Abstract:
:Pharmacotherapy for the management of obesity is primarily aimed at weight loss, weight loss maintenance and risk reduction, and has included thyroid hormone, amphetamines, phentermine, amfepramone (diethylpropion), phenylpropanolamine, mazindol, fenfluramines and, more recently, sibutramine and orlistat. These agents decrease appetite, reduce absorption of fat or increase energy expenditure. Primary endpoints used to evaluate anti-obesity drugs most frequently include mean weight loss, percentage weight loss and proportion of patients losing >or=5% and >or=10% of initial bodyweight. Secondary endpoints may include reduction in body fat, risk factors for cardiovascular disease and the incidences of diseases such as diabetes mellitus. Most pharmacotherapies have demonstrated significantly greater weight loss in patients on active treatment than those receiving placebo in short-term (
journal_name
Drugsjournal_title
Drugsauthors
Ioannides-Demos LL,Proietto J,McNeil JJdoi
10.2165/00003495-200565100-00006subject
Has Abstractpub_date
2005-01-01 00:00:00pages
1391-418issue
10eissn
0012-6667issn
1179-1950pii
65106journal_volume
65pub_type
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