Inflammatory bowel disease management. Some thoughts on future drug developments.

abstract：:A meta-analysis of 20 short term comparative studies of 5 selective serotonin reuptake inhibitors (SSRIs; citalopram, fluoxetine, fluvoxamine, paroxetine and sertraline) has shown no difference in efficacy between individual compounds but a slower onset of action of fluoxetine. There were suggestions that fluoxetine c...

journal_title：Drugs

authors： Edwards JG,Anderson I

更新日期：1999-04-01 00:00:00

abstract：:Certolizumab pegol (Cimzia(®)) is a recombinant, polyethylene glycolylated, antigen-binding fragment of a humanized monoclonal antibody that selectively targets and neutralizes tumour necrosis factor (TNF)-α. The drug is indicated for subcutaneous use every 2 or 4 weeks (q2w or q4w) for the treatment of adults with mo...

journal_title：Drugs

authors： Deeks ED

更新日期：2013-01-01 00:00:00

abstract：:Grapefruit juice and grapefruit product consumption have potential health benefits; however, their intake is also associated with interactions with certain drugs, including calcium channel blockers, immunosuppressants and antihistamines. The primary mechanism through which interactions are mediated is mechanism-based ...

journal_title：Drugs

authors： Seden K,Dickinson L,Khoo S,Back D

更新日期：2010-12-24 00:00:00

abstract：:The Janus kinase/signal transduction and activator of transcription (JAK-STAT) signaling pathway is implicated in the pathogenesis of inflammatory and autoimmune diseases including rheumatoid arthritis, psoriasis, and inflammatory bowel disease. Many cytokines involved in the pathogenesis of autoimmune and inflammator...

journal_title：Drugs

authors： Banerjee S,Biehl A,Gadina M,Hasni S,Schwartz DM

更新日期：2017-04-01 00:00:00

abstract：:Pharmacotherapy for the management of obesity is primarily aimed at weight loss, weight loss maintenance and risk reduction, and has included thyroid hormone, amphetamines, phentermine, amfepramone (diethylpropion), phenylpropanolamine, mazindol, fenfluramines and, more recently, sibutramine and orlistat. These agents...

journal_title：Drugs

authors： Ioannides-Demos LL,Proietto J,McNeil JJ

更新日期：2005-01-01 00:00:00

abstract：:Recent clinical trials have demonstrated beyond doubt that statins are effective in the prevention of acute coronary events. Critical analysis of these studies suggests that the benefits of statin therapy cannot be fully explained on the basis of reductions in plasma cholesterol levels. Accumulating knowledge of the a...

journal_title：Drugs

authors： Wheeler DC

更新日期：1998-10-01 00:00:00

abstract：:In human lung tissue in vitro, nedocromil sodium inhibited the release of histamine and leukotrienes induced by anti-IgE, as well as the contraction of isolated bronchi which followed this challenge. In the hamster cheek pouch in vivo, nedocromil sodium inhibited the inflammatory response induced by challenge with eit...

journal_title：Drugs

authors： Dahlén SE,Björck T,Kumlin M,Sydbom A,Raud J,Palmertz U,Franzén L,Grönneberg R,Hedqvist P

更新日期：1989-01-01 00:00:00

abstract：:Infliximab, the chimeric monoclonal antibody directed against tumour necrosis factor (TNF)-alpha, has profoundly changed therapy for Crohn's disease (CD). However, for ulcerative colitis (UC), before the publication of ACT 1 and ACT 2 (Active Ulcerative Colitis Trials 1 and 2), there were only a few open-label and con...

journal_title：Drugs

authors： Thukral C,Cheifetz A,Peppercorn MA

更新日期：2006-01-01 00:00:00

abstract：:Clopidogrel is a thienopyridine that irreversibly inhibits platelet aggregation by selectively binding to adenylate cyclase-coupled ADP receptors on the platelet surface. In animal models, clopidogrel reduced the formation of both arterial and venous thrombi. After oral administration, clopidogrel is rapidly absorbed ...

journal_title：Drugs

authors： Coukell AJ,Markham A

更新日期：1997-11-01 00:00:00

abstract：:Nizatidine is an H2-receptor antagonist which in animal studies was more active on a weight-for-weight basis than cimetidine in inhibiting basal and stimulated gastric acid secretion. Similarly, studies in humans have confirmed that nizatidine is a potent inhibitor of basal, nocturnal and stimulated gastric acid secre...

journal_title：Drugs

authors： Price AH,Brogden RN

更新日期：1988-11-01 00:00:00

abstract：:Eravacycline (Xerava™), a novel fully synthetic fluorocycline, consists of the tetracyclic core scaffold with unique modifications in the tetracyclic D ring; consequently, it exhibits potent in vitro activity against Gram-positive and -negative bacterial strains expressing certain common tetracycline-specific acquired...

journal_title：Drugs

authors： Scott LJ

更新日期：2019-02-01 00:00:00

abstract：:In type 1 and 2 diabetes mellitus patients, hyperglycaemia is independently related to the development of microvascular and macrovascular complications. Glycaemic targets and the benefits of intensive versus conventional glucose control are under debate. The purpose of this review is to provide an overview of the rand...

journal_title：Drugs

authors： Mattila TK,de Boer A

更新日期：2010-12-03 00:00:00

abstract：:Atenolol and nifedipine have been shown to be effective single agents in angina pectoris, but reports suggest that additional benefits may be conferred by combining the 2 drugs. Therefore, to establish that the combination regimen was at least as effective as either atenolol or nifedipine alone, a multicentre study wa...

journal_title：Drugs

authors： Sandberg M,Foale RA

更新日期：1988-01-01 00:00:00

abstract：:Nivolumab (Opdivo(®)) is a fully human monoclonal antibody against programmed death receptor-1, a negative regulatory checkpoint molecule with a role in immunosuppression. The drug is administered intravenously and is approved for the treatment of unresectable malignant melanoma in Japan. The potential for intravenous...

journal_title：Drugs

authors： Deeks ED

更新日期：2014-07-01 00:00:00

abstract：:During the last 2 decades, there has been a dramatic increase in the use of strong opioids for chronic non-cancer pain. This increase has been accompanied by a steep increase in abuse, misuse, and both fatal and non-fatal overdoses involving prescription opioids. The situation is already alarming in the US. Prescripti...

journal_title：Drugs

authors： Bannwarth B

更新日期：2012-09-10 00:00:00

abstract：:Along with nausea and vomiting, postanaesthetic shivering is one of the leading causes of discomfort for patients recovering from general anaesthesia. The distinguishing factor during electromyogram recordings between patients with postanaesthetic shivering and shivering in fully awake patients is the existence of clo...

journal_title：Drugs

authors： Alfonsi P

更新日期：2001-01-01 00:00:00

abstract：:The extra-oesophageal signs that are most commonly related to gastro-oesophageal reflux include chest pain, asthma, chronic cough, posterior laryngitis and dental erosions. It is characteristic to find in such patients a poor presence of symptoms and endoscopic and pH-metric findings that are common in typical reflux....

journal_title：Drugs

authors： Rodríguez-Téllez M

更新日期：2005-01-01 00:00:00

abstract：:Mortality and morbidity in gastroenteritis in children is the result of fluid loss, acid-base and electrolyte imbalance. Hence therapy should be aimed at preventing or correcting this imbalance. The use of intestinal antibiotics to treat the condition should not be a routine, but parenteral antibiotic therapy in the p...

journal_title：Drugs

authors： Tan G

更新日期：1976-01-01 00:00:00

abstract：:Nausea and vomiting continue to be critical problems in cancer chemotherapy, although considerable progress has been made toward understanding the neuropharmacological mechanisms of vomiting and how chemotherapeutic agents and antiemetics affect these mechanisms. The principles of behavioural psychology have also been...

journal_title：Drugs

authors： Triozzi PL,Laszlo J

更新日期：1987-07-01 00:00:00

abstract：UNLABELLED:Zolpidem is an imidazopyridine agent that is indicated for the short term (< or = 4 weeks) treatment of insomnia (recommended dosage 10 mg/day in adults and 5 or 10 mg/day in the elderly or patients with hepatic impairment). Data have shown that the hypnotic efficacy of zolpidem is generally comparable to th...

journal_title：Drugs

authors： Holm KJ,Goa KL

更新日期：2000-04-01 00:00:00

abstract：:The efficacy of cilazapril monotherapy was evaluated in 2 multicentre double-blind dose-response trials. After 4 weeks of a single-blind placebo run-in period, patients with uncomplicated mild to moderate essential hypertension and a sitting diastolic blood pressure of 100 to 115 mm Hg, 24 hours after the last placebo...

journal_title：Drugs

authors： Kobrin I,Güntzel P,Viskoper R,Paran E,Zimlichman R

更新日期：1991-01-01 00:00:00

abstract：:Pegaspargase (Oncaspar®), a pegylated form of native Escherichia coli-derived L-asparaginase (hereafter referred as E. coliL-asparaginase), is indicated in the USA and EU for the treatment of acute lymphoblastic leukaemia (ALL) as a component of multi-agent chemotherapy in paediatric and adult patients. Relative to E....

journal_title：Drugs

authors： Heo YA,Syed YY,Keam SJ

更新日期：2019-05-01 00:00:00

abstract：:Lung tissue remodelling in chronic inflammatory lung diseases has long been regarded as a follow-up event to inflammation. Recent studies have indicated that, although airway and lung tissue remodelling is often independent of inflammation, it precedes or causes inflammation. None of the available therapies has a sign...

journal_title：Drugs

authors： Roth M

更新日期：2015-01-01 00:00:00

abstract：:Vitamin A acid (retinoic acid: tretinoin) is a vitamin A derivative used in the topical treatment of acne. It acts by 'unseating' comedones, improvement developing slowly over a period of 2 to 3 or more months, and is also said to prevent the formation of new lesions. About three-quarters of patients with acne vulgari...

journal_title：Drugs

authors： Heel RC,Brogden RN,Speight TM,Avery GS

更新日期：1977-12-01 00:00:00

abstract：:Valsartan/hydrochlorothiazide is a fixed-dose (valsartan 80, 160 or 320mg plus hydrochlorothiazide 12.5 or 25mg) angiotensin II receptor blocker/diuretic drug combination indicated for the treatment of patients with essential hypertension not adequately controlled by monotherapy.There is ample evidence that valsartan/...

journal_title：Drugs

authors： Wagstaff AJ

更新日期：2006-01-01 00:00:00

abstract：:Anthracyclines are among the most active drugs for the treatment of advanced breast cancer. Epirubicin has been found to be as effective as doxorubicin at equimolar doses but significantly better tolerated, especially in terms of alopecia, leucopenia, and cardiac toxicity. The role of anthracycline-containing regimens...

journal_title：Drugs

authors： Fumoleau P,Devaux Y,Vo Van ML,Kerbrat P,Fargeot P,Schraub S,Mihura J,Namer M,Mercier M

更新日期：1993-01-01 00:00:00

abstract：:The concept of balanced analgesia was introduced to improve analgesic efficacy and reduce adverse effects. A large amount of clinical data has documented improved analgesia by combining different analgesics, but data on reducing adverse effects are inconclusive. Balanced analgesia should be used whenever possible, and...

journal_title：Drugs

authors： Kehlet H,Werner M,Perkins F

更新日期：1999-11-01 00:00:00

abstract：:Although venous thromboembolism has occasionally been reported after hospital discharge in patients who have undergone total hip replacement (THR), this risk has not been fully quantified and the usefulness of a prophylactic treatment has not been evaluated. We conducted a single-centre prospective randomised double-b...

journal_title：Drugs

authors： Planes A,Vochelle N,Darmon JY,Fagola M,Bellaud M,Compan D,Saliba E,Weisslinger N,Huet Y

更新日期：1996-01-01 00:00:00

abstract：:Schizophrenia is a severe mental illness characterised by abnormalities of thought and perception that affects 1-2% of the population. Patients who experience a first episode of schizophrenia should be treated early and optimally with antipsychotic agents to lessen the morbidity of the initial episode and possibly imp...

journal_title：Drugs

authors： Bradford DW,Perkins DO,Lieberman JA

更新日期：2003-01-01 00:00:00

abstract：:The treatment of a variety of inflammatory skin diseases was greatly changed by the introduction, in the early 1950s, of corticosteroids for topical use. Topical corticosteroids are still the most widely used drugs in dermatology, and many preparations with quite different potencies are now available. However, attempt...

journal_title：Drugs

authors： Ortonne JP

更新日期：1988-01-01 00:00:00