Aflibercept: A Review of Its Use in Diabetic Macular Oedema.

abstract：:During the 40 years since the initial synthesis of fluorouracil, there have been many attempts to improve fluoropyrimidine chemotherapy. These have included the utilisation of different schedules of fluorouracil administration, modulation of the metabolism of fluorouracil with other drugs to increase its therapeutic b...

journal_title：Drugs

authors： Diasio RB

更新日期：1999-01-01 00:00:00

abstract：:The new therapeutic options available to clinicians treating dyslipidaemia in the last decade have enabled effective treatment for many patients. The development of the HMG-CoA reductase inhibitors (statins) have been a major advance in that they possess multiple pharmacological effects (pleiotropic effects) resulting...

journal_title：Drugs

authors： Chong PH,Bachenheimer BS

更新日期：2000-07-01 00:00:00

abstract：:Novartis has developed oral and intravenous formulations of panobinostat (Farydak(®)), a histone deacetylase (HDAC) inhibitor, for the treatment of cancer. HDACs have important roles in maintaining chromatin structure and in regulating gene expression, including that of tumour suppressor genes, and thus represent vali...

journal_title：Drugs

authors： Garnock-Jones KP

更新日期：2015-04-01 00:00:00

abstract：:Cardiovascular disease continues to be the principal cause of death in Western countries. Epidemiological studies have repeatedly demonstrated a striking relationship between blood pressure and the risk of cardiovascular disease in that those with the highest levels of blood pressure are at the greatest risk for subse...

journal_title：Drugs

authors： Whelton PK,Klag MJ

更新日期：1986-01-01 00:00:00

abstract：:86 patients with a first myocardial infarction presenting within 6 hours of the onset of symptoms were randomly allocated to treatment with intravenous streptokinase or anisoylated plasminogen streptokinase activator complex (APSAC). Plasma concentrations of fibrinogen, plasminogen, alpha 2-antiplasmin and fibrinogen ...

journal_title：Drugs

authors： Monassier JP,Hanssen M

更新日期：1987-01-01 00:00:00

abstract：:Many drugs have a site of action within the inner ear. The list includes therapeutic, diagnostic and ototoxic agents. Therapeutic agents are most useful in cases of infections, endolymphatic hydrops, vascular insufficiency, vertigo of peripheral origin, autoimmune disease, otosclerosis (otospongiosis), sudden hearing ...

journal_title：Drugs

authors： Norris CH

更新日期：1988-12-01 00:00:00

abstract：:Gene rearrangements involving the neurotrophic receptor kinase genes NTRK1, NTRK2, and NTRK3 (referred to as TRK, encoding TRKA, TRKB, and TRKC, respectively) result in highly oncogenic fusions. TRK fusions are rare, with a prevalence of < 1% in solid tumors. Detection of TRK fusions can be based on fluorescence in-si...

journal_title：Drugs

authors： Rohrberg KS,Lassen U

更新日期：2021-01-05 00:00:00

abstract：:Hepatic encephalopathy (HE) is a challenging clinical complication of liver dysfunction with a wide spectrum of neuropsychiatric abnormalities that range from mild disturbances in cognitive function and consciousness to coma and death. The pathogenesis of HE in cirrhosis is complex and multifactorial, but a key role i...

journal_title：Drugs

authors： Phongsamran PV,Kim JW,Cupo Abbott J,Rosenblatt A

更新日期：2010-06-18 00:00:00

abstract：:Interstitial lung disease (ILD) can be associated with all connective tissue diseases and is an important cause of morbidity and mortality. The management of connective tissue disease-interstitial lung disease (CTD-ILD) is challenging due substantial heterogeneity in disease behaviour and paucity of controlled clinica...

journal_title：Drugs

authors： Jee AS,Corte TJ

更新日期：2019-09-01 00:00:00

abstract：:Empagliflozin/linagliptin (Glyxambi(®)) is a once-daily sodium glucose co-transporter type 2 (SGLT2) inhibitor and dipeptidyl peptidase (DPP)-4 inhibitor fixed-dose combination product that is approved in the USA as an adjunct to diet and exercise in adults with type 2 diabetes (T2D) when treatment with both empaglifl...

journal_title：Drugs

authors： Kim ES,Deeks ED

更新日期：2015-09-01 00:00:00

abstract：:Vivus' proprietary oral capsule containing phentermine and extended-release (ER) topiramate has been approved in the US for the treatment of obesity. Phentermine is an appetite suppressant, while topiramate is an anti-epileptic medication. The once-daily formulation, known as Qsymia™, is designed to produce weight los...

journal_title：Drugs

authors： Cameron F,Whiteside G,McKeage K

更新日期：2012-10-22 00:00:00

abstract：:Cancer-related anorexia/cachexia (CAC) is a complex phenomenon in which metabolic abnormalities, proinflammatory cytokines produced by the host immune system, circulating tumour-derived catabolic factors, decreased food intake, and probably additional unknown factors, all play different roles. This review examines the...

journal_title：Drugs

authors： Mantovani G,Macciò A,Massa E,Madeddu C

更新日期：2001-01-01 00:00:00

abstract：:A study was made of the clinical features and therapeutic response of 144 patients from whose sputum Branhamella catarrhalis was isolated. Typically, features of bronchopulmonary infection with cough productive of moderate amounts of purulent sputum, fever and dyspnoea were present. Of 74 patients who were infected in...

journal_title：Drugs

authors： McLeod DT,Ahmad F,Croughan MJ,Calder MA

更新日期：1986-01-01 00:00:00

abstract：:Eplerenone (Inspra) is a selective aldosterone blocker. Oral eplerenone is approved for use in patients with left ventricular (LV) systolic dysfunction and clinical evidence of heart failure following acute myocardial infarction (MI) in the US and in European countries (e.g. the UK and The Netherlands). The addition o...

journal_title：Drugs

authors： Keating GM,Plosker GL

更新日期：2004-01-01 00:00:00

abstract：:Opioid dependence, manifesting as addiction to heroin and pharmaceutical opioids is increasing. Internationally, there are an estimated 15.6 million illicit opioid users. The global economic burden of opioid dependence is profound both in terms of HIV and hepatitis C virus transmission, direct healthcare costs, and in...

journal_title：Drugs

authors： Tetrault JM,Fiellin DA

更新日期：2012-01-22 00:00:00

abstract：:Alzheimer's disease (AD) is the most common age-related neurodegenerative disease and has become an urgent public health problem in most areas of the world. Substantial progress has been made in understanding the basic neurobiology of AD and, as a result, new drugs for its treatment have become available. Cholinestera...

journal_title：Drugs

authors： Grutzendler J,Morris JC

更新日期：2001-01-01 00:00:00

abstract：:Pregabalin, the pharmacologically active S-enantiomer of 3-aminomethyl-5-methyl-hexanoic acid, has a similar pharmacological profile to that of its developmental predecessor gabapentin, but showed greater analgesic activity in rodent models of neuropathic pain. The exact mechanism of action of pregabalin is unclear, a...

journal_title：Drugs

authors： Frampton JE,Scott LJ

更新日期：2004-01-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a chronic and progressive inflammatory disease that ultimately leads to disability and functional decline. Because patients usually develop RA in mid-life, they may experience its consequences for 20-30 years or longer. Proinflammatory cytokines, notably interleukin (IL)-1 and tumour necro...

journal_title：Drugs

authors： Schiff MH

更新日期：2004-01-01 00:00:00

abstract：:Pruritus is an unpleasant sensation that provokes an urge to scratch. Many stimuli (notably histamine) are able to induce pruritus. The neural conduction of the itch sensation from the free unmyelinated nerve endings to the central nervous system mainly occurs on unmyelinated C fibres and the anterolateral spinothalam...

journal_title：Drugs

authors： Lorette G,Vaillant L

更新日期：1990-02-01 00:00:00

abstract：:Trimetrexate is a folinic acid analogue structurally related to methotrexate, whose primary mechanism of action is believed to be inhibition of dihydrofolate reductase. This reduces the production of DNA and RNA precursors and leads to cell death. Trimetrexate is lipophilic and can passively diffuse across cell membra...

journal_title：Drugs

authors： Fulton B,Wagstaff AJ,McTavish D

更新日期：1995-04-01 00:00:00

abstract：:The continuous-use combination oral contraceptive ethinylestradiol/levonorgestrel 20microg/90microg suppresses gonadotropins, and subsequently ovulation and endometrial thickening, and suppresses breakthrough bleeding. Amenorrhoea and absence of breakthrough bleeding increase in incidence with extended administration....

journal_title：Drugs

authors： Wagstaff AJ

更新日期：2007-01-01 00:00:00

abstract：:The naturally occurring catecholamines, noradrenaline, adrenaline and dopamine, have been found in a wide range of animal and vegetable tissues, but are particularly associated with nervous tissue in animals. Of the many processes affecting the response to stimulation of catecholamine containing nerves, the synthesis ...

journal_title：Drugs

authors： Laverty R

更新日期：1978-11-01 00:00:00

abstract：:Lemborexant (DAYVIGO™) is an orally administered, dual orexin receptor (OXR) antagonist that exhibits reversible competitive antagonism at OXR1 and OXR2 (> affinity at OXR2) that was discovered and developed by Eisai Inc. for the treatment of adult patients with insomnia. In December 2019, lemborexant received its fir...

journal_title：Drugs

authors： Scott LJ

更新日期：2020-03-01 00:00:00

abstract：:Aspirin (acetylsalicylic acid)-induced asthma (AIA) consists of the clinical triad of asthma, chronic rhinosinusitis with nasal polyps, and precipitation of asthma and rhinitis attacks in response to aspirin and other NSAIDs. The prevalence of the syndrome in the adult asthmatic populations is approximately 4-10%. Res...

journal_title：Drugs

authors： Hamad AM,Sutcliffe AM,Knox AJ

更新日期：2004-01-01 00:00:00

abstract：:This article is intended to stimulate thought and focus on those areas where we feel advances in drug therapy for inflammatory bowel disease may occur. It is not an extensive review of current practice, although this is considered where it is thought to be pertinent to future developments. There are several excellent ...

journal_title：Drugs

authors： Rhodes J,Thomas G,Evans BK

更新日期：1997-02-01 00:00:00

abstract：:When peripheral decarboxylation is blocked by carbidopa or benserazide, the main metabolic pathway of levodopa is O-methylation by catechol-O-methyltransferase (COMT). Entacapone and tolcapone are new potent, selective and reversible nitrocatechol-type COMT inhibitors. Animal studies have demonstrated that entacapone ...

journal_title：Drugs

authors： Kaakkola S

更新日期：2000-06-01 00:00:00

abstract：:Delayed gastric emptying, gastroparesis, is one of the sequelae of diabetes mellitus. Symptoms may include postprandial nausea, epigastric pain, bloating, vomiting, early satiety and unpredictable blood sugar fluctuations. Nowadays diagnosis is made by the measurement of gastric emptying with a radionuclide test meal....

journal_title：Drugs

authors： Drenth JP,Engels LG

更新日期：1992-10-01 00:00:00

abstract：BACKGROUND:While a variety of intervention options have been described for pemphigus vulgaris, the optimal treatment strategy has not been established. OBJECTIVES:The objective of this systematic review is to assess the literature on the efficacy and safety of interventions for the treatment of pemphigus vulgaris. DA...

journal_title：Drugs

authors： Zhao CY,Murrell DF

更新日期：2015-02-01 00:00:00

abstract：:Drotrecogin alfa (activated), recombinant human activated protein C, inhibits coagulation and inflammation and promotes fibrinolysis in patients with severe sepsis. 850 patients with severe sepsis treated with intravenous drotrecogin alfa (activated) 24 microg/kg/h for 96 hours had a significantly greater reduction in...

journal_title：Drugs

authors： Lyseng-Williamson KA,Perry CM

更新日期：2002-01-01 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) is a leading cause of cancer death in industrialised countries, with an overall 5-year survival rate of less than 10%. Good patient performance status is associated with a significantly improved prognosis, whereas the presence of metastases, particularly to the bone or liver, is asso...

journal_title：Drugs

authors： Faulds D

更新日期：1992-01-01 00:00:00