[Clinical experience with nifedipine in the treatment of angina pectoris in Japan].


:Developed by Bayer in Germany, nifedipine was shown to be effective in the treatment of patients with angina pectoris by Japanese investigators. Professor Kimura first reported the efficacy of nifedipine in patients with angina pectoris and those findings have been replicated in numerous trials conducted since then. Clinical trials found a low incidence of fixed coronary artery stenosis in Japanese patients with variant angina pectoris, and a complete antianginal response with Ca2+ channel antagonist such as nifedipine. It was hypothesised that the mechanism of this benefit with nifedipine was because of a strong coronary vasodilating action along with an inhibitory effect on coronary spasm. Recent evidence has established the tolerability and efficacy of once-daily dosage forms, which provide stable plasma nifedipine concentrations, in the management of coronary artery disorders.






Hosoda S




Has Abstract


2006-01-01 00:00:00








66 Spec No 1




  • Levocetirizine: a review of its use in the management of allergic rhinitis and skin allergies.

    abstract::Levocetirizine (Xyzal) is a selective, potent, oral histamine H(1) receptor antagonist of the latest generation that is licensed for the symptomatic treatment of allergic rhinitis (including persistent allergic rhinitis [PER]) and chronic idiopathic urticaria (CIU). Large, well designed trials indicate that levocetiri...


    pub_type: 杂志文章,评审


    authors: Hair PI,Scott LJ

    更新日期:2006-01-01 00:00:00

  • Appropriate use of antitussives and protussives. A practical review.

    abstract::As a symptom of an underlying condition, cough is one of the most common reasons patients see physicians. To the majority, a cough means that 'something is wrong' and it causes exhaustion and/or self-consciousness. Patients find these reasons as well as effects on lifestyle, fear of cancer and/or AIDS or tuberculosis ...


    pub_type: 杂志文章,评审


    authors: Irwin RS,Curley FJ,Bennett FM

    更新日期:1993-07-01 00:00:00

  • Drugs in the treatment of female infertility. Recent advances.

    abstract::Involuntary infertility is an increasing problem in this era of delayed childbearing. Fortunately, many advances have been made recently in the medical and surgical treatment of infertility. This article reviews the principal aetiologies of infertility and their treatments, and focuses on the current and future uses o...


    pub_type: 杂志文章,评审


    authors: Quigley MM

    更新日期:1986-08-01 00:00:00

  • Intravenous Minocycline: A Review in Acinetobacter Infections.

    abstract::Intravenous minocycline (Minocin®) is approved in the USA for use in patients with infections due to susceptible strains of Gram-positive and Gram-negative pathogens, including infections due to Acinetobacter spp. Minocycline is a synthetic tetracycline derivative that was originally introduced in the 1960s. A new int...


    pub_type: 杂志文章,评审


    authors: Greig SL,Scott LJ

    更新日期:2016-10-01 00:00:00

  • Nadroparin calcium. A review of its pharmacology and clinical applications in the prevention and treatment of thromboembolic disorders.

    abstract::Nadroparin calcium is a low molecular weight heparin with a mean molecular weight of 4.5 kD. Compared with unfractionated heparin, nadroparin calcium has a greater ratio of anti-factor Xa/anti-factor IIa activity. Nadroparin calcium has a longer half-life and greater bioavailability than unfractionated heparin and can...


    pub_type: 杂志文章,评审


    authors: Barradell LB,Buckley MM

    更新日期:1992-11-01 00:00:00

  • Diuretics. Clinical pharmacology and therapeutic use (Part II).

    abstract::25 years have elapsed since the introduction of the first effective oral diuretic, chlorothiazide. Diuretics are now amongst the most widely prescribed drugs in clinical practice worldwide. Availability of these drugs has not only brought therapeutic benefit to countless numbers of patients but it has at the same time...


    pub_type: 杂志文章,评审


    authors: Lant A

    更新日期:1985-02-01 00:00:00

  • Effects of ketanserin tartrate on serum lipids in patients with essential hypertension.

    abstract::Several antihypertensive agents such as thiazide diuretics and some beta-blockers have recently been shown to adversely affect lipid metabolism. Moreover, there is a growing suspicion that the adverse effect on plasma lipids might outweigh the favourable effect of lowering blood pressure. The effect of ketanserin tart...


    pub_type: 临床试验,杂志文章


    authors: Nakamura H,Hirata F,Yasugi T,Mizuno M,Saito E,Ishikawa T,Tada N,Nakaya N,Homma Y,Takeuchi I

    更新日期:1988-01-01 00:00:00

  • Prescribing oral contraceptives.

    abstract::The combined oral contraceptive pill is the most popular method of contraception worldwide, with modern low-dose formulations significantly improving tolerability. Breakthrough bleeding is the most significant adverse event associated with the low-dose combined oral contraceptives. Monophasic, biphasic, triphasic and ...


    pub_type: 杂志文章,评审


    authors: Weisberg E

    更新日期:1995-02-01 00:00:00

  • Drug treatment of haemorrhoids.

    abstract::Drug treatment for various anorectal conditions has been known since ancient times. Today, modern as well as traditional drugs are being increasingly used in all grades of symptomatic haemorrhoids. These drugs (oral and local) are used as a part of conservative management or as an adjuvant to invasive outpatient proce...


    pub_type: 杂志文章,评审


    authors: Misra MC,Imlitemsu

    更新日期:2005-01-01 00:00:00

  • Are there potential non-lipid-lowering uses of statins?

    abstract::Recent clinical trials have demonstrated beyond doubt that statins are effective in the prevention of acute coronary events. Critical analysis of these studies suggests that the benefits of statin therapy cannot be fully explained on the basis of reductions in plasma cholesterol levels. Accumulating knowledge of the a...


    pub_type: 杂志文章,评审


    authors: Wheeler DC

    更新日期:1998-10-01 00:00:00

  • Cannabinoids: Current and Future Options to Treat Chronic and Chemotherapy-Induced Neuropathic Pain.

    abstract::Increases in cancer diagnosis have tremendous negative impacts on patients and their families, and major societal and economic costs. The beneficial effect of chemotherapeutic agents on tumor suppression comes with major unwanted side effects such as weight and hair loss, nausea and vomiting, and neuropathic pain. Che...


    pub_type: 杂志文章,评审


    authors: Blanton HL,Brelsfoard J,DeTurk N,Pruitt K,Narasimhan M,Morgan DJ,Guindon J

    更新日期:2019-06-01 00:00:00

  • Elbasvir/Grazoprevir: First Global Approval.

    abstract::A fixed-dose combination tablet of the hepatitis C virus (HCV) NS5A inhibitor elbasvir and the HCV NS3/4A protease inhibitor grazoprevir (elbasvir/grazoprevir; Zepatier™) is under development by Merck. Oral elbasvir/grazoprevir 50/100 mg once daily has been approved in the USA for the treatment of adults with chronic ...


    pub_type: 杂志文章,评审


    authors: Keating GM

    更新日期:2016-04-01 00:00:00

  • HIV-1 antiretroviral resistance: scientific principles and clinical applications.

    abstract::The efficacy of an antiretroviral (ARV) treatment regimen depends on the activity of the regimen's individual ARV drugs and the number of HIV-1 mutations required for the development of resistance to each ARV - the genetic barrier to resistance. ARV resistance impairs the response to therapy in patients with transmitt...


    pub_type: 杂志文章,评审


    authors: Tang MW,Shafer RW

    更新日期:2012-06-18 00:00:00

  • Postanaesthetic shivering: epidemiology, pathophysiology, and approaches to prevention and management.

    abstract::Along with nausea and vomiting, postanaesthetic shivering is one of the leading causes of discomfort for patients recovering from general anaesthesia. The distinguishing factor during electromyogram recordings between patients with postanaesthetic shivering and shivering in fully awake patients is the existence of clo...


    pub_type: 杂志文章,评审


    authors: Alfonsi P

    更新日期:2001-01-01 00:00:00

  • Pharmacotherapy and weight-loss supplements for treatment of paediatric obesity.

    abstract::Childhood obesity has become the most common paediatric disorder in the developed world. Treatment of obesity in children may include lifestyle interventions, pharmacotherapy and weight-loss supplements. The outcome of lifestyle interventions, which classically include dietary modifications, increased activity and beh...


    pub_type: 杂志文章,评审


    authors: Rogovik AL,Chanoine JP,Goldman RD

    更新日期:2010-02-12 00:00:00

  • Alirocumab: First Global Approval.

    abstract::Alirocumab (Praluent®) is a fully human monoclonal antibody developed by Regeneron Pharmaceuticals and Sanofi that has been approved in the US as an adjunct to diet and maximally tolerated statin therapy for the treatment of adults with heterozygous familial hypercholesterolaemia (HeFH) or clinical atherosclerotic car...


    pub_type: 杂志文章,评审


    authors: Markham A

    更新日期:2015-09-01 00:00:00

  • Renal protection in hypertensive patients: selection of antihypertensive therapy.

    abstract::Hypertension is common in chronic renal disease and is a risk factor for the faster progression of renal damage, and reduction of blood pressure (BP) is an efficient way of preventing or slowing the progression of this damage. International guidelines recommend lowering BP to 140/90 mm Hg or less in patients with unco...


    pub_type: 杂志文章,评审


    authors: Wenzel RR

    更新日期:2005-01-01 00:00:00

  • Anti-tumour necrosis factor therapy for ulcerative colitis: evidence to date.

    abstract::Infliximab, the chimeric monoclonal antibody directed against tumour necrosis factor (TNF)-alpha, has profoundly changed therapy for Crohn's disease (CD). However, for ulcerative colitis (UC), before the publication of ACT 1 and ACT 2 (Active Ulcerative Colitis Trials 1 and 2), there were only a few open-label and con...


    pub_type: 杂志文章,评审


    authors: Thukral C,Cheifetz A,Peppercorn MA

    更新日期:2006-01-01 00:00:00

  • Lixisenatide: first global approval.

    abstract::The selective once-daily prandial glucagon-like peptide-1 (GLP-1) receptor agonist lixisenatide (Lyxumia(®)) is under development with Sanofi for the treatment of type 2 diabetes mellitus. Lixisenatide belongs to a class of GLP-1 compounds designed to mimic the endogenous hormone GLP-1. Native GLP-1 stimulates insulin...


    pub_type: 杂志文章,评审


    authors: Elkinson S,Keating GM

    更新日期:2013-03-01 00:00:00

  • Enoxaparin. A review of its clinical potential in the management of coronary artery disease.

    abstract:UNLABELLED:Enoxaparin (enoxaparin sodium) is a low molecular weight heparin (LMWH) that is widely used in the prevention of deep venous thrombosis and pulmonary embolism in patients undergoing orthopaedic or general surgery. Its efficacy in these indications has led to study of its use in patients with coronary artery ...


    pub_type: 杂志文章,评审


    authors: Noble S,Spencer CM

    更新日期:1998-08-01 00:00:00

  • Vasodilatation with pinacidil. Mode of action in rat resistance vessels.

    abstract::Pinacidil is a newly developed antihypertensive vasodilator, proposed to belong to the new group of smooth muscle relaxants, the K+ channel openers. The in vitro effects of pinacidil on induced tone, smooth muscle membrane potential and 86Rb and 42K efflux from rat resistance vessels (internal diameter about 200 micro...


    pub_type: 杂志文章


    authors: Videbaek LM,Aalkjaer C,Mulvany MJ

    更新日期:1988-01-01 00:00:00

  • Alprazolam: a review of its pharmacodynamic properties and efficacy in the treatment of anxiety and depression.

    abstract::Alprazolam is a triazolobenzodiazepine which is related to diazepam and other 1,4-benzodiazepines, and has a similar pharmacological profile. Relative to the newer benzodiazepines, alprazolam has an intermediate half-life of 10 to 12 hours in healthy young subjects. In placebo-controlled and double-blind comparative t...


    pub_type: 临床试验,杂志文章,评审


    authors: Dawson GW,Jue SG,Brogden RN

    更新日期:1984-02-01 00:00:00

  • Hypertension in pregnancy. Pathophysiology and management.

    abstract::Hypertension in pregnancy has implications for both maternal and fetal welfare. Extrapolation from concepts of mechanisms operating in hypertension in general to pregnancy-related hypertension is not justified. In the latter, the major features are a hyper-adrenergic state, plasma volume reduction and an increased sys...


    pub_type: 杂志文章,评审


    authors: Lubbe WF

    更新日期:1984-08-01 00:00:00

  • Antifracture efficacy of currently available therapies for postmenopausal osteoporosis.

    abstract::Osteoporosis is a systemic bone disease characterized by low bone mass and bone mineral density, and deterioration of the underlying structure of bone tissue. These changes lead to an increase in bone fragility and an increased risk for fracture, which are the clinical consequences of osteoporosis. The classical triad...


    pub_type: 杂志文章,评审


    authors: Reginster JY

    更新日期:2011-01-01 00:00:00

  • Dofetilide: a review of its use in atrial fibrillation and atrial flutter.

    abstract:UNLABELLED:Dofetilide is a 'pure' class III antiarrhythmic agent which has demonstrated efficacy in the conversion of atrial fibrillation or flutter to sinus rhythm and the maintenance of sinus rhythm. By blocking the rapid component of the cardiac delayed rectifier potassium current (I(Kr)), dofetilide prolongs the ca...


    pub_type: 杂志文章,评审


    authors: McClellan KJ,Markham A

    更新日期:1999-12-01 00:00:00

  • Safety profiles of the angiotensin-converting enzyme inhibitors.

    abstract::This review will discuss the safety profiles of the angiotensin-converting enzyme (ACE) inhibitors captopril, enalapril and lisinopril in patients with hypertension. In general, the safety profiles of ACE inhibitors compare favourably with those of other agents used for the treatment of hypertension. Adverse effects a...


    pub_type: 杂志文章,评审


    authors: Warner NJ,Rush JE

    更新日期:1988-01-01 00:00:00

  • Acamprosate. A review of its pharmacology and clinical potential in the management of alcohol dependence after detoxification.

    abstract::Acamprosate (calcium acetylhomotaurinate), a synthetic compound with a similar chemical structure to that of gamma-aminobutyric acid, is thought to act via several mechanisms affecting multiple neurotransmitter systems; inhibition of neuronal hyperexcitability by antagonism of excitatory amino acid activity and reduct...


    pub_type: 杂志文章,评审


    authors: Wilde MI,Wagstaff AJ

    更新日期:1997-06-01 00:00:00

  • 5-HT3 receptor antagonists for the prevention of chemotherapy-induced nausea and vomiting. A comparison of their pharmacology and clinical efficacy.

    abstract::In the mid-1980s it was discovered that serotonin (5-hydroxytryptamine; 5-HT) was at least partially responsible for producing chemotherapy-induced nausea and vomiting. It was therefore realised that serotonin receptor blockade with serotonin 5-HT3 receptor antagonists could inhibit chemotherapy-induced nausea and vom...


    pub_type: 杂志文章,评审


    authors: Gregory RE,Ettinger DS

    更新日期:1998-02-01 00:00:00

  • Sotagliflozin: A Review in Type 1 Diabetes.

    abstract::Sotagliflozin (Zynquista™) is the first dual inhibitor of sodium-glucose co-transporter-1 and -2 (SGLT1 and 2). In the phase 3, inTANDEM 1-3 trials, adjunctive use of oral sotagliflozin (200 mg or 400 mg once daily) improved glycaemic control and reduced bodyweight and insulin requirements relative to placebo over 24 ...


    pub_type: 杂志文章,评审


    authors: Deeks ED

    更新日期:2019-12-01 00:00:00

  • Tipranavir: a review of its use in the management of HIV infection.

    abstract::Tipranavir (Aptivus) is a selective nonpeptidic HIV-1 protease inhibitor (PI) that is used in the treatment of treatment-experienced adults with HIV-1 infection. Tipranavir is administered orally twice daily and must be given in combination with low-dose ritonavir, which is used to boost its bioavailability. The durab...


    pub_type: 杂志文章,评审


    authors: Orman JS,Perry CM

    更新日期:2008-01-01 00:00:00