitor of human epidermal growth factor receptor type 1 (HER1) and type 2 (HER2). In the EU, lapatinib in combination with capecitabine is indicated for the treatment of women with HER2-overexpressing, advanced or metas...

journal_title：Drugs

authors： Frampton JE

更新日期：2009-10-22 00:00:00

abstract：BACKGROUND:The lowering of cholesterol concentrations in individuals at high risk of cardiovascular disease improves outcome. No study, however, has assessed benefits of cholesterol lowering in the primary prevention of coronary heart disease (CHD) in hypertensive patients who are not conventionally deemed dyslipidaemi...

journal_title：Drugs

authors： Sever PS,Dahlöf B,Poulter NR,Wedel H,Beevers G,Caulfield M,Collins R,Kjeldsen SE,Kristinsson A,McInnes GT,Mehlsen J,Nieminen M,O'Brien E,Ostergren J,ASCOT Investigators.

更新日期：2004-01-01 00:00:00

abstract：UNLABELLED:5-Methoxypsoralen, a naturally occurring linear furocoumarin, has been successfully used in combination with ultraviolet (UV) A irradiation [psoralen plus UV (PUVA)] to manage psoriasis and vitiligo. In patients and volunteers, PUVA 5-methoxypsoralen causes a dose-related increase in cutaneous photosensitivi...

journal_title：Drugs

authors： McNeely W,Goa KL

更新日期：1998-10-01 00:00:00

abstract：:The optimal treatment of pain requires an understanding of the mechanisms involved. Pain is a sensory end-point that can be generated by a number of dissimilar processes. Consequently, the concept of treating pain as a unitary symptom is obsolete. The mechanisms responsible for specific types of pain need to be unders...

journal_title：Drugs

authors： Woolf CJ

更新日期：1994-01-01 00:00:00

abstract：:Childhood obesity has become the most common paediatric disorder in the developed world. Treatment of obesity in children may include lifestyle interventions, pharmacotherapy and weight-loss supplements. The outcome of lifestyle interventions, which classically include dietary modifications, increased activity and beh...

journal_title：Drugs

authors： Rogovik AL,Chanoine JP,Goldman RD

更新日期：2010-02-12 00:00:00

abstract：:Oral zonisamide (Zonegran(®)) is a benzisoxazole derivative chemically unrelated to other antiepileptic agents. It is indicated in the EU as monotherapy in the treatment of partial seizures, with or without secondary generalization, in adults with newly diagnosed epilepsy and as adjunctive therapy to other antiepilept...

journal_title：Drugs

authors： Hoy SM

更新日期：2013-08-01 00:00:00

abstract：:In general, hepatic encephalopathy (HE) is defined as a brain dysfunction caused by liver insufficiency and/or portal-systemic blood shunting. This article relates to the so-called type C HE: that is, HE in patients with liver cirrhosis. It manifests as a wide spectrum of neurological or psychiatric abnormalities, ran...

journal_title：Drugs

authors： Weissenborn K

更新日期：2019-02-01 00:00:00

abstract：:74 cirrhotic patients with a history of variceal or gastric bleeding were randomly assigned to treatment with propranolol (40 to 360 mg/day) or placebo. The patients were all in good condition and doses of propranolol were titrated until a 25% reduction in heart rate was achieved. After 2 years, the cumulative percent...

journal_title：Drugs

authors： Lebrec D,Poynard T,Bernuau J,Bercoff E,Nouel O,Capron JP,Poupon R,Bouvry M,Rueff B,Benhamou JP

更新日期：1989-01-01 00:00:00

abstract：:Drug-drug interactions (DDIs) occur commonly and may lead to severe adverse drug reactions if not handled appropriately. Considerable information to support clinical decision making regarding potential DDIs is available in the literature and through various systems providing electronic decision support for healthcare ...

journal_title：Drugs

authors： Lund M,Petersen TS,Dalhoff KP

更新日期：2017-05-01 00:00:00

abstract：:An enteral suspension (ES)/intestinal gel formulation of levodopa/carbidopa (hereafter referred to as levodopa/carbidopa ES) [Duodopa® (EU); Duopa™ (USA)] has been developed to overcome the fluctuating plasma levodopa concentrations associated with oral levodopa/carbidopa formulations. In various countries, including ...

journal_title：Drugs

authors： Hoy SM

更新日期：2019-10-01 00:00:00

abstract：:Aspirin (acetylsalicylic acid)-induced asthma (AIA) consists of the clinical triad of asthma, chronic rhinosinusitis with nasal polyps, and precipitation of asthma and rhinitis attacks in response to aspirin and other NSAIDs. The prevalence of the syndrome in the adult asthmatic populations is approximately 4-10%. Res...

journal_title：Drugs

authors： Hamad AM,Sutcliffe AM,Knox AJ

更新日期：2004-01-01 00:00:00

abstract：:Despite advances in the understanding of the mechanism of cerebral injury during focal ischaemia, the best treatment of cerebral ischaemia is still prevention. The pathophysiological mechanisms that contribute to cerebral ischaemia are discussed relative to the many therapeutic interventions that have been attempted. ...

journal_title：Drugs

authors： Sila CA,Furlan AJ

更新日期：1988-04-01 00:00:00

abstract：:Alfuzosin, a new quinazoline derivative, acts as a selective and competitive antagonist of alpha 1-adrenoceptor-mediated contraction of prostatic, prostatic capsule, bladder base and proximal urethral smooth muscle, thereby reducing the tone of these structures. Consequently, urethral pressure and resistance, bladder ...

journal_title：Drugs

authors： Wilde MI,Fitton A,McTavish D

更新日期：1993-03-01 00:00:00

abstract：:Azacitidine (Vidaza) is a pyrimidine nucleoside analogue of cytidine. Subcutaneous azacitidine was recently approved in the EU for the treatment of adults who are not eligible for haematopoietic stem cell transplantation and who have intermediate-2-risk or high-risk myelodysplastic syndromes (MDS) [according to Intern...

journal_title：Drugs

authors： Keating GM

更新日期：2009-01-01 00:00:00

abstract：:Pain is the main reason prompting patients to consult their physicians. In acute conditions, pain has a very particular significance as a warning sign, enabling the physician to attempt a diagnosis. Nevertheless, its detrimental effect upon the individual (even in the case of acute pain) and its cost to society are no...

journal_title：Drugs

authors： Brasseur L

更新日期：1997-01-01 00:00:00

abstract：UNLABELLED:Patients with beta-thalassaemia and other transfusion-dependent diseases develop iron overload from chronic blood transfusions and require regular iron chelation to prevent potentially fatal iron-related complications. The only iron chelator currently widely available is deferoxamine, which is expensive and ...

journal_title：Drugs

authors： Barman Balfour JA,Foster RH

更新日期：1999-09-01 00:00:00

abstract：:The extra-oesophageal signs that are most commonly related to gastro-oesophageal reflux include chest pain, asthma, chronic cough, posterior laryngitis and dental erosions. It is characteristic to find in such patients a poor presence of symptoms and endoscopic and pH-metric findings that are common in typical reflux....

journal_title：Drugs

authors： Rodríguez-Téllez M

更新日期：2005-01-01 00:00:00

abstract：:Aspirin is currently the most widely prescribed treatment in the prevention of cardiovascular complications. The indications for the use of aspirin during pregnancy are, however, the subject of much controversy. Since the first evidence of the obstetric efficacy of aspirin in 1985, numerous studies have tried to deter...

journal_title：Drugs

authors： Atallah A,Lecarpentier E,Goffinet F,Doret-Dion M,Gaucherand P,Tsatsaris V

更新日期：2017-11-01 00:00:00

abstract：:Four medicinal cancer biological blockbusters will end their patent lifespan by 2020. It is estimated that the total market for cancer biologicals will reach approximately US$68 billion at that time. Approximately 20 biosimilars have entered the European market since the launch of the original approval guidelines in 2...

journal_title：Drugs

authors： Camacho LH

更新日期：2017-06-01 00:00:00

abstract：:Filgrastim, a recombinant human granulocyte colony-stimulating factor (G-CSF), has identical biological activity to that of endogenous human G-CSF, but differs in that it contains an N-terminal methionine residue and is not glycosylated. It principally stimulates activation, proliferation and differentiation of neutro...

journal_title：Drugs

authors： Frampton JE,Lee CR,Faulds D

更新日期：1994-11-01 00:00:00

abstract：:Influenza vaccines form the mainstay of public health and personal protection against infection with seasonal influenza viruses. These vaccines are designed to protect people against infection with the currently circulating influenza viruses. Since the late 1970s, this has required the use of a trivalent vaccine consi...

journal_title：Drugs

authors： Barr IG,Jelley LL

更新日期：2012-12-03 00:00:00

abstract：:In this paper, several clinical problems associated with the diagnosis of hypertension are discussed. Blood pressure variability and reactivity are factors underlying the difficulties in the diagnosis of hypertension. These phenomena are interrelated and mixed. White coat hypertension (WCH), referring to the phenomeno...

journal_title：Drugs

authors： Ocón-Pujadas J,Mora-Maciá J

更新日期：1993-01-01 00:00:00

abstract：:The annual incidence of skin and soft tissue infections (SSTIs) has nearly tripled in the US since the early 1990s. Many purulent SSTIs in the community setting are caused by methicillin-resistant Staphylococcus aureus (MRSA). Incision and drainage (I&D) are indicated for most purulent MRSA infections; however, the us...

journal_title：Drugs

authors： Forcade NA,Wiederhold NP,Ryan L,Talbert RL,Frei CR

更新日期：2012-02-12 00:00:00

abstract：UNLABELLED:Candesartan cilexetil is converted to the angiotensin II receptor antagonist candesartan during absorption from the gastrointestinal tract. The selective and competitive binding of candesartan to the angiotensin II type 1 (AT(1)) receptor prevents binding of angiotensin II, a key mediator in the renin-angiot...

journal_title：Drugs

authors： Easthope SE,Jarvis B

更新日期：2002-01-01 00:00:00

abstract：:The management of mediastinitis involves directing appropriate antibacterial therapy against the potential bacterial pathogens. The increased recovery of anaerobic bacteria from mediastinal infections has led to a greater appreciation of their role in this condition and to re-evaluation of the proper treatment of this...

journal_title：Drugs

authors： Brook I

更新日期：2006-01-01 00:00:00

abstract：:Allergic rhinitis represents a global health burden. The disease can seriously affect quality of life and is associated with multiple co-morbidities. Histamine and leukotrienes are important pro-inflammatory mediators in nasal allergic inflammation. Their actions on target cells are mediated through specific receptors...

journal_title：Drugs

authors： Van Hoecke H,Vandenbulcke L,Van Cauwenberge P

更新日期：2007-01-01 00:00:00

abstract：:Estrogenic compounds are the most important group of drugs that can induce hypertension. Studies have shown an incidence of significant hypertension amounting to less than 1% after 1 year of taking oral contraceptives and about 2% after 5 years. The ratio of the incidence of hypertension among ''takers'' to that of ...

journal_title：Drugs

authors： Stokes GS

更新日期：1976-01-01 00:00:00

abstract：:The advent of thrombolytic therapy was a major advance in the treatment of ST-segment elevation myocardial infarction (STEMI). The administration of fibrinolytic reperfusion therapy can reduce mortality rates by as much as 30%, with the greatest benefit observed if therapy is administered soon after symptom onset. Out...

journal_title：Drugs

authors： Morse MA,Todd JW,Stouffer GA

更新日期：2009-10-01 00:00:00

abstract：:Trifluridine/tipiracil (Lonsurf(®)) is a novel, orally active, antimetabolite agent comprised of trifluridine, a thymidine-based nucleoside analogue, and tipiracil, a potent thymidine phosphorylase inhibitor. Trifluridine is incorporated into DNA via phosphorylation, ultimately inhibiting cell proliferation. Tipiracil...

journal_title：Drugs

authors： Burness CB,Duggan ST

更新日期：2016-09-01 00:00:00