Abstract:
:Eravacycline (Xerava™), a novel fully synthetic fluorocycline, consists of the tetracyclic core scaffold with unique modifications in the tetracyclic D ring; consequently, it exhibits potent in vitro activity against Gram-positive and -negative bacterial strains expressing certain common tetracycline-specific acquired resistance mechanisms. In vitro, eravacycline exhibits potent activity against a broad spectrum of clinically relevant Gram-positive and -negative aerobic and anaerobic bacteria. Intravenous eravacycline is approved in several countries for the treatment of complicated intra-abdominal infections (cIAIs) in adult patients. In two pivotal double-blind, multinational trials in this patient population, eravacycline (infusion ≈ 1 h) was noninferior to intravenous ertapenem or meropenem at the test-of-cure visit in terms of clinical response rates in all prespecified populations. Eravacycline had an acceptable tolerability profile, with infusion site reactions, nausea, vomiting and diarrhoea the most commonly reported adverse reactions, most of which were of mild to moderate severity. Given its broad spectrum of activity against common clinically relevant pathogens (including those expressing certain tetracycline- and other antibacterial-specific acquired resistance mechanisms) and its more potent in vitro activity and better tolerability profile than tigecycline, eravacycline provides a novel emerging option for the treatment of adult patients with cIAIs, especially as empirical therapy when coverage of resistant pathogens is required.
journal_name
Drugsjournal_title
Drugsauthors
Scott LJdoi
10.1007/s40265-019-01067-3subject
Has Abstractpub_date
2019-02-01 00:00:00pages
315-324issue
3eissn
0012-6667issn
1179-1950pii
10.1007/s40265-019-01067-3journal_volume
79pub_type
杂志文章,评审相关文献
DRUGS文献大全abstract::Lemborexant (DAYVIGO™) is an orally administered, dual orexin receptor (OXR) antagonist that exhibits reversible competitive antagonism at OXR1 and OXR2 (> affinity at OXR2) that was discovered and developed by Eisai Inc. for the treatment of adult patients with insomnia. In December 2019, lemborexant received its fir...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-020-01276-1
更新日期:2020-03-01 00:00:00
abstract::Saxagliptin (Onglyza™) is a dipeptidyl peptidase 4 inhibitor widely approved for the treatment of type 2 diabetes mellitus. In the EU, saxagliptin is indicated as combination therapy with metformin, a sulfonylurea, a thiazolidinedione, or insulin (with or without metformin) for the treatment of adult patients with typ...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/11208160-000000000-00000
更新日期:2012-01-22 00:00:00
abstract::Acyclovir (aciclovir) is a nucleoside antiviral drug with antiviral activity in vitro against members of the herpes group of DNA viruses. As an established treatment of herpes simplex infection, intravenous, oral and to a lesser extent topical formulations of acyclovir provide significant therapeutic benefit in genita...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-198937030-00002
更新日期:1989-03-01 00:00:00
abstract::In a double-blind, crossover study we have investigated the effect of nedocromil sodium on neurokinin A (NKA)-induced bronchoconstriction in asthmatics. 12 patients with mild asthma inhaled either nedocromil sodium 4mg or placebo, on 2 separate days, as 2 puffs from a metered-dose aerosol 30 minutes before challenge w...
journal_title:Drugs
pub_type: 临床试验,杂志文章
doi:10.2165/00003495-198900371-00019
更新日期:1989-01-01 00:00:00
abstract::The potential beneficial effects of antihypertensive drugs on cardiovascular morbidity and mortality may be compromised by their adverse effects on serum lipid levels. In our study we compared verapamil and captopril and evaluated their effects on blood pressure and on serum lipid and lipoprotein levels, with particul...
journal_title:Drugs
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2165/00003495-199200441-00016
更新日期:1992-01-01 00:00:00
abstract::The incidence of infection in clean surgery (i.e. surgery with no major contamination of the operative site) should be less than 2%, although the incidence of postoperative infections can be higher in patients with various risk factors (namely insertion of foreign bodies, a compromised immune status or prolonged durat...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199700546-00008
更新日期:1997-01-01 00:00:00
abstract::Dementia is commonly diagnosed at a time of major domestic breakdown, when symptoms are severe and family and community patience has been eroded. In order to encourage early referral and identification of patients with treatable conditions, a Memory Clinic is held at the University Hospital in Cardiff. The clinic prov...
journal_title:Drugs
pub_type: 杂志文章
doi:10.2165/00003495-198700332-00016
更新日期:1987-01-01 00:00:00
abstract::Opioid dependence, manifesting as addiction to heroin and pharmaceutical opioids is increasing. Internationally, there are an estimated 15.6 million illicit opioid users. The global economic burden of opioid dependence is profound both in terms of HIV and hepatitis C virus transmission, direct healthcare costs, and in...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/11597520-000000000-00000
更新日期:2012-01-22 00:00:00
abstract::The Diabetes Control and Complications Trial and the Stockholm Study have conclusively demonstrated that improving the blood glucose control in patients with insulin-dependent diabetes mellitus (IDDM) reduces the risk of developing retinopathy, nephropathy and neuropathy. Each patient with IDDM should be carefully eva...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199447040-00005
更新日期:1994-04-01 00:00:00
abstract::Sitagliptin (Januvia(®), Xelevia™, Glactiv(®), Tesavel(®)) is an orally administered, potent and highly selective inhibitor of dipeptidyl peptidase-4 (DPP-4) and was the first agent of its class to be approved for use in the management of adults with type 2 diabetes. Numerous randomized placebo- or active comparator-c...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-013-0169-1
更新日期:2014-02-01 00:00:00
abstract::Many drugs have a site of action within the inner ear. The list includes therapeutic, diagnostic and ototoxic agents. Therapeutic agents are most useful in cases of infections, endolymphatic hydrops, vascular insufficiency, vertigo of peripheral origin, autoimmune disease, otosclerosis (otospongiosis), sudden hearing ...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-198836060-00005
更新日期:1988-12-01 00:00:00
abstract::Coronary arterial thrombolysis is becoming an established treatment of acute myocardial infarction. If given early enough, it recanalises occluded coronary arteries, salvages myocardial function and reduces mortality. A reduction of mortality in patients with acute myocardial infarction has now been demonstrated for s...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-198938030-00003
更新日期:1989-09-01 00:00:00
abstract::Alectinib (Alecensa(®)) is a second-generation, orally active, potent and highly selective inhibitor of anaplastic lymphoma kinase (ALK). Alectinib is approved for the treatment of ALK fusion-gene positive, unresectable, advanced or recurrent non-small cell lung cancer (NSCLC) in Japan, where it has been given orphan ...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-014-0329-y
更新日期:2015-01-01 00:00:00
abstract::Sulbactam is a semisynthetic beta-lactamase inhibitor which when combined with certain beta-lactam antibacterials extends their activity against bacteria that are normally resistant to the antibiotic due to production of beta-lactamases. In combination with ampicillin it extends the antibacterial activity of ampicilli...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-198733060-00003
更新日期:1987-06-01 00:00:00
abstract::Damoctocog alfa pegol (Jivi®) is approved in the USA, EU, Japan and Canada for the treatment and prophylaxis of previously treated patients aged ≥ 12 years with haemophilia A. Formulated with a 60 kDa polyethylene glycol (PEG) moiety, damoctocog alfa pegol is an intravenously (IV) administered recombinant factor VIII ...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-019-01152-7
更新日期:2019-07-01 00:00:00
abstract::Eight patients about to have the whole or part of a lung resected were given a 2g bolus dose of temocillin. A series of serum samples and a piece of peripheral lung tissue were collected and assayed for temocillin concentration. 30 minutes after drug administration, the mean serum and tissue concentrations were 172 mg...
journal_title:Drugs
pub_type: 杂志文章
doi:10.2165/00003495-198500295-00031
更新日期:1985-01-01 00:00:00
abstract::Diuretics are used in first-step antihypertensive monotherapy or in combination with adrenergic-inhibiting agents in the majority of hypertensive patients in the United States. A 30-year experience has demonstrated that blood pressure is lowered to as great or greater a degree with diuretics than when many of the pres...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-198600314-00007
更新日期:1986-01-01 00:00:00
abstract::Goserelin is a gonadotrophin-releasing hormone (GnRH) analogue which, during continuous administration, down-regulates the pituitary-ovarian gonadal axis and reduces levels of the gonadotrophins, luteinising hormone and follicle-stimulating hormone. In women, this results in suppression of ovarian steroidogenesis and ...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199651020-00009
更新日期:1996-02-01 00:00:00
abstract::The effects of enalapril on clinical well-being, treadmill exercise performance, haemodynamic measurements, hormone levels, and plasma biochemistry in patients with moderate heart failure, were assessed in a 12-week placebo-controlled, double-blind study. Maintenance frusemide and digoxin treatment was continued throu...
journal_title:Drugs
pub_type: 临床试验,杂志文章
doi:10.2165/00003495-198500301-00011
更新日期:1985-01-01 00:00:00
abstract::Canagliflozin (Invokana™), an oral selective sodium-glucose co-transporter 2 (SGLT2) inhibitor, is under global development with Mitsubishi Tanabe Pharma and Janssen Pharmaceuticals, a subsidiary of Johnson and Johnson, for the treatment of type 2 diabetes mellitus. SGLT2 are mainly located in the proximal tubule of t...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-013-0064-9
更新日期:2013-06-01 00:00:00
abstract::Acamprosate (Campral(®), Aotal(®), Regtect(®)) is one of a limited number of pharmacological treatment options approved as an adjunct to psychosocial interventions to facilitate the maintenance of abstinence in alcohol-dependent patients. It has been used in Europe, the USA and other countries for many years and was r...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-015-0423-9
更新日期:2015-07-01 00:00:00
abstract::Osteoarthritis, the most common rheumatic disease, presents the clinician with a major therapeutic and management task. The chronic and progressive course of the disease is punctuated by pain, declining function and escalating disability. This article attempts to deal with the pharmacological therapeutic options avail...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199141020-00005
更新日期:1991-02-01 00:00:00
abstract:INTRODUCTION:Authorization of orphan medicinal products (OMPs) is often based on studies with several methodological shortcomings. Hence, data are difficult to interpret and efficacy does not always correspond to real-world effectiveness. We investigated to what extent an efficacy-effectiveness gap exists for OMPs for ...
journal_title:Drugs
pub_type: 杂志文章
doi:10.1007/s40265-017-0788-z
更新日期:2017-09-01 00:00:00
abstract::Zaleplon is a pyrazolopyrimidine hypnotic agent which is indicated for the short term (2 to 4 weeks) management of insomnia. Zaleplon 5 and 10 mg at bedtime (usual recommended doses) significantly reduced sleep latency compared with placebo in clinical trials in nonelderly and elderly patients with insomnia. In genera...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200060020-00014
更新日期:2000-08-01 00:00:00
abstract::Evidence suggests that arterial hypertension, in addition to being a cardiovascular and renal risk factor, may also be associated with an impairment of male sexual function. Since other cardiovascular risk factors, especially diabetes mellitus, have also been shown to correlate with impaired sexual function it has bee...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200565060-00005
更新日期:2005-01-01 00:00:00
abstract::Iloprost is an analogue of epoprostenol (prostacyclin; PGI2; a potent but short-lived prostanoid mainly produced in the vascular endothelium) and mimics the pharmacodynamic properties of this compound, namely: inhibition of platelet aggregation, vasodilatation and, as yet ill-defined, cytoprotection. Improved metaboli...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199243060-00008
更新日期:1992-06-01 00:00:00
abstract::The newest (third generation) fluoroquinolones are potentially useful agents in the management of community-acquired respiratory tract infections. This is mainly due to their increased activity against Streptococcuspneumoniae, a pathogen poorly susceptible to the second-generation compounds, and playing a major role i...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199957060-00002
更新日期:1999-06-01 00:00:00
abstract::Isradipine, a dihydropyridine derivative, inhibits the inward calcium flux through 'slow' channels of cardiac and vascular tissue, thereby eliciting potent coronary, cerebral and peripheral vasodilatation. In comparison with other calcium channel blockers the drug offers the advantages of minimal cardiodepressant acti...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199040010-00004
更新日期:1990-07-01 00:00:00
abstract::Nateglinide is a novel D-phenylalanine derivative that inhibits ATP-sensitive K+ channels in pancreatic beta-cells in the presence of glucose and thereby stimulates the prandial release of insulin. Nateglinide reduces fasting and mealtime blood glucose levels in animals, healthy volunteers, and patients with type 2 (n...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200060030-00007
更新日期:2000-09-01 00:00:00
abstract::The most common health problem encountered in international travellers to topical and subtropical areas is diarrhoea. Even though it is not a life-threatening condition, it may influence deeply the quality of a vacation or the success of a business trip. The majority of cases of travellers' diarrhoea are due to bacter...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199856010-00007
更新日期:1998-07-01 00:00:00