Abstract:
:There have been a number of controlled trials of antacids in the treatment of patients with peptic ulcer disease. As a general rule the size of studies has been small and there have been difficulties ensuring adequate binding, because of the formulation and taste of the antacids. Despite these difficulties, antacids appear to be effective ulcer healing agents with efficacies resembling those of other antiulcer drugs. Definite dose relationships are unclear but high doses of buffering capacity over 200 mmol/day appear unnecessary and are associated with increasingly frequent adverse effects. Low dose maintenance treatment is effective at limiting duodenal ulcer relapse.
journal_name
Drugsjournal_title
Drugsauthors
Walt RP,Langman MJdoi
10.2165/00003495-199142020-00003subject
Has Abstractpub_date
1991-08-01 00:00:00pages
205-12issue
2eissn
0012-6667issn
1179-1950journal_volume
42pub_type
临床试验,杂志文章,评审相关文献
DRUGS文献大全abstract::Pegylation of interferon-alpha-2a is associated with improved sustained virological response rates in patients with chronic hepatitis C. Subsequently, combination therapy with peginterferon-alpha-2a (40kD) [Pegasys] and ribavirin (Copegus trade mark, Rebetol) was investigated to establish if the efficacy of peginterfe...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200363070-00008
更新日期:2003-01-01 00:00:00
abstract::Dopamine agonists (DAs) represent an excellent treatment option for patients with Parkinson's disease, in both the early and advanced stages of the disease, improving motor symptoms, lowering the incidence of motor complications, and addressing several non-motor symptoms. Indeed, each of these compounds have different...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-019-01103-2
更新日期:2019-05-01 00:00:00
abstract::Systemic therapy for advanced non-small cell lung cancer (NSCLC) has evolved over the last two decades, with modest improvements in quality of life and overall survival. A plateau has been reached with traditional chemotherapy, and efforts are now being directed at developing molecularly targeted agents. To date, thre...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/11532200-000000000-00000
更新日期:2010-01-01 00:00:00
abstract::All 27 EU member states and another seven countries participate in the European Surveillance of Antimicrobial Consumption (ESAC) project. ESAC carried out three hospital point-prevalence surveys on antimicrobial use. Point-prevalence surveys linked antimicrobial use to indication and also assessed dosing using a stand...
journal_title:Drugs
pub_type: 杂志文章
doi:10.2165/11591180-000000000-00000
更新日期:2011-04-16 00:00:00
abstract::This paper reviews the evidence that, in patients with hypertension, end-organ damage correlates more closely with blood pressure values obtained by ambulatory blood pressure monitoring than with those obtained by conventional sphygmomanometry. However, ambulatory blood pressure monitoring is not suitable for routine ...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199200441-00004
更新日期:1992-01-01 00:00:00
abstract::Cephalosporins have a role in the treatment of gonorrhoea, and especially infections caused by strains that are penicillin-resistant, either because they produce plasmid-mediated beta-lactamase or they have chromosomally mediated diminished permeability or modified penicillin-binding proteins. Although none of the ora...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-198700342-00013
更新日期:1987-01-01 00:00:00
abstract::25 patients have been included in a randomised trial aimed to compare prehospital and hospital administration of anisoylated plasminogen streptokinase activator complex (AP-SAC). Patients were first seen, at home, by a noncardiologist doctor working in a mobile-care unit and were then evaluated for entry into the stud...
journal_title:Drugs
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2165/00003495-198700333-00042
更新日期:1987-01-01 00:00:00
abstract::Utilising a modified fixed-dose, 4 x 3 factorial design, the antihypertensive effects of all combinations of 4 doses of pinacidil (0, 12.5, 25 and 37.5 mg bid) with 3 doses of hydrochlorothiazide (0, 12.5 and 25 mg bid) were studied in patients with supine diastolic blood pressure of 95 to 110mm Hg. The decreases in s...
journal_title:Drugs
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2165/00003495-198800367-00015
更新日期:1988-01-01 00:00:00
abstract::Several antihypertensive agents such as thiazide diuretics and some beta-blockers have recently been shown to adversely affect lipid metabolism. Moreover, there is a growing suspicion that the adverse effect on plasma lipids might outweigh the favourable effect of lowering blood pressure. The effect of ketanserin tart...
journal_title:Drugs
pub_type: 临床试验,杂志文章
doi:10.2165/00003495-198800361-00006
更新日期:1988-01-01 00:00:00
abstract::Pimavanserin (Nuplazid™) is a selective and potent serotonin 2A (5-HT2A) receptor inverse agonist and antagonist developed by ACADIA Pharmaceuticals that has been approved in the US as a treatment for patients with hallucinations and delusions associated with Parkinson's disease psychosis. Up to 60 % of patients with ...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-016-0597-9
更新日期:2016-07-01 00:00:00
abstract::Oxatomide is an orally active H1-histamine receptor antagonist which, as appears to occur with some other antihistamines, also inhibits mast cell degranulation. Oxatomide has demonstrated response rates similar to those with other more established members of its drug class in a few studies of chronic urticaria and all...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-198427030-00003
更新日期:1984-03-01 00:00:00
abstract:UNLABELLED:Dofetilide is a 'pure' class III antiarrhythmic agent which has demonstrated efficacy in the conversion of atrial fibrillation or flutter to sinus rhythm and the maintenance of sinus rhythm. By blocking the rapid component of the cardiac delayed rectifier potassium current (I(Kr)), dofetilide prolongs the ca...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199958060-00007
更新日期:1999-12-01 00:00:00
abstract:BACKGROUND:While a variety of intervention options have been described for pemphigus vulgaris, the optimal treatment strategy has not been established. OBJECTIVES:The objective of this systematic review is to assess the literature on the efficacy and safety of interventions for the treatment of pemphigus vulgaris. DA...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-015-0353-6
更新日期:2015-02-01 00:00:00
abstract::Cilazapril is an orally active angiotensin converting enzyme (ACE) inhibitor which lowers peripheral vascular resistance without affecting heart rate. Like enalapril and ramipril it is a prodrug, and is hydrolysed after absorption to cilazaprilat, which has a long terminal phase elimination half-life permitting once d...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199141050-00008
更新日期:1991-05-01 00:00:00
abstract::The objective of surgical prophylaxis is to prevent wound infections associated with surgery. The rates of wound infections vary according to the procedure: less than 3 infections per 100 for clean procedures; up to 4 per 100 for clean-contaminated procedures; and up to 9 per 100 for contaminated procedures. Surgical ...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199300453-00018
更新日期:1993-01-01 00:00:00
abstract::Pain is an unpleasant sensation that originates from ongoing or impending tissue damage. Management of different types of pain (acute, postoperative, inflammatory, neuropathic or cancer) is the most frequent issue encountered by clinicians and pharmacological therapy is the first line of approach for the treatment of ...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200767150-00002
更新日期:2007-01-01 00:00:00
abstract::Four medicinal cancer biological blockbusters will end their patent lifespan by 2020. It is estimated that the total market for cancer biologicals will reach approximately US$68 billion at that time. Approximately 20 biosimilars have entered the European market since the launch of the original approval guidelines in 2...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-017-0743-z
更新日期:2017-06-01 00:00:00
abstract::Alterations of skin and hair pigmentation are important features that have warranted treatment from ancient history on up to modern time. In some cultures, even today patients with vitiligo are regarded as social outcasts and are affected considerably both emotionally and physically. This article presents current opti...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200464010-00006
更新日期:2004-01-01 00:00:00
abstract::The prevalence of use of long-term systemic glucocorticoid therapy in the general adult population is 1 %. This figure increases to up to 3 % in elderly women. Metabolic (i.e. diabetes mellitus, dyslipidemia, weight gain, lipodystrophy) and cardiovascular (i.e. hypertension, cardiovascular events) adverse events are c...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-014-0282-9
更新日期:2014-10-01 00:00:00
abstract::Insulin glargine 300 U/mL (Toujeo(®)) is a long-acting basal insulin analogue approved for the treatment of diabetes mellitus. Insulin glargine 300 U/mL has a more stable and prolonged pharmacokinetic/pharmacodynamic profile than insulin glargine 100 U/mL (Lantus(®)), with a duration of glucose-lowering activity excee...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-016-0541-z
更新日期:2016-03-01 00:00:00
abstract::Oral fidaxomicin (Dificid(®); Dificlir(®)) is a first-in-class macrocyclic antibacterial that is approved in several countries for the treatment of adult patients with Clostridium difficile-associated diarrhoea. Fidaxomicin 200 mg twice daily for 10 days was an effective and generally well tolerated treatment in adult...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-013-0134-z
更新日期:2013-10-01 00:00:00
abstract::Sitagliptin (Januvia(®), Xelevia™, Glactiv(®), Tesavel(®)) is an orally administered, potent and highly selective inhibitor of dipeptidyl peptidase-4 (DPP-4) and was the first agent of its class to be approved for use in the management of adults with type 2 diabetes. Numerous randomized placebo- or active comparator-c...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-013-0169-1
更新日期:2014-02-01 00:00:00
abstract::As a consequence of disparities in access to and utilization of preventative healthcare, the incidence and death rates from cervical cancer remain substantial in the face of indisputable evidence that screening saves lives. While disparities persist, there will be an urgent need for research into the treatment of adva...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-015-0481-z
更新日期:2015-11-01 00:00:00
abstract::Aspirin is currently the most widely prescribed treatment in the prevention of cardiovascular complications. The indications for the use of aspirin during pregnancy are, however, the subject of much controversy. Since the first evidence of the obstetric efficacy of aspirin in 1985, numerous studies have tried to deter...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-017-0823-0
更新日期:2017-11-01 00:00:00
abstract::Empagliflozin/linagliptin (Glyxambi(®)) is a once-daily sodium glucose co-transporter type 2 (SGLT2) inhibitor and dipeptidyl peptidase (DPP)-4 inhibitor fixed-dose combination product that is approved in the USA as an adjunct to diet and exercise in adults with type 2 diabetes (T2D) when treatment with both empaglifl...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-015-0457-z
更新日期:2015-09-01 00:00:00
abstract::Influenza vaccines form the mainstay of public health and personal protection against infection with seasonal influenza viruses. These vaccines are designed to protect people against infection with the currently circulating influenza viruses. Since the late 1970s, this has required the use of a trivalent vaccine consi...
journal_title:Drugs
pub_type: 杂志文章
doi:10.2165/11641110-000000000-00000
更新日期:2012-12-03 00:00:00
abstract::Insulin degludec (Tresiba(®)) is an ultra-long-acting insulin analogue that is also available as a coformulation with rapid-acting insulin aspart (insulin degludec/insulin aspart) [Ryzodeg(®)]. Insulin degludec has a flat, stable glucose-lowering profile with a duration of action of >42 h, and less within-patient day-...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-013-0051-1
更新日期:2013-05-01 00:00:00
abstract::Telavancin is the first available lipoglycopeptide antibacterial agent. It is active against Gram-positive bacteria, including meticillin/oxacillin-resistant Staphylococcus aureus (MRSA) strains associated with complicated skin and skin structure infections (cSSSIs). In randomized, double-blind trials, intravenous tel...
journal_title:Drugs
pub_type: 杂志文章
doi:10.2165/10481380-000000000-00000
更新日期:2009-01-01 00:00:00
abstract::Canagliflozin (Invokana™), an oral selective sodium-glucose co-transporter 2 (SGLT2) inhibitor, is under global development with Mitsubishi Tanabe Pharma and Janssen Pharmaceuticals, a subsidiary of Johnson and Johnson, for the treatment of type 2 diabetes mellitus. SGLT2 are mainly located in the proximal tubule of t...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-013-0064-9
更新日期:2013-06-01 00:00:00
abstract::The role of serotonin in the pathogenesis of hypertension is not clear. Serotonin is produced by the enterochromaffin cells of the gut; the greater part of this is metabolised in the liver and lungs and nearly all of the remainder is taken up by the platelets. Consequently, circulating levels of serotonin are extremel...
journal_title:Drugs
pub_type: 杂志文章
doi:10.2165/00003495-198800361-00011
更新日期:1988-01-01 00:00:00