Targeting the PI3K/AKT/mTOR Pathway in Hormone-Positive Breast Cancer.

Abstract:

:Approximately 70% of invasive breast cancers have some degree of dependence on the estrogen hormone for cell proliferation and growth. These tumors have estrogen and/or progesterone receptors (ER/PR+), generally referred to as hormone receptor positive (HR+) tumors, as indicated by the presence of positive staining and varying intensity levels of estrogen and/or progesterone receptors on immunohistochemistry. Therapies that inhibit ER signaling pathways, such as aromatase inhibitors (letrozole, anastrozole, exemestane), selective ER modulators (tamoxifen), and ER down-regulators (fulvestrant), are the mainstays of treatment for hormone-receptor-positive breast cancers. However, de novo or acquired resistance to ER targeted therapies is present in many tumors, leading to disease progression. The PI3K/AKT/mTOR pathway is implicated in sustaining endocrine resistance and has become the target of many new drugs for ER+ breast cancer. This article reviews the function of the phosphoinositide 3-kinase (PI3K)/AKT/mTOR pathway and the various classes of PI3K pathway inhibitors that have been developed to disrupt this pathway signaling for the treatment of hormone-receptor-positive breast cancer.

journal_name

Drugs

journal_title

Drugs

authors

Nunnery SE,Mayer IA

doi

10.1007/s40265-020-01394-w

subject

Has Abstract

pub_date

2020-11-01 00:00:00

pages

1685-1697

issue

16

eissn

0012-6667

issn

1179-1950

pii

10.1007/s40265-020-01394-w

journal_volume

80

pub_type

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