Abstract:
:Pimavanserin (Nuplazid™) is a selective and potent serotonin 2A (5-HT2A) receptor inverse agonist and antagonist developed by ACADIA Pharmaceuticals that has been approved in the US as a treatment for patients with hallucinations and delusions associated with Parkinson's disease psychosis. Up to 60 % of patients with Parkinson's disease may develop Parkinson's disease psychosis, which is associated with increased morbidity and mortality and has few treatment options. This article summarizes the milestones in the development of pimavanserin leading to this first approval for the treatment of hallucinations and delusions in patients with Parkinson's disease psychosis.
journal_name
Drugsjournal_title
Drugsauthors
Markham Adoi
10.1007/s40265-016-0597-9subject
Has Abstractpub_date
2016-07-01 00:00:00pages
1053-7issue
10eissn
0012-6667issn
1179-1950pii
10.1007/s40265-016-0597-9journal_volume
76pub_type
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