Abstract:
:Dopamine agonists (DAs) represent an excellent treatment option for patients with Parkinson's disease, in both the early and advanced stages of the disease, improving motor symptoms, lowering the incidence of motor complications, and addressing several non-motor symptoms. Indeed, each of these compounds have different pharmacokinetic and pharmacodynamic properties, resulting in a unique efficacy and safety profile. Comorbidities, prominent non-motor symptoms and individual subjects' clinical characteristics should guide the choice of a specific DA, allowing better management of the patient by optimizing the DA benefit/risk ratio. In this article we discuss brain distribution of dopamine receptors and their role in each of the dopaminergic pathways, the pharmacological profile of non-ergoline DAs and class-related adverse effects, as reported from post-marketing studies.
journal_name
Drugsjournal_title
Drugsauthors
Torti M,Bravi D,Vacca L,Stocchi Fdoi
10.1007/s40265-019-01103-2subject
Has Abstractpub_date
2019-05-01 00:00:00pages
693-703issue
7eissn
0012-6667issn
1179-1950pii
10.1007/s40265-019-01103-2journal_volume
79pub_type
杂志文章,评审相关文献
DRUGS文献大全abstract::Alzheimer's disease (AD) is the most common age-related neurodegenerative disease and has become an urgent public health problem in most areas of the world. Substantial progress has been made in understanding the basic neurobiology of AD and, as a result, new drugs for its treatment have become available. Cholinestera...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200161010-00005
更新日期:2001-01-01 00:00:00
abstract::Emicizumab (Hemlibra®), a recombinant, humanized, bispecific monoclonal antibody, restores the function of missing activated factor VIII (FVIII) by bridging FIXa and FX to facilitate effective haemostasis in patients with haemophilia A. Subcutaneous emicizumab is approved in several countries, including in the USA and...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-019-01200-2
更新日期:2019-10-01 00:00:00
abstract::Eravacycline (Xerava™), a novel fully synthetic fluorocycline, consists of the tetracyclic core scaffold with unique modifications in the tetracyclic D ring; consequently, it exhibits potent in vitro activity against Gram-positive and -negative bacterial strains expressing certain common tetracycline-specific acquired...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-019-01067-3
更新日期:2019-02-01 00:00:00
abstract::The prevalence of penicillin-resistant pneumococci is increasing worldwide. Methods for susceptibility testing, as well as in vitro susceptibility of penicillin-susceptible and -resistant strains to new and existing agents (including oral and parenteral streptogramins), are described. For all specimens except CSF, oxa...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199600511-00003
更新日期:1996-01-01 00:00:00
abstract::Hairy cell leukaemia is an uncommon B cell chronic lymphoproliferative disorder characterised by circulating lymphocytes displaying prominent cytoplasmic projections. Therapy is initiated for severe cytopenias or recurrent infections. Splenectomy, the first standard treatment, is now less commonly used as primary trea...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199549060-00006
更新日期:1995-06-01 00:00:00
abstract:BACKGROUND:The lowering of cholesterol concentrations in individuals at high risk of cardiovascular disease improves outcome. No study, however, has assessed benefits of cholesterol lowering in the primary prevention of coronary heart disease (CHD) in hypertensive patients who are not conventionally deemed dyslipidaemi...
journal_title:Drugs
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.2165/00003495-200464002-00005
更新日期:2004-01-01 00:00:00
abstract::Lemborexant (DAYVIGO™) is an orally administered, dual orexin receptor (OXR) antagonist that exhibits reversible competitive antagonism at OXR1 and OXR2 (> affinity at OXR2) that was discovered and developed by Eisai Inc. for the treatment of adult patients with insomnia. In December 2019, lemborexant received its fir...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-020-01276-1
更新日期:2020-03-01 00:00:00
abstract::Mild to moderate hypertension still remains poorly controlled. This relates to multiple factors including low antihypertensive efficacy of single drug therapies reluctance of primary care physicians to modify/titrate initially chosen therapy to obtain target blood pressure, and poor compliance with medication. Several...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200161070-00004
更新日期:2001-01-01 00:00:00
abstract::Approximately 15% of patients with ulcerative colitis will experience a severe episode requiring hospitalization. Although intravenous corticosteroids are the current first-line therapy for these patients, about 30% of patients do not respond to corticosteroids and require either an alternative anti-inflammatory agent...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200868090-00001
更新日期:2008-01-01 00:00:00
abstract::Intravenous susoctocog alfa (Obizur(®)) is a recombinant, B-domain deleted, porcine sequence antihaemophilic factor VIII (FVIII) product that has recently been approved for the treatment of bleeding episodes in adults with acquired haemophilia A (AHA). Intravenous susoctocog alfa was an effective and generally well to...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-016-0576-1
更新日期:2016-05-01 00:00:00
abstract::Terfenadine is a selective histamine H1-receptor antagonist which, in pharmacodynamic studies, is devoid of central nervous system depressant activity. In clinical studies terfenadine is well tolerated and at a dose of 60mg administered twice daily the drug provides effective relief of symptoms in patients with allerg...
journal_title:Drugs
pub_type: 临床试验,杂志文章,评审
doi:10.2165/00003495-199039040-00006
更新日期:1990-04-01 00:00:00
abstract::Vitamin A acid (retinoic acid: tretinoin) is a vitamin A derivative used in the topical treatment of acne. It acts by 'unseating' comedones, improvement developing slowly over a period of 2 to 3 or more months, and is also said to prevent the formation of new lesions. About three-quarters of patients with acne vulgari...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-197714060-00001
更新日期:1977-12-01 00:00:00
abstract::A randomised multicentre double-blind study was conducted to compare the efficacy and safety of roxatidine acetate 75 mg twice daily and ranitidine 150 mg twice daily in 295 patients with endoscopically confirmed gastric ulcers. Substantial reductions in ulcer diameters and healing rates of 85.6 and 88.2% for roxatidi...
journal_title:Drugs
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2165/00003495-198800353-00021
更新日期:1988-01-01 00:00:00
abstract::Second-generation histamine H1 receptor antagonists (antihistamines) have been developed to reduce or eliminate the sedation and anticholinergic adverse effects that occur with older H1 receptor antagonists. This article evaluates second-generation antihistamines, including acrivastine, astemizole, azelastine, cetiriz...
journal_title:Drugs
pub_type: 杂志文章,meta分析
doi:10.2165/00003495-199957010-00004
更新日期:1999-01-01 00:00:00
abstract::Delayed gastric emptying, gastroparesis, is one of the sequelae of diabetes mellitus. Symptoms may include postprandial nausea, epigastric pain, bloating, vomiting, early satiety and unpredictable blood sugar fluctuations. Nowadays diagnosis is made by the measurement of gastric emptying with a radionuclide test meal....
journal_title:Drugs
pub_type: 临床试验,杂志文章,评审
doi:10.2165/00003495-199244040-00002
更新日期:1992-10-01 00:00:00
abstract::In ten large, well-controlled, randomised trials (n = 203 to 1089), valdecoxib, a selective inhibitor of cyclo-oxygenase-2, was significantly more effective than placebo in the treatment of osteoarthritis, rheumatoid arthritis and pain associated with primary dysmenorrhoea, and for postsurgical analgesia. Valdecoxib 1...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200262140-00005
更新日期:2002-01-01 00:00:00
abstract::Botulinum neurotoxin type A (BTX-A) weakens voluntary muscle strength and is an effective therapy for focal dystonia, including cervical dystonia (CD) and benign essential blepharospasm (BEB). It is also known to relieve hemifacial spasm and focal spasticity in children and adults. In addition, BTX-A has been shown to...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200767050-00003
更新日期:2007-01-01 00:00:00
abstract::Nabumetone is a nonsteroidal anti-inflammatory drug (NSAID) of the 2,6-disubstituted naphthylalkanone class. It is a prodrug metabolised to an active metabolite, 6-methoxy-2-naphthylacetic acid (6-MNA), which preferentially inhibits cyclo-oxygenase-2 (COX-2) and has both anti-inflammatory and analgesic properties. The...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:
更新日期:2000-01-01 00:00:00
abstract::The cardinal haemodynamic disturbance in established hypertension is an increased total peripheral resistance and a subnormal blood flow, particularly during exercise. The spontaneously occurring changes in central haemodynamics have been followed in young males with essential hypertension over a 17-year period: a gra...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-198400282-00004
更新日期:1984-01-01 00:00:00
abstract::Bacterial meningitis in adults is a severe disease with high fatality and morbidity rates. Experimental studies have shown that the inflammatory response in the subarachnoid space is associated with an unfavourable outcome. In these experiments, corticosteroids, and in particular dexamethasone, were able to reduce the...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200666040-00002
更新日期:2006-01-01 00:00:00
abstract::Resting heart rate is associated with cardiovascular and all-cause mortality, and the mortality benefit of some cardiovascular drugs seems to be related in part to their heart rate-lowering effects. Since it is difficult to separate the benefit of heart rate lowering from other actions with currently available drugs, ...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200464160-00003
更新日期:2004-01-01 00:00:00
abstract::Eplerenone (Inspra) is a selective aldosterone blocker. Oral eplerenone is approved for use in patients with left ventricular (LV) systolic dysfunction and clinical evidence of heart failure following acute myocardial infarction (MI) in the US and in European countries (e.g. the UK and The Netherlands). The addition o...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200464230-00005
更新日期:2004-01-01 00:00:00
abstract::Budesonide is a glucocorticoid with high topical activity, but low systemic bio-availability which results in reduced systemic effects in comparison with other glucocorticoids. To date, it has been evaluated for use in patients with inflammatory bowel disease when administered either orally as a controlled ileal relea...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199550050-00006
更新日期:1995-11-01 00:00:00
abstract::Cilazapril is an orally active angiotensin converting enzyme (ACE) inhibitor which lowers peripheral vascular resistance without affecting heart rate. Like enalapril and ramipril it is a prodrug, and is hydrolysed after absorption to cilazaprilat, which has a long terminal phase elimination half-life permitting once d...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199141050-00008
更新日期:1991-05-01 00:00:00
abstract::Drug treatment for various anorectal conditions has been known since ancient times. Today, modern as well as traditional drugs are being increasingly used in all grades of symptomatic haemorrhoids. These drugs (oral and local) are used as a part of conservative management or as an adjuvant to invasive outpatient proce...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200565110-00003
更新日期:2005-01-01 00:00:00
abstract::Glipizide is a 'second generation' oral hypoglycaemic agent similar in potency to glibenclamide. It is completely absorbed after oral administration and has a rapid onset of action, but the duration of its hypoglycaemic effect is shorter than that of glibenclamide. It is rapidly metabolised to inactive metabolites whi...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-197918050-00001
更新日期:1979-11-01 00:00:00
abstract::Developments in drug delivery technology have expanded the formulations of 5-aminosalicylic acid (5-ASA) available to clinicians over the last 50 years. Delivery of adequate doses of 5-ASA to the colon can be achieved by pH-dependent, delayed-release or pro-drug formulations. Despite some variations in the pharmacokin...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200868080-00006
更新日期:2008-01-01 00:00:00
abstract::Cardiovascular diseases are the leading cause of mortality in industrialized countries. Treatment with statins is effective in primary prevention in patients at high cardiovascular risk. Statins are inhibitors of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase and are classed as lipid-lowering drugs. In 2010, ato...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/11632010-000000000-00000
更新日期:2012-04-16 00:00:00
abstract::Hepatitis C virus (HCV) infection is associated with a variable disease course and response to therapy. Some infected patients may develop little or no disease for 30 to 40 years, whereas others will develop cirrhosis within 5 to 10 years. Both host and viral factors influence the rate of disease progression. The mana...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199600522-00003
更新日期:1996-01-01 00:00:00
abstract::Viral respiratory tract infections (RTIs) are common causes of mild illness in immunocompetent children and adults, with occasional significant morbidity or mortality in the very young, very old or infirm. However, recipients of solid organ transplants (SOT) or haematopoietic stem cell transplants (HSCT) are at marked...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200767100-00004
更新日期:2007-01-01 00:00:00