Pharmacologic management of advanced cervical cancer: antiangiogenesis therapy and immunotherapeutic considerations.

Abstract:

:As a consequence of disparities in access to and utilization of preventative healthcare, the incidence and death rates from cervical cancer remain substantial in the face of indisputable evidence that screening saves lives. While disparities persist, there will be an urgent need for research into the treatment of advanced forms of this disease. In this review, we explore the evolution of the treatment of metastatic, recurrent, and persistent cervical cancer from cytotoxic agents to targeted therapy. We discuss why targeted therapies are unlikely to produce sustained responses alone but may be more successful in combination with immunotherapies. We also provide a rationale for the potential next phase in treatment of this challenging disease-combined therapy with antiangiogenic agents and immune checkpoint inhibitors. In doing so, we highlight recent paradigm shifts within cancer therapeutics, including the shift in focus from the tumor cell itself to the tumor microenvironment, and from stimulating the immune system to inhibiting the inhibitors of an adequate immune response.

journal_name

Drugs

journal_title

Drugs

authors

Longoria TC,Tewari KS

doi

10.1007/s40265-015-0481-z

subject

Has Abstract

pub_date

2015-11-01 00:00:00

pages

1853-65

issue

16

eissn

0012-6667

issn

1179-1950

pii

10.1007/s40265-015-0481-z

journal_volume

75

pub_type

杂志文章,评审

相关文献

DRUGS文献大全
  • Detecting and Targeting NTRK Fusions in Cancer in the Era of Tumor Agnostic Oncology.

    abstract::Gene rearrangements involving the neurotrophic receptor kinase genes NTRK1, NTRK2, and NTRK3 (referred to as TRK, encoding TRKA, TRKB, and TRKC, respectively) result in highly oncogenic fusions. TRK fusions are rare, with a prevalence of < 1% in solid tumors. Detection of TRK fusions can be based on fluorescence in-si...

    journal_title:Drugs

    pub_type: 杂志文章,评审

    doi:10.1007/s40265-020-01459-w

    authors: Rohrberg KS,Lassen U

    更新日期:2021-01-05 00:00:00

  • Miconazole: a preliminary review of its therapeutic efficacy in systemic fungal infections.

    abstract::Miconazole is an imidazole antifungal drug which has recently become available for systemic use. Its antifungal activity has been well studied and it is active in vitro against a wide range of fungi. Published and unpublished reports of the use of miconazole in conditions such as systemic or mucocutaneous candidosis, ...

    journal_title:Drugs

    pub_type: 杂志文章,评审

    doi:10.2165/00003495-198019010-00002

    authors: Heel RC,Brogden RN,Pakes GE,Speight TM,Avery GS

    更新日期:1980-01-01 00:00:00

  • Oral antidiabetic agents: current role in type 2 diabetes mellitus.

    abstract::Type 2 diabetes mellitus is a progressive and complex disorder that is difficult to treat effectively in the long term. The majority of patients are overweight or obese at diagnosis and will be unable to achieve or sustain near normoglycaemia without oral antidiabetic agents; a sizeable proportion of patients will eve...

    journal_title:Drugs

    pub_type: 杂志文章,评审

    doi:10.2165/00003495-200565030-00005

    authors: Krentz AJ,Bailey CJ

    更新日期:2005-01-01 00:00:00

  • Meningococcal groups C and Y and haemophilus B tetanus toxoid conjugate vaccine (HibMenCY-TT; MenHibrix(®)): a review.

    abstract::The meningococcal groups C and Y and Haemophilus b (Hib) tetanus toxoid conjugate vaccine (HibMenCY-TT) contains Neisseria meningitidis serogroup C and Y capsular polysaccharide antigens, and Hib capsular polysaccharide [polyribosyl-ribitol-phosphate (PRP)]. The HibMenCY-TT vaccine is available in the USA for use as a...

    journal_title:Drugs

    pub_type: 杂志文章,评审

    doi:10.1007/s40265-013-0048-9

    authors: Perry CM

    更新日期:2013-05-01 00:00:00

  • Zolpidem: an update of its pharmacology, therapeutic efficacy and tolerability in the treatment of insomnia.

    abstract:UNLABELLED:Zolpidem is an imidazopyridine agent that is indicated for the short term (< or = 4 weeks) treatment of insomnia (recommended dosage 10 mg/day in adults and 5 or 10 mg/day in the elderly or patients with hepatic impairment). Data have shown that the hypnotic efficacy of zolpidem is generally comparable to th...

    journal_title:Drugs

    pub_type: 杂志文章,评审

    doi:10.2165/00003495-200059040-00014

    authors: Holm KJ,Goa KL

    更新日期:2000-04-01 00:00:00

  • The clinical potential of endothelin receptor antagonists in cardiovascular medicine.

    abstract::The endothelin family of peptides are extremely potent endogenous vasoconstrictor and pressor agents. Of the 3 isoforms, endothelin-1 is the major isoform produced by the vascular endothelium and is, therefore, likely to be of most importance for regulation of vascular function. Two endothelin receptor subtypes have s...

    journal_title:Drugs

    pub_type: 杂志文章,评审

    doi:10.2165/00003495-199651010-00003

    authors: Ferro CJ,Webb DJ

    更新日期:1996-01-01 00:00:00

  • Gefitinib: a review of its use in the treatment of locally advanced/metastatic non-small cell lung cancer.

    abstract::Gefitinib (Iressa) is an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor that offers treatment for patients with locally advanced or metastatic non-small cell lung cancer (NSCLC), in particular in those who are harbouring EGFR mutations. In a large phase III trial (IPASS) in chemotherapy-naive Asian ...

    journal_title:Drugs

    pub_type: 杂志文章,评审

    doi:10.2165/10489100-000000000-00000

    authors: Sanford M,Scott LJ

    更新日期:2009-11-12 00:00:00

  • Cholinesterase inhibitors for Alzheimer's disease.

    abstract::Alzheimer's disease (AD) is the most common age-related neurodegenerative disease and has become an urgent public health problem in most areas of the world. Substantial progress has been made in understanding the basic neurobiology of AD and, as a result, new drugs for its treatment have become available. Cholinestera...

    journal_title:Drugs

    pub_type: 杂志文章,评审

    doi:10.2165/00003495-200161010-00005

    authors: Grutzendler J,Morris JC

    更新日期:2001-01-01 00:00:00

  • Anti-tumour necrosis factor therapy for ulcerative colitis: evidence to date.

    abstract::Infliximab, the chimeric monoclonal antibody directed against tumour necrosis factor (TNF)-alpha, has profoundly changed therapy for Crohn's disease (CD). However, for ulcerative colitis (UC), before the publication of ACT 1 and ACT 2 (Active Ulcerative Colitis Trials 1 and 2), there were only a few open-label and con...

    journal_title:Drugs

    pub_type: 杂志文章,评审

    doi:10.2165/00003495-200666160-00002

    authors: Thukral C,Cheifetz A,Peppercorn MA

    更新日期:2006-01-01 00:00:00

  • Safety profiles of the angiotensin-converting enzyme inhibitors.

    abstract::This review will discuss the safety profiles of the angiotensin-converting enzyme (ACE) inhibitors captopril, enalapril and lisinopril in patients with hypertension. In general, the safety profiles of ACE inhibitors compare favourably with those of other agents used for the treatment of hypertension. Adverse effects a...

    journal_title:Drugs

    pub_type: 杂志文章,评审

    doi:10.2165/00003495-198800355-00016

    authors: Warner NJ,Rush JE

    更新日期:1988-01-01 00:00:00

  • Pharmacological management of first-episode schizophrenia and related nonaffective psychoses.

    abstract::Schizophrenia is a severe mental illness characterised by abnormalities of thought and perception that affects 1-2% of the population. Patients who experience a first episode of schizophrenia should be treated early and optimally with antipsychotic agents to lessen the morbidity of the initial episode and possibly imp...

    journal_title:Drugs

    pub_type: 杂志文章,评审

    doi:10.2165/00003495-200363210-00001

    authors: Bradford DW,Perkins DO,Lieberman JA

    更新日期:2003-01-01 00:00:00

  • Drug-induced agranulocytosis.

    abstract::An unexpected precipitous fall in peripheral leucocyte count may occur during treatment of certain sensitised individuals with drugs usually well tolerated by most people. Three basic mechanisms for drug sensitivity have been found. One is characterised by sudden destruction of large numbers of leucocytes in periphera...

    journal_title:Drugs

    pub_type: 杂志文章,评审

    doi:10.2165/00003495-197815020-00003

    authors: Pisciotta V

    更新日期:1978-02-01 00:00:00

  • Interaction of lipoproteins with the artery wall.

    abstract::Atherosclerosis can be defined in terms of the processes involved rather than in morphological terms, and there is evidence for possible roles of the macrophage in atherogenesis. The relevance of hyperlipidaemia to the morphogenesis of the atherosclerotic plaque is important, and this has been described in animal mode...

    journal_title:Drugs

    pub_type: 杂志文章,评审

    doi:10.2165/00003495-198800363-00012

    authors: Woolf N

    更新日期:1988-01-01 00:00:00

  • Responsible prescribing of opioids for the management of chronic pain.

    abstract::The management of patients with chronic pain is a common clinical challenge. Indeed, chronic pain is often inadequately controlled in patients with cancer and in those with non-cancer chronic pain. Because of the complex nature of chronic pain, successful long-term treatment is more difficult than for acute pain. Most...

    journal_title:Drugs

    pub_type: 杂志文章,评审

    doi:10.2165/00003495-200363010-00002

    authors: Nicholson B

    更新日期:2003-01-01 00:00:00

  • Management of patients with advanced non-small cell lung cancer: current and emerging options.

    abstract::Systemic therapy for advanced non-small cell lung cancer (NSCLC) has evolved over the last two decades, with modest improvements in quality of life and overall survival. A plateau has been reached with traditional chemotherapy, and efforts are now being directed at developing molecularly targeted agents. To date, thre...

    journal_title:Drugs

    pub_type: 杂志文章,评审

    doi:10.2165/11532200-000000000-00000

    authors: Triano LR,Deshpande H,Gettinger SN

    更新日期:2010-01-01 00:00:00

  • Acarbose. An update of its pharmacology and therapeutic use in diabetes mellitus.

    abstract::Acarbose delays digestion of complex carbohydrates and disaccharides to absorbable monosaccharides, by reversibly inhibiting alpha-glucosidases within the intestinal brush border, thereby attenuating postprandial blood glucose peaks. Clinical trials have demonstrated that acarbose generally improves glycaemic control ...

    journal_title:Drugs

    pub_type: 杂志文章,评审

    doi:10.2165/00003495-199346060-00007

    authors: Balfour JA,McTavish D

    更新日期:1993-12-01 00:00:00

  • Inhibiting costimulatory activation of T cells : a viable treatment option for rheumatoid arthritis?

    abstract::There is now good evidence that T cells play a central role in the inflammatory pathway that leads to the persistent synovitis that causes joint damage in rheumatoid arthritis (RA). T cells require two signals to become activated. The second step in the activation of T cells involves costimulatory pathways, the best d...

    journal_title:Drugs

    pub_type: 杂志文章,评审

    doi:10.2165/00003495-200767010-00001

    authors: Pollard LC

    更新日期:2007-01-01 00:00:00

  • Sickle cell disease in children.

    abstract::Early identification of infants with sickle cell disease (SCD) by newborn screening, now universal in all 50 states in the US, has improved survival, mainly by preventing overwhelming sepsis with the early use of prophylactic penicillin. Routine transcranial Doppler screening with the institution of chronic transfusio...

    journal_title:Drugs

    pub_type: 杂志文章,评审

    doi:10.2165/11632890-000000000-00000

    authors: Meier ER,Miller JL

    更新日期:2012-05-07 00:00:00

  • Management of chronic obstructive pulmonary disease.

    abstract::Chronic obstructive pulmonary disease (COPD) is characterised by insidiously progressive airflow limitation. The necessarily multifactorial management programme should include smoking cessation, prevention of infections, bronchodilator and steroid therapy, supplemental oxygen, physical therapy, pulmonary rehabilitatio...

    journal_title:Drugs

    pub_type: 临床试验,杂志文章,评审

    doi:10.2165/00003495-198938010-00007

    authors: Kesten S,Rebuck AS

    更新日期:1989-07-01 00:00:00

  • Antiplatelet drugs: clinical pharmacology and therapeutic use.

    abstract::Because platelets are so important in thrombus formation, drugs which inhibit platelet function (the 'antiplatelet drugs') have considerable potential as antithrombotic agents. Among the antiplatelet drugs, only aspirin, sulphinpyrazone, dipyridamole, hydroxychloroquine, and clofibrate have had wide clinical trial. Th...

    journal_title:Drugs

    pub_type: 杂志文章,评审

    doi:10.2165/00003495-197918060-00002

    authors: Gallus AS

    更新日期:1979-12-01 00:00:00

  • Transdermal clonidine. A preliminary review of its pharmacodynamic properties and therapeutic efficacy.

    abstract::The clonidine transdermal therapeutic system (TTS) is a cutaneous delivery device which provides therapeutically effective doses of clonidine at a constant rate over 7 days. In clinical trials it reduces blood pressure in patients with mild to moderate hypertension as effectively as oral clonidine but with greater sta...

    journal_title:Drugs

    pub_type: 杂志文章,评审

    doi:10.2165/00003495-198835020-00003

    authors: Langley MS,Heel RC

    更新日期:1988-02-01 00:00:00

  • Immunotherapy Against Gliomas: is the Breakthrough Near?

    abstract::Immunotherapeutic approaches have been, and continue to be, aggressively investigated in the treatment of infiltrating gliomas. While the results of late-phase clinical studies have been disappointing in this disease space thus far, the success of immunotherapies in other malignancies as well as the incremental gains ...

    journal_title:Drugs

    pub_type: 杂志文章,评审

    doi:10.1007/s40265-019-01203-z

    authors: Lukas RV,Wainwright DA,Horbinski CM,Iwamoto FM,Sonabend AM

    更新日期:2019-11-01 00:00:00

  • The relevance of serotonin antagonism in the treatment of hypertension.

    abstract::The role of serotonin in the pathogenesis of hypertension is not clear. Serotonin is produced by the enterochromaffin cells of the gut; the greater part of this is metabolised in the liver and lungs and nearly all of the remainder is taken up by the platelets. Consequently, circulating levels of serotonin are extremel...

    journal_title:Drugs

    pub_type: 杂志文章

    doi:10.2165/00003495-198800361-00011

    authors: Doyle AE

    更新日期:1988-01-01 00:00:00

  • Balanced analgesia: what is it and what are its advantages in postoperative pain?

    abstract::The concept of balanced analgesia was introduced to improve analgesic efficacy and reduce adverse effects. A large amount of clinical data has documented improved analgesia by combining different analgesics, but data on reducing adverse effects are inconclusive. Balanced analgesia should be used whenever possible, and...

    journal_title:Drugs

    pub_type: 杂志文章,评审

    doi:10.2165/00003495-199958050-00002

    authors: Kehlet H,Werner M,Perkins F

    更新日期:1999-11-01 00:00:00

  • Osteoarthritis 1991. Current drug treatment regimens.

    abstract::Osteoarthritis, the most common rheumatic disease, presents the clinician with a major therapeutic and management task. The chronic and progressive course of the disease is punctuated by pain, declining function and escalating disability. This article attempts to deal with the pharmacological therapeutic options avail...

    journal_title:Drugs

    pub_type: 杂志文章,评审

    doi:10.2165/00003495-199141020-00005

    authors: al Arfag A,Davis P

    更新日期:1991-02-01 00:00:00

  • Clinical Implications of P-Glycoprotein Modulation in Drug-Drug Interactions.

    abstract::Drug-drug interactions (DDIs) occur commonly and may lead to severe adverse drug reactions if not handled appropriately. Considerable information to support clinical decision making regarding potential DDIs is available in the literature and through various systems providing electronic decision support for healthcare ...

    journal_title:Drugs

    pub_type: 杂志文章,评审

    doi:10.1007/s40265-017-0729-x

    authors: Lund M,Petersen TS,Dalhoff KP

    更新日期:2017-05-01 00:00:00

  • Practical treatment recommendations for the safe use of anaesthetics.

    abstract::General anaesthesia is the reversible depression of central nervous system function. There is still no agreement over what constitutes depth of anaesthesia, and the clinical anaesthetist must thus titrate drug input according to clinical signs (heart rate, blood pressure, somatic movement, autonomic responses). The po...

    journal_title:Drugs

    pub_type: 杂志文章,评审

    doi:10.2165/00003495-199243010-00006

    authors: Sear JW

    更新日期:1992-01-01 00:00:00

  • Prediction of response to cancer chemotherapy.

    abstract::Cytotoxic chemotherapy plays a key role in the treatment of carcinoma for thousands of patients annually who either present with metastatic disease or relapse after surgical excision of apparently localised disease. Unfortunately, there is such a wide range of responsiveness to drug therapy within individual tumour ty...

    journal_title:Drugs

    pub_type: 杂志文章,评审

    doi:10.2165/00003495-198326050-00004

    authors: Sarosdy MF,Von Hoff DD

    更新日期:1983-11-01 00:00:00

  • New directions for rabbit antithymocyte globulin (Thymoglobulin(®)) in solid organ transplants, stem cell transplants and autoimmunity.

    abstract::In the 30 years since the rabbit antithymocyte globulin (rATG) Thymoglobulin(®) was first licensed, its use in solid organ transplantation and hematology has expanded progressively. Although the evidence base is incomplete, specific roles for rATG in organ transplant recipients using contemporary dosing strategies are...

    journal_title:Drugs

    pub_type: 杂志文章,评审

    doi:10.1007/s40265-014-0277-6

    authors: Mohty M,Bacigalupo A,Saliba F,Zuckermann A,Morelon E,Lebranchu Y

    更新日期:2014-09-01 00:00:00

  • Terfenadine. An updated review of its pharmacological properties and therapeutic efficacy.

    abstract::Terfenadine is a selective histamine H1-receptor antagonist which, in pharmacodynamic studies, is devoid of central nervous system depressant activity. In clinical studies terfenadine is well tolerated and at a dose of 60mg administered twice daily the drug provides effective relief of symptoms in patients with allerg...

    journal_title:Drugs

    pub_type: 临床试验,杂志文章,评审

    doi:10.2165/00003495-199039040-00006

    authors: McTavish D,Goa KL,Ferrill M

    更新日期:1990-04-01 00:00:00