Cilazapril. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in cardiovascular disease.

abstract：:Knowledge of the structure, function and distribution of the components of the renin-angiotensin-aldosterone system (RAS) and the integrated physiological role of this hormonal system is rapidly increasing, although many questions remain unanswered. The primary structure and localisation of RAS such as renin, prorenin...

journal_title：Drugs

authors： Johnston CI

更新日期：1990-01-01 00:00:00

abstract：:The cardiovascular and cardiorenal disease continuum comprises the transition from cardiovascular risk factors to endothelial dysfunction and atherosclerosis, to clinical complications such as myocardial infarction (MI) and stroke, to the development of persistent target-organ damage and, ultimately, to chronic conges...

journal_title：Drugs

authors： Werner C,Pöss J,Böhm M

更新日期：2010-07-09 00:00:00

abstract：:Drug-drug interactions (DDIs) occur commonly and may lead to severe adverse drug reactions if not handled appropriately. Considerable information to support clinical decision making regarding potential DDIs is available in the literature and through various systems providing electronic decision support for healthcare ...

journal_title：Drugs

authors： Lund M,Petersen TS,Dalhoff KP

更新日期：2017-05-01 00:00:00

abstract：:Trifluridine/tipiracil (Lonsurf(®)) is a novel, orally active, antimetabolite agent comprised of trifluridine, a thymidine-based nucleoside analogue, and tipiracil, a potent thymidine phosphorylase inhibitor. Trifluridine is incorporated into DNA via phosphorylation, ultimately inhibiting cell proliferation. Tipiracil...

journal_title：Drugs

authors： Burness CB,Duggan ST

更新日期：2016-09-01 00:00:00

abstract：:Sore throats are most commonly due to infections, many of which are viral and do not require specific treatment. Symptoms and signs of the common cold, influenza or croup, the occurrence of conjunctivitis in some adenoviral infections, generalised lymphadenopathy and splenomegaly in glandular fever or the presence of ...

journal_title：Drugs

authors： Lang SD,Singh K

更新日期：1990-12-01 00:00:00

abstract：:Herbs are often administered in combination with therapeutic drugs, raising the potential of herb-drug interactions. An extensive review of the literature identified reported herb-drug interactions with clinical significance, many of which are from case reports and limited clinical observations. Cases have been publis...

journal_title：Drugs

authors： Hu Z,Yang X,Ho PC,Chan SY,Heng PW,Chan E,Duan W,Koh HL,Zhou S

更新日期：2005-01-01 00:00:00

abstract：:The incidence of squamous cell carcinoma of the head and neck (SCCHN) is on the rise in the US despite a drop in cigarette smoking rates. Much of this rise is due to the increasing incidence of SCCHN attributable to human papillomavirus (HPV). HPV-related SCCHN has a high cure rate, which contributes to the stable dea...

journal_title：Drugs

authors： Brockstein BE

更新日期：2011-08-20 00:00:00

abstract：:The size of the antibiotic market in developing countries is double that seen in developed countries. There are some valid reasons for this difference, one of which is the higher frequency of diverse infections in the developing world. However, other factors are involved: for example, antibiotics are available without...

journal_title：Drugs

authors： Rodríguez-Noriega E,Morfin-Otero R,Esparza-Ahumada S

更新日期：1993-01-01 00:00:00

abstract：:The lipid-modifying profile of bezafibrate is characterised by marked decreases in elevated triglyceride levels, increases in high density lipoprotein (HDL) cholesterol levels and decreases in total and low density lipoprotein (LDL) cholesterol levels. Bezafibrate also reduces elevated levels of lipoprotein(a) [Lp(a)]...

journal_title：Drugs

authors： Goa KL,Barradell LB,Plosker GL

更新日期：1996-11-01 00:00:00

abstract：:In the 30 years since the rabbit antithymocyte globulin (rATG) Thymoglobulin(®) was first licensed, its use in solid organ transplantation and hematology has expanded progressively. Although the evidence base is incomplete, specific roles for rATG in organ transplant recipients using contemporary dosing strategies are...

journal_title：Drugs

authors： Mohty M,Bacigalupo A,Saliba F,Zuckermann A,Morelon E,Lebranchu Y

更新日期：2014-09-01 00:00:00

abstract：:The comprehensive treatment of schizophrenia requires the full resources of a clinical team that is able to offer treatment for the acute psychotic state in a hospital environment, and appropriate rehabilitation following resolution of the florid symptoms. Following a second or subsequent relapse, maintenance therapy ...

journal_title：Drugs

authors： Johnson DA

更新日期：1977-10-01 00:00:00

abstract：:In ten large, well-controlled, randomised trials (n = 203 to 1089), valdecoxib, a selective inhibitor of cyclo-oxygenase-2, was significantly more effective than placebo in the treatment of osteoarthritis, rheumatoid arthritis and pain associated with primary dysmenorrhoea, and for postsurgical analgesia. Valdecoxib 1...

journal_title：Drugs

authors： Ormrod D,Wellington K,Wagstaff AJ

更新日期：2002-01-01 00:00:00

abstract：:Purine nucleoside analogues are a new class of drugs with activity against nondividing lymphocytes; thus, they should play a major role in the treatment of low grade lymphoid malignancies. As these drugs are active against resting lymphocytes, harmful effects related to this action were expected and have been reported...

journal_title：Drugs

authors： Dighiero G

更新日期：1994-01-01 00:00:00

abstract：:Clostridium difficile-associated disease (CDAD) is increasingly being reported in many regions throughout the world. The reasons for this are unknown, are likely to be multifactorial, and are the subject of several current investigations. In addition to the upsurge in frequency of CDAD, an increased rate of relapse/re...

journal_title：Drugs

authors： Owens RC

更新日期：2007-01-01 00:00:00

abstract：:Pimavanserin (Nuplazid™) is a selective and potent serotonin 2A (5-HT2A) receptor inverse agonist and antagonist developed by ACADIA Pharmaceuticals that has been approved in the US as a treatment for patients with hallucinations and delusions associated with Parkinson's disease psychosis. Up to 60 % of patients with ...

journal_title：Drugs

authors： Markham A

更新日期：2016-07-01 00:00:00

abstract：SYNOPSIS:Acitretin (etretin), a second generation monoaromatic retinoid for use in the treatment of severe psoriasis and other dermatoses, is the major active metabolite of etretinate and possesses a similar therapeutic index; i.e. a similar ratio of clinical efficacy to adverse effects. When used alone at a maintenanc...

journal_title：Drugs

authors： Pilkington T,Brogden RN

更新日期：1992-04-01 00:00:00

abstract：:Gastro-oesophageal reflux disease (GORD or GERD) is a very common disorder, and advancement in drug development over the years has markedly improved disease management. Proton pump inhibitors (PPIs) remain the mainstay of treatment for GERD due to their profound and consistent inhibitory effect on acid secretion. Howe...

journal_title：Drugs

authors： Hershcovici T,Fass R

更新日期：2011-12-24 00:00:00

abstract：:The bacteria most commonly responsible for early-onset (materno-fetal) infections in neonates are group B streptococci, enterococci, Enterobacteriaceae and Listeria monocytogenes. Coagulase-negative staphylococci, particularly Staphylococcus epidermidis, are the main pathogens in late-onset (nosocomial) infections, es...

journal_title：Drugs

authors： Fanos V,Dall'Agnola A

更新日期：1999-09-01 00:00:00

abstract：:The selective once-daily prandial glucagon-like peptide-1 (GLP-1) receptor agonist lixisenatide (Lyxumia(®)) is under development with Sanofi for the treatment of type 2 diabetes mellitus. Lixisenatide belongs to a class of GLP-1 compounds designed to mimic the endogenous hormone GLP-1. Native GLP-1 stimulates insulin...

journal_title：Drugs

authors： Elkinson S,Keating GM

更新日期：2013-03-01 00:00:00

abstract：:Numerous intervention studies have clearly demonstrated the value of antihypertensive treatment. By lowering diastolic blood pressure 5 to 6mm Hg in middle-aged hypertensive patients, a 42% reduction in stroke morbidity and a 14% reduction in coronary heart disease morbidity can be obtained. Recently published large i...

journal_title：Drugs

authors： Hansson L

更新日期：1993-01-01 00:00:00

abstract：:Discharge from the ear can be the result of many disease processes. The ear may discharge blood, pus, cerebrospinal fluid (CSF) or wax. Keratosis obturans, stenosis of the external meatus and benign tumours of the external meatus all lead to wax build-up, which may cause recurrent attacks of otitis externa. Malignant ...

journal_title：Drugs

authors： Ruddy J,Bickerton RC

更新日期：1992-02-01 00:00:00

abstract：:Childhood obesity has become the most common paediatric disorder in the developed world. Treatment of obesity in children may include lifestyle interventions, pharmacotherapy and weight-loss supplements. The outcome of lifestyle interventions, which classically include dietary modifications, increased activity and beh...

journal_title：Drugs

authors： Rogovik AL,Chanoine JP,Goldman RD

更新日期：2010-02-12 00:00:00

abstract：:The proton pump inhibitors (PPIs) are the most successful class of drugs that have been introduced for the treatment of gastro-oesophageal reflux disease (GORD) because of their profound and consistent effect on gastric acid secretion. The PPIs have demonstrated an excellent adverse effect profile after approximately ...

journal_title：Drugs

authors： Dekel R,Morse C,Fass R

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Opioid pharmacotherapies play an important role in the treatment of opioid-dependent women; however, very little is known about the safety of naltrexone in pregnant patients. OBJECTIVE:This study examined the obstetric health of opioid-dependent women who were treated with implant naltrexone during pregnanc...

journal_title：Drugs

authors： Kelty E,Hulse G

更新日期：2017-07-01 00:00:00

abstract：:In this paper, several clinical problems associated with the diagnosis of hypertension are discussed. Blood pressure variability and reactivity are factors underlying the difficulties in the diagnosis of hypertension. These phenomena are interrelated and mixed. White coat hypertension (WCH), referring to the phenomeno...

journal_title：Drugs

authors： Ocón-Pujadas J,Mora-Maciá J

更新日期：1993-01-01 00:00:00

abstract：:The efficacy and safety of rectally administered nimesulide 200mg and paracetamol 500mg were assessed in a double-blind study. The study was conducted in 39 elderly inpatients with infections of the upper or lower respiratory tract associated with fever; 18 patients received nimesulide and 21 received paracetamol. Bot...

journal_title：Drugs

authors： Cunietti E,Monti M,Viganò A,D'Aprile E,Saligari A,Scafuro E,Scaricabarozzi I

更新日期：1993-01-01 00:00:00

abstract：:Chlamydia trachomatis infections are exceedingly prevalent, and can be associated with significant sequelae. The major infections are urethritis, cervicitis, salpingitis, and ocular infection. Chlamydial genital infections present as syndromes, where C. trachomatis is one of the causes of the syndrome. Because specifi...

journal_title：Drugs

authors： Bowie WR

更新日期：1984-05-01 00:00:00

abstract：:The phosphoinositide 3-kinase (PI3K)/Akt/mTOR pathway is implicated in the pathogenesis of lymphoma. Deeper understanding of the diversity and biological impact of this pathway has led to the development of specific inhibitors to this pathway. Preclinical data in cell lines, patient samples and disease models have bro...

journal_title：Drugs

authors： Seiler T,Hutter G,Dreyling M

更新日期：2016-04-01 00:00:00

abstract：:Nausea and vomiting is a common and distressing symptom complex in patients with far-advanced cancer, affecting up to 60% of individuals at some stage of their illness. The current approach to the palliative care of patients with nausea and vomiting is based on identifying the cause, understanding its pathophysiology ...

journal_title：Drugs

authors： Glare PA,Dunwoodie D,Clark K,Ward A,Yates P,Ryan S,Hardy JR

更新日期：2008-01-01 00:00:00

abstract：:The clonidine transdermal therapeutic system (TTS) is a cutaneous delivery device which provides therapeutically effective doses of clonidine at a constant rate over 7 days. In clinical trials it reduces blood pressure in patients with mild to moderate hypertension as effectively as oral clonidine but with greater sta...

journal_title：Drugs

authors： Langley MS,Heel RC

更新日期：1988-02-01 00:00:00