Abstract:
:Developed by Bayer in Germany, nifedipine was shown to be effective in the treatment of patients with angina pectoris by Japanese investigators. Professor Kimura first reported the efficacy of nifedipine in patients with angina pectoris and those findings have been replicated in numerous trials conducted since then. Clinical trials found a low incidence of fixed coronary artery stenosis in Japanese patients with variant angina pectoris, and a complete antianginal response with Ca2+ channel antagonist such as nifedipine. It was hypothesised that the mechanism of this benefit with nifedipine was because of a strong coronary vasodilating action along with an inhibitory effect on coronary spasm. Recent evidence has established the tolerability and efficacy of once-daily dosage forms, which provide stable plasma nifedipine concentrations, in the management of coronary artery disorders.
journal_name
Drugsjournal_title
Drugsauthors
Hosoda Sdoi
10.2165/00003495-200666991-00003subject
Has Abstractpub_date
2006-01-01 00:00:00pages
4-6eissn
0012-6667issn
1179-1950journal_volume
66 Spec No 1pub_type
杂志文章,评审相关文献
DRUGS文献大全abstract::It is well documented that long term treatment with nonsteroidal anti-inflammatory drugs (NSAIDs) increases the risk of peptic ulcer and that gastroduodenal mucosal erosions can be demonstrated in volunteers within 1 week of treatment initiation. However, long term studies in nonsurgical patients have not documented g...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199200445-00006
更新日期:1992-01-01 00:00:00
abstract::Systemic therapy for advanced non-small cell lung cancer (NSCLC) has evolved over the last two decades, with modest improvements in quality of life and overall survival. A plateau has been reached with traditional chemotherapy, and efforts are now being directed at developing molecularly targeted agents. To date, thre...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/11532200-000000000-00000
更新日期:2010-01-01 00:00:00
abstract::Pinacidil is a newly developed antihypertensive vasodilator, proposed to belong to the new group of smooth muscle relaxants, the K+ channel openers. The in vitro effects of pinacidil on induced tone, smooth muscle membrane potential and 86Rb and 42K efflux from rat resistance vessels (internal diameter about 200 micro...
journal_title:Drugs
pub_type: 杂志文章
doi:10.2165/00003495-198800367-00006
更新日期:1988-01-01 00:00:00
abstract::Pharmacotherapy for the management of obesity is primarily aimed at weight loss, weight loss maintenance and risk reduction, and has included thyroid hormone, amphetamines, phentermine, amfepramone (diethylpropion), phenylpropanolamine, mazindol, fenfluramines and, more recently, sibutramine and orlistat. These agents...
journal_title:Drugs
pub_type: 杂志文章,meta分析,评审
doi:10.2165/00003495-200565100-00006
更新日期:2005-01-01 00:00:00
abstract::Heparin remains the most effective antithrombotic drug. It acts by combining with plasma antithrombin, thereby accelerating the neurtalisation of thrombin and other acitvated coagulation factors. Full-dose intravenous heparin is indicated in all cases of pulmonary embolism and established deep venous thrombosis, unles...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-197713010-00005
更新日期:1977-01-01 00:00:00
abstract::Many drugs have a site of action within the inner ear. The list includes therapeutic, diagnostic and ototoxic agents. Therapeutic agents are most useful in cases of infections, endolymphatic hydrops, vascular insufficiency, vertigo of peripheral origin, autoimmune disease, otosclerosis (otospongiosis), sudden hearing ...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-198836060-00005
更新日期:1988-12-01 00:00:00
abstract::Patients frequently come to the emergency department for pain. For decades, ketamine has been used in the emergency department for procedural sedation but is now receiving attention as a potential alternative to opioids because of its unique analgesic effects. Additionally, ketamine's dissociative properties have made...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-018-0904-8
更新日期:2018-05-01 00:00:00
abstract::Acamprosate (calcium acetylhomotaurinate), a synthetic compound with a similar chemical structure to that of gamma-aminobutyric acid, is thought to act via several mechanisms affecting multiple neurotransmitter systems; inhibition of neuronal hyperexcitability by antagonism of excitatory amino acid activity and reduct...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199753060-00008
更新日期:1997-06-01 00:00:00
abstract::Mortality and morbidity in gastroenteritis in children is the result of fluid loss, acid-base and electrolyte imbalance. Hence therapy should be aimed at preventing or correcting this imbalance. The use of intestinal antibiotics to treat the condition should not be a routine, but parenteral antibiotic therapy in the p...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-197611040-00004
更新日期:1976-01-01 00:00:00
abstract::The comprehensive treatment of schizophrenia requires the full resources of a clinical team that is able to offer treatment for the acute psychotic state in a hospital environment, and appropriate rehabilitation following resolution of the florid symptoms. Following a second or subsequent relapse, maintenance therapy ...
journal_title:Drugs
pub_type: 杂志文章
doi:10.2165/00003495-197714040-00004
更新日期:1977-10-01 00:00:00
abstract:UNLABELLED:Gatifloxacin is an 8-methoxy fluoroquinolone antibacterial agent. The drug has a broader spectrum of antibacterial activity than the older fluoroquinolones (e.g. ciprofloxacin) and shows good activity against many Gram-positive and Gram-negative pathogens, atypical organisms and some anaerobes. Notably, gati...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200262010-00007
更新日期:2002-01-01 00:00:00
abstract::Rapid progress has recently been encountered in pharmacologically treating the unborn baby. This unique area of drug therapy raises new methodological and ethical questions. This article is a systematic review of known modalities of fetal pharmacotherapy, and aims to highlight essential principles, difficulties and co...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200262050-00004
更新日期:2002-01-01 00:00:00
abstract::Oesophageal cancer is the eighth most common cancer diagnosed worldwide, with almost half a million new cases diagnosed each year. Despite improvements in surgical and radiotherapy techniques and refinements of chemotherapeutic regimens, long-term survival, even from localized oesophageal cancer, remains poor. Surgica...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/11585460-000000000-00000
更新日期:2011-03-26 00:00:00
abstract::The incidence of infection in clean surgery (i.e. surgery with no major contamination of the operative site) should be less than 2%, although the incidence of postoperative infections can be higher in patients with various risk factors (namely insertion of foreign bodies, a compromised immune status or prolonged durat...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199700546-00008
更新日期:1997-01-01 00:00:00
abstract::Antibacterial activities of cefotaxime and its major metabolite, desacetylcefotaxime, against 178 strains (of 10 species) were assessed in terms of minimum inhibitory concentrations (MIC50 and MIC80), and were compared with those of cefoperazone and ceftazidime. The activity of desacetylcefotaxime was several times le...
journal_title:Drugs
pub_type: 杂志文章
doi:10.2165/00003495-198800352-00013
更新日期:1988-01-01 00:00:00
abstract::Approximately 70% of invasive breast cancers have some degree of dependence on the estrogen hormone for cell proliferation and growth. These tumors have estrogen and/or progesterone receptors (ER/PR+), generally referred to as hormone receptor positive (HR+) tumors, as indicated by the presence of positive staining an...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-020-01394-w
更新日期:2020-11-01 00:00:00
abstract::Dementia is commonly diagnosed at a time of major domestic breakdown, when symptoms are severe and family and community patience has been eroded. In order to encourage early referral and identification of patients with treatable conditions, a Memory Clinic is held at the University Hospital in Cardiff. The clinic prov...
journal_title:Drugs
pub_type: 杂志文章
doi:10.2165/00003495-198700332-00016
更新日期:1987-01-01 00:00:00
abstract::The potential interaction between nimesulide, a nonsteroidal anti-inflammatory drug, and digoxin was studied in 9 patients [6 males, 3 females; mean age 67 (range 57 to 70) years] with mild heart failure. All patients were receiving maintenance therapy with digoxin (0.25 mg/day, orally) and were treated with oral nime...
journal_title:Drugs
pub_type: 杂志文章
doi:10.2165/00003495-199300461-00017
更新日期:1993-01-01 00:00:00
abstract::Cenobamate (XCOPRI®) is an oral, small molecule neurotherapeutic azole compound that is being developed by SK Life Science Inc. and Arvelle Therapeutics for the treatment of epilepsy. Based on results of two pivotal phase 2 trials, cenobamate was recently approved in the USA for use in the treatment of partial-onset s...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-019-01250-6
更新日期:2020-01-01 00:00:00
abstract::Intravenous minocycline (Minocin®) is approved in the USA for use in patients with infections due to susceptible strains of Gram-positive and Gram-negative pathogens, including infections due to Acinetobacter spp. Minocycline is a synthetic tetracycline derivative that was originally introduced in the 1960s. A new int...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-016-0636-6
更新日期:2016-10-01 00:00:00
abstract::In ten large, well-controlled, randomised trials (n = 203 to 1089), valdecoxib, a selective inhibitor of cyclo-oxygenase-2, was significantly more effective than placebo in the treatment of osteoarthritis, rheumatoid arthritis and pain associated with primary dysmenorrhoea, and for postsurgical analgesia. Valdecoxib 1...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200262140-00005
更新日期:2002-01-01 00:00:00
abstract::Through years of evolutionary selection pressures, organisms have developed potent toxins that coincidentally have marked antineoplastic activity. These natural products have been vital for the development of multiagent treatment regimens currently employed in cancer chemotherapy, and are used in the treatment of a va...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-015-0489-4
更新日期:2015-11-01 00:00:00
abstract::The Diabetes Control and Complications Trial and the Stockholm Study have conclusively demonstrated that improving the blood glucose control in patients with insulin-dependent diabetes mellitus (IDDM) reduces the risk of developing retinopathy, nephropathy and neuropathy. Each patient with IDDM should be carefully eva...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199447040-00005
更新日期:1994-04-01 00:00:00
abstract::The chronic fatigue syndrome (CFS) was formally defined in 1988 to describe a syndrome of severe and disabling fatigue of uncertain aetiology associated with a variable number of somatic and/or psychological symptoms. CFS has been reported in most industrialised countries and is most prevalent in women aged between 20...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199346040-00005
更新日期:1993-10-01 00:00:00
abstract::In a study of the effects of various NSAIDs on renal function in the elderly, indomethacin, tiaprofenic acid and sulindac were administered to patients ranging in age from 54 to 97 years for a period of 3 months. Indomethacin sustained release (25 mg tid) was administered to 66 patients, tiaprofenic acid (200 mg tid) ...
journal_title:Drugs
pub_type: 杂志文章
doi:10.2165/00003495-198800351-00022
更新日期:1988-01-01 00:00:00
abstract:UNLABELLED:Dofetilide is a 'pure' class III antiarrhythmic agent which has demonstrated efficacy in the conversion of atrial fibrillation or flutter to sinus rhythm and the maintenance of sinus rhythm. By blocking the rapid component of the cardiac delayed rectifier potassium current (I(Kr)), dofetilide prolongs the ca...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199958060-00007
更新日期:1999-12-01 00:00:00
abstract:UNLABELLED:Darunavir is an oral nonpeptidic HIV-1 protease inhibitor (PI) that is used, together with a low boosting dose of ritonavir, as part of an antiretroviral therapy (ART) regimen in treatment-experienced and -naive patients with HIV-1 infection. Compared with early-generation PIs, boosted darunavir has a high g...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200969040-00007
更新日期:2009-01-01 00:00:00
abstract::HMG-CoA reductase inhibitors (statins) have been shown to reduce mortality and cardiovascular morbidity in patients with hyperlipidaemia and those with coronary artery disease. However, evidence for statin treatment in patients with chronic heart failure (CHF) remains a subject of debate. Patients with heart failure w...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200666020-00002
更新日期:2006-01-01 00:00:00
abstract::Accumulating evidence suggests the involvement of estrogen in depression. Estrogen can modulate neurotransmitter turnover, enhancing the levels of serotonin and noradrenaline (norepinephrine), and it is involved in the regulation of serotonin receptor number and function. Across the female reproductive life, fluctuati...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/11635960-000000000-00000
更新日期:2012-09-10 00:00:00
abstract::Pegaspargase (Oncaspar®), a pegylated form of native Escherichia coli-derived L-asparaginase (hereafter referred as E. coliL-asparaginase), is indicated in the USA and EU for the treatment of acute lymphoblastic leukaemia (ALL) as a component of multi-agent chemotherapy in paediatric and adult patients. Relative to E....
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-019-01120-1
更新日期:2019-05-01 00:00:00